THOC1 (THO complex subunit 1) - Rat Genome Database

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Gene: THOC1 (THO complex subunit 1) Canis lupus familiaris
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Symbol: THOC1
Name: THO complex subunit 1
RGD ID: 12199503
Description: INVOLVED IN mRNA export from nucleus (inferred); regulation of DNA-templated transcription elongation (inferred); signal transduction (inferred); PARTICIPATES IN NXF1-NXT1 export pathway; ASSOCIATED WITH autistic disorder (ortholog); Autosomal Dominant Nonsyndromic Deafness 86 (ortholog); genetic disease (ortholog); FOUND IN chromosome, telomeric region (inferred); cytoplasm (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: THO complex 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1767,082,100 - 67,136,592 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl767,082,231 - 67,136,525 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha766,535,949 - 66,590,326 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0767,147,395 - 67,201,773 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl767,147,409 - 67,364,861 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1766,811,589 - 66,865,828 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0766,835,972 - 66,890,373 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0767,138,026 - 67,192,666 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
THOC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1767,082,100 - 67,136,592 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl767,082,231 - 67,136,525 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha766,535,949 - 66,590,326 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0767,147,395 - 67,201,773 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl767,147,409 - 67,364,861 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1766,811,589 - 66,865,828 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0766,835,972 - 66,890,373 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0767,138,026 - 67,192,666 (-)NCBIUU_Cfam_GSD_1.0
THOC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3818214,520 - 268,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl18214,520 - 268,050 (-)EnsemblGRCh38hg38GRCh38
GRCh3718214,520 - 268,047 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3618204,520 - 258,059 (-)NCBINCBI36Build 36hg18NCBI36
Build 3418204,521 - 258,023NCBI
Celera1889,677 - 143,220 (-)NCBICelera
Cytogenetic Map18p11.32NCBI
HuRef18174,232 - 227,731 (-)NCBIHuRef
CHM1_118213,796 - 267,049 (-)NCBICHM1_1
T2T-CHM13v2.018368,271 - 422,046 (-)NCBIT2T-CHM13v2.0
Thoc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39189,958,176 - 9,995,486 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl189,957,906 - 9,995,489 (+)EnsemblGRCm39 Ensembl
GRCm38189,958,180 - 9,995,484 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl189,957,906 - 9,995,489 (+)EnsemblGRCm38mm10GRCm38
MGSCv37189,958,178 - 9,995,482 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36189,958,178 - 9,995,482 (+)NCBIMGSCv36mm8
Celera189,987,590 - 10,024,843 (+)NCBICelera
Cytogenetic Map18A1NCBI
cM Map184.91NCBI
Thoc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8181,253,041 - 1,291,956 (+)NCBIGRCr8
mRatBN7.218983,824 - 1,019,123 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl18983,824 - 1,019,114 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx181,210,687 - 1,246,930 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0181,998,516 - 2,034,760 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0181,212,584 - 1,248,828 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,142,540 - 1,177,084 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,142,782 - 1,176,974 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,185,400 - 1,220,171 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,256,731 - 1,290,988 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1181,256,490 - 1,292,340 (+)NCBI
Celera18877,009 - 911,268 (+)NCBICelera
Cytogenetic Map18p13NCBI
Thoc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554029,675,204 - 9,708,045 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554029,675,211 - 9,708,045 (+)NCBIChiLan1.0ChiLan1.0
THOC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21738,229,329 - 38,279,621 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11823,921,934 - 23,972,214 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01814,052,858 - 14,102,559 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11817,692,797 - 17,742,572 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1817,692,797 - 17,742,570 (+)Ensemblpanpan1.1panPan2
