ANGPT2 (angiopoietin 2) - Rat Genome Database

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Gene: ANGPT2 (angiopoietin 2) Canis lupus familiaris
Analyze
Symbol: ANGPT2
Name: angiopoietin 2
RGD ID: 12090693
Description: ENCODES a protein that exhibits metal ion binding (inferred); receptor tyrosine kinase binding (inferred); INVOLVED IN angiogenesis (ortholog); animal organ regeneration (ortholog); blood vessel morphogenesis (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); Alcoholic Liver Diseases (ortholog); angiosarcoma (ortholog); FOUND IN cell projection (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ANG-2; angiopoietin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11658,404,049 - 58,458,344 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1658,405,259 - 58,457,701 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1653,935,215 - 53,987,886 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01657,592,625 - 57,645,271 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1657,592,730 - 57,645,741 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11658,549,239 - 58,616,758 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01655,601,814 - 55,654,409 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01655,977,188 - 56,030,293 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:16545849   PMID:30032202   PMID:33964126  


Genomics

Comparative Map Data
ANGPT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11658,404,049 - 58,458,344 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1658,405,259 - 58,457,701 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1653,935,215 - 53,987,886 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01657,592,625 - 57,645,271 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1657,592,730 - 57,645,741 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11658,549,239 - 58,616,758 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01655,601,814 - 55,654,409 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01655,977,188 - 56,030,293 (+)NCBIUU_Cfam_GSD_1.0
ANGPT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3886,499,632 - 6,563,245 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl86,499,632 - 6,563,409 (-)EnsemblGRCh38hg38GRCh38
GRCh3786,357,153 - 6,420,766 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3686,347,601 - 6,408,170 (-)NCBINCBI36Build 36hg18NCBI36
Build 3486,347,600 - 6,408,172NCBI
Celera86,334,650 - 6,398,296 (-)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef86,139,162 - 6,202,785 (-)NCBIHuRef
CHM1_186,445,906 - 6,509,954 (-)NCBICHM1_1
T2T-CHM13v2.086,254,102 - 6,317,682 (-)NCBIT2T-CHM13v2.0
Angpt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39818,740,279 - 18,791,578 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl818,740,279 - 18,791,578 (-)EnsemblGRCm39 Ensembl
GRCm38818,690,263 - 18,741,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl818,690,263 - 18,741,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv37818,691,337 - 18,741,551 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36818,691,314 - 18,741,528 (-)NCBIMGSCv36mm8
Celera818,824,534 - 18,875,113 (-)NCBICelera
Cytogenetic Map8A1.3NCBI
cM Map810.3NCBI
Angpt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,790,760 - 77,841,241 (+)NCBIGRCr8
mRatBN7.21671,088,364 - 71,138,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1671,088,364 - 71,138,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1676,365,217 - 76,415,702 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,811,900 - 79,862,566 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01675,061,325 - 75,111,991 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,966,480 - 76,016,147 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,966,352 - 76,016,195 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01675,572,301 - 75,621,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,891,757 - 75,942,255 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11675,934,743 - 75,941,749 (+)NCBI
Celera1668,933,847 - 68,984,314 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
Angpt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540354,139,823 - 54,195,032 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540354,139,823 - 54,193,740 (+)NCBIChiLan1.0ChiLan1.0
ANGPT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2721,294,413 - 21,380,483 (-)NCBINHGRI_mPanPan1-v2
Mhudiblu_PPA_v08718,367 - 782,534 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.186,506,012 - 6,566,915 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl86,506,014 - 6,566,915 (-)Ensemblpanpan1.1panPan2
Angpt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049434,473,275 - 4,524,605 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366154,472,247 - 4,524,556 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366154,472,261 - 4,524,537 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANGPT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1537,544,707 - 37,599,041 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11537,544,177 - 37,600,925 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21542,687,923 - 42,787,653 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANGPT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.186,283,619 - 6,345,320 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl86,280,584 - 6,344,729 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605448,397,826 - 48,458,677 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Angpt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248614,457,158 - 4,509,623 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248614,457,519 - 4,510,035 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ANGPT2
691 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8
Low 5 5 18 2 6 2 6 4 12 10 6
Below cutoff 4 4 4 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000013697   ⟹   ENSCAFP00000012670
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1658,405,259 - 58,457,701 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000081623   ⟹   ENSCAFP00000043986
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1658,405,259 - 58,457,684 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845039788   ⟹   ENSCAFP00845031162
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1657,592,730 - 57,645,741 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845039859   ⟹   ENSCAFP00845031217
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1657,592,740 - 57,645,741 (+)Ensembl
RefSeq Acc Id: NM_001048126   ⟹   NP_001041591
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11658,405,259 - 58,457,710 (-)NCBI
Dog10K_Boxer_Tasha1653,935,215 - 53,987,886 (-)NCBI
ROS_Cfam_1.01657,593,057 - 57,645,271 (+)NCBI
UMICH_Zoey_3.11658,549,239 - 58,616,758 (-)NCBI
UNSW_CanFamBas_1.01655,601,814 - 55,654,409 (+)NCBI
UU_Cfam_GSD_1.01655,977,188 - 56,030,293 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038688893   ⟹   XP_038544821
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01657,592,625 - 57,644,792 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001041591   ⟸   NM_001048126
- Peptide Label: precursor
- UniProtKB: A0A8J8 (UniProtKB/Swiss-Prot),   A0A8C0R006 (UniProtKB/TrEMBL),   A0A8C0QPL8 (UniProtKB/TrEMBL),   A0A8I3S5R4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000012670   ⟸   ENSCAFT00000013697
RefSeq Acc Id: ENSCAFP00000043986   ⟸   ENSCAFT00000081623
RefSeq Acc Id: XP_038544821   ⟸   XM_038688893
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845031162   ⟸   ENSCAFT00845039788
RefSeq Acc Id: ENSCAFP00845031217   ⟸   ENSCAFT00845039859
Protein Domains
Fibrinogen C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008597 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030008722 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00040008101 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00805006504 UniProtKB/Swiss-Prot
  ENSCAFG00845022531 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000013697.5 UniProtKB/Swiss-Prot
  ENSCAFT00000081623.2 UniProtKB/TrEMBL
  ENSCAFT00030016221.1 UniProtKB/Swiss-Prot
  ENSCAFT00030016290.1 UniProtKB/TrEMBL
  ENSCAFT00040015200.1 UniProtKB/Swiss-Prot
  ENSCAFT00040015232.1 UniProtKB/TrEMBL
  ENSCAFT00805011863 UniProtKB/Swiss-Prot
  ENSCAFT00845039788.1 UniProtKB/TrEMBL
  ENSCAFT00845039859 ENTREZGENE
  ENSCAFT00845039859.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.215.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fibrinogen-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:607616 UniProtKB/Swiss-Prot
NCBI Gene ANGPT2 ENTREZGENE
PANTHER FIBRINOGEN/TENASCIN/ANGIOPOEITIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19143:SF199 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Fibrinogen_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FIBRINOGEN_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIBRINOGEN_C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FBG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56496 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0QPL8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0R006 ENTREZGENE
  A0A8I3S5R4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:37855 ENTREZGENE