MAPK13 (mitogen-activated protein kinase 13) - Rat Genome Database

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Gene: MAPK13 (mitogen-activated protein kinase 13) Canis lupus familiaris
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Symbol: MAPK13 (Ensembl: MAPK14)
Name: mitogen-activated protein kinase 13
RGD ID: 12109610
Description: ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase activity (ortholog); INVOLVED IN protein phosphorylation (ortholog); PARTICIPATES IN p38 MAPK signaling pathway; ASSOCIATED WITH cholestasis (ortholog); genetic disease (ortholog); proteasome-associated autoinflammatory syndrome 1 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,239,783 - 5,248,197 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,239,750 - 5,248,196 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,259,690 - 5,268,114 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0125,587,473 - 5,595,899 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl125,587,535 - 5,595,894 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1125,242,126 - 5,250,558 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,321,188 - 5,329,595 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,421,369 - 5,429,783 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MAPK13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,239,783 - 5,248,197 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,239,750 - 5,248,196 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,259,690 - 5,268,114 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0125,587,473 - 5,595,899 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl125,587,535 - 5,595,894 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1125,242,126 - 5,250,558 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,321,188 - 5,329,595 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,421,369 - 5,429,783 (+)NCBIUU_Cfam_GSD_1.0
MAPK13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38636,130,513 - 36,144,521 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl636,127,809 - 36,144,524 (+)EnsemblGRCh38hg38GRCh38
GRCh37636,098,290 - 36,112,298 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,206,240 - 36,215,820 (+)NCBINCBI36Build 36hg18NCBI36
Build 34636,206,239 - 36,215,820NCBI
Celera637,652,800 - 37,662,381 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef635,818,129 - 35,832,173 (+)NCBIHuRef
CHM1_1636,100,011 - 36,114,054 (+)NCBICHM1_1
T2T-CHM13v2.0635,950,829 - 35,964,842 (+)NCBIT2T-CHM13v2.0
Mapk13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391728,988,260 - 28,997,678 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1728,988,271 - 28,999,207 (+)EnsemblGRCm39 Ensembl
GRCm381728,769,286 - 28,778,704 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,769,297 - 28,780,233 (+)EnsemblGRCm38mm10GRCm38
MGSCv371728,906,262 - 28,915,649 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361728,496,946 - 28,506,293 (+)NCBIMGSCv36mm8
Celera1729,324,078 - 29,333,467 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.0NCBI
Mapk13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8206,836,979 - 6,847,197 (+)NCBIGRCr8
mRatBN7.2206,835,277 - 6,845,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,835,320 - 6,844,222 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,546,408 - 7,555,599 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,908,260 - 6,917,454 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,389,575 - 7,399,109 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0206,018,374 - 6,027,467 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,018,374 - 6,027,473 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,272,098 - 8,281,191 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,055,313 - 7,064,405 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1207,055,597 - 7,064,383 (+)NCBI
Celera208,389,500 - 8,398,583 (+)NCBICelera
Cytogenetic Map20p12NCBI
Mapk13
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554373,899,950 - 3,909,114 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554373,899,988 - 3,907,781 (+)NCBIChiLan1.0ChiLan1.0
MAPK13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2550,589,442 - 50,619,036 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1646,458,940 - 46,488,555 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0635,689,475 - 35,711,990 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1636,890,205 - 36,904,528 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl636,890,974 - 36,899,388 (+)Ensemblpanpan1.1panPan2
Mapk13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494640,741,448 - 40,748,117 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647623,212,074 - 23,218,775 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647623,212,116 - 23,218,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK13
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl731,880,638 - 31,889,455 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1731,880,643 - 31,889,586 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAPK13
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11735,982,749 - 35,993,956 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1735,983,430 - 35,992,468 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604436,084,986 - 36,097,950 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk13
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475421,506,369 - 21,513,801 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475421,506,086 - 21,513,803 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAPK13
120 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 16 6 12 8 10 6
Low 5 6 6 6 6
Below cutoff 6

Sequence


RefSeq Acc Id: ENSCAFT00000002131   ⟹   ENSCAFP00000001972
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl125,239,750 - 5,248,196 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000060028   ⟹   ENSCAFP00000057112
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl125,239,750 - 5,247,940 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845014969   ⟹   ENSCAFP00845011607
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl125,587,535 - 5,595,894 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845015025   ⟹   ENSCAFP00845011653
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl125,587,535 - 5,595,894 (+)Ensembl
RefSeq Acc Id: XM_005627266   ⟹   XP_005627323
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1125,239,783 - 5,248,197 (+)NCBI
Dog10K_Boxer_Tasha125,259,690 - 5,268,114 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038491634   ⟹   XP_038347562
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1125,242,126 - 5,250,558 (+)NCBI
RefSeq Acc Id: XM_038553858   ⟹   XP_038409786
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0125,421,369 - 5,429,783 (+)NCBI
RefSeq Acc Id: XM_038617716   ⟹   XP_038473644
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0125,321,188 - 5,329,595 (+)NCBI
RefSeq Acc Id: XM_038683312   ⟹   XP_038539240
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0125,587,473 - 5,595,899 (+)NCBI
RefSeq Acc Id: XP_005627323   ⟸   XM_005627266
- UniProtKB: A0A8C0K294 (UniProtKB/TrEMBL),   A0A8C0T102 (UniProtKB/TrEMBL),   A0A8I3NKJ3 (UniProtKB/TrEMBL),   A0A8C0T3B3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000057112   ⟸   ENSCAFT00000060028
RefSeq Acc Id: ENSCAFP00000001972   ⟸   ENSCAFT00000002131
RefSeq Acc Id: XP_038347562   ⟸   XM_038491634
RefSeq Acc Id: XP_038473644   ⟸   XM_038617716
RefSeq Acc Id: XP_038539240   ⟸   XM_038683312
- UniProtKB: A0A8C0K294 (UniProtKB/TrEMBL),   A0A8C0T102 (UniProtKB/TrEMBL),   A0A8I3NKJ3 (UniProtKB/TrEMBL),   A0A8C0T3B3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038409786   ⟸   XM_038553858
- UniProtKB: A0A8C0T3B3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845011653   ⟸   ENSCAFT00845015025
RefSeq Acc Id: ENSCAFP00845011607   ⟸   ENSCAFT00845014969
Protein Domains
Protein kinase

Promoters
RGD ID:13685399
Promoter ID:EPDNEW_C3467
Type:multiple initiation site
Name:MAPK13_1
Description:mitogen-activated protein kinase 13
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1125,239,787 - 5,239,847EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001382 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040017597 UniProtKB/TrEMBL
  ENSCAFG00845008508 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000002131.5 UniProtKB/TrEMBL
  ENSCAFT00000060028.2 UniProtKB/TrEMBL
  ENSCAFT00040033155.1 UniProtKB/TrEMBL
  ENSCAFT00040033389.1 UniProtKB/TrEMBL
  ENSCAFT00845014969 ENTREZGENE
  ENSCAFT00845014969.1 UniProtKB/TrEMBL
  ENSCAFT00845015025.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  MAPK_p38-like UniProtKB/TrEMBL
  p38delta UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
KEGG Report cfa:612821 UniProtKB/TrEMBL
NCBI Gene MAPK13 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 13 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PRINTS P38MAPKINASE UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0K294 ENTREZGENE
  A0A8C0T102 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T3B3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MZM9_CANLF UniProtKB/TrEMBL
  A0A8I3NKJ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0P6F2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:42994 ENTREZGENE