TGM1 (transglutaminase 1) - Rat Genome Database

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Gene: TGM1 (transglutaminase 1) Canis lupus familiaris
Analyze
Symbol: TGM1
Name: transglutaminase 1
RGD ID: 12173519
Description: ENCODES a protein that exhibits acyltransferase activity (inferred); identical protein binding (inferred); metal ion binding (inferred); INVOLVED IN animal organ morphogenesis (ortholog); positive regulation of cell cycle (ortholog); positive regulation of keratinocyte proliferation (ortholog); ASSOCIATED WITH autosomal recessive congenital ichthyosis 1; autosomal dominant dyskeratosis congenita 1 (ortholog); autosomal dominant dyskeratosis congenita 3 (ortholog); FOUND IN adherens junction (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: epidermal TGase; protein-glutamine gamma-glutamyltransferase K; TG(K); TGase K; TGase-1; TGK; transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); transglutaminase K
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,229,410 - 4,244,768 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,229,614 - 4,241,644 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,151,291 - 4,163,321 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,340,192 - 4,355,545 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,340,391 - 4,352,420 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,030,778 - 4,042,799 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,092,571 - 4,104,607 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,354,922 - 4,366,945 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
adherens junction  (ISO)
membrane  (IEA,ISS)

Molecular Function

References
Additional References at PubMed
PMID:11474183   PMID:19438474   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TGM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,229,410 - 4,244,768 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,229,614 - 4,241,644 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,151,291 - 4,163,321 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,340,192 - 4,355,545 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,340,391 - 4,352,420 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,030,778 - 4,042,799 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,092,571 - 4,104,607 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,354,922 - 4,366,945 (-)NCBIUU_Cfam_GSD_1.0
TGM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,249,114 - 24,263,177 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,249,114 - 24,264,432 (-)EnsemblGRCh38hg38GRCh38
GRCh371424,718,320 - 24,732,383 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,788,160 - 23,802,256 (-)NCBINCBI36Build 36hg18NCBI36
Build 341423,788,161 - 23,802,212NCBI
Celera144,582,959 - 4,597,032 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,833,089 - 4,847,573 (-)NCBIHuRef
CHM1_11424,716,943 - 24,731,017 (-)NCBICHM1_1
T2T-CHM13v2.01418,447,487 - 18,461,522 (-)NCBIT2T-CHM13v2.0
Tgm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,937,466 - 55,951,378 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,937,466 - 55,951,383 (-)EnsemblGRCm39 Ensembl
GRCm381455,700,009 - 55,713,921 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,700,009 - 55,713,926 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,318,846 - 56,332,329 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,654,090 - 54,667,159 (-)NCBIMGSCv36mm8
Celera1453,505,022 - 53,518,505 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Tgm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,160,985 - 33,175,632 (-)NCBIGRCr8
mRatBN7.21529,191,039 - 29,206,000 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,191,041 - 29,204,523 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,036,752 - 31,049,999 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,183,977 - 32,197,224 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,426,310 - 30,439,558 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,378,136 - 34,393,150 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,378,148 - 34,392,066 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,268,112 - 38,282,132 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,846,367 - 33,859,615 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,862,066 - 33,875,315 (-)NCBI
Celera1528,767,463 - 28,780,710 (-)NCBICelera
Cytogenetic Map15p13NCBI
TGM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,604,115 - 25,618,834 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,820,632 - 24,836,103 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,025,345 - 5,041,557 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,148,905 - 23,163,249 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,148,905 - 23,162,477 (-)Ensemblpanpan1.1panPan2
Tgm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,082,429 - 36,096,863 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722292,143 - 306,572 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722292,999 - 306,540 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,029,923 - 75,047,300 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,030,123 - 75,045,157 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,298,974 - 80,316,080 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TGM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,231,827 - 1,248,018 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,232,004 - 1,245,462 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603612,916,544 - 12,930,178 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,239,904 - 8,252,541 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,239,087 - 8,252,716 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TGM1
97 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6
Low
Below cutoff 5 5 22 6 6 6 6 12 8 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000019351   ⟹   ENSCAFP00000017949
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,229,614 - 4,241,644 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845011672   ⟹   ENSCAFP00845009111
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,340,391 - 4,352,420 (-)Ensembl
RefSeq Acc Id: NM_001003079   ⟹   NP_001003079
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.184,229,614 - 4,241,644 (-)NCBI
Dog10K_Boxer_Tasha84,151,291 - 4,163,321 (-)NCBI
ROS_Cfam_1.084,340,391 - 4,352,420 (-)NCBI
UMICH_Zoey_3.184,030,778 - 4,042,799 (-)NCBI
UNSW_CanFamBas_1.084,092,571 - 4,104,607 (-)NCBI
UU_Cfam_GSD_1.084,354,922 - 4,366,945 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038672837   ⟹   XP_038528765
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.084,340,192 - 4,355,362 (-)NCBI
RefSeq Acc Id: XM_038672838   ⟹   XP_038528766
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.084,340,192 - 4,355,545 (-)NCBI
RefSeq Acc Id: XM_038672839   ⟹   XP_038528767
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.084,340,192 - 4,355,360 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001003079   ⟸   NM_001003079
- UniProtKB: Q9GLK0 (UniProtKB/Swiss-Prot),   A0A8I3MV56 (UniProtKB/TrEMBL),   A0A8P0NE93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000017949   ⟸   ENSCAFT00000019351
RefSeq Acc Id: XP_038528766   ⟸   XM_038672838
- Peptide Label: isoform X2
- UniProtKB: A0A8I3MV56 (UniProtKB/TrEMBL),   A0A8P0NE93 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038528765   ⟸   XM_038672837
- Peptide Label: isoform X1
- UniProtKB: A0A8I3MV56 (UniProtKB/TrEMBL),   A0A8P0NE93 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038528767   ⟸   XM_038672839
- Peptide Label: isoform X3
- UniProtKB: A0A8I3MV56 (UniProtKB/TrEMBL),   A0A8P0NE93 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845009111   ⟸   ENSCAFT00845011672
Protein Domains
Transglutaminase-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012182 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040004039 UniProtKB/TrEMBL
  ENSCAFG00845006564 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019351.5 UniProtKB/TrEMBL
  ENSCAFT00040007724.1 UniProtKB/TrEMBL
  ENSCAFT00040007730.1 UniProtKB/TrEMBL
  ENSCAFT00845011672 ENTREZGENE
  ENSCAFT00845011672.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.260.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403630 UniProtKB/Swiss-Prot
NCBI Gene TGM1 ENTREZGENE
PANTHER PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Transglut_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglut_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglut_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF TGM_EBP42 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRANSGLUTAMINASES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49309 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0Q184_CANLF UniProtKB/TrEMBL
  A0A8C0Q734_CANLF UniProtKB/TrEMBL
  A0A8I3MV56 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NE93 ENTREZGENE, UniProtKB/TrEMBL
  Q9GLK0 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:47315 ENTREZGENE