PRKDC (protein kinase, DNA-activated, catalytic subunit) - Rat Genome Database

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Pathways
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Gene: PRKDC (protein kinase, DNA-activated, catalytic subunit) Pan paniscus
Analyze
Symbol: PRKDC
Name: protein kinase, DNA-activated, catalytic subunit
RGD ID: 12010833
Description: ENCODES a protein that exhibits ATP binding (inferred); DNA-dependent protein kinase activity (inferred); double-stranded DNA binding (inferred); INVOLVED IN B cell lineage commitment (ortholog); brain development (ortholog); double-strand break repair (ortholog); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Brain Hypoxia-Ischemia (ortholog); breast cancer (ortholog); FOUND IN DNA-dependent protein kinase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA-dependent protein kinase catalytic subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2763,407,112 - 63,593,508 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1839,100,871 - 39,287,251 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0844,201,391 - 44,386,803 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1841,593,022 - 41,778,299 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl841,593,029 - 41,778,299 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (IEA)
B cell lineage commitment  (IEA,ISO)
brain development  (IEA,ISO)
cellular response to insulin stimulus  (IEA)
chromatin remodeling  (IEA)
DNA damage response  (IEA)
DNA repair  (IEA)
double-strand break repair  (IEA,ISO)
double-strand break repair via nonhomologous end joining  (IEA,ISO)
ectopic germ cell programmed cell death  (IEA,ISO)
heart development  (IEA,ISO)
immature B cell differentiation  (IEA,ISO)
immunoglobulin production  (ISO)
immunoglobulin V(D)J recombination  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
lymphocyte differentiation  (IEA,ISO)
maturation of 5.8S rRNA  (IEA)
mitotic G1 DNA damage checkpoint signaling  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of cellular senescence  (ISO)
negative regulation of cGAS/STING signaling pathway  (IEA)
negative regulation of immunoglobulin production  (ISO)
negative regulation of protein phosphorylation  (IEA)
negative regulation of response to gamma radiation  (ISO)
obsolete regulation of nitrogen compound metabolic process  (IEA)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of developmental growth  (ISO)
positive regulation of double-strand break repair via nonhomologous end joining  (IEA)
positive regulation of erythrocyte differentiation  (IEA)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of immune system process  (ISO)
positive regulation of lymphocyte differentiation  (IEA)
positive regulation of platelet formation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of translation  (IEA)
pro-B cell differentiation  (IEA,ISO)
protein destabilization  (IEA,ISO)
regulation of cellular response to stress  (IEA)
regulation of circadian rhythm  (IEA)
regulation of epithelial cell proliferation  (IEA)
regulation of hematopoietic stem cell differentiation  (IEA)
regulation of macromolecule metabolic process  (IEA)
regulation of primary metabolic process  (IEA)
regulation of smooth muscle cell proliferation  (IEA)
response to activity  (ISO)
response to gamma radiation  (IEA,ISO)
response to ionizing radiation  (IEA,ISO)
small-subunit processome assembly  (IEA)
somitogenesis  (IEA,ISO)
spleen development  (ISO)
T cell differentiation in thymus  (IEA,ISO)
T cell lineage commitment  (IEA,ISO)
T cell receptor V(D)J recombination  (IEA,ISO)
telomere capping  (IEA)
telomere maintenance  (IEA,ISO)
thymus development  (ISO)
V(D)J recombination  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PRKDC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2763,407,112 - 63,593,508 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1839,100,871 - 39,287,251 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0844,201,391 - 44,386,803 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1841,593,022 - 41,778,299 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl841,593,029 - 41,778,299 (-)Ensemblpanpan1.1panPan2
PRKDC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38847,773,111 - 47,960,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl847,773,111 - 47,960,178 (-)EnsemblGRCh38hg38GRCh38
GRCh37848,685,672 - 48,872,696 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36848,848,222 - 49,035,296 (-)NCBINCBI36Build 36hg18NCBI36
Build 34848,848,221 - 49,035,296NCBI
Celera844,671,051 - 44,858,151 (-)NCBICelera
Cytogenetic Map8q11.21NCBI
HuRef844,148,581 - 44,335,706 (-)NCBIHuRef
CHM1_1848,738,053 - 48,925,105 (-)NCBICHM1_1
T2T-CHM13v2.0848,149,356 - 48,336,384 (-)NCBIT2T-CHM13v2.0
Prkdc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391615,455,698 - 15,660,103 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1615,455,730 - 15,660,099 (+)EnsemblGRCm39 Ensembl
GRCm381615,637,444 - 15,842,239 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1615,637,866 - 15,842,235 (+)EnsemblGRCm38mm10GRCm38
MGSCv371615,637,959 - 15,842,332 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361615,551,467 - 15,755,813 (+)NCBIMGSCv36mm8
Celera1616,214,291 - 16,413,213 (+)NCBICelera
Cytogenetic Map16A2NCBI
cM Map1610.09NCBI
Prkdc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,544,952 - 98,762,499 (-)NCBIGRCr8
