ABCC1 (ATP binding cassette subfamily C member 1) - Rat Genome Database

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Gene: ABCC1 (ATP binding cassette subfamily C member 1) Canis lupus familiaris
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Symbol: ABCC1
Name: ATP binding cassette subfamily C member 1
RGD ID: 12050846
Description: ENCODES a protein that exhibits ABC-type glutathione S-conjugate transporter activity (ortholog); ABC-type transporter activity (ortholog); ABC-type vitamin B12 transporter activity (ortholog); INVOLVED IN astrocyte differentiation (ortholog); cell chemotaxis (ortholog); cellular response to amyloid-beta (ortholog); PARTICIPATES IN docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); asthma (ortholog); autistic disorder (ortholog); FOUND IN basal plasma membrane (ortholog); basolateral plasma membrane (ortholog); INTERACTS WITH calcein am; etoposide; leukotriene C4
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-binding cassette sub-family C member 1; glutathione-S-conjugate-translocating ATPase ABCC1; leukotriene C(4) transporter; LTC4 transporter; MRP1; multidrug resistance protein 1; multidrug resistance-associated protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1627,855,702 - 27,950,140 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl627,855,702 - 27,989,331 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,219,306 - 29,353,121 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0628,018,483 - 28,152,589 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl628,010,824 - 28,152,766 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1627,821,973 - 27,955,836 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0627,711,967 - 27,845,729 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0628,117,166 - 28,251,282 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:12429346   PMID:12516967   PMID:15459206   PMID:22301074   PMID:23373631   PMID:23773525   PMID:26560472   PMID:30032202  


Genomics

Comparative Map Data
ABCC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1627,855,702 - 27,950,140 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl627,855,702 - 27,989,331 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,219,306 - 29,353,121 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0628,018,483 - 28,152,589 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl628,010,824 - 28,152,766 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1627,821,973 - 27,955,836 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0627,711,967 - 27,845,729 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0628,117,166 - 28,251,282 (-)NCBIUU_Cfam_GSD_1.0
ABCC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381615,949,143 - 16,143,053 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1615,949,138 - 16,143,257 (+)EnsemblGRCh38hg38GRCh38
GRCh371616,043,473 - 16,236,910 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361615,950,935 - 16,144,432 (+)NCBINCBI36Build 36hg18NCBI36
Build 341615,950,934 - 16,143,774NCBI
Celera1615,781,784 - 15,917,085 (+)NCBICelera
Cytogenetic Map16p13.11NCBI
HuRef1615,436,705 - 15,630,893 (+)NCBIHuRef
CHM1_11616,185,916 - 16,321,192 (+)NCBICHM1_1
T2T-CHM13v2.01615,954,068 - 16,147,908 (+)NCBIT2T-CHM13v2.0
Abcc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391614,179,317 - 14,292,743 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1614,179,422 - 14,293,601 (+)EnsemblGRCm39 Ensembl
GRCm381614,361,453 - 14,474,878 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1614,361,558 - 14,475,737 (+)EnsemblGRCm38mm10GRCm38
MGSCv371614,361,653 - 14,474,968 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361614,275,138 - 14,388,453 (+)NCBIMGSCv36mm8
Celera1614,966,079 - 15,077,783 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.75NCBI
Abcc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8101,022,041 - 1,162,431 (-)NCBIGRCr8
mRatBN7.210528,961 - 655,179 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10531,812 - 655,114 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx105,228,580 - 5,351,880 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01035,213,968 - 35,337,275 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010543,174 - 666,513 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010549,537 - 672,235 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10549,883 - 672,196 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01011,232,233 - 11,354,931 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410452,239 - 575,705 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110452,238 - 575,705 (-)NCBI
Celera1011,130,945 - 11,246,232 (-)NCBICelera
Cytogenetic Map10q11NCBI
Abcc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955442729,316 - 860,290 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955442729,322 - 858,826 (+)NCBIChiLan1.0ChiLan1.0
ABCC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21816,295,604 - 16,482,561 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11619,921,573 - 20,108,728 (+)NCBINHGRI_mPanPan1
Abcc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344115,297,821 - 115,369,238 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365013,401,285 - 3,470,460 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365013,400,971 - 3,467,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl328,360,873 - 28,473,456 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1328,360,868 - 28,472,940 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2329,082,788 - 29,172,693 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1514,972,589 - 15,164,594 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl514,972,646 - 15,164,567 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606814,816,018 - 14,953,501 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624782449,288 - 591,310 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624782449,217 - 590,306 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ABCC1
1566 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 3 6 6 5 2
Low 3 5 19 6 6 6 12 8 5 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000027269   ⟹   ENSCAFP00000025361
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl627,855,702 - 27,989,331 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000028933   ⟹   ENSCAFP00000026911
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl627,855,702 - 27,970,580 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000067722   ⟹   ENSCAFP00000066267
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl627,857,049 - 27,989,331 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013516   ⟹   ENSCAFP00845010489
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl628,010,824 - 28,152,766 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013662   ⟹   ENSCAFP00845010609
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl628,017,221 - 28,152,766 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013903   ⟹   ENSCAFP00845010777
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl628,017,221 - 28,152,586 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845014070   ⟹   ENSCAFP00845010905
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl628,020,094 - 28,152,586 (-)Ensembl
RefSeq Acc Id: NM_001002971   ⟹   NP_001002971
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1627,855,702 - 27,950,140 (-)NCBI
Dog10K_Boxer_Tasha629,219,306 - 29,353,121 (-)NCBI
ROS_Cfam_1.0628,018,757 - 28,152,547 (-)NCBI
UMICH_Zoey_3.1627,821,973 - 27,955,836 (-)NCBI
UNSW_CanFamBas_1.0627,711,967 - 27,845,729 (-)NCBI
UU_Cfam_GSD_1.0628,117,166 - 28,251,282 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038667549   ⟹   XP_038523477
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0628,019,591 - 28,152,589 (-)NCBI
RefSeq Acc Id: XR_005427955
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0628,018,483 - 28,152,589 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001002971   ⟸   NM_001002971
- UniProtKB: Q6UR05 (UniProtKB/Swiss-Prot),   A0A8P0NJI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000066267   ⟸   ENSCAFT00000067722
RefSeq Acc Id: ENSCAFP00000026911   ⟸   ENSCAFT00000028933
RefSeq Acc Id: ENSCAFP00000025361   ⟸   ENSCAFT00000027269
RefSeq Acc Id: XP_038523477   ⟸   XM_038667549
- Peptide Label: isoform X1
- UniProtKB: A0A8I3N7J9 (UniProtKB/TrEMBL),   A0A8C0RW12 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845010905   ⟸   ENSCAFT00845014070
RefSeq Acc Id: ENSCAFP00845010489   ⟸   ENSCAFT00845013516
RefSeq Acc Id: ENSCAFP00845010609   ⟸   ENSCAFT00845013662
RefSeq Acc Id: ENSCAFP00845010777   ⟸   ENSCAFT00845013903
Protein Domains
ABC transmembrane type-1   ABC transporter


