CYP4V2 (cytochrome P450 family 4 subfamily V member 2)

Gene: CYP4V2 (cytochrome P450 family 4 subfamily V member 2) Pan paniscus

Analyze

Symbol:

CYP4V2

Name:

cytochrome P450 family 4 subfamily V member 2

RGD ID:

12049954

Description:

ENCODES a protein that exhibits heme binding (inferred); iron ion binding (inferred); metal ion binding (inferred); INVOLVED IN fatty acid omega-oxidation (inferred); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); Bietti crystalline corneoretinal dystrophy (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cytochrome P450 4V2; LOC100985937

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	183,932,985 - 183,955,540 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	184,282,569 - 184,304,590 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	178,361,611 - 178,384,381 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	190,568,496 - 190,588,409 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	190,568,743 - 190,588,025 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

autistic disorder (ISO)

Bietti crystalline corneoretinal dystrophy (ISO)

corneal dystrophy (ISO)

factor XI deficiency (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

Herpes Simplex Encephalitis 1 (ISO)

retinitis pigmentosa (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid omega-oxidation (IEA)

Cellular Component

endoplasmic reticulum membrane (IEA)

membrane (IEA)

Molecular Function

heme binding (IEA)

iron ion binding (IEA)

metal ion binding (IEA)

monooxygenase activity (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

CYP4V2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	183,932,985 - 183,955,540 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	184,282,569 - 184,304,590 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	178,361,611 - 178,384,381 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	190,568,496 - 190,588,409 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	190,568,743 - 190,588,025 (+)	Ensembl	panpan1.1		panPan2

CYP4V2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	186,191,567 - 186,213,463 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	186,191,567 - 186,213,463 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	187,112,721 - 187,134,617 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	187,349,668 - 187,371,606 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	184,435,120 - 184,457,152 (+)	NCBI		Celera
Cytogenetic Map	4	q35.1-q35.2	NCBI
HuRef	4	182,865,016 - 182,886,685 (+)	NCBI		HuRef
CHM1_1	4	187,089,103 - 187,111,056 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	189,531,931 - 189,553,879 (+)	NCBI		T2T-CHM13v2.0

Cyp4v3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	45,758,838 - 45,786,200 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	45,757,981 - 45,786,253 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	45,305,801 - 45,333,163 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	45,304,944 - 45,333,216 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	46,391,156 - 46,418,550 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	46,804,619 - 46,832,013 (-)	NCBI		MGSCv36	mm8
Celera	8	47,992,790 - 48,020,649 (-)	NCBI		Celera
Cytogenetic Map	8	B1.1	NCBI
cM Map	8	25.17	NCBI

Cyp4v3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	53,650,978 - 53,675,916 (+)	NCBI		GRCr8
mRatBN7.2	16	46,917,929 - 46,958,735 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	46,918,401 - 46,943,395 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	52,311,401 - 52,336,349 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	55,688,719 - 55,713,657 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	50,950,790 - 50,975,739 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	50,111,803 - 50,136,741 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	50,111,306 - 50,136,727 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	49,834,760 - 49,859,698 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	50,208,687 - 50,233,625 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	50,230,694 - 50,234,530 (+)	NCBI
Celera	16	44,908,995 - 44,933,933 (+)	NCBI		Celera
Cytogenetic Map	16	q11	NCBI

LOC102018145
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	22,870,299 - 22,912,221 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	22,870,299 - 22,912,221 (-)	NCBI	ChiLan1.0	ChiLan1.0

CYP4V2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	44,523,583 - 44,541,781 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	45,011,284 - 45,031,527 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	46,738,051 - 46,758,685 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	46,738,064 - 46,758,788 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	44,706,622 - 44,726,822 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	45,319,495 - 45,339,725 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	45,450,728 - 45,470,965 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101967774
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	34,816,709 - 34,837,194 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936554	3,272,073 - 3,293,564 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936554	3,272,139 - 3,293,288 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYP4V2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	47,046,269 - 47,068,304 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	47,038,078 - 47,068,315 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	53,904,343 - 53,909,542 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CYP4V2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	132,108,650 - 132,129,338 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	132,108,551 - 132,130,962 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	112,428,993 - 112,451,338 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LOC101716986
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624769	17,025,500 - 17,048,965 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624769	17,026,203 - 17,046,366 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003823491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034959527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000030222 ⟹ ENSPPAP00000007677

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	4	190,568,743 - 190,588,025 (+)	Ensembl

RefSeq Acc Id:

XM_003823491 ⟹ XP_003823539

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	3	183,932,985 - 183,955,540 (+)	NCBI
NHGRI_mPanPan1	4	184,282,569 - 184,304,590 (+)	NCBI
Mhudiblu_PPA_v0	4	178,361,611 - 178,384,381 (+)	NCBI
PanPan1.1	4	190,568,496 - 190,588,409 (+)	NCBI

