PMEL (premelanosome protein) - Rat Genome Database

Name: PMEL
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: PMEL (premelanosome protein) Canis lupus familiaris

Analyze

Symbol:

PMEL

Name:

premelanosome protein

RGD ID:

12194613

Description:

ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN melanin biosynthetic process (ortholog); ASSOCIATED WITH coat/hair pigmentation trait; genetic disease (ortholog); melanoma (ortholog); FOUND IN cis-Golgi network membrane (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

melanocyte protein PMEL; Pmel17; pre-melanosomal protein 17; SILV

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PMEL (premelanosome protein)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Pmel (premelanosome protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Pmel (premelanosome protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pmel (premelanosome protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PMEL (premelanosome protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pmel (premelanosome protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PMEL (premelanosome protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PMEL (premelanosome protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pmel (premelanosome protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	292,595 - 327,618 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	292,597 - 300,098 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	354,530 - 362,031 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	299,404 - 334,246 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	299,405 - 306,904 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	277,211 - 284,717 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	519,995 - 527,495 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	644,259 - 651,766 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Experimental Data Annotations Click to see Annotation Detail View

Vertebrate Trait

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
coat/hair pigmentation trait		IAGP		12801476	Coat colour and merle	OMIA	PMID:330141 more ...

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

melanoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

melanin biosynthetic process (IEA,ISO)

melanosome organization (IEA)

positive regulation of melanin biosynthetic process (IEA)

Cellular Component

cis-Golgi network membrane (IEA)

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

extracellular exosome (IEA)

Golgi apparatus (IEA)

melanosome (IEA)

melanosome membrane (IEA)

membrane (IEA)

multivesicular body membrane (IEA)

multivesicular body, internal vesicle (IEA)

Molecular Function

identical protein binding (IEA)

protein binding (ISO)

Experimental Data Annotations Click to see Annotation Detail View

Vertebrate Trait

coat/hair pigmentation trait (IAGP)

References

Additional References at PubMed

PMID:16407134	PMID:17931401	PMID:18052939	PMID:30032202	PMID:31238727	PMID:32560567	PMID:34370083

Genomics

Comparative Map Data

PMEL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	292,595 - 327,618 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	292,597 - 300,098 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	354,530 - 362,031 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	299,404 - 334,246 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	299,405 - 306,904 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	277,211 - 284,717 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	519,995 - 527,495 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	644,259 - 651,766 (-)	NCBI		UU_Cfam_GSD_1.0

PMEL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	55,954,105 - 55,966,709 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	55,954,105 - 55,973,317 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	56,347,889 - 56,360,493 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	54,634,156 - 54,646,093 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	54,634,156 - 54,646,093	NCBI
Celera	12	56,000,543 - 56,012,534 (-)	NCBI		Celera
Cytogenetic Map	12	q13.2	NCBI
HuRef	12	53,386,917 - 53,399,406 (-)	NCBI		HuRef
CHM1_1	12	56,315,023 - 56,327,629 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	55,921,167 - 55,933,772 (-)	NCBI		T2T-CHM13v2.0

Pmel
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	128,531,757 - 128,555,993 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	128,540,064 - 128,556,107 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	128,695,888 - 128,720,238 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	128,704,195 - 128,720,238 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	128,143,314 - 128,157,294 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	128,109,207 - 128,123,073 (+)	NCBI		MGSCv36	mm8
Celera	10	131,098,390 - 131,112,396 (+)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	77.13	NCBI

Pmel
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	1,721,948 - 1,733,248 (+)	NCBI		GRCr8
mRatBN7.2	7	1,138,202 - 1,148,735 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	1,138,586 - 1,148,746 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	7	3,133,347 - 3,143,827 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	3,133,506 - 3,143,911 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	3,105,316 - 3,116,614 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	2,007,882 - 2,018,998 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	2,008,881 - 2,018,859 (+)	NCBI
Celera	7	1,008,541 - 1,019,007 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

Pmel
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	3,544,961 - 3,554,619 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	3,544,855 - 3,555,453 (-)	NCBI	ChiLan1.0	ChiLan1.0

