ADAMTS4 (ADAM metallopeptidase with thrombospondin type 1 motif 4) - Rat Genome Database

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Gene: ADAMTS4 (ADAM metallopeptidase with thrombospondin type 1 motif 4) Canis lupus familiaris
Analyze
Symbol: ADAMTS4
Name: ADAM metallopeptidase with thrombospondin type 1 motif 4
RGD ID: 12109492
Description: ENCODES a protein that exhibits metal ion binding (inferred); metalloendopeptidase activity (inferred); metallopeptidase activity (inferred); INVOLVED IN defense response to bacterium (ortholog); proteolysis (ortholog); ASSOCIATED WITH autoimmune interstitial lung, joint, and kidney disease (ortholog); degenerative disc disease (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN extracellular matrix (inferred); extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: A disintegrin and metalloproteinase with thrombospondin motifs 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,283,555 - 21,292,432 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,284,330 - 21,292,437 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,358,398 - 21,367,289 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,401,386 - 21,410,283 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,402,174 - 21,409,517 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,289,243 - 21,298,133 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,703,669 - 21,712,554 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,112,816 - 22,121,707 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADAMTS4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,283,555 - 21,292,432 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,284,330 - 21,292,437 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,358,398 - 21,367,289 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,401,386 - 21,410,283 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,402,174 - 21,409,517 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,289,243 - 21,298,133 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,703,669 - 21,712,554 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,112,816 - 22,121,707 (+)NCBIUU_Cfam_GSD_1.0
ADAMTS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,184,302 - 161,199,054 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,184,302 - 161,199,054 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,154,092 - 161,168,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,426,162 - 159,435,469 (-)NCBINCBI36Build 36hg18NCBI36
Build 341157,972,611 - 157,981,917NCBI
Celera1134,226,690 - 134,235,997 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,516,482 - 132,525,790 (-)NCBIHuRef
CHM1_11162,555,776 - 162,565,083 (-)NCBICHM1_1
T2T-CHM13v2.01160,321,737 - 160,336,495 (-)NCBIT2T-CHM13v2.0
Adamts4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,077,698 - 171,089,836 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,077,990 - 171,088,206 (+)EnsemblGRCm39 Ensembl
GRCm381171,250,129 - 171,262,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,250,421 - 171,260,637 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,180,553 - 173,190,053 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,087,097 - 173,096,597 (+)NCBIMGSCv36mm8
Celera1173,706,617 - 173,716,194 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.28NCBI
Adamts4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,203,011 - 86,212,500 (+)NCBIGRCr8
mRatBN7.21383,670,556 - 83,680,045 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,670,183 - 83,680,065 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,176,431 - 86,185,920 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,574,636 - 87,584,125 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,806,145 - 84,815,616 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,622,996 - 89,632,485 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,622,632 - 89,634,419 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,249,862 - 94,259,351 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,142,442 - 87,151,783 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,336,962 - 87,339,836 (+)NCBI
Celera1383,301,254 - 83,310,782 (+)NCBICelera
Cytogenetic Map13q24NCBI
Adamts4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,951,155 - 12,958,212 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,950,333 - 12,958,599 (-)NCBIChiLan1.0ChiLan1.0
ADAMTS4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,652,642 - 88,667,740 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,343,086 - 88,352,613 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,602,140 - 136,611,469 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,514,247 - 140,523,623 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,514,247 - 140,523,623 (-)Ensemblpanpan1.1panPan2
Adamts4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,282,484 - 7,291,864 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903491,139 - 500,443 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936903490,718 - 500,443 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,260,461 - 89,269,244 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,260,354 - 89,269,238 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,117,041 - 97,125,927 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,781,184 - 2,791,464 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,783,855 - 2,792,170 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,829,936 - 1,842,272 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794188,207 - 198,934 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794187,589 - 196,465 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADAMTS4
129 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 1
Low 5 5 22 6 6 6 6 6 11 8 10 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000020354   ⟹   ENSCAFP00000018886
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3821,284,330 - 21,292,437 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845052198   ⟹   ENSCAFP00845040938
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3821,402,174 - 21,409,517 (+)Ensembl
RefSeq Acc Id: XM_038448621   ⟹   XP_038304549
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03821,401,386 - 21,410,283 (+)NCBI
RefSeq Acc Id: XM_038522506   ⟹   XP_038378434
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13821,289,243 - 21,298,133 (+)NCBI
RefSeq Acc Id: XM_038586287   ⟹   XP_038442215
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03822,112,816 - 22,121,707 (+)NCBI
RefSeq Acc Id: XM_038650707   ⟹   XP_038506635
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03821,703,669 - 21,712,554 (+)NCBI
RefSeq Acc Id: XM_545768   ⟹   XP_545768
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13821,283,555 - 21,292,432 (+)NCBI
Dog10K_Boxer_Tasha3821,358,398 - 21,367,289 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_545768   ⟸   XM_545768
- UniProtKB: A0A8C0SKI4 (UniProtKB/TrEMBL),   A0A8I3Q3A2 (UniProtKB/TrEMBL),   A0A8C0QT61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000018886   ⟸   ENSCAFT00000020354
RefSeq Acc Id: XP_038378434   ⟸   XM_038522506
RefSeq Acc Id: XP_038506635   ⟸   XM_038650707
RefSeq Acc Id: XP_038304549   ⟸   XM_038448621
- UniProtKB: A0A8C0SKI4 (UniProtKB/TrEMBL),   A0A8I3Q3A2 (UniProtKB/TrEMBL),   A0A8C0QT61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038442215   ⟸   XM_038586287
- UniProtKB: A0A8C0NWG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845040938   ⟸   ENSCAFT00845052198
Protein Domains
Peptidase M12B

Promoters
RGD ID:13689221
Promoter ID:EPDNEW_C7289
Type:single initiation site
Name:ADAMTS4_1
Description:ADAM metallopeptidase with thrombospondin type 1 motif 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13821,284,363 - 21,284,423EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012836 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030019435 UniProtKB/TrEMBL
  ENSCAFG00040013576 UniProtKB/TrEMBL
  ENSCAFG00845029491 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000020354.6 UniProtKB/TrEMBL
  ENSCAFT00030035759.1 UniProtKB/TrEMBL
  ENSCAFT00040025074.1 UniProtKB/TrEMBL
  ENSCAFT00845052198 ENTREZGENE
  ENSCAFT00845052198.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  2.60.120.830 UniProtKB/TrEMBL
  3.40.1620.60 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_Cys-rich UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
KEGG Report cfa:488651 UniProtKB/TrEMBL
NCBI Gene ADAMTS4 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 4 UniProtKB/TrEMBL
  ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE UniProtKB/TrEMBL
Pfam ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PRINTS ADAMTSFAMILY UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF82895 UniProtKB/TrEMBL
UniProt A0A8C0NWG0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QT61 ENTREZGENE
  A0A8C0SKI4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q3A2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:37600 ENTREZGENE