ANXA1 (annexin A1) - Rat Genome Database

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Gene: ANXA1 (annexin A1) Canis lupus familiaris
Analyze
Symbol: ANXA1
Name: annexin A1
RGD ID: 12100173
Description: ENCODES a protein that exhibits DNA/DNA annealing activity (ortholog); double-stranded DNA helicase activity (ortholog); identical protein binding (ortholog); INVOLVED IN arachidonic acid secretion (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to hydrogen peroxide (ortholog); PARTICIPATES IN cyclooxygenase mediated pathway of arachidonic acid metabolism; ASSOCIATED WITH acute kidney failure (ortholog); Animal Mammary Neoplasms (ortholog); asthma (ortholog); FOUND IN cornified envelope (ortholog); early endosome membrane (ortholog); extracellular space (ortholog); INTERACTS WITH masitinib
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: annexin I
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1184,744,159 - 84,763,011 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl184,744,163 - 84,763,011 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha185,210,169 - 85,229,021 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0185,194,249 - 85,213,101 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl185,194,253 - 85,213,101 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1184,963,509 - 84,982,291 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0184,666,120 - 84,684,901 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0185,425,388 - 85,444,242 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Animal Mammary Neoplasms  (ISO)
asthma  (ISO)
autistic disorder  (ISO)
Blister  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cataract  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
colitis  (ISO)
contact dermatitis  (ISO)
COVID-19  (ISO)
Craniofacial Abnormalities  (ISO)
Delayed Hypersensitivity  (ISO)
Discoid Lupus Erythematosus  (ISO)
dry eye syndrome  (ISO)
ductal carcinoma in situ  (ISO)
encephalitis  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
genetic disease  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
hypothyroidism  (ISO)
Inflammation  (ISO)
invasive ductal carcinoma  (ISO)
ischemia  (ISO)
keratosis follicularis  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant astrocytoma  (ISO)
Mouth Neoplasms  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Ocular Toxoplasmosis  (ISO)
pancreatic cancer  (ISO)
paranasal sinus benign neoplasm  (ISO)
pleurisy  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
Rhinosinusitis  (ISO)
seborrheic keratosis  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
stomach disease  (ISO)
transitional cell carcinoma  (ISO)
uveitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
masitinib  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA)
adaptive immune response  (IEA)
alpha-beta T cell differentiation  (IEA)
arachidonic acid secretion  (IEA,ISO)
cell surface receptor signaling pathway  (IEA,ISO)
cell-cell adhesion  (IEA)
cellular response to glucocorticoid stimulus  (IEA)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to vascular endothelial growth factor stimulus  (IEA)
DNA duplex unwinding  (IEA,ISO)
endocrine pancreas development  (IEA,ISO)
estrous cycle  (IEA,ISO)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IEA)
gliogenesis  (IEA,ISO)
granulocyte chemotaxis  (IEA)
hepatocyte differentiation  (IEA,ISO)
inflammatory response  (IEA)
insulin secretion  (IEA,ISO)
keratinocyte differentiation  (IEA)
monocyte chemotaxis  (IEA)
myoblast migration involved in skeletal muscle regeneration  (IEA)
negative regulation of exocytosis  (IEA)
negative regulation of interleukin-8 production  (IEA)
negative regulation of phospholipase A2 activity  (ISO)
negative regulation of protein secretion  (ISO)
negative regulation of T-helper 2 cell differentiation  (IEA)
neutrophil activation  (IEA)
neutrophil clearance  (IEA)
neutrophil homeostasis  (IEA)
phagocytosis  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA)
positive regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
positive regulation of interleukin-2 production  (IEA)
positive regulation of neutrophil apoptotic process  (IEA)
positive regulation of prostaglandin biosynthetic process  (IEA,ISO)
positive regulation of T cell proliferation  (IEA)
positive regulation of T-helper 1 cell differentiation  (IEA)
positive regulation of vesicle fusion  (IEA)
positive regulation of wound healing  (IEA)
prolactin secretion  (IEA,ISO)
prostate gland development  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of cell shape  (IEA)
regulation of hormone secretion  (IEA)
regulation of inflammatory response  (IEA)
regulation of interleukin-1 production  (IEA)
regulation of leukocyte migration  (IEA)
response to estradiol  (IEA,ISO)
response to glucocorticoid  (ISO)
response to hormone  (ISO)
response to interleukin-1  (IEA,ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (IEA,ISO)
response to X-ray  (IEA,ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:22640262   PMID:30032202   PMID:37756605  


