HKDC1 (hexokinase domain containing 1) - Rat Genome Database

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Gene: HKDC1 (hexokinase domain containing 1) Canis lupus familiaris
Analyze
Symbol: HKDC1
Name: hexokinase domain containing 1
RGD ID: 12111795
Description: ENCODES a protein that exhibits ATP binding (inferred); fructokinase activity (inferred); glucokinase activity (inferred); INVOLVED IN carbohydrate metabolic process (inferred); carbohydrate phosphorylation (inferred); glucose 6-phosphate metabolic process (inferred); ASSOCIATED WITH Dwarfism (ortholog); genetic disease (ortholog); Keratoconus 1 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hexokinase HKDC1; putative hexokinase HKDC1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1420,353,941 - 20,395,429 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl420,353,355 - 20,394,634 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha420,484,075 - 20,525,712 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0420,625,796 - 20,667,351 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl420,625,349 - 20,667,051 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1420,526,423 - 20,567,841 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0420,729,648 - 20,771,687 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0421,073,106 - 21,114,762 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HKDC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1420,353,941 - 20,395,429 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl420,353,355 - 20,394,634 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha420,484,075 - 20,525,712 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0420,625,796 - 20,667,351 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl420,625,349 - 20,667,051 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1420,526,423 - 20,567,841 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0420,729,648 - 20,771,687 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0421,073,106 - 21,114,762 (+)NCBIUU_Cfam_GSD_1.0
HKDC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381069,220,332 - 69,267,552 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1069,220,332 - 69,267,552 (+)EnsemblGRCh38hg38GRCh38
GRCh371070,980,088 - 71,027,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361070,650,065 - 70,697,321 (+)NCBINCBI36Build 36hg18NCBI36
Celera1064,255,904 - 64,303,168 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1064,980,307 - 65,027,150 (+)NCBIHuRef
CHM1_11071,261,818 - 71,308,763 (+)NCBICHM1_1
T2T-CHM13v2.01070,088,688 - 70,135,592 (+)NCBIT2T-CHM13v2.0
Hkdc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391062,218,916 - 62,259,490 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1062,218,916 - 62,258,270 (-)EnsemblGRCm39 Ensembl
GRCm381062,383,137 - 62,423,711 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1062,383,137 - 62,422,491 (-)EnsemblGRCm38mm10GRCm38
MGSCv371061,845,885 - 61,885,205 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361061,778,494 - 61,817,814 (-)NCBIMGSCv36mm8
Celera1063,486,364 - 63,525,623 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.4NCBI
Hkdc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82030,878,037 - 30,917,044 (-)NCBIGRCr8
mRatBN7.22030,335,322 - 30,373,792 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2030,335,628 - 30,373,867 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02032,018,027 - 32,054,494 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2032,018,673 - 32,052,855 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.02033,805,753 - 33,840,534 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2031,757,004 - 31,794,582 (-)NCBICelera
Cytogenetic Map20q11NCBI
Hkdc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543721,825,397 - 21,868,435 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543721,825,647 - 21,873,698 (-)NCBIChiLan1.0ChiLan1.0
HKDC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2881,366,586 - 81,413,556 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11081,371,908 - 81,418,779 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01065,687,378 - 65,734,281 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11068,220,475 - 68,267,321 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1068,220,475 - 68,267,321 (+)Ensemblpanpan1.1panPan2
