AKR1C3 (aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)) - Rat Genome Database

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Pathways
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Gene: AKR1C3 (aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)) Canis lupus familiaris
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Symbol: AKR1C3
Name: aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
RGD ID: 12071242
Description: ENCODES a protein that exhibits 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity (ortholog); 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity (ortholog); aldo-keto reductase (NADPH) activity (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cellular response to corticosteroid stimulus (ortholog); cellular response to follicle-stimulating hormone stimulus (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); B-lymphoblastic leukemia/lymphoma (ortholog); castration-resistant prostate carcinoma (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: aldo-keto reductase family 1 member C21; PGFS; prostaglandin F synthase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Pig
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1230,661,333 - 30,691,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl230,674,558 - 30,690,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha227,694,812 - 27,719,595 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0231,042,072 - 31,071,570 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl231,045,998 - 31,070,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1228,135,405 - 28,160,172 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,972,376 - 28,997,157 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0229,696,602 - 29,721,383 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to calcium ion  (ISO)
cellular response to corticosteroid stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to forskolin  (ISO)
cellular response to gonadotropin-releasing hormone  (ISO)
cellular response to jasmonic acid stimulus  (ISO)
cellular response to prolactin  (ISO)
cellular response to prostaglandin D stimulus  (ISO)
cellular response to prostaglandin stimulus  (ISO)
cellular response to starvation  (ISO)
cellular response to testosterone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
daunorubicin metabolic process  (ISO)
doxorubicin metabolic process  (ISO)
farnesol catabolic process  (ISO)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
keratinocyte differentiation  (ISO)
male gonad development  (ISO)
negative regulation of retinoic acid biosynthetic process  (ISO)
parturition  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
progesterone catabolic process  (ISO)
progesterone metabolic process  (ISO)
prostaglandin metabolic process  (ISO)
regulation of retinoic acid receptor signaling pathway  (ISO)
regulation of steroid biosynthetic process  (ISO)
regulation of testosterone biosynthetic process  (ISO)
response to nutrient  (ISO)
retinal metabolic process  (ISO)
steroid metabolic process  (IEA)
testosterone biosynthetic process  (ISO)

Cellular Component
cytoplasm  (ISO)
cytosol  (IEA)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:4918753   PMID:17689894   PMID:23677986   PMID:30032202  


