ADCY10 (adenylate cyclase 10) - Rat Genome Database

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Gene: ADCY10 (adenylate cyclase 10) Canis lupus familiaris
Analyze
Symbol: ADCY10
Name: adenylate cyclase 10
RGD ID: 12177118
Description: ENCODES a protein that exhibits adenylate cyclase activity (ortholog); ATPase binding (ortholog); manganese ion binding (ortholog); INVOLVED IN cAMP biosynthetic process (ortholog); glucose catabolic process (ortholog); mitochondrial ATP transmembrane transport (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Cardiomegaly (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN apical part of cell (ortholog); astrocyte end-foot (ortholog); axon (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenylate cyclase 10, soluble; adenylate cyclase type 10
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC481790  
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1730,576,445 - 30,660,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl730,577,591 - 30,660,926 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha730,114,468 - 30,197,885 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0730,395,203 - 30,479,360 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl730,395,909 - 30,479,360 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1730,235,622 - 30,319,191 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0730,266,955 - 30,350,402 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0730,505,414 - 30,588,892 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cAMP biosynthetic process  (IEA,ISO)
cellular response to inorganic substance  (IEA)
cyclic nucleotide biosynthetic process  (IEA)
epithelial cilium movement involved in extracellular fluid movement  (IEA)
glucose catabolic process  (ISO)
intracellular signal transduction  (IEA)
mitochondrial ATP transmembrane transport  (ISO)
negative regulation of cardiac muscle cell contraction  (ISO)
negative regulation of mitochondrial membrane potential  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
neuron projection extension  (ISO)
neuron projection maintenance  (ISO)
neuron projection retraction  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cAMP-dependent protein kinase activity  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of glycogen catabolic process  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of mitochondrial depolarization  (ISO)
positive regulation of ossification  (ISO)
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of protein targeting to mitochondrion  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
regulation of membrane repolarization  (ISO)
regulation of mitophagy  (ISO)
spermatid development  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADCY10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1730,576,445 - 30,660,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl730,577,591 - 30,660,926 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha730,114,468 - 30,197,885 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0730,395,203 - 30,479,360 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl730,395,909 - 30,479,360 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1730,235,622 - 30,319,191 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0730,266,955 - 30,350,402 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0730,505,414 - 30,588,892 (+)NCBIUU_Cfam_GSD_1.0
ADCY10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,809,386 - 167,914,134 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1167,809,386 - 167,914,215 (-)EnsemblGRCh38hg38GRCh38
GRCh371167,778,623 - 167,883,372 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,045,506 - 166,149,964 (-)NCBINCBI36Build 36hg18NCBI36
Build 341164,510,540 - 164,614,998NCBI
Celera1140,887,888 - 140,992,712 (-)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1139,024,896 - 139,129,092 (-)NCBIHuRef
CHM1_11169,200,865 - 169,305,664 (-)NCBICHM1_1
T2T-CHM13v2.01167,160,872 - 167,265,599 (-)NCBIT2T-CHM13v2.0
Adcy10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391165,309,114 - 165,404,347 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1165,312,752 - 165,404,343 (+)EnsemblGRCm39 Ensembl
GRCm381165,483,518 - 165,576,778 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,485,183 - 165,576,774 (+)EnsemblGRCm38mm10GRCm38
MGSCv371167,415,314 - 167,506,904 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361167,321,858 - 167,413,448 (+)NCBIMGSCv36mm8
Celera1167,931,319 - 168,021,551 (+)NCBICelera
Cytogenetic Map1H2.3NCBI
cM Map172.83NCBI
Adcy10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81380,280,595 - 80,366,939 (+)NCBIGRCr8
mRatBN7.21377,747,752 - 77,833,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1377,768,468 - 77,833,951 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1380,364,714 - 80,453,344 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01381,668,713 - 81,757,332 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01378,914,792 - 79,003,063 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01383,701,952 - 83,787,010 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1383,721,300 - 83,787,018 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01388,583,534 - 88,667,840 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41381,208,090 - 81,302,902 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11381,222,277 - 81,317,089 (+)NCBI
Celera1377,464,675 - 77,547,216 (+)NCBICelera
Cytogenetic Map13q23NCBI
