ACR (acrosin) - Rat Genome Database

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Gene: ACR (acrosin) Canis lupus familiaris
Analyze
Symbol: ACR
Name: acrosin
RGD ID: 12066561
Description: ENCODES a protein that exhibits amidase activity (ortholog); fucose binding (ortholog); INVOLVED IN acrosome matrix dispersal (ortholog); binding of sperm to zona pellucida (ortholog); penetration of zona pellucida (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); chromosome 22q13 duplication syndrome (ortholog); genetic disease (ortholog); FOUND IN acrosomal vesicle (ortholog); Golgi-associated vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11016,607,514 - 16,615,399 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1016,609,915 - 16,615,354 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1016,588,068 - 16,593,422 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01017,336,704 - 17,342,058 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1017,333,872 - 17,342,013 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11017,061,215 - 17,066,544 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01017,384,291 - 17,389,647 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01017,516,077 - 17,521,431 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ACR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11016,607,514 - 16,615,399 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1016,609,915 - 16,615,354 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1016,588,068 - 16,593,422 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01017,336,704 - 17,342,058 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1017,333,872 - 17,342,013 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11017,061,215 - 17,066,544 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01017,384,291 - 17,389,647 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01017,516,077 - 17,521,431 (-)NCBIUU_Cfam_GSD_1.0
ACR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382250,738,204 - 50,745,339 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2250,738,196 - 50,745,339 (+)EnsemblGRCh38hg38GRCh38
GRCh372251,176,632 - 51,183,767 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362249,523,518 - 49,530,593 (+)NCBINCBI36Build 36hg18NCBI36
Build 342249,466,790 - 49,473,870NCBI
Celera2235,052,700 - 35,059,775 (+)NCBICelera
Cytogenetic Map22q13.33ENTREZGENE
HuRef2234,069,063 - 34,075,048 (+)NCBIHuRef
CHM1_12251,135,444 - 51,142,475 (+)NCBICHM1_1
T2T-CHM13v2.02251,251,783 - 51,258,912 (+)NCBIT2T-CHM13v2.0
Acr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391589,452,549 - 89,458,790 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1589,452,529 - 89,458,788 (+)EnsemblGRCm39 Ensembl
GRCm381589,568,326 - 89,578,853 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1589,568,326 - 89,574,585 (+)EnsemblGRCm38mm10GRCm38
MGSCv371589,398,757 - 89,405,015 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361589,396,129 - 89,402,195 (+)NCBIMGSCv36mm8
Celera1591,697,705 - 91,703,952 (+)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1544.96NCBI
Acr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87122,517,910 - 122,524,110 (+)NCBIGRCr8
mRatBN7.27120,636,581 - 120,644,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,638,321 - 120,644,474 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7122,390,433 - 122,396,624 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,616,577 - 124,622,768 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,585,008 - 124,591,223 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,541,320 - 130,548,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,542,202 - 130,548,356 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07130,227,661 - 130,233,848 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,885,399 - 127,891,552 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17127,919,648 - 127,925,612 (+)NCBI
Celera7117,109,902 - 117,116,056 (+)NCBICelera
RH 3.4 Map7958.3RGD
Cytogenetic Map7q34NCBI
Acr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541333,721,984 - 33,728,088 (+)NCBIChiLan1.0ChiLan1.0
ACR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22360,654,211 - 60,661,728 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12263,344,652 - 63,352,083 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02230,978,598 - 30,985,739 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12250,085,719 - 50,092,869 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2250,085,719 - 50,092,869 (+)Ensemblpanpan1.1panPan2
Acr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945104,213 - 109,801 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936629104,301 - 111,377 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl530,127 - 36,005 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1530,127 - 36,005 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap5p15NCBI
ACR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11933,231,521 - 33,236,141 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604592,102,118 - 92,110,449 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475242,847 - 49,438 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ACR
63 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8
Low 1 1
Below cutoff 5 4 11 1 6 1 3 3 10 8 3