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018208 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017310 UniProtKB/TrEMBL
  ENSCAFG00040002016 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00845007668 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000027269.5 UniProtKB/TrEMBL
  ENSCAFT00000028933.6 UniProtKB/TrEMBL
  ENSCAFT00000067722.2 UniProtKB/TrEMBL
  ENSCAFT00000106554.1 UniProtKB/TrEMBL
  ENSCAFT00000108623.1 UniProtKB/TrEMBL
  ENSCAFT00030032195.1 UniProtKB/TrEMBL
  ENSCAFT00030032302.1 UniProtKB/TrEMBL
  ENSCAFT00040003830.1 UniProtKB/TrEMBL
  ENSCAFT00040003892.1 UniProtKB/Swiss-Prot
  ENSCAFT00040003938.1 UniProtKB/TrEMBL
  ENSCAFT00845013516.1 UniProtKB/TrEMBL
  ENSCAFT00845013662 ENTREZGENE
  ENSCAFT00845013662.1 UniProtKB/TrEMBL
  ENSCAFT00845013903 ENTREZGENE
  ENSCAFT00845013903.1 UniProtKB/TrEMBL
  ENSCAFT00845014070 ENTREZGENE
  ENSCAFT00845014070.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Multidrug-R_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403453 UniProtKB/Swiss-Prot
NCBI Gene ABCC1 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0RMD7_CANLF UniProtKB/TrEMBL
  A0A8C0RMH7_CANLF UniProtKB/TrEMBL
  A0A8C0RVS2_CANLF UniProtKB/TrEMBL
  A0A8C0RW12 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N1A2_CANLF UniProtKB/TrEMBL
  A0A8I3N1I8_CANLF UniProtKB/TrEMBL
  A0A8I3N3X8_CANLF UniProtKB/TrEMBL
  A0A8I3N7J9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NJI4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PES4_CANLF UniProtKB/TrEMBL
  A0A8P0PR96_CANLF UniProtKB/TrEMBL
  A0A8P0SLJ5_CANLF UniProtKB/TrEMBL
  A0A8P0TTZ7_CANLF UniProtKB/TrEMBL
  MRP1_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:54275 ENTREZGENE