CYBA (cytochrome b-245 alpha chain) - Rat Genome Database

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Gene: CYBA (cytochrome b-245 alpha chain) Canis lupus familiaris
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Symbol: CYBA
Name: cytochrome b-245 alpha chain
RGD ID: 12107592
Description: ENCODES a protein that exhibits electron transfer activity (ortholog); protein heterodimerization activity (ortholog); SH3 domain binding (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to angiotensin (ortholog); cellular response to gamma radiation (ortholog); PARTICIPATES IN thyroid hormone biosynthetic pathway; ASSOCIATED WITH 16Q24.3 Microdeletion Syndrome (ortholog); acute lymphoblastic leukemia (ortholog); asthma (ortholog); FOUND IN apical plasma membrane (ortholog); cytoplasm (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytochrome b-245, alpha polypeptide; predicted cytochrome b-245, alpha polypeptide
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1564,692,865 - 64,701,056 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl564,692,123 - 64,704,893 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha564,703,545 - 64,711,735 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0564,912,202 - 64,920,393 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl564,911,577 - 64,920,464 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1564,938,335 - 64,946,503 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0564,770,091 - 64,778,279 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0565,176,122 - 65,184,313 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid stimulus  (ISO)
cellular response to angiotensin  (ISO)
cellular response to gamma radiation  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to L-glutamine  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to organic substance  (ISO)
cellular response to tumor necrosis factor  (ISO)
cytochrome complex assembly  (ISO)
establishment of localization in cell  (ISO)
hydrogen peroxide biosynthetic process  (ISO)
inflammatory response  (ISO)
innate immune response  (ISO)
mucus secretion  (ISO)
negative regulation of glomerular filtration by angiotensin  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of defense response to bacterium  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of mucus secretion  (ISO)
positive regulation of NAD(P)H oxidase activity  (ISO)
positive regulation of oxygen metabolic process  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of toll-like receptor 2 signaling pathway  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
reactive oxygen species metabolic process  (ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO)
respiratory burst  (ISO)
response to activity  (ISO)
response to aldosterone  (ISO)
response to hypoxia  (ISO)
response to interleukin-1  (ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
smooth muscle hypertrophy  (ISO)
superoxide anion generation  (ISO)
superoxide metabolic process  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381931   PMID:17612411   PMID:19168727   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CYBA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1564,692,865 - 64,701,056 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl564,692,123 - 64,704,893 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha564,703,545 - 64,711,735 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0564,912,202 - 64,920,393 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl564,911,577 - 64,920,464 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1564,938,335 - 64,946,503 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0564,770,091 - 64,778,279 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0565,176,122 - 65,184,313 (+)NCBIUU_Cfam_GSD_1.0
CYBA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381688,643,289 - 88,651,053 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1688,643,275 - 88,651,083 (-)EnsemblGRCh38hg38GRCh38
GRCh371688,709,697 - 88,717,461 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361687,237,198 - 87,244,958 (-)NCBINCBI36Build 36hg18NCBI36
Build 341687,237,198 - 87,244,950NCBI
Celera1673,779,369 - 73,787,129 (-)NCBICelera
Cytogenetic Map16q24.2NCBI
HuRef1674,403,728 - 74,411,523 (-)NCBIHuRef
CHM1_11690,120,999 - 90,128,842 (-)NCBICHM1_1
T2T-CHM13v2.01694,711,169 - 94,718,983 (-)NCBIT2T-CHM13v2.0
Cyba
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,151,510 - 123,159,679 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,151,515 - 123,159,669 (-)EnsemblGRCm39 Ensembl
GRCm388122,424,771 - 122,432,940 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8122,424,776 - 122,432,930 (-)EnsemblGRCm38mm10GRCm38
MGSCv378124,948,671 - 124,956,840 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368125,310,866 - 125,319,017 (-)NCBIMGSCv36mm8
Celera8126,653,882 - 126,662,049 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map871.04NCBI
Cyba
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81967,396,143 - 67,404,214 (-)NCBIGRCr8