Adcy10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554629,207,314 - 9,278,621 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554629,196,984 - 9,278,850 (+)NCBIChiLan1.0ChiLan1.0
ADCY10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,848,277 - 81,957,079 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1181,516,261 - 81,625,530 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01143,239,576 - 143,404,038 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,023,671 - 147,129,705 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,023,671 - 147,129,705 (-)Ensemblpanpan1.1panPan2
Adcy10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344100,415,703 - 100,483,395 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648118,274,154 - 18,330,173 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648118,274,158 - 18,330,136 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl483,098,290 - 83,205,454 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1483,103,768 - 83,205,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2490,773,869 - 90,880,759 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12561,129,837 - 61,228,180 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2561,140,293 - 61,230,117 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605562,864,231 - 62,951,686 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcy10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248265,845,001 - 5,897,497 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248265,844,868 - 5,897,541 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADCY10
722 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8
Low 1 12 5 5 1 12 5 1
Below cutoff 5 4 10 1 6 1 6 5 5 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000024423   ⟹   ENSCAFP00000022672
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl730,577,591 - 30,660,926 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845005820   ⟹   ENSCAFP00845004619
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl730,395,909 - 30,479,360 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845005828   ⟹   ENSCAFP00845004627
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl730,395,909 - 30,479,360 (+)Ensembl
RefSeq Acc Id: NM_001253833   ⟹   NP_001240762
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1730,577,591 - 30,660,926 (+)NCBI
Dog10K_Boxer_Tasha730,114,468 - 30,197,885 (+)NCBI
ROS_Cfam_1.0730,395,909 - 30,479,360 (+)NCBI
UMICH_Zoey_3.1730,235,622 - 30,319,191 (+)NCBI
UNSW_CanFamBas_1.0730,266,955 - 30,350,402 (+)NCBI
UU_Cfam_GSD_1.0730,505,414 - 30,588,892 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038670517   ⟹   XP_038526445
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0730,395,203 - 30,479,003 (+)NCBI
RefSeq Acc Id: XM_038670518   ⟹   XP_038526446
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0730,395,205 - 30,479,360 (+)NCBI
RefSeq Acc Id: XM_038670519   ⟹   XP_038526447
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0730,395,205 - 30,479,360 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001240762   ⟸   NM_001253833
- UniProtKB: A0A8C0Q753 (UniProtKB/TrEMBL),   A0A8P0SJQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000022672   ⟸   ENSCAFT00000024423
RefSeq Acc Id: XP_038526445   ⟸   XM_038670517
- Peptide Label: isoform X1
- UniProtKB: A0A8I3MS78 (UniProtKB/TrEMBL),   A0A8C0Q753 (UniProtKB/TrEMBL),   A0A8P0SJQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038526446   ⟸   XM_038670518
- Peptide Label: isoform X1
- UniProtKB: A0A8I3MS78 (UniProtKB/TrEMBL),   A0A8C0Q753 (UniProtKB/TrEMBL),   A0A8P0SJQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038526447   ⟸   XM_038670519
- Peptide Label: isoform X2
- UniProtKB: A0A8I3MQL7 (UniProtKB/TrEMBL),   A0A8C0PRD9 (UniProtKB/TrEMBL),   A0A8P0PP87 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845004627   ⟸   ENSCAFT00845005828
RefSeq Acc Id: ENSCAFP00845004619   ⟸   ENSCAFT00845005820
Protein Domains
Guanylate cyclase

Promoters
RGD ID:13683958
Promoter ID:EPDNEW_C2027
Type:single initiation site
Name:ADCY10_1
Description:adenylate cyclase type 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1730,577,594 - 30,577,654EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015387 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030023027 UniProtKB/TrEMBL
  ENSCAFG00040001713 UniProtKB/TrEMBL
  ENSCAFG00845003255 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000024423.5 UniProtKB/TrEMBL
  ENSCAFT00000101911.1 UniProtKB/TrEMBL
  ENSCAFT00030042540.1 UniProtKB/TrEMBL
  ENSCAFT00040003365.1 UniProtKB/TrEMBL
  ENSCAFT00040003390.1 UniProtKB/TrEMBL
  ENSCAFT00845005820 ENTREZGENE
  ENSCAFT00845005820.1 UniProtKB/TrEMBL
  ENSCAFT00845005828 ENTREZGENE
  ENSCAFT00845005828.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene ADCY10 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 10 UniProtKB/TrEMBL
  TESTICULAR SOLUBLE ADENYLYL CYCLASE UniProtKB/TrEMBL
Pfam Guanylate_cyc UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF55073 UniProtKB/TrEMBL
UniProt A0A8C0PRD9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q753 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MQL7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MS78 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PP87 ENTREZGENE
  A0A8P0SJQ5 ENTREZGENE
UniProt Secondary A0A8P0PP87 UniProtKB/TrEMBL
  A0A8P0SJQ5 UniProtKB/TrEMBL
VGNC ID VGNC:53325 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-04 ADCY10  adenylate cyclase 10    adenylate cyclase 10, soluble  Symbol and/or name change 5135510 APPROVED