TGFB3 (transforming growth factor beta 3)

Gene: TGFB3 (transforming growth factor beta 3) Pan paniscus

Analyze

Symbol:

TGFB3

Name:

transforming growth factor beta 3

RGD ID:

12022335

Description:

ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); cell population proliferation (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN glypican signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); arrhythmogenic right ventricular dysplasia 1 (ortholog); Brugada syndrome (ortholog); FOUND IN cell surface (ortholog); extracellular matrix (ortholog); extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

transforming growth factor beta-3; transforming growth factor beta-3 proprotein

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	77,047,367 - 77,072,727 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	76,263,873 - 76,289,264 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	56,516,697 - 56,542,097 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	75,359,505 - 75,382,412 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	75,359,505 - 75,382,412 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

arrhythmogenic right ventricular cardiomyopathy (ISO)

arrhythmogenic right ventricular dysplasia 1 (ISO)

Brugada syndrome (ISO)

cardiomyopathy (ISO)

Carotid Artery Injuries (ISO)

cleft palate (ISO)

colon cancer (ISO)

colorectal cancer (ISO)

Contracture (ISO)

cranioectodermal dysplasia (ISO)

Developmental Disease (ISO)

diabetic neuropathy (ISO)

dilated cardiomyopathy (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

hypertension (ISO)

hypertrophic cardiomyopathy (ISO)

intellectual disability (ISO)

left ventricular noncompaction (ISO)

Loeys-Dietz syndrome (ISO)

Loeys-Dietz syndrome 4 (ISO)

Loeys-Dietz syndrome 5 (ISO)

long QT syndrome (ISO)

nonsyndromic deafness (ISO)

pancreatic ductal adenocarcinoma (ISO)

Respiratory System Abnormalities (ISO)

thoracic aortic aneurysm (ISO)

Ventricular Premature Complexes (ISO)

Wounds and Injuries (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ morphogenesis (ISO)

cell population proliferation (ISO)

cell-cell junction organization (IEA)

cellular response to growth factor stimulus (ISO)

detection of hypoxia (IEA)

digestive tract development (ISO)

embryonic neurocranium morphogenesis (ISO)

epithelial cell proliferation (ISO)

face morphogenesis (IEA)

female pregnancy (ISO)

filopodium assembly (ISO)

frontal suture morphogenesis (ISO)

gene expression (ISO)

in utero embryonic development (ISO)

inner ear development (ISO)

lung alveolus development (ISO)

mammary gland development (ISO)

negative regulation of cell population proliferation (IEA,ISO)

negative regulation of epithelial cell proliferation (ISO)

negative regulation of macrophage cytokine production (IEA)

negative regulation of neuron apoptotic process (ISO)

negative regulation of transforming growth factor beta receptor signaling pathway (ISO)

negative regulation of vascular associated smooth muscle cell proliferation (IEA)

neuron apoptotic process (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of cell division (IEA)

positive regulation of cell population proliferation (IEA)

positive regulation of collagen biosynthetic process (IEA)

positive regulation of DNA-templated transcription (IEA)

positive regulation of epithelial to mesenchymal transition (IEA)

positive regulation of filopodium assembly (ISO)

positive regulation of gene expression (ISO)

positive regulation of MAPK cascade (ISO)

positive regulation of protein secretion (IEA)

positive regulation of SMAD protein signal transduction (ISO)

positive regulation of stress fiber assembly (IEA)

positive regulation of tight junction disassembly (IEA)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of cell population proliferation (IEA)

regulation of epithelial to mesenchymal transition involved in endocardial cushion formation (ISO)

response to estrogen (ISO)

response to hypoxia (IEA,ISO)

response to laminar fluid shear stress (ISO)

response to progesterone (IEA)

roof of mouth development (ISO)

salivary gland morphogenesis (IEA)

secondary palate development (ISO)

transforming growth factor beta receptor signaling pathway (IEA)

Cellular Component

cell surface (ISO)

collagen-containing extracellular matrix (IEA)

extracellular matrix (ISO)

extracellular region (IEA)

extracellular space (IEA,ISO)

intracellular membrane-bounded organelle (IEA)

neuronal cell body (ISO)

secretory granule (ISO)

T-tubule (ISO)

Molecular Function

cytokine activity (IEA)

growth factor activity (IEA)

identical protein binding (IEA)

protein binding (ISO)

protein-containing complex binding (ISO)

transforming growth factor beta binding (IEA)

transforming growth factor beta receptor binding (IEA)

type I transforming growth factor beta receptor binding (IEA)

type II transforming growth factor beta receptor binding (IEA)

type III transforming growth factor beta receptor binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

glypican signaling pathway (ISO)

transforming growth factor-beta Smad dependent signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

TGFB3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	77,047,367 - 77,072,727 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	76,263,873 - 76,289,264 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	56,516,697 - 56,542,097 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	75,359,505 - 75,382,412 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	75,359,505 - 75,382,412 (-)	Ensembl	panpan1.1		panPan2

TGFB3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	75,958,097 - 75,983,011 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	75,958,097 - 75,983,011 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	76,424,440 - 76,449,354 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	75,494,195 - 75,517,242 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	75,494,194 - 75,517,242	NCBI
Celera	14	56,462,579 - 56,486,236 (-)	NCBI		Celera
Cytogenetic Map	14	q24.3	NCBI
HuRef	14	56,593,103 - 56,616,766 (-)	NCBI		HuRef
CHM1_1	14	76,362,235 - 76,385,896 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	70,167,287 - 70,192,202 (-)	NCBI		T2T-CHM13v2.0

Tgfb3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	86,103,517 - 86,125,815 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	86,103,519 - 86,125,815 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	86,056,743 - 86,079,041 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	86,056,745 - 86,079,041 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	87,397,693 - 87,419,991 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	86,945,847 - 86,967,637 (-)	NCBI		MGSCv36	mm8
Celera	12	87,516,891 - 87,539,154 (-)	NCBI		Celera
Cytogenetic Map	12	D2	NCBI
cM Map	12	40.09	NCBI

Tgfb3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	111,435,170 - 111,457,646 (-)	NCBI		GRCr8
mRatBN7.2	6	105,704,058 - 105,726,661 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	105,704,236 - 105,726,564 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	105,874,132 - 105,895,952 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	106,173,012 - 106,194,830 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	105,542,654 - 105,564,473 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	109,913,757 - 109,936,217 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	109,913,757 - 109,935,533 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	119,222,052 - 119,244,512 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	110,173,443 - 110,195,215 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	110,176,974 - 110,198,746 (-)	NCBI
Celera	6	103,530,785 - 103,552,563 (-)	NCBI		Celera
RH 3.4 Map	6	742.1	RGD
Cytogenetic Map	6	q31	NCBI

Tgfb3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	29,415 - 55,180 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955438	33,129 - 55,180 (-)	NCBI	ChiLan1.0	ChiLan1.0

TGFB3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	48,920,874 - 48,946,037 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	48,923,423 - 48,945,816 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	48,603,511 - 48,629,028 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	49,145,129 - 49,170,643 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	49,147,212 - 49,170,366 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	48,817,670 - 48,843,148 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	48,839,598 - 48,865,116 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	49,235,714 - 49,261,227 (-)	NCBI		UU_Cfam_GSD_1.0

Tgfb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	27,060,257 - 27,083,429 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936488	4,986,748 - 5,008,496 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936488	4,986,712 - 5,008,728 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TGFB3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	99,133,879 - 99,162,232 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	99,133,873 - 99,162,239 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	105,178,639 - 105,208,968 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TGFB3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	53,203,593 - 53,227,483 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	53,203,301 - 53,227,325 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	41,419,765 - 41,443,760 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tgfb3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	25,716,972 - 25,739,199 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	25,717,011 - 25,739,942 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003824191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034937884	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063596342	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000040040 ⟹ ENSPPAP00000017338

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	14	75,359,505 - 75,382,412 (-)	Ensembl

RefSeq Acc Id:

XM_003824191 ⟹ XP_003824239

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	15	77,047,367 - 77,071,412 (-)	NCBI
NHGRI_mPanPan1	14	76,263,873 - 76,287,971 (-)	NCBI
Mhudiblu_PPA_v0	14	56,516,733 - 56,540,814 (-)	NCBI
PanPan1.1	14	75,359,505 - 75,382,412 (-)	NCBI

Sequence:

show sequence

CACACAGTCCGCTTCTTCGTCCTCAGGGTTGCCAGCGCTTCCTGGAAGTCCTGAAGCTCTCGCA
GTGCAGTGAGTTCATGCACCTTCTTGCCAAGCCTCAGTCTTTGGGATCTGGGGAGGCCGCCTGG
TTTTCCTCCCTCCTTCTGCACGTCTGCTGGGGTCTCTTCCTCTCCAGGCCTTGCCGTCCCCCTG
GCCTCTCTTCCCAGCTCACACATGAAGATGCACTTGCAAAGGGCTCTGGTGGTCCTGGCCCTGC
TGAACTTTGCCACGGTCAGCCTCTCTCTGTCCACTTGCACCACCTTGGACTTCGGCCACATCAA
GAAGAAGAGGGTGGAAGCCATTAGGGGACAGATCTTGAGCAAGCTCAGGCTCACCAGCCCCCCT
GAGCCAACGGTGATGACCCACGTCCCCTATCAGGTCCTGGCCCTTTACAACAGCACCCGGGAGC
TGCTGGAGGAGATGCATGGGGAGAGGGAGGAAGGCTGCACCCAGGAAAACACCGAGTCGGAATA
CTATGCCAAAGAAATCCATAAATTCGACATGATCCAGGGGCTGGCGGAGCACAACGAACTGGCT
GTCTGCCCTAAAGGAATTACCTCCAAGGTTTTCCGCTTCAATGTGTCCTCAGTGGAGAAAAATA
GAACCAACCTATTCCGAGCAGAATTCCGGGTCTTGCGGGTGCCCAACCCCAGCTCTAAGCGGAA
TGAGCAGAGGATCGAGCTCTTCCAGATCCTTCGGCCAGATGAGCACATTGCCAAACAGCGCTAT
ATCGGTGGCAAGAATCTGCCCACACGGGGCACTGCCGAGTGGCTGTCCTTTGATGTCACTGACA
CTGTGCGTGAGTGGCTGTTGAGAAGAGAGTCCAACTTAGGTCTAGAAATCAGCATTCACTGTCC
ATGTCACACCTTTCAGCCCAATGGAGATATCCTGGAAAACATTCACGAGGTGATGGAAATCAAA
TTCAAAGGCGTGGACAATGAGGATGACCATGGCCGTGGAGATCTGGGGCGCCTCAAGAAGCAGA
AGGATCACCACAACCCTCATCTAATCCTCATGATGATTCCCCCACACCGGCTCGACAACCCGGG
CCAGGGGGGTCAGAGGAAGAAGAGGGCCTTGGACACCAATTACTGCTTCCGCAACTTGGAGGAG
AACTGCTGTGTGCGCCCCCTCTACATTGACTTCCGACAGGATCTGGGCTGGAAGTGGGTCCATG
AACCTAAGGGCTACTATGCCAACTTCTGCTCAGGCCCTTGCCCATACCTCCGCAGTGCAGACAC
AACCCACAGCACGGTGCTGGGACTGTACAACACTCTGAACCCTGAAGCATCTGCCTCGCCTTGC
TGCGTGCCCCAGGACCTGGAGCCCCTGACCATCCTGTACTATGTTGGGAGGACCCCCAAAGTGG
AGCAGCTCTCCAACATGGTGGTGAAGTCTTGTAAATGTAGCTGAGACCCCACCTGCGACAGAGA
GAGGGGAGAGAGAACCACCACTGCCTGACTGCCCGCTCCTCGGGAAACACACAAGCAACAAACC
TCACTGAGAGGCCTGGAGCCCACAACCTTCGGCTCCGGGCAGATGGCTGAGATGGAGGTTTCCT
TTTGGAACATTTCTTTCTTGCTGGCTCTGAGAATCATGGTGGTAAAGAAAGTGTGGGTTTGGTT
AGAGGAAGGCTGAACTCTTCAGAACACACAGACTTTCTGTGACGCAGACAGAGGGGATGGGGAT
AGAGGAAAGGGATGGCAAGTTGAGATGTTGTGTGGCAATGGGATTTGGGCTACCCTAAAGGGAG
GAGGAAGGGCAGAGAATGGCCGGGTCAGGGCCAGACTGGAAGACACTTCAGATCTGAGGTTGGA
TTTGCTCATTGCTGTACCACATCTGCTCTAGGGAATCTGGATTATGTTATACAAGGCAAGCATT
TTTTTTTTTAAAGACAGGTTACGAAGACAAAGTCCCAGAATTGTATCTCATACTGTCTGGGATT
AAGGGCAAATCTATTACTTTTGCAAACTGTCCTCTACATCAATTAACATCGTGGGTCACTACAG
GGAGAAAATCCAGGTCATGCAGTTCCTGGCCCATCAACTGTATCGGGCCTTTTGGATATGCTGA
ACGCAGAAGAAAGGGTGGAAATCAACCCTCTCCTGTCTGCCCTCTGGGTCCCTCCTCTCACCTC
TCCCTCGATCATATTTCCCCTTGGACACTTGGTTAGACGCCTTCCAGGTCAGGATGCACATTTC
TGGATTGTGGTTCCATGCAGCCTTGGGGCATTATGGGTTCTTCCCCCACTTCCCCTCCAAGACC
CTGTGTTCATTTGGTGTTCCTGGAAGCAGGTGCTACAACATGTGAGGCATTCGGGGAAGCTGCA
CATGTGCCACACAGTGACTTGGCCCCAGACGCATAGACTGAGGTATAAAGACAAGTATGAATAT
TACTCTCAAAATCTTTGTATAAATAAATATTTTTGGGGCATCTTGGATGATTTCATCTTCTGGA
AGATTGTTTCTAGAACAGTAAAAGCCTTATTCTAAGGTGTA

hide sequence

RefSeq Acc Id:

XM_034937884 ⟹ XP_034793775

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	15	77,047,367 - 77,072,727 (-)	NCBI
NHGRI_mPanPan1	14	76,263,873 - 76,289,264 (-)	NCBI
Mhudiblu_PPA_v0	14	56,516,697 - 56,542,097 (-)	NCBI

RefSeq Acc Id:

XM_063596342 ⟹ XP_063452412

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	15	77,047,367 - 77,071,258 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003824239	(Get FASTA)	NCBI Sequence Viewer
	XP_034793775	(Get FASTA)	NCBI Sequence Viewer
	XP_063452412	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000017338
	ENSPPAP00000017338.1

RefSeq Acc Id:

XP_003824239 ⟸ XM_003824191

- UniProtKB:

A0A2R9AJT4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTH
VPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGIT
SKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLP
TRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNE
DDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPL
YIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLE
PLTILYYVGRTPKVEQLSNMVVKSCKCS

hide sequence

RefSeq Acc Id:	XP_034793775 ⟸ XM_034937884
- UniProtKB:	A0A2R9AJT4 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSPPAP00000017338 ⟸ ENSPPAT00000040040

RefSeq Acc Id:

XP_063452412 ⟸ XM_063596342

Protein Domains

TGF-beta family profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000031753	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000040040.1	UniProtKB/TrEMBL
Gene3D-CATH	2.10.90.10	UniProtKB/TrEMBL
	2.60.120.970	UniProtKB/TrEMBL
InterPro	Cystine-knot_cytokine	UniProtKB/TrEMBL
	TGF-b_C	UniProtKB/TrEMBL
	TGF-b_propeptide	UniProtKB/TrEMBL
	TGF-beta	UniProtKB/TrEMBL
	TGF-beta-rel	UniProtKB/TrEMBL
	TGFB3	UniProtKB/TrEMBL
	TGFb_CS	UniProtKB/TrEMBL
KEGG Report	pps:100990987	UniProtKB/TrEMBL
NCBI Gene	TGFB3	ENTREZGENE
PANTHER	PTHR11848	UniProtKB/TrEMBL
	TRANSFORMING GROWTH FACTOR BETA-3 PROPROTEIN	UniProtKB/TrEMBL
Pfam	TGF_beta	UniProtKB/TrEMBL
	TGFb_propeptide	UniProtKB/TrEMBL
PIRSF	TGF-beta	UniProtKB/TrEMBL
PRINTS	TGFBETA	UniProtKB/TrEMBL
	TGFBETA3	UniProtKB/TrEMBL
PROSITE	TGF_BETA_1	UniProtKB/TrEMBL
	TGF_BETA_2	UniProtKB/TrEMBL
SMART	TGFB	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57501	UniProtKB/TrEMBL
UniProt	A0A2R9AJT4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)