PMEL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	38,363,001 - 38,374,882 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	38,359,773 - 38,371,654 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	32,946,951 - 32,958,205 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	33,196,656 - 33,207,610 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	33,196,040 - 33,207,610 (+)	Ensembl	panpan1.1		panPan2

Pmel
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	58,491,116 - 58,502,171 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936646	365,809 - 379,130 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936646	368,064 - 379,085 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PMEL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	21,355,619 - 21,364,987 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	21,355,611 - 21,365,609 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PMEL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	51,892,131 - 51,905,073 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	51,887,730 - 51,904,324 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	194,082,197 - 194,095,017 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pmel
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	12,083,090 - 12,092,767 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624802	12,073,932 - 12,092,885 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in PMEL
475 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium										8
Low			15	1	2	1	5		11		6	6
Below cutoff	5	5	7	5	4	5	1	5	1		4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001103216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022423998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022423999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022424000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022424001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022424002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022424003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022424004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022424005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038678780	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038678781	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038678782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038678783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038678784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038678785	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038678787	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038678788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ306880	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EF090519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EF601583	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000097	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	MG733981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	MG739568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000000132 ⟹ ENSCAFP00000000115

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	292,597 - 300,098 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000060394 ⟹ ENSCAFP00000050108

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	292,597 - 300,093 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000064306 ⟹ ENSCAFP00000045181

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	292,597 - 298,088 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000084493 ⟹ ENSCAFP00000046863

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	292,597 - 300,093 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845010244 ⟹ ENSCAFP00845007977

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	299,405 - 306,904 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845010252 ⟹ ENSCAFP00845007984

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	299,405 - 306,904 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845010266 ⟹ ENSCAFP00845007996

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	299,405 - 304,899 (-)	Ensembl

RefSeq Acc Id:

NM_001103216 ⟹ NP_001096686

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	10	292,597 - 300,098 (-)	NCBI
Dog10K_Boxer_Tasha	10	354,530 - 362,031 (-)	NCBI
ROS_Cfam_1.0	10	299,405 - 306,909 (-)	NCBI
UMICH_Zoey_3.1	10	277,211 - 284,717 (-)	NCBI
UNSW_CanFamBas_1.0	10	519,995 - 527,495 (-)	NCBI
UU_Cfam_GSD_1.0	10	644,259 - 651,766 (-)	NCBI

Sequence:

show sequence

ACAAGATGAATCTGGTGCCGAGAAAATGCCTTCTCCATGTGGCTGTGATGGGTGTTCTTCTGGC
TGTGGGGGCCACAGAAGGACCCAGAGACCAGGACTGGCTTGGTGTCCCAAGGCAGCTCACAACT
AAAGCCTGGAACAGACAGCTGTATCCAGAGTGGACAGAAACCCAGAGGCCTGACTGCTGGAGAG
GTGGCCAGGTGTCCCTGAAGGTCAGTAATGATGGGCCTACACTGGTTGGTGCAAATGCCTCCTT
CTCTATTGCCCTGCACTTCCCTGAAAGCCAAAAGGTACTGCCAGATGGGCAGGTTGTCTGGGCC
AACAACACTATCATCGATGGGAGCCAGGTGTGGGGAGGACAGCCAGTGTATCCCCAGGTACTTG
ATGATGCCTGCATCTTCCCTGATGGGAGGGCCTGCCCATCTGGCCCTTGGTCTCAGACAAGAAG
CTTTGTTTATGTCTGGAAGACCTGGGGCCAATACTGGCAAGTTCTGGGGGGTCCAGTGTCTGGG
CTGAGCATTGTGACAGGCAAGGCGGTGCTGGGCACACATACCATGGAAGTGACTGTCTACCACC
GCCGGGAGTCCCAGAGCTACGTGCCCCTTGCTCACTCCTGCTCAGCCTTCACCATTACTGACCA
GGTGCCCTTCTCCGTGAGTGTGTCTCAGCTGCAGGCCTTGGATGGAGGGAACAAGCATTTCCTG
AGAAATCATCCTCTGACCTTTGCCCTCCGGCTCCATGACCCCAGCGGCTATTTGTCTGGGGCTG
ACCTCTCCTACACCTGGGACTTTGGAGACCATACCGGGACCCTGATCTCTCGGGCACTTGTGGT
CACTCACACTTACCTAGAGTCTGGCCCAATCACTGCCCAGGTGGTCCTGCAGGCTGCCATTCCT
CTCACTTCCTGTGGCTCCTCCCCAGTTCCAGTCACCACAGATGGGCATGCGCCAACTGCAGAGA
TCCCTGGCACCACAGCTGGGCGAGTGCCTACTGCAGAAGTCATAAGTACTACACCTGGTCAGGT
GCCAACTGCAGAGCCCTCGGGAGCAACAGCAGTGCAGATGACGACCACGGAGGTCACAGGCACT
ACGCTTGCACAGATGCCAACTACAGAGGGCATAGGTACTACACCTGAGCAGGTGCCAACCTCAG
AGGTCATAAGTACCACACTTGCAGAGACCACAGGTACAACACCTGAAGGGTCAACCGCAGAGCC
CTCTGGAACCACAGGCGAGCAGGTAACGACTAAAGAGTCAGTGGAGCCCACAGCTGGAGAGGGA
CCCACGCCTGAGACCAAGGGTCCAGATACCAATCTGTTCGTGCCTACAGAAGGTATTACAGGTT
CCCAGAGCGCCCTGCTGGATGGCACAGCTACCTTAATCCTGGCAAAGCGAGAAACCCCCCTGGA
TTGTGTTCTGTATCGATATGGCTCCTTTTCTCTCACCCTGGACATTGTCCGGGGTATTGAGAAT
GCTGAGATCCTGCAGGCTGTGCCATCCAGTGAAGGGGATGCATTTGAGCTGACTGTGTCTTGCC
AAGGCGGACTGCCCAAGGAAGCCTGCATGGACATCTCATCACCAGGGTGCCAGCCCCCTGCCCA
GAGGCTATGTCAGCCTGTGCCGCCCAGCCCAGCCTGCCAGCTGGTTTTGCACCAAGTGCTGAAG
GGTGGCTCAGGGACCTACTGCCTCAATGTGTCTTTGGCTGATGCTAACAGTCTGGCAATGGTCA
GCACTCAGCTTGTAATGCCTGGTCAAGAAGCAGGCGTTGGACAGGCTCCCCTGTTCATGGGCAT
CTTGCTGGTGTTGCTGGCTATGGTGCTGGTATCTCTGATATATAGGCGAAGACTTCTGAAGCAG
GGCTCAGCTCTCCCCCTTCCCCAGCTACCACGTGGTAGCACCCACTGGCTACGCCTGCCCCAGG
TCTTCCGCTCTTGCCCCATTGGTGAGAACAGACCCCTCCTCAATGGGCAGCAGCAGGTCTGAGG
ACTCTCATGTGATGCTGTGATTTGCCGAGGGTGGACAGCAATGCCTATCTTTTCTCCAGACTTC
CCTTGGAGACTACCATTACCTGAAATAAATACTCAGAACCTG

hide sequence

RefSeq Acc Id:

XM_038678780 ⟹ XP_038534708

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	10	299,404 - 334,246 (-)	NCBI

RefSeq Acc Id:

XM_038678781 ⟹ XP_038534709

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	10	299,404 - 314,654 (-)	NCBI

RefSeq Acc Id:

XM_038678782 ⟹ XP_038534710

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	10	299,404 - 334,246 (-)	NCBI

RefSeq Acc Id:

XM_038678783 ⟹ XP_038534711

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	10	299,404 - 334,246 (-)	NCBI

RefSeq Acc Id:

XM_038678784 ⟹ XP_038534712

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	10	299,404 - 315,549 (-)	NCBI

RefSeq Acc Id:

XM_038678785 ⟹ XP_038534713

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	10	299,404 - 310,410 (-)	NCBI

RefSeq Acc Id:

XM_038678787 ⟹ XP_038534715

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	10	299,404 - 334,246 (-)	NCBI

RefSeq Acc Id:

XM_038678788 ⟹ XP_038534716

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	10	299,404 - 334,246 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001096686	(Get FASTA)	NCBI Sequence Viewer
	XP_038534708	(Get FASTA)	NCBI Sequence Viewer
	XP_038534709	(Get FASTA)	NCBI Sequence Viewer
	XP_038534710	(Get FASTA)	NCBI Sequence Viewer
	XP_038534711	(Get FASTA)	NCBI Sequence Viewer
	XP_038534712	(Get FASTA)	NCBI Sequence Viewer
	XP_038534713	(Get FASTA)	NCBI Sequence Viewer
	XP_038534715	(Get FASTA)	NCBI Sequence Viewer
	XP_038534716	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABK76293	(Get FASTA)	NCBI Sequence Viewer
	ABU88099	(Get FASTA)	NCBI Sequence Viewer
	AXB87342	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000000115.5
	ENSCAFP00000046863.1
	ENSCAFP00000050108.1
	ENSCAFP00030026170.1
	ENSCAFP00030026208.1
	ENSCAFP00030026270.1
	ENSCAFP00030026317.1
	ENSCAFP00030026371.1
	ENSCAFP00030026431.1
	ENSCAFP00030026483.1
	ENSCAFP00040006404.1
	ENSCAFP00040006427.1
	ENSCAFP00040006434.1
	ENSCAFP00845007977.1
	ENSCAFP00845007984.1
	ENSCAFP00845007996
	ENSCAFP00845007996.1

RefSeq Acc Id:	NP_001096686 ⟸ NM_001103216
- Peptide Label:	precursor
- UniProtKB:	A0A8C0NRE6 (UniProtKB/TrEMBL), A0A8P0N3A4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNLVPRKCLLHVAVMGVLLAVGATEGPRDQDWLGVPRQLTTKAWNRQLYPEWTETQRPDCWRGG QVSLKVSNDGPTLVGANASFSIALHFPESQKVLPDGQVVWANNTIIDGSQVWGGQPVYPQVLDD ACIFPDGRACPSGPWSQTRSFVYVWKTWGQYWQVLGGPVSGLSIVTGKAVLGTHTMEVTVYHRR ESQSYVPLAHSCSAFTITDQVPFSVSVSQLQALDGGNKHFLRNHPLTFALRLHDPSGYLSGADL SYTWDFGDHTGTLISRALVVTHTYLESGPITAQVVLQAAIPLTSCGSSPVPVTTDGHAPTAEIP GTTAGRVPTAEVISTTPGQVPTAEPSGATAVQMTTTEVTGTTLAQMPTTEGIGTTPEQVPTSEV ISTTLAETTGTTPEGSTAEPSGTTGEQVTTKESVEPTAGEGPTPETKGPDTNLFVPTEGITGSQ SALLDGTATLILAKRETPLDCVLYRYGSFSLTLDIVRGIENAEILQAVPSSEGDAFELTVSCQG GLPKEACMDISSPGCQPPAQRLCQPVPPSPACQLVLHQVLKGGSGTYCLNVSLADANSLAMVST QLVMPGQEAGVGQAPLFMGILLVLLAMVLVSLIYRRRLLKQGSALPLPQLPRGSTHWLRLPQVF RSCPIGENRPLLNGQQQV hide sequence

RefSeq Acc Id:

ENSCAFP00000045181 ⟸ ENSCAFT00000064306

RefSeq Acc Id:

ENSCAFP00000050108 ⟸ ENSCAFT00000060394

RefSeq Acc Id:

ENSCAFP00000046863 ⟸ ENSCAFT00000084493

RefSeq Acc Id:

