ADAP1 (ArfGAP with dual PH domains 1) - Rat Genome Database

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Gene: ADAP1 (ArfGAP with dual PH domains 1) Canis lupus familiaris
Analyze
Symbol: ADAP1
Name: ArfGAP with dual PH domains 1
RGD ID: 12056864
Description: ENCODES a protein that exhibits inositol 1,3,4,5 tetrakisphosphate binding (ortholog); phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH genetic disease (ortholog); inflammatory bowel disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); intracellular membrane-bounded organelle (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: arf-GAP with dual PH domain-containing protein 1; CENTA1; centaurin, alpha 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1615,921,865 - 15,976,101 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl615,898,326 - 15,973,771 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,394,927 - 17,448,262 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,052,553 - 16,105,914 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,028,493 - 16,105,914 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1615,855,375 - 15,908,735 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0615,781,938 - 15,835,092 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,070,134 - 16,124,464 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1615,921,865 - 15,976,101 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl615,898,326 - 15,973,771 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,394,927 - 17,448,262 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,052,553 - 16,105,914 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,028,493 - 16,105,914 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1615,855,375 - 15,908,735 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0615,781,938 - 15,835,092 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,070,134 - 16,124,464 (+)NCBIUU_Cfam_GSD_1.0
ADAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387897,900 - 955,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7897,900 - 955,407 (-)EnsemblGRCh38hg38GRCh38
GRCh377937,537 - 995,043 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367904,066 - 960,811 (-)NCBINCBI36Build 36hg18NCBI36
Build 347710,780 - 767,508NCBI
Celera7906,136 - 962,035 (-)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef7855,527 - 893,573 (-)NCBIHuRef
CHM1_17936,645 - 993,431 (-)NCBICHM1_1
T2T-CHM13v2.071,001,683 - 1,060,405 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27992,062 - 1,048,924 (-)NCBI
Adap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,257,631 - 139,311,516 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5139,257,631 - 139,311,377 (-)EnsemblGRCm39 Ensembl
GRCm385139,271,876 - 139,325,763 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,271,876 - 139,325,622 (-)EnsemblGRCm38mm10GRCm38
MGSCv375139,747,830 - 139,801,418 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,525,518 - 139,559,961 (-)NCBIMGSCv36mm8
Celera5136,325,945 - 136,379,615 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map578.27NCBI
Adap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,438,091 - 20,489,961 (+)NCBIGRCr8
mRatBN7.21215,323,913 - 15,376,110 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,324,209 - 15,380,831 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,134,353 - 16,186,232 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,758,093 - 16,809,976 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,784,243 - 15,836,094 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,416,327 - 17,468,212 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,416,327 - 17,468,212 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,402,559 - 19,454,794 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,825,017 - 15,877,643 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11215,855,021 - 15,906,562 (+)NCBI
Celera1217,078,350 - 17,130,259 (+)NCBICelera
Cytogenetic Map12q11NCBI
Adap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,635,463 - 8,674,455 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,635,463 - 8,674,455 (-)NCBIChiLan1.0ChiLan1.0
ADAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v265,841,176 - 5,899,642 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1754,165,865 - 54,224,306 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v071,054,499 - 1,112,240 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.171,269,235 - 1,316,351 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl71,269,235 - 1,326,102 (-)Ensemblpanpan1.1panPan2
Adap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344143,855,837 - 143,879,769 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367541,131,500 - 1,154,528 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367541,130,585 - 1,154,459 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3547,364 - 615,471 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13548,823 - 615,471 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23429,376 - 430,952 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.23695,020 - 722,372 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,617,948 - 20,677,848 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2820,617,995 - 20,680,628 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660901,013,133 - 1,073,527 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474026,481,054 - 26,518,469 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474026,481,036 - 26,518,315 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADAP1