mRatBN7.21950,487,598 - 50,495,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,487,597 - 50,495,721 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1957,282,778 - 57,290,847 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,962,531 - 57,970,602 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,181,396 - 60,189,465 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01955,249,634 - 55,257,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,249,616 - 55,257,876 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01965,959,818 - 65,967,224 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,713,150 - 52,721,609 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11952,718,030 - 52,726,490 (-)NCBI
Celera1949,727,142 - 49,735,154 (-)NCBICelera
Cytogenetic Map19q12NCBI
LOC102004641
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555412,569,727 - 2,574,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555412,570,843 - 2,573,822 (-)NCBIChiLan1.0ChiLan1.0
LOC100986914
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21898,416,331 - 98,424,174 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116104,328,442 - 104,336,271 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01669,356,396 - 69,364,225 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11689,016,349 - 89,024,719 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1689,016,349 - 89,024,719 (-)Ensemblpanpan1.1panPan2
LOC101967032
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934925,283,408 - 25,291,407 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366411,036,967 - 1,044,991 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366411,036,967 - 1,044,954 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYBA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl61,015,162 - 1,021,420 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.161,015,212 - 1,021,422 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103233451
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1574,023,134 - 74,030,793 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl574,023,082 - 74,030,750 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660471,654,155 - 1,661,751 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101717043
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624746911,842 - 919,362 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624746911,852 - 919,361 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CYBA
103 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 12 8 10 6
Low 6
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000031633   ⟹   ENSCAFP00000029449
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl564,697,219 - 64,701,127 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000081224   ⟹   ENSCAFP00000054508
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl564,692,123 - 64,704,893 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845006275   ⟹   ENSCAFP00845004982
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl564,911,577 - 64,920,464 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845006285   ⟹   ENSCAFP00845004990
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl564,916,556 - 64,920,464 (+)Ensembl
RefSeq Acc Id: NM_001100290   ⟹   NP_001093760
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1564,692,865 - 64,701,056 (+)NCBI
Dog10K_Boxer_Tasha564,703,545 - 64,711,735 (+)NCBI
ROS_Cfam_1.0564,912,202 - 64,920,393 (+)NCBI
UMICH_Zoey_3.1564,938,335 - 64,946,503 (+)NCBI
UNSW_CanFamBas_1.0564,770,091 - 64,778,279 (+)NCBI
UU_Cfam_GSD_1.0565,176,122 - 65,184,313 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001093760 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000029449.3
  ENSCAFP00000068777.1
  ENSCAFP00030027024.1
  ENSCAFP00040018695.1
  ENSCAFP00845004982.1
  ENSCAFP00845004990
  ENSCAFP00845004990.1
GenBank Protein FAA00353 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001093760   ⟸   NM_001100290
- UniProtKB: A7E3M4 (UniProtKB/TrEMBL),   A0A8C0JUI7 (UniProtKB/TrEMBL),   A0A8C0SBY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000029449   ⟸   ENSCAFT00000031633
RefSeq Acc Id: ENSCAFP00000054508   ⟸   ENSCAFT00000081224
RefSeq Acc Id: ENSCAFP00845004982   ⟸   ENSCAFT00845006275
RefSeq Acc Id: ENSCAFP00845004990   ⟸   ENSCAFT00845006285

Promoters
RGD ID:13683402
Promoter ID:EPDNEW_C1472
Type:multiple initiation site
Name:CYBA_1
Description:cytochrome b-245 alpha chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1564,692,824 - 64,692,884EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019881 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030016739 UniProtKB/TrEMBL
  ENSCAFG00040011667 UniProtKB/TrEMBL
  ENSCAFG00845003520 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000031633.4 UniProtKB/TrEMBL
  ENSCAFT00000096219.1 UniProtKB/TrEMBL
  ENSCAFT00030030979.1 UniProtKB/TrEMBL
  ENSCAFT00040021534.1 UniProtKB/TrEMBL
  ENSCAFT00845006275.1 UniProtKB/TrEMBL
  ENSCAFT00845006285 ENTREZGENE
  ENSCAFT00845006285.1 UniProtKB/TrEMBL
InterPro Cyt_b558_asu UniProtKB/TrEMBL
KEGG Report cfa:489664 UniProtKB/TrEMBL
NCBI Gene CYBA ENTREZGENE
PANTHER CYTOCHROME B-245 LIGHT CHAIN UniProtKB/TrEMBL
  PTHR15168 UniProtKB/TrEMBL
Pfam Cytochrom_B558a UniProtKB/TrEMBL
PIRSF Cytochr_b558a UniProtKB/TrEMBL
UniProt A0A8C0JUI7 ENTREZGENE
  A0A8C0RLW5_CANLF UniProtKB/TrEMBL
  A0A8C0SBY9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MRE7_CANLF UniProtKB/TrEMBL
  A0A8I3MT07_CANLF UniProtKB/TrEMBL
  A0A8P0PI07_CANLF UniProtKB/TrEMBL
  A7E3M4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:50284 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-09 CYBA  cytochrome b-245 alpha chain    cytochrome b-245, alpha polypeptide  Symbol and/or name change 5135510 APPROVED