BRCA2 (BRCA2 DNA repair associated) - Rat Genome Database

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Pathways
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Gene: BRCA2 (BRCA2 DNA repair associated) Pan paniscus
Analyze
Symbol: BRCA2
Name: BRCA2 DNA repair associated
RGD ID: 12017566
Description: ENCODES a protein that exhibits histone acetyltransferase activity (ortholog); single-stranded DNA binding (ortholog); INVOLVED IN brain development (ortholog); cell population proliferation (ortholog); cellular senescence (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH atrophy of testis (ortholog); bilateral breast cancer (ortholog); breast cancer (ortholog); FOUND IN DNA repair complex (ortholog); nuclear ubiquitin ligase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BRCA2, DNA repair associated; breast cancer 2 early onset
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21431,881,434 - 31,965,986 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11322,987,931 - 23,072,490 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01313,574,422 - 13,658,967 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11332,009,039 - 32,092,463 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1332,010,066 - 32,091,332 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
atrophy of testis  (ISO)
bilateral breast cancer  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
breast ductal carcinoma  (ISO)
Breast Neoplasms  (ISO)
cancer  (ISO)
cataract  (ISO)
cerebral palsy  (ISO)
chordoma  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
COVID-19  (ISO)
diffuse large B-cell lymphoma  (ISO)
diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype  (ISO)
ductal carcinoma in situ  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
endometrial serous adenocarcinoma  (ISO)
esophageal atresia/tracheoesophageal fistula  (ISO)
esophageal cancer  (ISO)
esophageal carcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Fanconi anemia  (ISO)
Fanconi anemia complementation group D1  (ISO)
focal epilepsy  (ISO)
genetic disease  (ISO)
hematopoietic system disease  (ISO)
hepatoblastoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
hereditary mixed polyposis syndrome 1  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
ichthyosis vulgaris  (ISO)
infertility  (ISO)
intellectual disability  (ISO)
Invasive Breast Carcinoma  (ISO)
invasive ductal carcinoma  (ISO)
invasive lobular carcinoma  (ISO)
isolated growth hormone deficiency type IA  (ISO)
Lung Neoplasms  (ISO)
Lynch syndrome  (ISO)
male breast cancer  (ISO)
male breast carcinoma  (ISO)
Male Breast Neoplasms  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
migraine  (ISO)
nephroblastoma  (ISO)
neuroblastoma  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
ovary serous adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic endocrine carcinoma  (ISO)
polydactyly  (ISO)
primary ovarian insufficiency 16  (ISO)
prostate cancer  (ISO)
prostate small cell carcinoma  (ISO)
Prostatic Neoplasms  (ISO)
rhabdomyosarcoma  (ISO)
skin melanoma  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell neoplasm  (ISO)
stomach cancer  (ISO)
Tracheoesophageal Fistula  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
uterine corpus cancer  (ISO)
uveal melanoma  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain development  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to ionizing radiation  (IEA)
cellular senescence  (IEA,ISO)
centrosome duplication  (IEA)
chordate embryonic development  (IEA,ISO)
chromatin remodeling  (IEA)
chromosome organization  (IEA,ISO)
DNA damage response  (IEA)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  (IEA,ISO)
DNA recombination  (IEA,ISO)
DNA repair  (IEA)
double-strand break repair  (IEA,ISO)
double-strand break repair via homologous recombination  (IEA,ISO)
establishment of protein localization to telomere  (IEA)
female gonad development  (IEA,ISO)
hematopoietic stem cell proliferation  (IEA,ISO)
hemopoiesis  (IEA,ISO)
homologous chromosome orientation in meiotic metaphase I  (ISO)
inner cell mass cell proliferation  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
male meiosis I  (IEA,ISO)
mammary gland development  (ISO)
mitotic recombination-dependent replication fork processing  (IEA)
multicellular organism growth  (ISO)
negative regulation of mammary gland epithelial cell proliferation  (IEA)
nucleotide-excision repair  (IEA)
oocyte maturation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of mitotic cell cycle  (IEA,ISO)
regulation of cytokinesis  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
replication fork processing  (IEA,ISO)
response to estradiol  (ISO)
response to gamma radiation  (IEA,ISO)
response to nutrient  (ISO)
response to UV-C  (IEA,ISO)
response to X-ray  (IEA,ISO)
spermatogenesis  (IEA,ISO)
stem cell proliferation  (IEA,ISO)
telomere maintenance via recombination  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BRCA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21431,881,434 - 31,965,986 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11322,987,931 - 23,072,490 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01313,574,422 - 13,658,967 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11332,009,039 - 32,092,463 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1332,010,066 - 32,091,332 (+)Ensemblpanpan1.1panPan2
BRCA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381332,315,508 - 32,400,268 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1332,315,086 - 32,400,268 (+)EnsemblGRCh38hg38GRCh38
