CALCA (calcitonin related polypeptide alpha) - Rat Genome Database

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Gene: CALCA (calcitonin related polypeptide alpha) Pan paniscus
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Symbol: CALCA
Name: calcitonin related polypeptide alpha
RGD ID: 12004212
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure (ortholog); ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); amyotrophic lateral sclerosis (ortholog); Animal Disease Models (ortholog); FOUND IN axon (ortholog); hippocampal mossy fiber to CA3 synapse (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calcitonin; calcitonin gene-related peptide 1
RGD Orthologs
Human
Mouse
Rat
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2917,335,385 - 17,340,053 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11117,296,273 - 17,300,935 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01115,055,897 - 15,061,539 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11114,745,588 - 14,751,267 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1114,745,588 - 14,751,267 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure  (IEA,ISO)
calcitonin gene-related peptide receptor signaling pathway  (ISO)
cell adhesion  (ISO)
cellular response to nerve growth factor stimulus  (IEA,ISO)
cellular response to tumor necrosis factor  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (IEA,ISO)
embryo implantation  (IEA)
endothelial cell migration  (ISO)
endothelial cell proliferation  (ISO)
feeding behavior  (IEA,ISO)
G protein-coupled receptor internalization  (ISO)
inflammatory response  (IEA,ISO)
innate immune response  (ISO)
intracellular calcium ion homeostasis  (IEA,ISO)
leukocyte cell-cell adhesion  (ISO)
monocyte chemotaxis  (IEA)
negative regulation of blood pressure  (IEA,ISO)
negative regulation of bone resorption  (IEA)
negative regulation of calcium ion transport into cytosol  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of nervous system process  (ISO)
negative regulation of ossification  (IEA,ISO)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of smooth muscle contraction  (IEA,ISO)
nervous system process involved in regulation of systemic arterial blood pressure  (ISO)
neuromuscular junction development  (ISO)
neuropeptide signaling pathway  (IEA,ISO)
ossification  (IEA,ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cytosolic calcium ion concentration  (IEA)
positive regulation of interleukin-1 alpha production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of ossification  (ISO)
receptor internalization  (ISO)
regulation of blood pressure  (ISO)
regulation of cytosolic calcium ion concentration  (IEA)
regulation of heart rate  (ISO)
response to heat  (IEA,ISO)
response to pain  (IEA,ISO)
signal transduction  (IEA)
smooth muscle contraction  (IEA,ISO)
vasculature development  (ISO)
vasodilation  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CALCA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2917,335,385 - 17,340,053 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11117,296,273 - 17,300,935 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01115,055,897 - 15,061,539 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11114,745,588 - 14,751,267 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1114,745,588 - 14,751,267 (-)Ensemblpanpan1.1panPan2
CALCA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381114,966,668 - 14,972,351 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1114,966,622 - 14,972,354 (-)EnsemblGRCh38hg38GRCh38
GRCh371114,988,214 - 14,993,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,944,792 - 14,950,408 (-)NCBINCBI36Build 36hg18NCBI36
Build 341114,946,625 - 14,950,427NCBI
Celera1115,115,335 - 15,120,952 (-)NCBICelera
Cytogenetic Map11p15.2NCBI
HuRef1114,671,857 - 14,677,473 (-)NCBIHuRef
CHM1_11114,987,226 - 14,992,843 (-)NCBICHM1_1
T2T-CHM13v2.01115,063,025 - 15,068,708 (-)NCBIT2T-CHM13v2.0
Calca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397114,225,223 - 114,236,145 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7114,230,713 - 114,235,592 (-)EnsemblGRCm39 Ensembl
GRCm387114,625,981 - 114,636,910 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7114,631,478 - 114,636,357 (-)EnsemblGRCm38mm10GRCm38
MGSCv377121,774,992 - 121,779,871 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367114,422,640 - 114,427,439 (-)NCBIMGSCv36mm8
Celera7114,584,937 - 114,589,792 (-)NCBICelera
Cytogenetic Map7F1NCBI
cM Map759.99NCBI
Calca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,312,636 - 178,317,588 (-)NCBIGRCr8
mRatBN7.21168,878,212 - 168,883,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,878,214 - 168,883,105 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,192,440 - 177,197,339 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,378,496 - 184,383,399 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,090,892 - 177,095,773 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,184,018 - 184,188,922 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,184,020 - 184,188,911 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,158,061 - 191,162,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41172,686,168 - 172,691,061 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11172,824,299 - 172,827,127 (-)NCBI
