BTG2 (BTG anti-proliferation factor 2) - Rat Genome Database

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Gene: BTG2 (BTG anti-proliferation factor 2) Canis lupus familiaris
Analyze
Symbol: BTG2
Name: BTG anti-proliferation factor 2
RGD ID: 12154286
Description: ENCODES a protein that exhibits transcription corepressor activity (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); associative learning (ortholog); cellular response to phorbol 13-acetate 12-myristate (ortholog); ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); brain ischemia (ortholog); breast cancer (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein BTG2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13870,921 - 75,149 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3870,452 - 72,976 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha38161,110 - 165,136 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03867,926 - 71,934 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3867,702 - 71,934 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13860,447 - 64,469 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.038454,515 - 458,533 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.038668,563 - 672,594 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
BTG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13870,921 - 75,149 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3870,452 - 72,976 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha38161,110 - 165,136 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03867,926 - 71,934 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3867,702 - 71,934 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13860,447 - 64,469 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.038454,515 - 458,533 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.038668,563 - 672,594 (+)NCBIUU_Cfam_GSD_1.0
BTG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381203,305,519 - 203,309,602 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1203,305,491 - 203,309,602 (+)EnsemblGRCh38hg38GRCh38
GRCh371203,274,647 - 203,278,730 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,541,287 - 201,545,353 (+)NCBINCBI36Build 36hg18NCBI36
Build 341200,006,320 - 200,010,384NCBI
Celera1176,403,938 - 176,408,003 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1174,439,723 - 174,443,788 (+)NCBIHuRef
CHM1_11204,697,045 - 204,701,100 (+)NCBICHM1_1
T2T-CHM13v2.01202,568,370 - 202,572,442 (+)NCBIT2T-CHM13v2.0
Btg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,002,603 - 134,006,893 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,002,908 - 134,006,858 (-)EnsemblGRCm39 Ensembl
GRCm381134,074,865 - 134,079,155 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,075,170 - 134,079,120 (-)EnsemblGRCm38mm10GRCm38
MGSCv371135,971,442 - 135,975,732 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361135,891,276 - 135,895,566 (-)NCBIMGSCv36mm8
Celera1136,692,103 - 136,696,393 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.1NCBI
Btg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81348,083,931 - 48,087,690 (-)NCBIGRCr8
mRatBN7.21345,531,881 - 45,535,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,531,925 - 45,535,628 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1348,140,195 - 48,143,949 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,428,246 - 49,432,002 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,692,987 - 46,696,744 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01350,913,185 - 50,916,944 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,913,180 - 50,916,982 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,966,299 - 55,970,058 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,026,986 - 47,030,745 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11347,041,028 - 47,044,788 (-)NCBI
Celera1345,860,186 - 45,864,450 (-)NCBICelera
Cytogenetic Map13q13NCBI
Btg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540639,303,175 - 39,308,778 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540639,303,221 - 39,307,308 (+)NCBIChiLan1.0ChiLan1.0
BTG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2146,068,366 - 46,072,485 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1146,035,354 - 46,039,474 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01178,907,317 - 178,911,410 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11183,201,297 - 183,205,404 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1183,201,297 - 183,205,404 (+)Ensemblpanpan1.1panPan2
Btg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934472,075,888 - 72,079,831 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365671,309,658 - 1,314,515 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365671,310,525 - 1,314,469 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BTG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl964,031,832 - 64,035,837 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1964,033,853 - 64,037,795 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,327,454 - 70,331,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9q21-q25NCBI
BTG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12526,032,404 - 26,036,500 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2526,034,632 - 26,036,538 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605526,808,911 - 26,813,028 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Btg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248077,540,602 - 7,545,521 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248077,541,335 - 7,545,412 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BTG2
41 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 19 6 6 6 6 4 5 8 2
Low 3 2 7 1 2 4
Below cutoff 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000015026   ⟹   ENSCAFP00000013904
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3870,452 - 72,976 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845033943   ⟹   ENSCAFP00845026562
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3867,702 - 71,934 (+)Ensembl
RefSeq Acc Id: XM_005640759   ⟹   XP_005640816
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13870,921 - 75,149 (+)NCBI
Dog10K_Boxer_Tasha38161,110 - 165,136 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038448182   ⟹   XP_038304110
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03867,926 - 71,934 (+)NCBI
RefSeq Acc Id: XM_038522123   ⟹   XP_038378051
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13860,447 - 64,469 (+)NCBI
RefSeq Acc Id: XM_038585942   ⟹   XP_038441870
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.038668,563 - 672,594 (+)NCBI
RefSeq Acc Id: XM_038650323   ⟹   XP_038506251
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.038454,515 - 458,533 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005640816   ⟸   XM_005640759
- UniProtKB: A0A8C0KI03 (UniProtKB/TrEMBL),   A0A8C0SEC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000013904   ⟸   ENSCAFT00000015026
RefSeq Acc Id: XP_038378051   ⟸   XM_038522123
RefSeq Acc Id: XP_038506251   ⟸   XM_038650323
RefSeq Acc Id: XP_038304110   ⟸   XM_038448182
- UniProtKB: A0A8C0KI03 (UniProtKB/TrEMBL),   A0A8C0SEC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038441870   ⟸   XM_038585942
- UniProtKB: A0A8C0KI03 (UniProtKB/TrEMBL),   A0A8C0SEC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845026562   ⟸   ENSCAFT00845033943
Protein Domains
Anti-proliferative protein

Promoters
RGD ID:13689173
Promoter ID:EPDNEW_C7240
Type:initiation region
Name:BTG2_1
Description:BTG anti-proliferation factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13871,080 - 71,140EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009450 Ensembl
  ENSCAFG00000053235 UniProtKB/TrEMBL
  ENSCAFG00030013039 UniProtKB/TrEMBL
  ENSCAFG00040012648 UniProtKB/TrEMBL
  ENSCAFG00845019253 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000097576.1 UniProtKB/TrEMBL
  ENSCAFT00030024105.1 UniProtKB/TrEMBL
  ENSCAFT00040023326.1 UniProtKB/TrEMBL
  ENSCAFT00845033943.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.640.90 UniProtKB/TrEMBL
InterPro Anti_prolifrtn UniProtKB/TrEMBL
  BTG UniProtKB/TrEMBL
  BTG-like_sf UniProtKB/TrEMBL
NCBI Gene BTG2 ENTREZGENE
PANTHER PTHR22978 UniProtKB/TrEMBL
  PTHR22978:SF29 UniProtKB/TrEMBL
Pfam BTG UniProtKB/TrEMBL
PRINTS ANTIPRLFBTG1 UniProtKB/TrEMBL
PROSITE BTG_1 UniProtKB/TrEMBL
  BTG_2 UniProtKB/TrEMBL
SMART btg1 UniProtKB/TrEMBL
Superfamily-SCOP SSF160696 UniProtKB/TrEMBL
UniProt A0A8C0KI03 ENTREZGENE
  A0A8C0SEC9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PG89_CANLF UniProtKB/TrEMBL
  A0A8P0TPN6_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:54278 ENTREZGENE