Genomics

Comparative Map Data
ANXA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1184,744,159 - 84,763,011 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl184,744,163 - 84,763,011 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha185,210,169 - 85,229,021 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0185,194,249 - 85,213,101 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl185,194,253 - 85,213,101 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1184,963,509 - 84,982,291 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0184,666,120 - 84,684,901 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0185,425,388 - 85,444,242 (-)NCBIUU_Cfam_GSD_1.0
ANXA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38973,151,865 - 73,170,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl973,151,865 - 73,170,393 (+)EnsemblGRCh38hg38GRCh38
GRCh37975,766,781 - 75,785,309 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36974,956,601 - 74,975,127 (+)NCBINCBI36Build 36hg18NCBI36
Build 34972,996,334 - 73,014,861NCBI
Celera946,339,417 - 46,357,944 (+)NCBICelera
Cytogenetic Map9q21.13ENTREZGENE
HuRef945,589,147 - 45,607,684 (+)NCBIHuRef
CHM1_1975,913,630 - 75,932,174 (+)NCBICHM1_1
T2T-CHM13v2.0985,303,301 - 85,321,829 (+)NCBIT2T-CHM13v2.0
Anxa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391920,350,798 - 20,368,035 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1920,350,792 - 20,368,308 (-)EnsemblGRCm39 Ensembl
GRCm381920,373,434 - 20,390,671 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1920,373,428 - 20,390,944 (-)EnsemblGRCm38mm10GRCm38
MGSCv371920,447,924 - 20,465,161 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361920,440,455 - 20,457,696 (-)NCBIMGSCv36mm8
Celera1921,098,423 - 21,115,607 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1913.83NCBI
Anxa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,287,713 - 227,306,739 (-)NCBIGRCr8
mRatBN7.21217,861,175 - 217,877,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1217,861,175 - 217,877,343 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1226,201,607 - 226,217,642 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,138,171 - 233,154,203 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01225,956,194 - 225,972,229 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01237,893,983 - 237,910,002 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1237,893,966 - 237,910,012 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01245,192,875 - 245,220,057 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,478,436 - 223,494,455 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,642,460 - 223,658,478 (-)NCBI
Celera1215,138,950 - 215,154,969 (-)NCBICelera
Cytogenetic Map1q51NCBI
Anxa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555125,686,508 - 5,703,645 (-)NCBIChiLan1.0ChiLan1.0
ANXA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21172,336,793 - 72,355,498 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1972,342,859 - 72,361,441 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0951,647,404 - 51,665,990 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1971,930,148 - 71,948,779 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl971,929,728 - 71,948,779 (+)Ensemblpanpan1.1panPan2
Anxa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947132,030,632 - 132,048,702 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365039,124,264 - 9,142,413 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365039,124,314 - 9,142,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANXA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,414,306 - 226,432,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,414,200 - 226,431,963 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,989,694 - 253,007,485 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANXA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11284,207,818 - 84,226,438 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1284,207,820 - 84,226,562 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603872,640,484 - 72,659,219 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Anxa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624811764,940 - 782,198 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624811765,338 - 782,203 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ANXA1
259 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 1 2
Medium 5 5 22 6 6 6 6 2 11 9 4
Low 4 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000002795   ⟹   ENSCAFP00000002591
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl184,744,163 - 84,763,011 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845000063   ⟹   ENSCAFP00845000044
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl185,194,253 - 85,213,101 (-)Ensembl
RefSeq Acc Id: NM_001286970   ⟹   NP_001273899
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1184,744,159 - 84,763,011 (-)NCBI
Dog10K_Boxer_Tasha185,210,169 - 85,229,021 (-)NCBI
ROS_Cfam_1.0185,194,249 - 85,213,101 (-)NCBI
UMICH_Zoey_3.1184,963,509 - 84,982,291 (-)NCBI
UNSW_CanFamBas_1.0184,666,120 - 84,684,901 (-)NCBI
UU_Cfam_GSD_1.0185,425,388 - 85,444,242 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001273899 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT44542 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000002591.3
  ENSCAFP00030036974.1
  ENSCAFP00040009243.1
  ENSCAFP00845000044
  ENSCAFP00845000044.1
Reference Protein Sequences
RefSeq Acc Id: NP_001273899   ⟸   NM_001286970
- UniProtKB: A0A8C0LJI6 (UniProtKB/TrEMBL),   A0A8C0PB64 (UniProtKB/TrEMBL),   A0A8I3M9P4 (UniProtKB/TrEMBL),   A0A8C0Q5K3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000002591   ⟸   ENSCAFT00000002795
RefSeq Acc Id: ENSCAFP00845000044   ⟸   ENSCAFT00845000063

Promoters
RGD ID:13682084
Promoter ID:EPDNEW_C153
Type:multiple initiation site
Name:ANXA1_1
Description:annexin A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1184,762,938 - 84,762,998EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001778 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030023048 UniProtKB/TrEMBL
  ENSCAFG00040005675 UniProtKB/TrEMBL
  ENSCAFG00845000040 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000002795.5 UniProtKB/TrEMBL
  ENSCAFT00030042374.1 UniProtKB/TrEMBL
  ENSCAFT00040010658.1 UniProtKB/TrEMBL
  ENSCAFT00845000063 ENTREZGENE
  ENSCAFT00845000063.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.220.10 UniProtKB/TrEMBL
InterPro Annexin UniProtKB/TrEMBL
  Annexin_repeat UniProtKB/TrEMBL
  Annexin_repeat_CS UniProtKB/TrEMBL
  Annexin_sf UniProtKB/TrEMBL
  ANX1 UniProtKB/TrEMBL
KEGG Report cfa:476322 UniProtKB/TrEMBL
NCBI Gene ANXA1 ENTREZGENE
PANTHER ANNEXIN UniProtKB/TrEMBL
  PTHR10502:SF17 UniProtKB/TrEMBL
Pfam Annexin UniProtKB/TrEMBL
PRINTS ANNEXIN UniProtKB/TrEMBL
  ANNEXINI UniProtKB/TrEMBL
PROSITE ANNEXIN_1 UniProtKB/TrEMBL
  ANNEXIN_2 UniProtKB/TrEMBL
SMART ANX UniProtKB/TrEMBL
Superfamily-SCOP SSF47874 UniProtKB/TrEMBL
UniProt A0A8C0LJI6 ENTREZGENE
  A0A8C0PB64 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q5K3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3M9P4 ENTREZGENE, UniProtKB/TrEMBL
  Q6JDN3_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:37937 ENTREZGENE