ENSCAFP00000000115 ⟸ ENSCAFT00000000132

RefSeq Acc Id:	XP_038534711 ⟸ XM_038678783
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0NRE6 (UniProtKB/TrEMBL), A0A8P0N3A4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038534708 ⟸ XM_038678780
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0NRE6 (UniProtKB/TrEMBL), A0A8P0N3A4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038534716 ⟸ XM_038678788
- Peptide Label:	isoform X4
- UniProtKB:	A0A8C0NRE6 (UniProtKB/TrEMBL), A0A8P0N3A4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038534710 ⟸ XM_038678782
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0NRE6 (UniProtKB/TrEMBL), A0A8P0N3A4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038534715 ⟸ XM_038678787
- Peptide Label:	isoform X4
- UniProtKB:	A0A8C0NRE6 (UniProtKB/TrEMBL), A0A8P0N3A4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038534712 ⟸ XM_038678784
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0NRE6 (UniProtKB/TrEMBL), A0A8P0N3A4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038534709 ⟸ XM_038678781
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0NRE6 (UniProtKB/TrEMBL), A0A8P0N3A4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038534713 ⟸ XM_038678785
- Peptide Label:	isoform X4
- UniProtKB:	A0A8C0NRE6 (UniProtKB/TrEMBL), A0A8P0N3A4 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845007977 ⟸ ENSCAFT00845010244

RefSeq Acc Id:

ENSCAFP00845007996 ⟸ ENSCAFT00845010266

RefSeq Acc Id:

ENSCAFP00845007984 ⟸ ENSCAFT00845010252

Protein Domains

PKAT KLD PKD

Promoters

RGD ID:

13684862

Promoter ID:

EPDNEW_C2930

Type:

single initiation site

Name:

PMEL_1

Description:

premelanosome protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	10	308,106 - 308,166	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000000080	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030016260	UniProtKB/TrEMBL
	ENSCAFG00040003852	UniProtKB/TrEMBL
	ENSCAFG00845005780	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000000132.5	UniProtKB/TrEMBL
	ENSCAFT00000060394.2	UniProtKB/TrEMBL
	ENSCAFT00000084493.2	UniProtKB/TrEMBL
	ENSCAFT00030030015.1	UniProtKB/TrEMBL
	ENSCAFT00030030056.1	UniProtKB/TrEMBL
	ENSCAFT00030030123.1	UniProtKB/TrEMBL
	ENSCAFT00030030177.1	UniProtKB/TrEMBL
	ENSCAFT00030030237.1	UniProtKB/TrEMBL
	ENSCAFT00030030310.1	UniProtKB/TrEMBL
	ENSCAFT00030030372.1	UniProtKB/TrEMBL
	ENSCAFT00040007354.1	UniProtKB/TrEMBL
	ENSCAFT00040007377.1	UniProtKB/TrEMBL
	ENSCAFT00040007385.1	UniProtKB/TrEMBL
	ENSCAFT00845010244.1	UniProtKB/TrEMBL
	ENSCAFT00845010252.1	UniProtKB/TrEMBL
	ENSCAFT00845010266	ENTREZGENE
	ENSCAFT00845010266.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	Ig-like_fold	UniProtKB/TrEMBL
	PKAT	UniProtKB/TrEMBL
	PKAT_KLD	UniProtKB/TrEMBL
	PKD/Chitinase_dom	UniProtKB/TrEMBL
	PKD_dom	UniProtKB/TrEMBL
	PKD_dom_sf	UniProtKB/TrEMBL
NCBI Gene	PMEL	ENTREZGENE
PANTHER	MELANOCYTE PROTEIN PMEL	UniProtKB/TrEMBL
	PTHR11861	UniProtKB/TrEMBL
Pfam	PKAT_KLD	UniProtKB/TrEMBL
	PKD	UniProtKB/TrEMBL
PROSITE	PKD	UniProtKB/TrEMBL
SMART	PKD	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49299	UniProtKB/TrEMBL
UniProt	A0A8C0NFF6_CANLF	UniProtKB/TrEMBL
	A0A8C0NN94_CANLF	UniProtKB/TrEMBL
	A0A8C0NRE6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0QBU0_CANLF	UniProtKB/TrEMBL
	A0A8C0RLL3_CANLF	UniProtKB/TrEMBL
	A0A8C0RLM1_CANLF	UniProtKB/TrEMBL
	A0A8C0RXH2_CANLF	UniProtKB/TrEMBL
	A0A8I3MZ91_CANLF	UniProtKB/TrEMBL
	A0A8I3MZ98_CANLF	UniProtKB/TrEMBL
	A0A8I3RUB9_CANLF	UniProtKB/TrEMBL
	A0A8P0N3A4	ENTREZGENE
UniProt Secondary	A0A8P0N3A4	UniProtKB/TrEMBL
VGNC ID	VGNC:44730	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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