807 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 5 6 5 2
Low 22 6 6 6 6 1 6 6 5 4
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000018028   ⟹   ENSCAFP00000016695
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl615,921,926 - 15,973,575 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000088820   ⟹   ENSCAFP00000053786
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl615,898,326 - 15,973,771 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845015556   ⟹   ENSCAFP00845012086
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl616,028,493 - 16,105,914 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845015618   ⟹   ENSCAFP00845012139
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl616,052,099 - 16,105,897 (+)Ensembl
RefSeq Acc Id: XM_038478440   ⟹   XP_038334368
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1615,855,375 - 15,908,735 (+)NCBI
RefSeq Acc Id: XM_038478441   ⟹   XP_038334369
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1615,872,316 - 15,908,735 (+)NCBI
RefSeq Acc Id: XM_038539698   ⟹   XP_038395626
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0616,070,134 - 16,124,464 (+)NCBI
RefSeq Acc Id: XM_038539699   ⟹   XP_038395627
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0616,087,086 - 16,124,464 (+)NCBI
RefSeq Acc Id: XM_038541761   ⟹   XP_038397689
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha617,411,872 - 17,448,262 (+)NCBI
RefSeq Acc Id: XM_038603782   ⟹   XP_038459710
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0615,781,938 - 15,835,092 (+)NCBI
RefSeq Acc Id: XM_038603783   ⟹   XP_038459711
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0615,798,882 - 15,835,092 (+)NCBI
RefSeq Acc Id: XM_038668500   ⟹   XP_038524428
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0616,052,553 - 16,105,914 (+)NCBI
RefSeq Acc Id: XM_038668501   ⟹   XP_038524429
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0616,069,501 - 16,105,914 (+)NCBI
RefSeq Acc Id: XM_843423   ⟹   XP_848516
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1615,921,865 - 15,976,101 (+)NCBI
Dog10K_Boxer_Tasha617,394,927 - 17,448,262 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_848516   ⟸   XM_843423
- Peptide Label: isoform X1
- UniProtKB: A0A8C0L4P6 (UniProtKB/TrEMBL),   A0A8I3RWD5 (UniProtKB/TrEMBL),   A0A8P0PMN2 (UniProtKB/TrEMBL),   A0A8P0PQW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000053786   ⟸   ENSCAFT00000088820
RefSeq Acc Id: ENSCAFP00000016695   ⟸   ENSCAFT00000018028
RefSeq Acc Id: XP_038334368   ⟸   XM_038478440
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038334369   ⟸   XM_038478441
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038459710   ⟸   XM_038603782
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038459711   ⟸   XM_038603783
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038524428   ⟸   XM_038668500
- Peptide Label: isoform X1
- UniProtKB: A0A8C0L4P6 (UniProtKB/TrEMBL),   A0A8I3RWD5 (UniProtKB/TrEMBL),   A0A8P0PMN2 (UniProtKB/TrEMBL),   A0A8P0PQW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038524429   ⟸   XM_038668501
- Peptide Label: isoform X2
- UniProtKB: A0A8I3N9L9 (UniProtKB/TrEMBL),   A0A8P0TVC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038397689   ⟸   XM_038541761
- Peptide Label: isoform X2
- UniProtKB: A0A8I3N9L9 (UniProtKB/TrEMBL),   A0A8P0TVC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395626   ⟸   XM_038539698
- Peptide Label: isoform X1
- UniProtKB: A0A8P0PQW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395627   ⟸   XM_038539699
- Peptide Label: isoform X2
- UniProtKB: A0A8I3N9L9 (UniProtKB/TrEMBL),   A0A8P0TVC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845012086   ⟸   ENSCAFT00845015556
RefSeq Acc Id: ENSCAFP00845012139   ⟸   ENSCAFT00845015618
Protein Domains
Arf-GAP   PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011344 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040008226 UniProtKB/TrEMBL
  ENSCAFG00845008846 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000018028.5 UniProtKB/TrEMBL
  ENSCAFT00000088820.2 UniProtKB/TrEMBL
  ENSCAFT00000100125.1 UniProtKB/TrEMBL
  ENSCAFT00000104245.1 UniProtKB/TrEMBL
  ENSCAFT00000106110.1 UniProtKB/TrEMBL
  ENSCAFT00040015529.1 UniProtKB/TrEMBL
  ENSCAFT00845015556 ENTREZGENE
  ENSCAFT00845015556.1 UniProtKB/TrEMBL
  ENSCAFT00845015618 ENTREZGENE
  ENSCAFT00845015618.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.220.150 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro ARFGAP/RecO UniProtKB/TrEMBL
  ArfGAP_dom UniProtKB/TrEMBL
  ArfGAP_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH1_ADAP UniProtKB/TrEMBL
  PH2_ADAP UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
NCBI Gene ADAP1 ENTREZGENE
PANTHER ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN UniProtKB/TrEMBL
Pfam ArfGap UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PRINTS REVINTRACTNG UniProtKB/TrEMBL
PROSITE ARFGAP UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART ArfGap UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF57863 UniProtKB/TrEMBL
UniProt A0A8C0L4P6 ENTREZGENE
  A0A8C0QRE5_CANLF UniProtKB/TrEMBL
  A0A8I3N9L9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RWD5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PMN2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PQW8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SG39_CANLF UniProtKB/TrEMBL
  A0A8P0TVC6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8P0P3A9 UniProtKB/TrEMBL
VGNC ID VGNC:37610 ENTREZGENE