Sequence


RefSeq Acc Id: ENSCAFT00000000859   ⟹   ENSCAFP00000000786
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1016,609,915 - 16,615,354 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000088728   ⟹   ENSCAFP00000048035
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1016,609,915 - 16,614,573 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845046799   ⟹   ENSCAFP00845036707
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1017,333,872 - 17,342,013 (-)Ensembl
RefSeq Acc Id: XM_022424241   ⟹   XP_022279949
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11016,610,026 - 16,615,366 (-)NCBI
Dog10K_Boxer_Tasha1016,588,068 - 16,593,408 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038488170   ⟹   XP_038344098
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11017,061,215 - 17,066,544 (-)NCBI
RefSeq Acc Id: XM_038488171   ⟹   XP_038344099
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11017,061,215 - 17,066,530 (-)NCBI
RefSeq Acc Id: XM_038550064   ⟹   XP_038405992
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01017,516,077 - 17,521,431 (-)NCBI
RefSeq Acc Id: XM_038550065   ⟹   XP_038405993
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01017,516,077 - 17,521,417 (-)NCBI
RefSeq Acc Id: XM_038614060   ⟹   XP_038469988
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01017,384,291 - 17,389,647 (-)NCBI
RefSeq Acc Id: XM_038679406   ⟹   XP_038535334
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01017,336,704 - 17,342,058 (-)NCBI
RefSeq Acc Id: XM_038679407   ⟹   XP_038535335
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01017,336,704 - 17,342,044 (-)NCBI
RefSeq Acc Id: XM_843155   ⟹   XP_848248
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11016,610,026 - 16,615,399 (-)NCBI
Dog10K_Boxer_Tasha1016,588,068 - 16,593,422 (-)NCBI
Sequence:
RefSeq Acc Id: XP_848248   ⟸   XM_843155
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RLN6 (UniProtKB/TrEMBL),   A0A8C0K2C3 (UniProtKB/TrEMBL),   A0A8I3PYH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022279949   ⟸   XM_022424241
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000048035   ⟸   ENSCAFT00000088728
RefSeq Acc Id: ENSCAFP00000000786   ⟸   ENSCAFT00000000859
RefSeq Acc Id: XP_038344098   ⟸   XM_038488170
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038344099   ⟸   XM_038488171
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038469988   ⟸   XM_038614060
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038535334   ⟸   XM_038679406
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RLN6 (UniProtKB/TrEMBL),   A0A8C0K2C3 (UniProtKB/TrEMBL),   A0A8I3PYH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038535335   ⟸   XM_038679407
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038405992   ⟸   XM_038550064
- Peptide Label: isoform X2
- UniProtKB: A0A8C0K2C3 (UniProtKB/TrEMBL),   A0A8C0RLN6 (UniProtKB/TrEMBL),   A0A8I3PYH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405993   ⟸   XM_038550065
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845036707   ⟸   ENSCAFT00845046799
Protein Domains
Peptidase S1

Promoters
RGD ID:13684910
Promoter ID:EPDNEW_C2980
Type:single initiation site
Name:ACR_1
Description:acrosin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11016,615,367 - 16,615,427EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000558 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030016465 UniProtKB/TrEMBL
  ENSCAFG00040013469 UniProtKB/TrEMBL
  ENSCAFG00845026531 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000859.5 UniProtKB/TrEMBL
  ENSCAFT00030030337.1 UniProtKB/TrEMBL
  ENSCAFT00040024888.1 UniProtKB/TrEMBL
  ENSCAFT00845046799 ENTREZGENE
  ENSCAFT00845046799.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Pept_S1A_acrosin UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
NCBI Gene ACR ENTREZGENE
PANTHER ACROSIN UniProtKB/TrEMBL
  ACROSIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PIRSF Acrosin UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
UniProt A0A8C0K2C3 ENTREZGENE
  A0A8C0RLN6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PYH1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:37526 ENTREZGENE