SOST (sclerostin) - Rat Genome Database

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Pathways
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Gene: SOST (sclerostin) Canis lupus familiaris
Analyze
Symbol: SOST
Name: sclerostin
RGD ID: 12123434
Description: ENCODES a protein that exhibits carbohydrate binding (ortholog); INVOLVED IN BMP signaling pathway (ortholog); canonical Wnt signaling pathway (ortholog); negative regulation of BMP signaling pathway (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant craniodiaphyseal dysplasia (ortholog); bone development disease (ortholog); genetic disease (ortholog); FOUND IN extracellular space (ortholog); Golgi apparatus (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sclerosteosis
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,538,713 - 19,544,650 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,539,435 - 19,544,651 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,928,494 - 18,933,390 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,234,523 - 20,239,413 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,234,719 - 20,239,089 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,087,300 - 19,092,190 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,270,262 - 19,275,387 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0919,415,616 - 19,420,514 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SOST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,538,713 - 19,544,650 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,539,435 - 19,544,651 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,928,494 - 18,933,390 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,234,523 - 20,239,413 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,234,719 - 20,239,089 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,087,300 - 19,092,190 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,270,262 - 19,275,387 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0919,415,616 - 19,420,514 (+)NCBIUU_Cfam_GSD_1.0
SOST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381743,753,738 - 43,758,791 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1743,753,738 - 43,758,791 (-)EnsemblGRCh38hg38GRCh38
GRCh371741,831,106 - 41,836,159 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,186,625 - 39,191,682 (-)NCBINCBI36Build 36hg18NCBI36
Build 341739,186,624 - 39,191,682NCBI
Celera1738,539,106 - 38,544,164 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1737,595,207 - 37,600,265 (-)NCBIHuRef
CHM1_11742,066,723 - 42,071,781 (-)NCBICHM1_1
T2T-CHM13v2.01744,606,296 - 44,611,349 (-)NCBIT2T-CHM13v2.0
Sost
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,853,284 - 101,857,841 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,853,284 - 101,857,841 (-)EnsemblGRCm39 Ensembl
GRCm3811101,962,458 - 101,967,015 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,962,458 - 101,967,015 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,823,772 - 101,828,329 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,778,626 - 101,783,105 (-)NCBIMGSCv36mm8
Celera11113,667,734 - 113,672,291 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.48NCBI
Sost
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,412,722 - 87,415,766 (-)NCBIGRCr8
mRatBN7.21086,912,517 - 86,915,561 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,911,517 - 86,915,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,941,934 - 91,944,978 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,417,549 - 91,420,598 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,810,861 - 86,813,910 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,897,087 - 89,900,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,897,087 - 89,900,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,689,512 - 89,692,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,023,712 - 91,026,759 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11091,038,081 - 91,041,129 (-)NCBI
Celera1085,631,705 - 85,634,749 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Sost
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,054,939 - 17,058,027 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,054,939 - 17,058,027 (-)NCBIChiLan1.0ChiLan1.0
SOST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21921,149,763 - 21,155,219 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11723,114,052 - 23,119,508 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01713,639,088 - 13,644,152 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,804,374 - 13,809,432 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,804,374 - 13,809,432 (+)Ensemblpanpan1.1panPan2
Sost
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,876,390 - 18,881,316 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541313,287 - 318,176 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936541313,308 - 318,109 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,355,234 - 19,360,352 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11219,354,912 - 19,360,348 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,588,864 - 19,592,789 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,649,053 - 62,656,192 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,651,146 - 62,654,570 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607733,418,277 - 33,423,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sost
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,006,813 - 1,008,685 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,006,811 - 1,009,437 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SOST
55 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 2
Below cutoff 4 4 13 2 6 2 6 3 8 8 7 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000046151   ⟹   ENSCAFP00000042377
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl919,539,435 - 19,544,651 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845018673   ⟹   ENSCAFP00845014577
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl920,234,719 - 20,239,089 (+)Ensembl
RefSeq Acc Id: XM_038487591   ⟹   XP_038343519
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1919,087,300 - 19,092,190 (+)NCBI
RefSeq Acc Id: XM_038546097   ⟹   XP_038402025
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0919,415,616 - 19,420,514 (+)NCBI
RefSeq Acc Id: XM_038610121   ⟹   XP_038466049
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0919,270,262 - 19,275,387 (+)NCBI
RefSeq Acc Id: XM_038675186   ⟹   XP_038531114
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0920,234,523 - 20,239,413 (+)NCBI
RefSeq Acc Id: XM_548071   ⟹   XP_548071
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1919,538,713 - 19,544,650 (+)NCBI
Dog10K_Boxer_Tasha918,928,494 - 18,933,390 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_548071   ⟸   XM_548071
- Peptide Label: isoform X1
- UniProtKB: A0A8C0T2N1 (UniProtKB/TrEMBL),   A0A8I3NHP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000042377   ⟸   ENSCAFT00000046151
RefSeq Acc Id: XP_038343519   ⟸   XM_038487591
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038466049   ⟸   XM_038610121
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038531114   ⟸   XM_038675186
- Peptide Label: isoform X1
- UniProtKB: A0A8C0T2N1 (UniProtKB/TrEMBL),   A0A8I3NHP7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038402025   ⟸   XM_038546097
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845014577   ⟸   ENSCAFT00845018673
Protein Domains
CTCK


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000028730 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030002373 UniProtKB/TrEMBL
  ENSCAFG00040018529 UniProtKB/TrEMBL
  ENSCAFG00845010604 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000046151.3 UniProtKB/TrEMBL
  ENSCAFT00030004382.1 UniProtKB/TrEMBL
  ENSCAFT00040034234.1 UniProtKB/TrEMBL
  ENSCAFT00845018673 ENTREZGENE
  ENSCAFT00845018673.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  Sclerostin/SOSTDC1 UniProtKB/TrEMBL
NCBI Gene SOST ENTREZGENE
PANTHER PTHR14903 UniProtKB/TrEMBL
  PTHR14903:SF4 UniProtKB/TrEMBL
Pfam Sclerostin UniProtKB/TrEMBL
SMART SM00041 UniProtKB/TrEMBL
UniProt A0A8C0T2N1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NHP7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46667 ENTREZGENE