Celera1166,711,610 - 166,716,491 (-)NCBICelera
RH 3.4 Map11317.6RGD
RH 2.0 Map1757.3RGD
Cytogenetic Map1q34NCBI
CRSP-3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12137,676,841 - 37,680,643 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2137,676,841 - 37,680,645 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2137,176,307 - 37,180,108 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02138,770,713 - 38,774,520 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2138,770,713 - 38,774,522 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.02137,993,320 - 37,997,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02138,281,026 - 38,284,825 (+)NCBIUU_Cfam_GSD_1.0
Calca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494747,766,690 - 47,772,207 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365283,800,577 - 3,805,004 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365283,800,801 - 3,806,000 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALCB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1244,043,135 - 44,048,651 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2247,248,414 - 47,253,904 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103239768
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1149,946,574 - 49,956,010 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl149,951,694 - 49,954,092 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038147,447,203 - 147,453,110 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Calca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247666,766,185 - 6,768,173 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247666,764,388 - 6,771,396 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000057830   ⟹   ENSPPAP00000034945
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1114,745,588 - 14,751,267 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000057834   ⟹   ENSPPAP00000034949
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1114,747,414 - 14,751,267 (-)Ensembl
RefSeq Acc Id: XM_003818194   ⟹   XP_003818242
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2917,336,205 - 17,340,053 (-)NCBI
NHGRI_mPanPan11117,297,087 - 17,300,935 (-)NCBI
Mhudiblu_PPA_v01115,057,316 - 15,061,539 (-)NCBI
PanPan1.11114,747,414 - 14,751,267 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008971460   ⟹   XP_008969708
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2917,335,385 - 17,340,047 (-)NCBI
NHGRI_mPanPan11117,296,273 - 17,299,776 (-)NCBI
Mhudiblu_PPA_v01115,055,897 - 15,061,535 (-)NCBI
PanPan1.11114,745,588 - 14,751,267 (-)NCBI
Sequence:
RefSeq Acc Id: XM_057299101   ⟹   XP_057155084
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2917,336,205 - 17,340,053 (-)NCBI
NHGRI_mPanPan11117,297,087 - 17,300,935 (-)NCBI
RefSeq Acc Id: XM_057299102   ⟹   XP_057155085
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2917,336,205 - 17,340,053 (-)NCBI
NHGRI_mPanPan11117,297,087 - 17,300,935 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003818242 (Get FASTA)   NCBI Sequence Viewer  
  XP_008969708 (Get FASTA)   NCBI Sequence Viewer  
  XP_057155084 (Get FASTA)   NCBI Sequence Viewer  
  XP_057155085 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000034945.1
  ENSPPAP00000034949.1
RefSeq Acc Id: XP_008969708   ⟸   XM_008971460
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003818242   ⟸   XM_003818194
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSPPAP00000034949   ⟸   ENSPPAT00000057834
RefSeq Acc Id: ENSPPAP00000034945   ⟸   ENSPPAT00000057830
RefSeq Acc Id: XP_057155084   ⟸   XM_057299101
- Peptide Label: isoform X1
RefSeq Acc Id: XP_057155085   ⟸   XM_057299102
- Peptide Label: isoform X1
Protein Domains
Calcitonin peptide-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040307 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000057830.1 UniProtKB/TrEMBL
  ENSPPAT00000057834.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.2190 UniProtKB/TrEMBL
InterPro Calcitonin UniProtKB/TrEMBL
  Calcitonin-like UniProtKB/TrEMBL
  Calcitonin/adrenomedullin UniProtKB/TrEMBL
  Calcitonin_CS UniProtKB/TrEMBL
  Calcitonin_gene-rel_peptide UniProtKB/TrEMBL
  Calcitonin_peptide-like UniProtKB/TrEMBL
KEGG Report pps:100973996 UniProtKB/TrEMBL
NCBI Gene CALCA ENTREZGENE
PANTHER CALCITONIN UniProtKB/TrEMBL
  CALCITONIN GENE-RELATED PEPTIDE 2 UniProtKB/TrEMBL
  PTHR10505 UniProtKB/TrEMBL
Pfam Calc_CGRP_IAPP UniProtKB/TrEMBL
PRINTS CALCITONINA UniProtKB/TrEMBL
  CALCITONINB UniProtKB/TrEMBL
PROSITE CALCITONIN UniProtKB/TrEMBL
SMART CALCITONIN UniProtKB/TrEMBL
UniProt A0A2R9C2C6_PANPA UniProtKB/TrEMBL
  A0A2R9C976_PANPA UniProtKB/TrEMBL