Hkdc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721360,683,196 - 60,730,681 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365219,175,447 - 9,223,583 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365219,175,916 - 9,223,546 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HKDC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1472,283,845 - 72,335,886 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11472,285,941 - 72,343,990 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21478,302,927 - 78,353,257 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HKDC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1962,051,098 - 62,099,986 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl962,052,027 - 62,099,221 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604822,791,409 - 22,839,449 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hkdc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247543,511,730 - 3,556,184 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247543,511,947 - 3,556,131 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HKDC1
400 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 6 9 1
Below cutoff 5 4 10 1 3 1 4 3 8 8 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000046047   ⟹   ENSCAFP00000035961
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl420,353,355 - 20,394,634 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000080470   ⟹   ENSCAFP00000058990
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl420,353,355 - 20,394,634 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845006065   ⟹   ENSCAFP00845004822
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl420,625,349 - 20,667,051 (+)Ensembl
RefSeq Acc Id: XM_038474366   ⟹   XP_038330294
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1420,526,423 - 20,567,841 (+)NCBI
RefSeq Acc Id: XM_038533722   ⟹   XP_038389650
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0421,073,106 - 21,114,762 (+)NCBI
RefSeq Acc Id: XM_038598023   ⟹   XP_038453951
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0420,729,648 - 20,771,687 (+)NCBI
RefSeq Acc Id: XM_038662319   ⟹   XP_038518247
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0420,625,796 - 20,667,351 (+)NCBI
RefSeq Acc Id: XM_546137   ⟹   XP_546137
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1420,353,941 - 20,395,429 (+)NCBI
Dog10K_Boxer_Tasha420,484,075 - 20,525,712 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_546137   ⟸   XM_546137
- Peptide Label: isoform X5
- UniProtKB: A0A8C0NLX0 (UniProtKB/TrEMBL),   A0A8C0R835 (UniProtKB/TrEMBL),   A0A8P0NNB7 (UniProtKB/TrEMBL),   A0A8I3MK58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000058990   ⟸   ENSCAFT00000080470
RefSeq Acc Id: ENSCAFP00000035961   ⟸   ENSCAFT00000046047
RefSeq Acc Id: XP_038330294   ⟸   XM_038474366
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038453951   ⟸   XM_038598023
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038518247   ⟸   XM_038662319
- Peptide Label: isoform X1
- UniProtKB: A0A8I3MK58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038389650   ⟸   XM_038533722
- Peptide Label: isoform X4
- UniProtKB: A0A8C0NLX0 (UniProtKB/TrEMBL),   A0A8C0R835 (UniProtKB/TrEMBL),   A0A8I3MK58 (UniProtKB/TrEMBL),   A0A8P0NNB7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845004822   ⟸   ENSCAFT00845006065
Protein Domains
Hexokinase C-terminal   Hexokinase N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000032754 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030016464 UniProtKB/TrEMBL
  ENSCAFG00040003686 UniProtKB/TrEMBL
  ENSCAFG00845003417 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000046047.3 UniProtKB/TrEMBL
  ENSCAFT00030030504.1 UniProtKB/TrEMBL
  ENSCAFT00040007046.1 UniProtKB/TrEMBL
  ENSCAFT00845006065 ENTREZGENE
  ENSCAFT00845006065.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/TrEMBL
  3.40.367.20 UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/TrEMBL
  Hexokinase UniProtKB/TrEMBL
  Hexokinase_BS UniProtKB/TrEMBL
  Hexokinase_C UniProtKB/TrEMBL
  Hexokinase_N UniProtKB/TrEMBL
KEGG Report cfa:489019 UniProtKB/TrEMBL
NCBI Gene HKDC1 ENTREZGENE
PANTHER HEXOKINASE HKDC1 UniProtKB/TrEMBL
  PTHR19443 UniProtKB/TrEMBL
Pfam Hexokinase_1 UniProtKB/TrEMBL
  Hexokinase_2 UniProtKB/TrEMBL
PRINTS HEXOKINASE UniProtKB/TrEMBL
PROSITE HEXOKINASE_1 UniProtKB/TrEMBL
  HEXOKINASE_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
UniProt A0A8C0NLX0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0R835 ENTREZGENE
  A0A8I3MK58 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NNB7 ENTREZGENE
UniProt Secondary A0A8P0NNB7 UniProtKB/TrEMBL
VGNC ID VGNC:41701 ENTREZGENE