CTSL (cathepsin L) - Rat Genome Database

Name: CTSL
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: CTSL (cathepsin L) Pan paniscus

Analyze

Symbol:

CTSL

Name:

cathepsin L

RGD ID:

12025472

Description:

ENCODES a protein that exhibits aminopeptidase activity (ortholog); cysteine-type carboxypeptidase activity (ortholog); cysteine-type endopeptidase activity (ortholog); INVOLVED IN antigen processing and presentation of peptide antigen (ortholog); autophagic cell death (ortholog); CD4-positive, alpha-beta T cell lineage commitment (ortholog); PARTICIPATES IN chaperone mediated autophagy pathway; ASSOCIATED WITH Albuminuria (ortholog); atherosclerosis (ortholog); brain ischemia (ortholog); FOUND IN apical part of cell (ortholog); cytoplasmic vesicle (ortholog); external side of plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cathepsin L1; CTSL1; LOC100987260; procathepsin L

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CTSL (cathepsin L)	NCBI	Ortholog
Mus musculus (house mouse):	Ctsl (cathepsin L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ctsl (cathepsin L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CTSL3 (cathepsin L family member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ctsl (cathepsin L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CTSL (cathepsin L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CTSL (cathepsin L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	51,694,521 - 51,700,365 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	51,696,841 - 51,702,165 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	58,851,899 - 58,857,170 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	86,903,001 - 86,908,303 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	86,903,006 - 86,908,303 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Albuminuria (ISO)

atherosclerosis (ISO)

brain ischemia (ISO)

colitis (ISO)

Contusions (ISO)

Coronavirus infectious disease (ISO)

COVID-19 (ISO)

dilated cardiomyopathy (ISO)

Experimental Autoimmune Myasthenia Gravis (ISO)

Experimental Diabetes Mellitus (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

hyperthyroidism (ISO)

hypertrophic cardiomyopathy (ISO)

Intervertebral Disc Displacement (ISO)

meningioma (ISO)

multiple sclerosis (ISO)

muscular atrophy (ISO)

nephrotic syndrome (ISO)

otitis media (ISO)

pancreatitis (ISO)

proteinuria (ISO)

Recurrence (ISO)

Reoviridae Infections (ISO)

severe acute respiratory syndrome (ISO)

Sprains and Strains (ISO)

Stomach Neoplasms (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (IEA)

antigen processing and presentation of peptide antigen (ISO)

apoptotic process (IEA)

autophagic cell death (ISO)

CD4-positive, alpha-beta T cell lineage commitment (ISO)

cellular response to starvation (ISO)

cellular response to thyroid hormone stimulus (IEA)

collagen catabolic process (IEA)

decidualization (ISO)

elastin catabolic process (ISO)

epithelial tube branching involved in lung morphogenesis (ISO)

fusion of virus membrane with host endosome membrane (IEA)

fusion of virus membrane with host plasma membrane (IEA)

hair follicle morphogenesis (ISO)

immune response (IEA)

keratinocyte proliferation (ISO)

male gonad development (ISO)

negative regulation of keratinocyte proliferation (ISO)

nerve development (ISO)

positive regulation of apoptotic signaling pathway (IEA)

protein autoprocessing (IEA)

protein catabolic process (ISO)

proteolysis (IEA)

proteolysis involved in protein catabolic process (IEA)

receptor-mediated endocytosis of virus by host cell (IEA)

response to glucocorticoid (ISO)

response to glucose (ISO)

response to gonadotropin (ISO)

response to odorant (ISO)

response to organic cyclic compound (ISO)

Sertoli cell differentiation (ISO)

spermatogenesis (ISO)

symbiont entry into host cell (IEA)

thyroid hormone generation (ISO)

zymogen activation (IEA)

Cellular Component

apical part of cell (ISO)

cytoplasmic vesicle (ISO)

external side of plasma membrane (ISO)

extracellular space (IEA)

