SCN2B (sodium voltage-gated channel beta subunit 2) - Rat Genome Database

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Gene: SCN2B (sodium voltage-gated channel beta subunit 2) Canis lupus familiaris
Analyze
Symbol: SCN2B
Name: sodium voltage-gated channel beta subunit 2
RGD ID: 12210041
Description: ENCODES a protein that exhibits voltage-gated sodium channel activity (ortholog); INVOLVED IN cardiac conduction (ortholog); gene expression (ortholog); nervous system development (ortholog); ASSOCIATED WITH CD3epsilon deficiency (ortholog); Chromosome 11, Partial Trisomy 11q (ortholog); dilated cardiomyopathy (ortholog); FOUND IN T-tubule (ortholog); voltage-gated sodium channel complex (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cardiomyocyte sodium channel beta-2 subunit; sodium channel subunit beta-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1515,514,760 - 15,534,179 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl515,521,481 - 15,534,179 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha515,572,346 - 15,585,043 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0515,463,692 - 15,476,337 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl515,456,869 - 15,476,337 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1515,601,775 - 15,614,477 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0515,505,329 - 15,518,028 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0515,546,638 - 15,559,352 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:21705762   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SCN2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1515,514,760 - 15,534,179 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl515,521,481 - 15,534,179 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha515,572,346 - 15,585,043 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0515,463,692 - 15,476,337 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl515,456,869 - 15,476,337 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1515,601,775 - 15,614,477 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0515,505,329 - 15,518,028 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0515,546,638 - 15,559,352 (+)NCBIUU_Cfam_GSD_1.0
SCN2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811118,162,806 - 118,176,639 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11118,162,806 - 118,176,639 (-)EnsemblGRCh38hg38GRCh38
GRCh3711118,033,521 - 118,047,354 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611117,538,729 - 117,552,546 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411117,538,728 - 117,552,546NCBI
Celera11115,191,374 - 115,205,190 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11113,967,183 - 113,980,997 (-)NCBIHuRef
CHM1_111117,919,350 - 117,933,166 (-)NCBICHM1_1
T2T-CHM13v2.011118,179,198 - 118,193,026 (-)NCBIT2T-CHM13v2.0
Scn2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39945,029,174 - 45,041,368 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl945,029,080 - 45,041,368 (+)EnsemblGRCm39 Ensembl
GRCm38945,117,876 - 45,130,070 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl945,117,782 - 45,130,070 (+)EnsemblGRCm38mm10GRCm38
MGSCv37944,925,959 - 44,938,153 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36944,868,876 - 44,881,065 (+)NCBIMGSCv36mm8
Celera942,393,438 - 42,405,653 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
Scn2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8854,322,383 - 54,334,519 (+)NCBIGRCr8
mRatBN7.2845,425,629 - 45,437,765 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl845,425,629 - 45,437,765 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx850,921,042 - 50,933,209 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0849,199,783 - 49,211,951 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0847,070,360 - 47,082,527 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0849,419,003 - 49,431,110 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl849,418,965 - 49,427,689 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0848,045,397 - 48,057,559 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4848,068,843 - 48,078,632 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1848,077,608 - 48,087,398 (+)NCBI
Celera845,010,175 - 45,018,724 (+)NCBICelera
Cytogenetic Map8q22NCBI
Scn2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541219,340,947 - 19,354,062 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541219,341,008 - 19,353,563 (-)NCBIChiLan1.0ChiLan1.0
SCN2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29118,863,121 - 118,876,923 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111119,968,076 - 119,981,881 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011112,996,609 - 113,010,412 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111116,928,676 - 116,942,506 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11116,928,676 - 116,942,500 (-)Ensemblpanpan1.1panPan2
