SIRT3 (sirtuin 3) - Rat Genome Database

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Pathways
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Gene: SIRT3 (sirtuin 3) Pan paniscus
Analyze
Symbol: SIRT3
Name: sirtuin 3
RGD ID: 11981751
Description: ENCODES a protein that exhibits enzyme binding (ortholog); NAD-dependent protein lysine deacetylase activity (ortholog); INVOLVED IN negative regulation of ERK1 and ERK2 cascade (ortholog); negative regulation of peptidyl-lysine acetylation (ortholog); negative regulation of reactive oxygen species metabolic process (ortholog); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); Alzheimer's disease (ortholog); congestive heart failure (ortholog); FOUND IN membrane (ortholog); mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NAD-dependent protein deacetylase sirtuin-3, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v292,582,959 - 2,605,626 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1111,737,925 - 1,761,366 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011210,052 - 233,969 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111255,191 - 863,031 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11255,191 - 278,732 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SIRT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v292,582,959 - 2,605,626 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1111,737,925 - 1,761,366 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011210,052 - 233,969 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111255,191 - 863,031 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11255,191 - 278,732 (-)Ensemblpanpan1.1panPan2
SIRT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811215,030 - 236,931 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11215,030 - 236,931 (-)EnsemblGRCh38hg38GRCh38
GRCh3711215,030 - 236,931 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611205,030 - 226,362 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411206,138 - 226,416NCBI
Celera11322,773 - 343,832 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef1135,047 - 56,030 (-)NCBIHuRef
CHM1_111213,704 - 234,799 (-)NCBICHM1_1
T2T-CHM13v2.011256,228 - 277,937 (-)NCBIT2T-CHM13v2.0
Sirt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,443,576 - 140,462,222 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,443,579 - 140,462,222 (-)EnsemblGRCm39 Ensembl
GRCm387140,863,663 - 140,882,309 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,863,666 - 140,882,309 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,049,562 - 148,068,208 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367140,714,990 - 140,733,629 (-)NCBIMGSCv36mm8
Celera7140,655,950 - 140,674,596 (-)NCBICelera
Cytogenetic Map7F4- F5NCBI
cM Map786.07NCBI
Sirt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,371,703 - 205,394,145 (-)NCBIGRCr8
mRatBN7.21195,942,066 - 195,964,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1195,942,073 - 195,964,808 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,294,536 - 204,318,293 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,421,447 - 211,445,196 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,095,300 - 204,119,047 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,613,502 - 213,636,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,613,513 - 213,635,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,539,132 - 220,561,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,021,391 - 201,043,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,172,601 - 201,193,816 (-)NCBI
Celera1193,586,014 - 193,607,810 (-)NCBICelera
Cytogenetic Map1q41NCBI
Sirt3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,794,951 - 11,826,237 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,794,951 - 11,826,244 (+)NCBIChiLan1.0ChiLan1.0
SIRT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,369,183 - 25,388,126 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1825,369,382 - 25,388,118 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,019,130 - 25,038,115 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01825,895,720 - 25,914,839 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1825,895,722 - 25,914,795 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11825,463,734 - 25,482,834 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,108,512 - 25,127,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01825,721,366 - 25,740,351 (-)NCBIUU_Cfam_GSD_1.0
Sirt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494763,131 - 78,513 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493688863,546 - 77,950 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493688863,131 - 78,536 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl238,464 - 55,101 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1238,465 - 55,074 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22162,169,820 - 162,186,214 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1125,740 - 49,471 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl126,927 - 48,944 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603897,040,657 - 97,063,458 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476622,199,601 - 22,233,933 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476622,199,741 - 22,233,933 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000044868   ⟹   ENSPPAP00000022062
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11255,191 - 278,732 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000044875   ⟹   ENSPPAP00000022068
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11255,191 - 277,677 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000044884   ⟹   ENSPPAP00000022077
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11256,845 - 277,677 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000044887   ⟹   ENSPPAP00000022080
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11256,845 - 277,677 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000044894   ⟹   ENSPPAP00000022087
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11258,904 - 274,705 (-)Ensembl
RefSeq Acc Id: XM_014346649   ⟹   XP_014202135
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v292,582,959 - 2,605,605 (-)NCBI
NHGRI_mPanPan1111,737,925 - 1,761,359 (-)NCBI
Mhudiblu_PPA_v011210,052 - 233,484 (-)NCBI
PanPan1.111255,192 - 277,672 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034931780   ⟹   XP_034787671
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v292,582,959 - 2,605,605 (-)NCBI
NHGRI_mPanPan1111,737,925 - 1,761,359 (-)NCBI
Mhudiblu_PPA_v011210,052 - 233,485 (-)NCBI
RefSeq Acc Id: XM_034931781   ⟹   XP_034787672
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v292,582,959 - 2,605,615 (-)NCBI
NHGRI_mPanPan1111,737,925 - 1,761,359 (-)NCBI
Mhudiblu_PPA_v011210,052 - 233,484 (-)NCBI
RefSeq Acc Id: XM_034931782   ⟹   XP_034787673
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v292,582,959 - 2,605,626 (-)NCBI
NHGRI_mPanPan1111,737,925 - 1,761,366 (-)NCBI
Mhudiblu_PPA_v011210,052 - 233,483 (-)NCBI
RefSeq Acc Id: XM_063607983   ⟹   XP_063464053
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v292,582,959 - 2,602,241 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_014202135   ⟸   XM_014346649
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AY82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034787671   ⟸   XM_034931780
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034787672   ⟸   XM_034931781
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AY82 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034787673   ⟸   XM_034931782
- Peptide Label: isoform X4
- UniProtKB: A0A2R9AY82 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000022080   ⟸   ENSPPAT00000044887
RefSeq Acc Id: ENSPPAP00000022077   ⟸   ENSPPAT00000044884
RefSeq Acc Id: ENSPPAP00000022087   ⟸   ENSPPAT00000044894
RefSeq Acc Id: ENSPPAP00000022062   ⟸   ENSPPAT00000044868
RefSeq Acc Id: ENSPPAP00000022068   ⟸   ENSPPAT00000044875
RefSeq Acc Id: XP_063464053   ⟸   XM_063607983
- Peptide Label: isoform X5
Protein Domains
Deacetylase sirtuin-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034226 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000044868.1 UniProtKB/TrEMBL
  ENSPPAT00000044875.1 UniProtKB/TrEMBL
  ENSPPAT00000044884.1 UniProtKB/TrEMBL
  ENSPPAT00000044887.1 UniProtKB/TrEMBL
  ENSPPAT00000044894.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1600.10 UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/TrEMBL
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  Sirtuin UniProtKB/TrEMBL
  Sirtuin_cat_small_dom_sf UniProtKB/TrEMBL
  Sirtuin_class_I UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/TrEMBL
NCBI Gene SIRT3 ENTREZGENE
PANTHER NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/TrEMBL
PIRSF SIR2_euk UniProtKB/TrEMBL
PROSITE SIRTUIN UniProtKB/TrEMBL
Superfamily-SCOP SSF52467 UniProtKB/TrEMBL
UniProt A0A2R9AXX0_PANPA UniProtKB/TrEMBL
  A0A2R9AY76_PANPA UniProtKB/TrEMBL
  A0A2R9AY82 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B1Q6_PANPA UniProtKB/TrEMBL
  A0A2R9B1R6_PANPA UniProtKB/TrEMBL