Genomics

Comparative Map Data
AKR1C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1230,661,333 - 30,691,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl230,674,558 - 30,690,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha227,694,812 - 27,719,595 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0231,042,072 - 31,071,570 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl231,045,998 - 31,070,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1228,135,405 - 28,160,172 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,972,376 - 28,997,157 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0229,696,602 - 29,721,383 (+)NCBIUU_Cfam_GSD_1.0
AKR1C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38105,048,781 - 5,107,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl105,035,354 - 5,107,686 (+)EnsemblGRCh38hg38GRCh38
GRCh37105,090,973 - 5,149,878 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,126,568 - 5,139,878 (+)NCBINCBI36Build 36hg18NCBI36
Build 34105,126,567 - 5,139,878NCBI
Celera105,076,549 - 5,089,836 (+)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,024,814 - 5,083,613 (+)NCBIHuRef
CHM1_1105,091,312 - 5,150,193 (+)NCBICHM1_1
T2T-CHM13v2.0105,049,294 - 5,108,188 (+)NCBIT2T-CHM13v2.0
Akr1c18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,182,614 - 4,200,645 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,182,614 - 4,200,653 (-)EnsemblGRCm39 Ensembl
GRCm38134,132,615 - 4,150,646 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,132,615 - 4,150,654 (-)EnsemblGRCm38mm10GRCm38
MGSCv37134,131,873 - 4,149,877 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,131,873 - 4,149,877 (-)NCBIMGSCv36mm8
Celera134,108,614 - 4,126,601 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.31NCBI
Akr1c3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,020,884 - 71,037,779 (+)NCBIGRCr8
mRatBN7.21766,110,970 - 66,127,867 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,110,963 - 66,127,873 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1769,596,139 - 69,613,038 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,424,984 - 73,441,883 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,467,962 - 67,484,861 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,761,126 - 69,778,021 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,761,118 - 69,778,021 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,465,942 - 71,482,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,269,626 - 77,286,521 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,280,458 - 77,297,354 (+)NCBI
Celera1765,626,116 - 65,643,004 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
AKR1C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2817,590,820 - 17,668,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11017,660,905 - 17,732,534 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0105,079,580 - 5,157,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1105,061,119 - 5,139,818 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl105,081,214 - 5,139,812 (+)Ensemblpanpan1.1panPan2
AKR1C3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1065,576,464 - 65,678,248 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11065,650,223 - 65,679,878 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,902,088 - 71,931,228 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in AKR1C3
401 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 11 6 6 5
Low 6 8 2
Below cutoff 5 5 11 6 6 12 3 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008524   ⟹   ENSCAFP00000007901
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl230,674,558 - 30,686,877 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000008529   ⟹   ENSCAFP00000007906
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl230,675,838 - 30,690,043 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845005292   ⟹   ENSCAFP00845004208
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl231,045,998 - 31,070,795 (+)Ensembl
RefSeq Acc Id: NM_001012344   ⟹   NP_001012344
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1230,665,258 - 30,690,041 (+)NCBI
Dog10K_Boxer_Tasha227,694,812 - 27,719,595 (+)NCBI
ROS_Cfam_1.0231,045,998 - 31,070,793 (+)NCBI
UMICH_Zoey_3.1228,135,405 - 28,160,172 (+)NCBI
UNSW_CanFamBas_1.0228,972,376 - 28,997,157 (+)NCBI
UU_Cfam_GSD_1.0229,696,602 - 29,721,383 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038657847   ⟹   XP_038513775
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0231,042,072 - 31,071,570 (+)NCBI
RefSeq Acc Id: XM_038657848   ⟹   XP_038513776
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0231,042,072 - 31,071,570 (+)NCBI
RefSeq Acc Id: XM_038657849   ⟹   XP_038513777
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0231,056,684 - 31,071,570 (+)NCBI
RefSeq Acc Id: XM_038657850   ⟹   XP_038513778
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0231,056,674 - 31,071,570 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001012344   ⟸   NM_001012344
- UniProtKB: Q5FYA7 (UniProtKB/TrEMBL),   A0A8C0LYD8 (UniProtKB/TrEMBL),   A0A8C0M3N9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000007906   ⟸   ENSCAFT00000008529
RefSeq Acc Id: ENSCAFP00000007901   ⟸   ENSCAFT00000008524
RefSeq Acc Id: XP_038513776   ⟸   XM_038657848
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JT19 (UniProtKB/TrEMBL),   A0A8C0PUD9 (UniProtKB/TrEMBL),   A0A8I3MRB2 (UniProtKB/TrEMBL),   A0A8C0M3N9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038513775   ⟸   XM_038657847
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JT19 (UniProtKB/TrEMBL),   A0A8C0PUD9 (UniProtKB/TrEMBL),   A0A8I3MRB2 (UniProtKB/TrEMBL),   A0A8C0M3N9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038513778   ⟸   XM_038657850
- Peptide Label: isoform X3
- UniProtKB: A0A8C0M3N9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038513777   ⟸   XM_038657849
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RVJ1 (UniProtKB/TrEMBL),   A0A8C0M3N9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845004208   ⟸   ENSCAFT00845005292
Protein Domains
NADP-dependent oxidoreductase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005276 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030002178 UniProtKB/TrEMBL
  ENSCAFG00040001451 UniProtKB/TrEMBL
  ENSCAFG00845002994 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000008529.6 UniProtKB/TrEMBL
  ENSCAFT00030003988.1 UniProtKB/TrEMBL
  ENSCAFT00030004015.1 UniProtKB/TrEMBL
  ENSCAFT00040002751.1 UniProtKB/TrEMBL
  ENSCAFT00040002769.1 UniProtKB/TrEMBL
  ENSCAFT00845005292 ENTREZGENE
  ENSCAFT00845005292.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
InterPro AKR UniProtKB/TrEMBL
  AKR1C UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:497070 UniProtKB/TrEMBL
NCBI Gene AKR1C3 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
PIRSF AKR UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/TrEMBL
UniProt A0A8C0JT19 ENTREZGENE
  A0A8C0LYD8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0M3N9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PUD9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RVJ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MRB2 ENTREZGENE, UniProtKB/TrEMBL
  Q5FYA7 ENTREZGENE, UniProtKB/TrEMBL