Scn2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947100,340,752 - 100,353,142 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365423,261,533 - 3,274,623 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365423,262,161 - 3,274,545 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCN2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl945,484,998 - 45,498,465 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1945,484,994 - 45,502,578 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2950,526,026 - 50,543,574 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SCN2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11109,538,694 - 109,552,745 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1109,538,652 - 109,552,740 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604316,476,980 - 16,490,889 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scn2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478413,580,313 - 13,593,169 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478413,580,427 - 13,593,055 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SCN2B
253 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6
Low 5 2 12 2 6 4 8 6 6
Below cutoff 3 10 6 4 6 6 2 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000045172   ⟹   ENSCAFP00000042471
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl515,521,481 - 15,534,179 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004871   ⟹   ENSCAFP00845003895
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl515,456,869 - 15,476,337 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004884   ⟹   ENSCAFP00845003904
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl515,463,633 - 15,476,337 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004895   ⟹   ENSCAFP00845003911
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl515,466,753 - 15,476,337 (+)Ensembl
RefSeq Acc Id: NM_001168459   ⟹   NP_001161931
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1515,521,481 - 15,534,179 (+)NCBI
Dog10K_Boxer_Tasha515,572,346 - 15,585,043 (+)NCBI
ROS_Cfam_1.0515,463,692 - 15,476,337 (+)NCBI
UMICH_Zoey_3.1515,601,775 - 15,614,477 (+)NCBI
UNSW_CanFamBas_1.0515,505,329 - 15,518,028 (+)NCBI
UU_Cfam_GSD_1.0515,546,638 - 15,559,352 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038664052   ⟹   XP_038519980
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0515,466,533 - 15,476,337 (+)NCBI
RefSeq Acc Id: XM_038664054   ⟹   XP_038519982
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0515,466,782 - 15,476,337 (+)NCBI
RefSeq Acc Id: XM_038664055   ⟹   XP_038519983
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0515,464,889 - 15,476,337 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001161931   ⟸   NM_001168459
- Peptide Label: precursor
- UniProtKB: Q864L3 (UniProtKB/Swiss-Prot),   A0A8C0JL81 (UniProtKB/TrEMBL),   A0A8C0MN25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000042471   ⟸   ENSCAFT00000045172
RefSeq Acc Id: XP_038519983   ⟸   XM_038664055
- Peptide Label: isoform X3
- UniProtKB: Q864L3 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038519980   ⟸   XM_038664052
- Peptide Label: isoform X1
- UniProtKB: Q864L3 (UniProtKB/Swiss-Prot),   A0A8I3MN22 (UniProtKB/TrEMBL),   A0A8P0PLU4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038519982   ⟸   XM_038664054
- Peptide Label: isoform X2
- UniProtKB: Q864L3 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSCAFP00845003904   ⟸   ENSCAFT00845004884
RefSeq Acc Id: ENSCAFP00845003895   ⟸   ENSCAFT00845004871
RefSeq Acc Id: ENSCAFP00845003911   ⟸   ENSCAFT00845004895
Protein Domains
Ig-like   Ig-like C2-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029322 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008827 UniProtKB/TrEMBL
  ENSCAFG00040001373 UniProtKB/TrEMBL
  ENSCAFG00845002736 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000045172.3 UniProtKB/TrEMBL
  ENSCAFT00000094414.1 UniProtKB/TrEMBL
  ENSCAFT00000097982.1 UniProtKB/TrEMBL
  ENSCAFT00030016313.1 UniProtKB/TrEMBL
  ENSCAFT00040002597.1 UniProtKB/TrEMBL
  ENSCAFT00845004871 ENTREZGENE
  ENSCAFT00845004871.1 UniProtKB/TrEMBL
  ENSCAFT00845004884 ENTREZGENE
  ENSCAFT00845004884.1 UniProtKB/TrEMBL
  ENSCAFT00845004895 ENTREZGENE
  ENSCAFT00845004895.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myelin_P0-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403485 UniProtKB/TrEMBL
NCBI Gene SCN2B ENTREZGENE
PANTHER PTHR13869 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13869:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MYELINP0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGv UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0JL81 ENTREZGENE
  A0A8C0MN25 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MME7_CANLF UniProtKB/TrEMBL
  A0A8I3MN22 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RSE8_CANLF UniProtKB/TrEMBL
  A0A8P0NT77_CANLF UniProtKB/TrEMBL
  A0A8P0PLU4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TQ50_CANLF UniProtKB/TrEMBL
  Q864L3 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:45917 ENTREZGENE