RAG2 (recombination activating 2) - Rat Genome Database

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Gene: RAG2 (recombination activating 2) Canis lupus familiaris
Analyze
Symbol: RAG2
Name: recombination activating 2
RGD ID: 12180486
Description: ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); metal ion binding (inferred); INVOLVED IN B cell differentiation (ortholog); B cell homeostatic proliferation (ortholog); B cell lineage commitment (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH combined cellular and humoral immune defects with granulomas (ortholog); common variable immunodeficiency (ortholog); Eosinophilia (ortholog); FOUND IN DNA recombinase complex (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: V(D)J recombination-activating protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11831,614,143 - 31,621,489 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1831,618,481 - 31,620,064 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1831,225,259 - 31,228,771 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01832,228,286 - 32,231,796 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1832,228,787 - 32,230,370 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11831,798,300 - 31,801,806 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01831,382,649 - 31,386,158 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01832,019,854 - 32,023,367 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RAG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11831,614,143 - 31,621,489 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1831,618,481 - 31,620,064 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1831,225,259 - 31,228,771 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01832,228,286 - 32,231,796 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1832,228,787 - 32,230,370 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11831,798,300 - 31,801,806 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01831,382,649 - 31,386,158 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01832,019,854 - 32,023,367 (+)NCBIUU_Cfam_GSD_1.0
RAG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381136,590,996 - 36,598,236 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1136,575,574 - 36,598,279 (-)EnsemblGRCh38hg38GRCh38
GRCh371136,613,493 - 36,619,786 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361136,570,069 - 36,576,388 (-)NCBINCBI36Build 36hg18NCBI36
Celera1136,765,924 - 36,772,260 (-)NCBICelera
Cytogenetic Map11p12NCBI
HuRef1136,316,277 - 36,322,614 (-)NCBIHuRef
CHM1_11136,612,179 - 36,618,515 (-)NCBICHM1_1
T2T-CHM13v2.01136,734,171 - 36,741,410 (-)NCBIT2T-CHM13v2.0
Rag2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392101,455,057 - 101,462,873 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2101,455,063 - 101,462,874 (+)EnsemblGRCm39 Ensembl
GRCm382101,624,712 - 101,632,528 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2101,624,718 - 101,632,529 (+)EnsemblGRCm38mm10GRCm38
MGSCv372101,464,905 - 101,472,685 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362101,425,587 - 101,433,367 (+)NCBIMGSCv36mm8
Celera2102,849,742 - 102,857,519 (+)NCBICelera
Cytogenetic Map2E2NCBI
cM Map253.87NCBI
Rag2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83108,357,399 - 108,367,186 (+)NCBIGRCr8
mRatBN7.2387,902,373 - 87,910,227 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl387,902,238 - 87,911,066 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx391,393,248 - 91,401,103 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0399,992,269 - 100,000,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0397,824,520 - 97,832,368 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0391,191,837 - 91,200,134 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl391,191,837 - 91,200,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0397,851,318 - 97,859,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4386,764,810 - 86,773,438 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1386,661,236 - 86,668,153 (+)NCBI
Celera387,008,586 - 87,016,420 (+)NCBICelera
Cytogenetic Map3q31NCBI
Rag2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554229,867,307 - 9,869,732 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554229,867,307 - 9,869,732 (+)NCBIChiLan1.0ChiLan1.0
RAG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2938,806,254 - 38,808,778 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11138,810,920 - 38,813,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,558,419 - 36,564,997 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11136,431,067 - 36,437,390 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1136,431,703 - 36,433,286 (-)Ensemblpanpan1.1panPan2
Rag2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494728,680,736 - 28,683,548 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365331,801,391 - 1,807,431 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365331,801,207 - 1,807,431 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl224,547,644 - 24,558,403 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1224,547,605 - 24,553,944 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2226,716,416 - 26,717,999 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1128,645,175 - 28,653,823 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl128,649,930 - 28,651,513 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038125,790,092 - 125,792,520 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rag2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476710,678,359 - 10,680,132 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476710,678,547 - 10,680,130 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RAG2
119 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 8
Below cutoff 1 2 9 2 1 1 8 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000010949   ⟹   ENSCAFP00000010147
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1831,618,481 - 31,620,064 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845035637   ⟹   ENSCAFP00845027880
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1832,228,787 - 32,230,370 (+)Ensembl
RefSeq Acc Id: XM_005631105   ⟹   XP_005631162
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11831,618,030 - 31,621,489 (+)NCBI
Dog10K_Boxer_Tasha1831,225,259 - 31,228,771 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038424077   ⟹   XP_038280005
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01832,228,286 - 32,231,796 (+)NCBI
RefSeq Acc Id: XM_038500428   ⟹   XP_038356356
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11831,798,300 - 31,801,806 (+)NCBI
RefSeq Acc Id: XM_038562997   ⟹   XP_038418925
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01832,019,854 - 32,023,367 (+)NCBI
RefSeq Acc Id: XM_038627119   ⟹   XP_038483047
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01831,382,649 - 31,386,158 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005631162   ⟸   XM_005631105
- UniProtKB: A0A8C0RCC2 (UniProtKB/TrEMBL),   A0A8I3P8Z4 (UniProtKB/TrEMBL),   A0A8C0K058 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010147   ⟸   ENSCAFT00000010949
RefSeq Acc Id: XP_038356356   ⟸   XM_038500428
RefSeq Acc Id: XP_038483047   ⟸   XM_038627119
RefSeq Acc Id: XP_038280005   ⟸   XM_038424077
- UniProtKB: A0A8C0RCC2 (UniProtKB/TrEMBL),   A0A8I3P8Z4 (UniProtKB/TrEMBL),   A0A8C0K058 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038418925   ⟸   XM_038562997
- UniProtKB: A0A8C0K058 (UniProtKB/TrEMBL),   A0A8C0RCC2 (UniProtKB/TrEMBL),   A0A8I3P8Z4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845027880   ⟸   ENSCAFT00845035637
Protein Domains
Recombination activating protein 2 PHD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006803 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004179 UniProtKB/TrEMBL
  ENSCAFG00845020240 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010949.2 UniProtKB/TrEMBL
  ENSCAFT00030007689.1 UniProtKB/TrEMBL
  ENSCAFT00845035637 ENTREZGENE
  ENSCAFT00845035637.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.80 UniProtKB/TrEMBL
  Rag2 PHD finger UniProtKB/TrEMBL
InterPro Gal_Oxase/kelch_b-propeller UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  RAG2 UniProtKB/TrEMBL
  RAG2_PHD UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
KEGG Report cfa:483419 UniProtKB/TrEMBL
NCBI Gene RAG2 ENTREZGENE
PANTHER PTHR10960 UniProtKB/TrEMBL
  V(D)J RECOMBINATION-ACTIVATING PROTEIN 2 UniProtKB/TrEMBL
Pfam RAG2 UniProtKB/TrEMBL
  RAG2_PHD UniProtKB/TrEMBL
Superfamily-SCOP SSF50965 UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
UniProt A0A8C0K058 ENTREZGENE
  A0A8C0RCC2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P8Z4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45327 ENTREZGENE