Golgi apparatus (IEA)

intracellular membrane-bounded organelle (IEA)

lysosome (IEA)

microvillus (ISO)

multivesicular body (IEA)

nucleolus (ISO)

nucleus (ISO)

perikaryon (ISO)

plasma membrane (IEA)

secretory granule (ISO)

Molecular Function

aminopeptidase activity (ISO)

collagen binding (IEA)

cysteine-type carboxypeptidase activity (ISO)

cysteine-type endopeptidase activator activity involved in apoptotic process (IEA)

cysteine-type endopeptidase activity (IEA,ISO)

cysteine-type peptidase activity (IEA)

endopeptidase activity (ISO)

fibronectin binding (IEA)

histone binding (IEA)

kininogen binding (ISO)

peptide binding (ISO)

protein binding (ISO)

protein-containing complex binding (ISO)

proteoglycan binding (IEA)

serpin family protein binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

chaperone mediated autophagy pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

CTSL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	51,694,521 - 51,700,365 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	51,696,841 - 51,702,165 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	58,851,899 - 58,857,170 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	86,903,001 - 86,908,303 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	86,903,006 - 86,908,303 (+)	Ensembl	panpan1.1		panPan2

CTSL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	87,726,119 - 87,731,469 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	87,724,051 - 87,731,469 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	90,341,034 - 90,346,384 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	89,530,794 - 89,536,204 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	87,570,533 - 87,575,862	NCBI
Celera	9	60,911,195 - 60,916,605 (+)	NCBI		Celera
Cytogenetic Map	9	q21.33	NCBI
HuRef	9	60,165,416 - 60,170,826 (+)	NCBI		HuRef
CHM1_1	9	90,488,740 - 90,494,151 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	99,879,735 - 99,885,089 (+)	NCBI		T2T-CHM13v2.0

Ctsl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	64,509,704 - 64,518,586 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	64,507,151 - 64,518,704 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	64,361,890 - 64,370,772 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	64,359,337 - 64,370,890 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	64,464,522 - 64,471,614 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	64,377,945 - 64,385,037 (-)	NCBI		MGSCv36	mm8
Celera	13	66,025,830 - 66,032,878 (-)	NCBI		Celera
Cytogenetic Map	13	B3	NCBI
cM Map	13	33.26	NCBI

Ctsl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	770,104 - 776,266 (+)	NCBI		GRCr8
mRatBN7.2	17	764,370 - 770,533 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	764,309 - 770,548 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	783,032 - 789,194 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	2,325,609 - 2,331,773 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	780,461 - 786,622 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	1,873,105 - 1,879,266 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	1,872,848 - 1,879,279 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	1,861,403 - 1,867,564 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	6,288,013 - 6,294,174 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	6,288,015 - 6,294,173 (+)	NCBI
Celera	17	1,745,833 - 1,751,993 (-)	NCBI		Celera
RH 3.4 Map	17	16.0	RGD
Cytogenetic Map	17	p14	NCBI

CTSL3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	72,215,774 - 72,219,093 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	72,978,019 - 72,981,188 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	72,520,707 - 72,523,876 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	72,520,707 - 72,523,900 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	72,331,483 - 72,334,652 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	72,097,122 - 72,100,291 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	72,802,852 - 72,806,021 (-)	NCBI		UU_Cfam_GSD_1.0

Ctsl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	118,687,401 - 118,693,831 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936680	3,047,355 - 3,050,640 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CTSL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	27,668,264 - 27,674,618 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	27,668,523 - 27,674,705 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	31,907,421 - 31,913,554 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CTSL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	98,347,770 - 98,353,426 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	98,347,800 - 98,353,467 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	86,669,582 - 86,675,194 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003806680	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003806681	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008956250	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034967644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000037283 ⟹ ENSPPAP00000014596

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	9	86,903,006 - 86,908,303 (+)	Ensembl

RefSeq Acc Id:

XM_003806680 ⟹ XP_003806728

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	11	51,694,521 - 51,700,365 (-)	NCBI
NHGRI_mPanPan1	9	51,696,841 - 51,702,017 (-)	NCBI
Mhudiblu_PPA_v0	9	58,851,905 - 58,857,170 (+)	NCBI
PanPan1.1	9	86,903,006 - 86,908,303 (+)	NCBI

Sequence:

show sequence

TGCCGGCCGAACCCAGACCCGAGGTTTTAGAAGCAGAGTCAGGCGAAGCTGGGCCAGAACCGCG
ATCTCCGCAACCTTGAGCGGCGTCCGTGGAGTGCGCCTGCGCAGCTACGACCGCAGCAGGAAAG
CGCCGCCGGCCAGGCCCAGCTGTGGCCGGACAGGGACTGGAAGAGAGGACGCGGTCGAGTAGGT
GTGCACCAGCCCTGGCAACGAGAGCGTCTACCCCGAACTCTGCTGGCCTTGAGGTGGGGAAGCC
GGGGAGGGCAGTTGAGGACCCCGCGGAGGCGCGTGACTGGTTGAGCGGGCAGGCCAGCCTCCGA
GCCGGGTGGACACAGGTTTTAAAACATGAATCCTACACTCATCCTTGCTGCCTTTTGCCTGGGA
ATTGCCTCAGCTACTCTAACATTTGATCACAGTTTAGAGGCACAGTGGACCAAGTGGAAGGCGA
TGCACAACAGATTATACGGCATGAATGAAGAAGGATGGAGGAGAGCAGTGTGGGAGAAGAACAT
GAAGATGATTGAACTGCACAATCAGGAATACAGGGAAGGGAAACACAGCTTCACAATGGCCATG
AACGCCTTTGGAGACATGACCAGTGAAGAATTCAGGCAGGTGATGAATGGCTTTCAAAACCGTA
AGCCCAGGAAGGGGAAAGTGTTCCAGGAACCTCTGTTTTATGAGGCCCCCAGATCTGTGGATTG
GAGAGAGAAAGGCTACGTGACTCCTGTGAAGAATCAGGGTCAGTGTGGTTCTTGTTGGGCTTTT
AGCGCTACTGGTGCTCTTGAAGGACAGATGTTCCGGAAAACTGGGAGGCTTATCTCACTGAGTG
AGCAGAATCTGGTAGACTGCTCTGGGCCTCAAGGCAATGAGGGCTGCAATGGTGGCCTAATGGA
TTATGCTTTCCAGTATGTTCAGGATAATGGAGGCCTGGACTCTGAGGAATCCTATCCATATGAG
GCAACAGAAGAATCCTGTAAGTACAATCCCAAGTATTCTGTTGCTAATGACACCGGCTTTGTGG
ACATCCCTAAGCAGGAGAAGGCCCTGATGAAGGCAGTTGCAACTGTGGGGCCCATTTCTGTTGC
TATTGATGCAGGTCATGAGTCCTTCCTGTTCTATAAAGAAGGCATTTATTTTGAGCCAGACTGT
AGCAGTGAAGACATGGATCATGGTGTGCTGGTGGTTGGCTACGGATTTGAAAGCACAGAATCGG
ATAACAATAAATATTGGCTGGTGAAGAACAGCTGGGGTGAAGAATGGGGCATGGGTGGCTACGT
AAAGATGGCCAAAGACCGGAGAAACCATTGTGGAATTGCCTCAGCAGCCAGCTACCCCACTGTG
TGAGCTGGTGGACGGTGATGAGGAAGGACTTGACTGAGGATGGCGCATGCATGGGAGGAATTCA
TCTTCAGTCTACCAGCCCCCGCTGTGTCGGATACACACTCGAATCATTGAAGATCCAAGTGTGA
TTTGAATTCTGTGATATTTTCACACTGGTAAATGTTACCTCTATTTTAATTACTGCTATAAATA
GGTTTATATTATTGATTCACTTACTGACTTTGCATTTTCATTTTTAAAAGGATGTATAAATTTT
TACCTGTTTAAATAAAATTTAATTTCAAATGTA

hide sequence

RefSeq Acc Id:

XM_003806681 ⟹ XP_003806729

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	11	51,694,521 - 51,700,357 (-)	NCBI
NHGRI_mPanPan1	9	51,696,841 - 51,702,107 (-)	NCBI
Mhudiblu_PPA_v0	9	58,851,904 - 58,857,170 (+)	NCBI
PanPan1.1	9	86,903,001 - 86,908,303 (+)	NCBI

Sequence:

show sequence

GGCGGTGCCGGCCGAACCCAGACCCGAGGTTTTAGAAGCAGAGTCAGGCGAAGCTGGGCCAGAA
CCGCGATCTCCGCAACCTTGAGCGGCGTCCGTGGAGTGCGCCTGCGCAGCTACGACCGCAGCAG
GAAAGCGCCGCCGGCCAGGCCCAGCTGTGGCCGGACAGGGACTGGAAGAGAGGACGCGGTCGAG
TAGGTGTGCACCAGCCCTGGCAACGAGAGCGTCTACCCCGAACTCTGCTGGCCTTGAGGTTTTA
AAACATGAATCCTACACTCATCCTTGCTGCCTTTTGCCTGGGAATTGCCTCAGCTACTCTAACA
TTTGATCACAGTTTAGAGGCACAGTGGACCAAGTGGAAGGCGATGCACAACAGATTATACGGCA
TGAATGAAGAAGGATGGAGGAGAGCAGTGTGGGAGAAGAACATGAAGATGATTGAACTGCACAA
TCAGGAATACAGGGAAGGGAAACACAGCTTCACAATGGCCATGAACGCCTTTGGAGACATGACC
AGTGAAGAATTCAGGCAGGTGATGAATGGCTTTCAAAACCGTAAGCCCAGGAAGGGGAAAGTGT
TCCAGGAACCTCTGTTTTATGAGGCCCCCAGATCTGTGGATTGGAGAGAGAAAGGCTACGTGAC
TCCTGTGAAGAATCAGGGTCAGTGTGGTTCTTGTTGGGCTTTTAGCGCTACTGGTGCTCTTGAA
GGACAGATGTTCCGGAAAACTGGGAGGCTTATCTCACTGAGTGAGCAGAATCTGGTAGACTGCT
CTGGGCCTCAAGGCAATGAGGGCTGCAATGGTGGCCTAATGGATTATGCTTTCCAGTATGTTCA
GGATAATGGAGGCCTGGACTCTGAGGAATCCTATCCATATGAGGCAACAGAAGAATCCTGTAAG
TACAATCCCAAGTATTCTGTTGCTAATGACACCGGCTTTGTGGACATCCCTAAGCAGGAGAAGG
CCCTGATGAAGGCAGTTGCAACTGTGGGGCCCATTTCTGTTGCTATTGATGCAGGTCATGAGTC
CTTCCTGTTCTATAAAGAAGGCATTTATTTTGAGCCAGACTGTAGCAGTGAAGACATGGATCAT
GGTGTGCTGGTGGTTGGCTACGGATTTGAAAGCACAGAATCGGATAACAATAAATATTGGCTGG
TGAAGAACAGCTGGGGTGAAGAATGGGGCATGGGTGGCTACGTAAAGATGGCCAAAGACCGGAG
AAACCATTGTGGAATTGCCTCAGCAGCCAGCTACCCCACTGTGTGAGCTGGTGGACGGTGATGA
GGAAGGACTTGACTGAGGATGGCGCATGCATGGGAGGAATTCATCTTCAGTCTACCAGCCCCCG
CTGTGTCGGATACACACTCGAATCATTGAAGATCCAAGTGTGATTTGAATTCTGTGATATTTTC
ACACTGGTAAATGTTACCTCTATTTTAATTACTGCTATAAATAGGTTTATATTATTGATTCACT
TACTGACTTTGCATTTTCATTTTTAAAAGGATGTATAAATTTTTACCTGTTTAAATAAAATTTA
ATTTCAAATGTA

hide sequence

RefSeq Acc Id:

XM_008956250 ⟹ XP_008954498

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	11	51,694,521 - 51,700,319 (-)	NCBI
NHGRI_mPanPan1	9	51,696,841 - 51,702,163 (-)	NCBI
Mhudiblu_PPA_v0	9	58,851,899 - 58,857,170 (+)	NCBI
PanPan1.1	9	86,903,001 - 86,908,303 (+)	NCBI

Sequence:

show sequence

GGCGGTGCCGGCCGAACCCAGACCCGAGGTTTTAGAAGCAGAGTCAGGCGAAGCTGGGCCAGAA
CCGCGATCTCCGCAACCTTGAGCGGCGTCCGTGGAGTGCGCCTGCGCAGCTACGACCGCAGCAG
GAAAGCGCCGCCGGCCAGGCCCAGCTGTGGCCGGACAGGGACTGGAAGAGAGGACGCGGTCGAG
TAGGTTTTAAAACATGAATCCTACACTCATCCTTGCTGCCTTTTGCCTGGGAATTGCCTCAGCT
ACTCTAACATTTGATCACAGTTTAGAGGCACAGTGGACCAAGTGGAAGGCGATGCACAACAGAT
TATACGGCATGAATGAAGAAGGATGGAGGAGAGCAGTGTGGGAGAAGAACATGAAGATGATTGA
ACTGCACAATCAGGAATACAGGGAAGGGAAACACAGCTTCACAATGGCCATGAACGCCTTTGGA
GACATGACCAGTGAAGAATTCAGGCAGGTGATGAATGGCTTTCAAAACCGTAAGCCCAGGAAGG
GGAAAGTGTTCCAGGAACCTCTGTTTTATGAGGCCCCCAGATCTGTGGATTGGAGAGAGAAAGG
CTACGTGACTCCTGTGAAGAATCAGGGTCAGTGTGGTTCTTGTTGGGCTTTTAGCGCTACTGGT
GCTCTTGAAGGACAGATGTTCCGGAAAACTGGGAGGCTTATCTCACTGAGTGAGCAGAATCTGG
TAGACTGCTCTGGGCCTCAAGGCAATGAGGGCTGCAATGGTGGCCTAATGGATTATGCTTTCCA
GTATGTTCAGGATAATGGAGGCCTGGACTCTGAGGAATCCTATCCATATGAGGCAACAGAAGAA
TCCTGTAAGTACAATCCCAAGTATTCTGTTGCTAATGACACCGGCTTTGTGGACATCCCTAAGC
AGGAGAAGGCCCTGATGAAGGCAGTTGCAACTGTGGGGCCCATTTCTGTTGCTATTGATGCAGG
TCATGAGTCCTTCCTGTTCTATAAAGAAGGCATTTATTTTGAGCCAGACTGTAGCAGTGAAGAC
ATGGATCATGGTGTGCTGGTGGTTGGCTACGGATTTGAAAGCACAGAATCGGATAACAATAAAT
ATTGGCTGGTGAAGAACAGCTGGGGTGAAGAATGGGGCATGGGTGGCTACGTAAAGATGGCCAA
AGACCGGAGAAACCATTGTGGAATTGCCTCAGCAGCCAGCTACCCCACTGTGTGAGCTGGTGGA
CGGTGATGAGGAAGGACTTGACTGAGGATGGCGCATGCATGGGAGGAATTCATCTTCAGTCTAC
CAGCCCCCGCTGTGTCGGATACACACTCGAATCATTGAAGATCCAAGTGTGATTTGAATTCTGT
GATATTTTCACACTGGTAAATGTTACCTCTATTTTAATTACTGCTATAAATAGGTTTATATTAT
TGATTCACTTACTGACTTTGCATTTTCATTTTTAAAAGGATGTATAAATTTTTACCTGTTTAAA
TAAAATTTAATTTCAAATGTA

hide sequence

RefSeq Acc Id:

XM_034967644 ⟹ XP_034823535

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	11	51,694,521 - 51,700,293 (-)	NCBI
NHGRI_mPanPan1	9	51,696,841 - 51,702,165 (-)	NCBI
Mhudiblu_PPA_v0	9	58,851,905 - 58,857,170 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003806728	(Get FASTA)	NCBI Sequence Viewer
	XP_003806729	(Get FASTA)	NCBI Sequence Viewer
	XP_008954498	(Get FASTA)	NCBI Sequence Viewer
	XP_034823535	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000014596
	ENSPPAP00000014596.1

RefSeq Acc Id:

XP_003806729 ⟸ XM_003806681

- UniProtKB:

A0A2R9ACG6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQ
EYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTP
VKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQD
NGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESF
LFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRN
HCGIASAASYPTV

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RefSeq Acc Id:

XP_008954498 ⟸ XM_008956250

- UniProtKB:

A0A2R9ACG6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQ
EYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTP
VKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQD
NGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESF
LFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRN
HCGIASAASYPTV

hide sequence

RefSeq Acc Id:

XP_003806728 ⟸ XM_003806680

- UniProtKB:

A0A2R9ACG6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQ
EYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTP
VKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQD
NGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESF
LFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRN
HCGIASAASYPTV

hide sequence

RefSeq Acc Id:	XP_034823535 ⟸ XM_034967644
- UniProtKB:	A0A2R9ACG6 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSPPAP00000014596 ⟸ ENSPPAT00000037283

Protein Domains

Cathepsin propeptide inhibitor Peptidase C1A papain C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000030463	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000037283.1	UniProtKB/TrEMBL
Gene3D-CATH	Cysteine proteinases	UniProtKB/TrEMBL
InterPro	Papain-like_cys_pep_sf	UniProtKB/TrEMBL
	Pept_asp_AS	UniProtKB/TrEMBL
	Pept_cys_AS	UniProtKB/TrEMBL
	Pept_his_AS	UniProtKB/TrEMBL
	Peptidase_C1A	UniProtKB/TrEMBL
	Peptidase_C1A_C	UniProtKB/TrEMBL
	Peptidase_C1A_papain-like	UniProtKB/TrEMBL
	Prot_inhib_I29	UniProtKB/TrEMBL
KEGG Report	pps:100987260	UniProtKB/TrEMBL
NCBI Gene	CTSL	ENTREZGENE
PANTHER	CYSTEINE PROTEASE FAMILY C1-RELATED	UniProtKB/TrEMBL
	PROCATHEPSIN L	UniProtKB/TrEMBL
Pfam	Inhibitor_I29	UniProtKB/TrEMBL
	Peptidase_C1	UniProtKB/TrEMBL
PRINTS	PAPAIN	UniProtKB/TrEMBL
PROSITE	THIOL_PROTEASE_ASN	UniProtKB/TrEMBL
	THIOL_PROTEASE_CYS	UniProtKB/TrEMBL
	THIOL_PROTEASE_HIS	UniProtKB/TrEMBL
SMART	Inhibitor_I29	UniProtKB/TrEMBL
	Pept_C1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54001	UniProtKB/TrEMBL
UniProt	A0A2R9ACG6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-03-13	CTSL	cathepsin L	LOC100987260	procathepsin L	Symbol and/or name change	5135510	APPROVED
2023-06-21	LOC100987260	procathepsin L	CTSL	cathepsin L	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

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