Thoc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494463,177,925 - 63,226,024 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936550590,058 - 641,390 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936550590,119 - 638,152 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THOC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6106,040,042 - 106,088,021 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16106,039,262 - 106,088,125 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
THOC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11859,624,623 - 59,676,133 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1859,624,729 - 59,676,117 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605034,414,870 - 34,466,454 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thoc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477010,771,785 - 10,811,287 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in THOC1
530 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 16 6 6 11 8 10 4
Low 1 5 6 6 6 6 1 2
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000029114   ⟹   ENSCAFP00000027073
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl767,082,231 - 67,136,525 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000045552   ⟹   ENSCAFP00000036832
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl767,112,050 - 67,136,525 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845002857   ⟹   ENSCAFP00845002275
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl767,147,409 - 67,201,698 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845002895   ⟹   ENSCAFP00845002307
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl767,160,002 - 67,364,861 (-)Ensembl
RefSeq Acc Id: XM_038482260   ⟹   XP_038338188
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1766,811,589 - 66,865,828 (-)NCBI
RefSeq Acc Id: XM_038543697   ⟹   XP_038399625
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0767,138,026 - 67,192,666 (-)NCBI
RefSeq Acc Id: XM_038607822   ⟹   XP_038463750
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0766,835,972 - 66,890,373 (-)NCBI
RefSeq Acc Id: XM_038672504   ⟹   XP_038528432
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0767,147,395 - 67,201,773 (-)NCBI
RefSeq Acc Id: XM_547651   ⟹   XP_547651
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1767,082,100 - 67,136,592 (-)NCBI
Dog10K_Boxer_Tasha766,535,949 - 66,590,326 (-)NCBI
Sequence:
RefSeq Acc Id: XP_547651   ⟸   XM_547651
- UniProtKB: A0A8C0KZP7 (UniProtKB/TrEMBL),   A0A8C0NVM3 (UniProtKB/TrEMBL),   A0A8I3ML03 (UniProtKB/TrEMBL),   A0A8C0PQ11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000036832   ⟸   ENSCAFT00000045552
RefSeq Acc Id: ENSCAFP00000027073   ⟸   ENSCAFT00000029114
RefSeq Acc Id: XP_038338188   ⟸   XM_038482260
RefSeq Acc Id: XP_038463750   ⟸   XM_038607822
RefSeq Acc Id: XP_038528432   ⟸   XM_038672504
- UniProtKB: A0A8C0KZP7 (UniProtKB/TrEMBL),   A0A8C0NVM3 (UniProtKB/TrEMBL),   A0A8I3ML03 (UniProtKB/TrEMBL),   A0A8C0PQ11 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038399625   ⟸   XM_038543697
- UniProtKB: A0A8C0KZP7 (UniProtKB/TrEMBL),   A0A8C0NVM3 (UniProtKB/TrEMBL),   A0A8C0PQ11 (UniProtKB/TrEMBL),   A0A8I3ML03 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845002307   ⟸   ENSCAFT00845002895
RefSeq Acc Id: ENSCAFP00845002275   ⟸   ENSCAFT00845002857
Protein Domains
Death

Promoters
RGD ID:13684089
Promoter ID:EPDNEW_C2157
Type:multiple initiation site
Name:THOC1_1
Description:THO complex 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1767,136,552 - 67,136,612EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018324 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030016205 UniProtKB/TrEMBL
  ENSCAFG00040001120 UniProtKB/TrEMBL
  ENSCAFG00845001637 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000029114.6 UniProtKB/TrEMBL
  ENSCAFT00000045552.3 UniProtKB/TrEMBL
  ENSCAFT00030029826.1 UniProtKB/TrEMBL
  ENSCAFT00030029912.1 UniProtKB/TrEMBL
  ENSCAFT00030030063.1 UniProtKB/TrEMBL
  ENSCAFT00040002095.1 UniProtKB/TrEMBL
  ENSCAFT00040002135.1 UniProtKB/TrEMBL
  ENSCAFT00040002163.1 UniProtKB/TrEMBL
  ENSCAFT00845002857 ENTREZGENE
  ENSCAFT00845002857.1 UniProtKB/TrEMBL
  ENSCAFT00845002895.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  THO_THOC1 UniProtKB/TrEMBL
KEGG Report cfa:490529 UniProtKB/TrEMBL
NCBI Gene THOC1 ENTREZGENE
PANTHER PTHR13265 UniProtKB/TrEMBL
  THO COMPLEX SUBUNIT 1 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  efThoc1 UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
SMART DEATH UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
UniProt A0A8C0KZP7 ENTREZGENE
  A0A8C0NFW8_CANLF UniProtKB/TrEMBL
  A0A8C0NVM3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PQ11 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RLI8_CANLF UniProtKB/TrEMBL
  A0A8I3ME90_CANLF UniProtKB/TrEMBL
  A0A8I3ML03 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:47348 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-29 THOC1  THO complex subunit 1  THOC1  THO complex 1  Symbol and/or name change 19259463 PROVISIONAL