mRatBN7.21185,040,790 - 85,258,357 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1185,040,792 - 85,257,952 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,767,902 - 93,984,974 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,429,067 - 86,646,132 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,482,663 - 85,699,739 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,293,547 - 89,510,948 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,293,696 - 89,510,871 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01192,347,175 - 92,565,022 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,951,420 - 87,169,229 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,992,362 - 87,209,825 (-)NCBI
Celera1183,781,535 - 83,998,574 (-)NCBICelera
Cytogenetic Map11q23NCBI
Prkdc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554547,733,978 - 7,890,867 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554547,733,697 - 7,890,896 (-)NCBIChiLan1.0ChiLan1.0
PRKDC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12924,904 - 243,926 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2935,007 - 243,895 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha29449,958 - 669,362 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02920,665 - 241,975 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2922,025 - 241,944 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12920,944 - 240,298 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.029218,160 - 435,150 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.029285,564 - 503,393 (-)NCBIUU_Cfam_GSD_1.0
Prkdc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530379,533,069 - 79,697,823 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365904,722,873 - 4,890,156 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365904,722,914 - 4,887,615 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKDC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl479,687,375 - 79,846,656 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1479,687,375 - 79,850,146 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2487,185,946 - 87,343,690 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKDC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1843,915,226 - 44,119,547 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl843,914,636 - 44,119,541 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603997,968,963 - 98,158,648 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkdc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247357,534,506 - 7,700,305 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247357,534,483 - 7,702,079 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000036473   ⟹   ENSPPAP00000013799
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl841,593,029 - 41,778,299 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000036485   ⟹   ENSPPAP00000013811
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl841,594,088 - 41,778,248 (-)Ensembl
RefSeq Acc Id: XM_055116533   ⟹   XP_054972508
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2763,407,112 - 63,593,508 (-)NCBI
NHGRI_mPanPan1839,100,871 - 39,287,251 (-)NCBI
RefSeq Acc Id: XM_055116534   ⟹   XP_054972509
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2763,407,112 - 63,593,508 (-)NCBI
NHGRI_mPanPan1839,100,871 - 39,287,251 (-)NCBI
RefSeq Acc Id: XM_055116535   ⟹   XP_054972510
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2763,407,112 - 63,593,508 (-)NCBI
NHGRI_mPanPan1839,100,871 - 39,287,251 (-)NCBI
RefSeq Acc Id: XM_055116536   ⟹   XP_054972511
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2763,407,112 - 63,593,508 (-)NCBI
NHGRI_mPanPan1839,100,871 - 39,287,251 (-)NCBI
Protein Sequences
Protein RefSeqs XP_054972508 (Get FASTA)   NCBI Sequence Viewer  
  XP_054972509 (Get FASTA)   NCBI Sequence Viewer  
  XP_054972510 (Get FASTA)   NCBI Sequence Viewer  
  XP_054972511 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000013799.1
  ENSPPAP00000013811.1
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000013811   ⟸   ENSPPAT00000036485
RefSeq Acc Id: ENSPPAP00000013799   ⟸   ENSPPAT00000036473
RefSeq Acc Id: XP_054972511   ⟸   XM_055116536
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054972509   ⟸   XM_055116534
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054972510   ⟸   XM_055116535
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054972508   ⟸   XM_055116533
- Peptide Label: isoform X1
Protein Domains
FAT   FATC   PI3K/PI4K catalytic


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029994 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000036473.1 UniProtKB/TrEMBL
  ENSPPAT00000036485.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  DNA-PK_dom UniProtKB/TrEMBL
  DNA-PKcs_N UniProtKB/TrEMBL
  DNAPKcs_CC1-2 UniProtKB/TrEMBL
  DNAPKcs_CC5 UniProtKB/TrEMBL
  FATC_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  NUC194 UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PIK-rel_kinase_FAT UniProtKB/TrEMBL
  PIK_FAT UniProtKB/TrEMBL
NCBI Gene PRKDC ENTREZGENE
PANTHER ATAXIA TELANGIECTASIA MUTATED ATM -RELATED UniProtKB/TrEMBL
  DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT UniProtKB/TrEMBL
Pfam DNA-PKcs_N UniProtKB/TrEMBL
  DNAPKcs_CC1-2 UniProtKB/TrEMBL
  DNAPKcs_CC5 UniProtKB/TrEMBL
  FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  NUC194 UniProtKB/TrEMBL
  PI3_PI4_kinase UniProtKB/TrEMBL
PROSITE FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
SMART FATC UniProtKB/TrEMBL
  NUC194 UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9A952_PANPA UniProtKB/TrEMBL
  A0A2R9AA94_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-06-26 PRKDC  protein kinase, DNA-activated, catalytic subunit    protein kinase, DNA-activated, catalytic polypeptide  Symbol and/or name change 5135510 APPROVED