Sequence:

show sequence

CTTTCGGCTGGGGCGTGGAGGCCGCGGTGCTGCGTAGGCTGGGCCGGGCGCAGGAACAGCCCCG
TGGAGCCCTCCCTGGCCGCCGGCCAGGCGGGAAACGTCGTTCCGGGGACCGGGCGACCCCGCAG
CGGGGAGCGCGCCAGGTCCGCGCGGGGAAGTGGGCGGCGTACGGCCGGCACCGCCTCGCACCAC
GCCCCCGCGGGCCCGCACTTTCCCGGAGTGCACCCCGCGGCCGCCAGCCGGGGCGATGGCGGGG
CTCTGGCTGGGGCTCGTGTGGCAGAAGCTGCTGCTGTGGGGCGCGGCGAGTGCCGTTTCCCTGG
CCGGCGCCAGTCTGGTCCTGAGCCTGCTGCAGAGGGTGGCGACCTACGCGCGGAAATGGCAGCA
GATGCGGCCCATCCCCACGGTGGCCCGCGCCTACCCACTGGTGGGCCACGCGCTGCTGATGAAG
CCGGACGGGCGAGAATTTTTTCAGCAGATCATTGAGTACACAGAGGAGTACCGCCACATGCCGC
TGCTGAAGCTCTGGGTCGGGCCGGTGCCCATGGTGGCCCTTTATAATGCAGAAAATGTGGAGGT
AATTTTAACTAGTTCAAAGCAAATTGACAAATCCTCTATGTACAAGTTTTTAGAACCATGGCTT
GGCCTAGGACTTCTTACAAGTACTGGAAACAAATGGCGCTCCAGGAGAAAGATGTTAACACCCA
CTTTCCATTTTACCATTCTGGAAGATTTCTTAGATATCATGAATGAACAAGCAAATATATTGGT
TAAGAAACTTGAAAAACACATTAACCAAGAAGCATTTAACTGCTTTTTTTACATCACTCTTTGT
GCCTTAGATATCATCTGTGAAACAGCTATGGGGAAGAATATTGGTGCTCAAAGTAATGATGATT
CCGAGTATGTCCGTGCAGTTTATAGAATGAGTGAGATGATATTTCGAAGAATAAAGATGCCCTG
GCTTTGGCTTGATCTCTGGTACCTTATGTTTAAAGAAGGATGGGAACACAAAAAGAGCCTTAAG
ATCCTACATACTTTTACCAACAGTGTCATCGCTGAACGGGCCAATGAAATGAACGCCAATGAAG
ACTGTAGAGGTGATGGCAGGGGCTCTGCCCCCTCCAAAAATAAACGCAGGGCCTTTCTTGACTT
GCTTTTAAGTGTGACTGATGACGAAGGGAACAGGCTAAGTCATGAAGATATTCGAGAAGAAGTT
GACACCTTCATGTTTGAGGGGCACGACACAACTGCAGCTGCAATAAACTGGTCCTTATACCTGT
TGGGTTCTAACCCAGAAGTCCAGAAAAAAGTGGATCATGAATTGGATGACGTGTTTGGGAAGTC
TGACCGTCCCGCTACGGTAGAAGACCTGAAGAAACTTCGGTATTTGGAATGTGTTATTAAGGAG
ACCCTTCGCCTTTTTCCTTCTGTTCCTTTATTTGCCCGTAGTGTTAGTGAAGATTGTGAAGTGG
CAGGTTACAGAGTTCTAAAAGGCACTGAAGCCGTCATCATTCCCTATGCATTGCACAGAGATCC
GAGATACTTCCCCAACCCCGAGGAGTTCCAGCCTGAGCGGTTCTTCCCCAAGAATGCACAAGGG
CGCCATCCATATGCCTATGTGCCCTTCTCTGCTGGCCCCAGGAACTGTATAGGTCAAAAGTTTG
CTGTGATGGAGGAAAAGACCATTCTTTCATGCATCCTGAGGCACTTTTGGATAGAATCCAACCA
GAAAAGAGAAGAGCTTGGTCTAGAAGGACAGTTGATTCTTCGTCCAAGTAATGGCATCTGGATC
AAGTTGAAGAGGAGAAATGCAGATGAACGCTAACTATATTATTGGGTTGTGCCTTTATCATGAG
AAAGGTCTTTATTTTAAGAGATCCTTGTCATTTACAACTTACAGATCATGAGTTCAATATGCTT
GAATCCCCTAGACCTAATTTTTCCTTGATCCCACTGATCTTGACATCAAGTCTAACAAAGAAAG
AGTTTTGAGTTTTGTATTTTCTTTTTTCTTTTTTTTTTTTGTAAACCGTGTCTCACTCTGTCGC
CCAGGCTGGAGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAG
CAATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCTGCCACCATGCCTGGCTA
ATTTTTTTGTATTTTTAGTAGAAACAGGGTTTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_003823539	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000007677
	ENSPPAP00000007677.1

RefSeq Acc Id:

XP_003823539 ⟸ XM_003823491

- UniProtKB:

A0A2R8ZRT4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGLWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVATYARKWQQMRPIPTVARAYPLVGHAL
LMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLE
PWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYI
TLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKK
SLKILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIR
EEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECV
IKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPKN
AQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNG
IWIKLKRRNADER

hide sequence

RefSeq Acc Id:

ENSPPAP00000007677 ⟸ ENSPPAT00000030222

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000026990	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000030222.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.630.10	UniProtKB/TrEMBL
InterPro	Cyt_P450	UniProtKB/TrEMBL
	Cyt_P450_CS	UniProtKB/TrEMBL
	Cyt_P450_E_grp-I	UniProtKB/TrEMBL
	Cyt_P450_sf	UniProtKB/TrEMBL
KEGG Report	pps:100985937	UniProtKB/TrEMBL
NCBI Gene	LOC100985937	ENTREZGENE
PANTHER	CYTOCHROME P450 4V2	UniProtKB/TrEMBL
	CYTOCHROME P450 FAMILY 4	UniProtKB/TrEMBL
Pfam	p450	UniProtKB/TrEMBL
PRINTS	EP450I	UniProtKB/TrEMBL
	P450	UniProtKB/TrEMBL
PROSITE	CYTOCHROME_P450	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48264	UniProtKB/TrEMBL
UniProt	A0A2R8ZRT4	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:83020	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-02-25	CYP4V2	cytochrome P450 family 4 subfamily V member 2	LOC100985937	cytochrome P450 4V2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM