IMPDH2 (inosine monophosphate dehydrogenase 2) - Rat Genome Database

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Gene: IMPDH2 (inosine monophosphate dehydrogenase 2) Pan paniscus
Analyze
Symbol: IMPDH2
Name: inosine monophosphate dehydrogenase 2
RGD ID: 12033114
Description: ENCODES a protein that exhibits identical protein binding (ortholog); IMP dehydrogenase activity (ortholog); INVOLVED IN cellular response to interleukin-4 (ortholog); lymphocyte proliferation (ortholog); purine nucleotide biosynthetic process (ortholog); PARTICIPATES IN de novo purine biosynthetic pathway; mycophenolic acid pharmacokinetics pathway; ASSOCIATED WITH Aicardi-Goutieres Syndrome 1 (ortholog); Animal Disease Models (ortholog); dystonia (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inosine-5'-monophosphate dehydrogenase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,002,115 - 49,008,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,007,028 - 49,013,216 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,948,965 - 48,954,276 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,030,291 - 50,035,676 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,030,303 - 50,035,676 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IMPDH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,002,115 - 49,008,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,007,028 - 49,013,216 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,948,965 - 48,954,276 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,030,291 - 50,035,676 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,030,303 - 50,035,676 (-)Ensemblpanpan1.1panPan2
IMPDH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,024,325 - 49,029,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,024,325 - 49,029,447 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,061,758 - 49,066,831 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,036,762 - 49,041,879 (-)NCBINCBI36Build 36hg18NCBI36
Build 34349,036,766 - 49,041,826NCBI
Celera349,018,480 - 49,023,597 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,119,623 - 49,124,740 (-)NCBIHuRef
CHM1_1349,014,319 - 49,019,436 (-)NCBICHM1_1
T2T-CHM13v2.0349,052,365 - 49,057,438 (-)NCBIT2T-CHM13v2.0
Impdh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,437,635 - 108,442,776 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,437,485 - 108,442,783 (+)EnsemblGRCm39 Ensembl
GRCm389108,560,436 - 108,565,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,560,286 - 108,565,584 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,462,832 - 108,467,904 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,418,604 - 108,423,676 (+)NCBIMGSCv36mm8
Celera9108,171,703 - 108,176,814 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.5NCBI
Impdh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,135,204 - 118,139,892 (+)NCBIGRCr8
mRatBN7.28109,256,705 - 109,261,365 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,256,728 - 109,261,359 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,874,980 - 114,879,615 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,074,314 - 113,078,949 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,916,954 - 110,921,589 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,346,983 - 117,351,619 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,347,029 - 117,351,610 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,691,495 - 116,696,122 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,607,025 - 113,611,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,626,482 - 113,631,068 (+)NCBI
Celera8108,552,537 - 108,557,125 (+)NCBICelera
Cytogenetic Map8q32NCBI
Impdh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,045,833 - 1,051,978 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,047,138 - 1,051,980 (-)NCBIChiLan1.0ChiLan1.0
IMPDH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,136,106 - 40,140,983 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,136,154 - 40,140,972 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2040,054,292 - 40,059,168 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,493,283 - 40,498,161 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,493,262 - 40,498,161 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,859,889 - 39,864,764 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,263,666 - 40,268,542 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,543,176 - 40,548,052 (+)NCBIUU_Cfam_GSD_1.0
Impdh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560263,988,280 - 63,993,092 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529745,511 - 753,581 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936529748,777 - 753,582 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IMPDH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,658,650 - 31,663,552 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,658,642 - 31,663,660 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,901,646 - 34,906,719 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IMPDH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,424,646 - 10,429,917 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2210,421,996 - 10,429,662 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041156,652,325 - 156,657,621 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Impdh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,071,141 - 3,075,882 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,071,132 - 3,075,870 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000033756   ⟹   ENSPPAP00000011101
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl350,030,303 - 50,035,676 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000033765   ⟹   ENSPPAP00000011110
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl350,030,348 - 50,035,319 (-)Ensembl
RefSeq Acc Id: XM_008971680   ⟹   XP_008969928
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2249,002,115 - 49,008,297 (-)NCBI
NHGRI_mPanPan1349,007,028 - 49,013,213 (-)NCBI
Mhudiblu_PPA_v0348,948,965 - 48,954,262 (-)NCBI
PanPan1.1350,030,291 - 50,035,676 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008971681   ⟹   XP_008969929
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2249,002,115 - 49,008,260 (-)NCBI
NHGRI_mPanPan1349,007,028 - 49,013,216 (-)NCBI
Mhudiblu_PPA_v0348,948,965 - 48,954,265 (-)NCBI
PanPan1.1350,030,291 - 50,035,676 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063602346   ⟹   XP_063458416
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2249,002,115 - 49,008,245 (-)NCBI
RefSeq Acc Id: XM_063602347   ⟹   XP_063458417
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2249,002,115 - 49,008,245 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008969928 (Get FASTA)   NCBI Sequence Viewer  
  XP_008969929 (Get FASTA)   NCBI Sequence Viewer  
  XP_063458416 (Get FASTA)   NCBI Sequence Viewer  
  XP_063458417 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000011101.1
  ENSPPAP00000011110.1
Reference Protein Sequences
RefSeq Acc Id: XP_008969929   ⟸   XM_008971681
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008969928   ⟸   XM_008971680
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A6W6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000011110   ⟸   ENSPPAT00000033765
RefSeq Acc Id: ENSPPAP00000011101   ⟸   ENSPPAT00000033756
RefSeq Acc Id: XP_063458417   ⟸   XM_063602347
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063458416   ⟸   XM_063602346
- Peptide Label: isoform X2
Protein Domains
CBS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028755 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000033756.1 UniProtKB/TrEMBL
  ENSPPAT00000033765.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  CBS_dom UniProtKB/TrEMBL
  IMP_DH UniProtKB/TrEMBL
  IMP_DH/GMP_Rdtase_CS UniProtKB/TrEMBL
  IMP_DH_GMPRt UniProtKB/TrEMBL
NCBI Gene IMPDH2 ENTREZGENE
PANTHER INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 UniProtKB/TrEMBL
  PTHR11911 UniProtKB/TrEMBL
Pfam CBS UniProtKB/TrEMBL
  IMPDH UniProtKB/TrEMBL
PIRSF IMPDH UniProtKB/TrEMBL
PROSITE CBS UniProtKB/TrEMBL
  IMP_DH_GMP_RED UniProtKB/TrEMBL
SMART CBS UniProtKB/TrEMBL
  IMPDH UniProtKB/TrEMBL
Superfamily-SCOP Inosine monophosphate dehydrogenase (IMPDH) UniProtKB/TrEMBL
UniProt A0A2R9A5Y5_PANPA UniProtKB/TrEMBL
  A0A2R9A6W6 ENTREZGENE, UniProtKB/TrEMBL