GRCh371332,889,645 - 32,974,405 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361331,787,617 - 31,871,809 (+)NCBINCBI36Build 36hg18NCBI36
Build 341331,787,616 - 31,871,805NCBI
Celera1313,956,447 - 14,040,613 (+)NCBICelera
Cytogenetic Map13q13.1NCBI
HuRef1313,701,252 - 13,785,592 (+)NCBIHuRef
CHM1_11332,857,164 - 32,941,322 (+)NCBICHM1_1
T2T-CHM13v2.01331,532,753 - 31,617,510 (+)NCBIT2T-CHM13v2.0
Brca2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395150,445,759 - 150,493,612 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5150,446,095 - 150,493,794 (+)EnsemblGRCm39 Ensembl
GRCm385150,522,297 - 150,570,147 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5150,522,630 - 150,570,329 (+)EnsemblGRCm38mm10GRCm38
MGSCv375151,325,198 - 151,372,324 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365150,791,554 - 150,838,126 (+)NCBIMGSCv36mm8
Celera5148,527,149 - 148,574,274 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.52NCBI
Brca2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8124,895,092 - 4,939,340 (+)NCBIGRCr8
mRatBN7.21259,492 - 103,789 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1259,819 - 100,567 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx12628,555 - 669,267 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0121,150,791 - 1,191,504 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,374 - 91,100 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.012503,660 - 544,754 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12504,007 - 544,748 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.012490,733 - 535,090 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4124,282,952 - 4,323,693 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1124,282,951 - 4,323,693NCBI
Celera121,769,467 - 1,810,212 (+)NCBICelera
Cytogenetic Map12p12NCBI
Brca2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543113,449,543 - 13,527,432 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543113,449,287 - 13,526,878 (-)NCBIChiLan1.0ChiLan1.0
BRCA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1257,734,450 - 7,797,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl257,734,453 - 7,797,815 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha257,764,412 - 7,827,765 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0257,830,897 - 7,895,637 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl257,831,514 - 7,895,646 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,730,810 - 7,794,166 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,729,079 - 7,792,446 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0257,786,384 - 7,849,984 (-)NCBIUU_Cfam_GSD_1.0
Brca2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945168,936,254 - 169,007,337 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647226,945,659 - 27,017,693 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRCA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl118,805,953 - 8,858,418 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1118,805,950 - 8,858,128 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BRCA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1311,070,086 - 11,155,257 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl311,071,682 - 11,155,213 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605733,194,816 - 33,282,150 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brca2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247765,497,779 - 5,550,993 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247765,497,552 - 5,573,465 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000003886   ⟹   ENSPPAP00000000836
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1332,010,066 - 32,091,332 (+)Ensembl
RefSeq Acc Id: XM_003826866   ⟹   XP_003826914
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21431,881,434 - 31,965,986 (+)NCBI
NHGRI_mPanPan11322,987,931 - 23,072,490 (+)NCBI
Mhudiblu_PPA_v01313,574,424 - 13,658,967 (+)NCBI
PanPan1.11332,009,039 - 32,092,463 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003826914 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AIG88499 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000000836.1
Reference Protein Sequences
RefSeq Acc Id: XP_003826914   ⟸   XM_003826866
- Sequence:
RefSeq Acc Id: ENSPPAP00000000836   ⟸   ENSPPAT00000003886
Protein Domains
Tower


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000002166 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000003886.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
  6.10.70.10 UniProtKB/TrEMBL
InterPro BRCA2 UniProtKB/TrEMBL
  BRCA2_hlx UniProtKB/TrEMBL
  BRCA2_hlx_sf UniProtKB/TrEMBL
  BRCA2_OB_1 UniProtKB/TrEMBL
  BRCA2_OB_2_dom UniProtKB/TrEMBL
  BRCA2_OB_3 UniProtKB/TrEMBL
  BRCA2_repeat UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  Tower_dom UniProtKB/TrEMBL
NCBI Gene BRCA2 ENTREZGENE
PANTHER BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN UniProtKB/TrEMBL
  PTHR11289 UniProtKB/TrEMBL
Pfam BRCA-2_helical UniProtKB/TrEMBL
  BRCA-2_OB1 UniProtKB/TrEMBL
  BRCA-2_OB3 UniProtKB/TrEMBL
  BRCA2 UniProtKB/TrEMBL
  BRCA2DBD_OB2 UniProtKB/TrEMBL
  Tower UniProtKB/TrEMBL
PIRSF BRCA2 UniProtKB/TrEMBL
PROSITE BRCA2_REPEAT UniProtKB/TrEMBL
SMART Tower UniProtKB/TrEMBL
Superfamily-SCOP BRCA2 tower domain UniProtKB/TrEMBL
  SSF50249 UniProtKB/TrEMBL
  SSF81872 UniProtKB/TrEMBL
UniProt A0A075VNS4_PANPA UniProtKB/TrEMBL
  A0A2R8ZDX5_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 BRCA2  BRCA2 DNA repair associated    BRCA2, DNA repair associated  Symbol and/or name change 5135510 APPROVED