SYNGAP1 (synaptic Ras GTPase activating protein 1) - Rat Genome Database

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Gene: SYNGAP1 (synaptic Ras GTPase activating protein 1) Pan paniscus
Analyze
Symbol: SYNGAP1
Name: synaptic Ras GTPase activating protein 1
RGD ID: 11976358
Description: ENCODES a protein that exhibits GTPase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN axonogenesis (ortholog); dendrite development (ortholog); negative regulation of axonogenesis (ortholog); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); autosomal dominant intellectual developmental disorder 5 (ortholog); autosomal dominant nocturnal frontal lobe epilepsy (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density, intracellular component (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ras/Rap GTPase-activating protein SynGAP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,905,069 - 47,938,759 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,772,255 - 43,805,902 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,999,408 - 33,033,067 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,111,285 - 34,144,490 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,110,652 - 34,144,490 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
SYNGAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,905,069 - 47,938,759 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,772,255 - 43,805,902 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,999,408 - 33,033,067 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,111,285 - 34,144,490 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,110,652 - 34,144,490 (+)Ensemblpanpan1.1panPan2
SYNGAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,418,167 - 33,453,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,419,661 - 33,453,689 (+)EnsemblGRCh38hg38GRCh38
GRCh37633,387,842 - 33,421,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,495,825 - 33,529,444 (+)NCBINCBI36Build 36hg18NCBI36
Celera634,942,270 - 34,975,892 (+)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef633,129,996 - 33,162,361 (+)NCBIHuRef
CHM1_1633,389,741 - 33,423,358 (+)NCBICHM1_1
T2T-CHM13v2.0633,239,529 - 33,275,052 (+)NCBIT2T-CHM13v2.0
Syngap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,160,186 - 27,191,408 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,160,227 - 27,191,408 (+)EnsemblGRCm39 Ensembl
GRCm381726,941,212 - 26,972,434 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,941,253 - 26,972,434 (+)EnsemblGRCm38mm10GRCm38
MGSCv371727,078,397 - 27,107,590 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361726,669,086 - 26,698,234 (+)NCBIMGSCv36mm8
Celera1727,478,075 - 27,507,298 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.6NCBI
Syngap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,028,226 - 5,058,519 (+)NCBIGRCr8
mRatBN7.2205,026,366 - 5,056,659 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,026,364 - 5,056,672 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,751,876 - 5,782,170 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,113,613 - 5,143,907 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,591,920 - 5,622,090 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,535,434 - 5,564,657 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,535,432 - 5,564,437 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,594,614 - 7,623,865 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,178,523 - 5,208,449 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,191,049 - 5,207,973 (+)NCBI
Celera206,608,780 - 6,637,810 (+)NCBICelera
Cytogenetic Map20p12NCBI
Syngap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,950,602 - 1,979,251 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,950,559 - 1,981,004 (+)NCBIChiLan1.0ChiLan1.0
SYNGAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,829,274 - 2,862,888 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,829,306 - 2,851,432 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,910,079 - 2,943,658 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,162,881 - 3,194,514 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,162,894 - 3,194,511 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,828,036 - 2,861,597 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,909,144 - 2,942,686 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,007,257 - 3,040,837 (+)NCBIUU_Cfam_GSD_1.0
Syngap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,485,483 - 38,513,743 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,445,775 - 25,474,899 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,446,524 - 25,474,793 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYNGAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl729,723,588 - 29,753,933 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1729,723,745 - 29,752,351 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,341,195 - 34,373,397 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SYNGAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,612,777 - 38,646,382 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,617,679 - 38,646,192 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604433,268,732 - 33,302,381 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Syngap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,366,912 - 23,396,575 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,367,585 - 23,396,643 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008960633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008960637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055113472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055113473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055113474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055113475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_057302483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063604821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063604822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063604823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063604824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063604825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063604826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004671946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000049526   ⟹   ENSPPAP00000026691
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl634,110,652 - 34,142,713 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000049528   ⟹   ENSPPAP00000026693
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl634,110,652 - 34,131,511 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000049545   ⟹   ENSPPAP00000026710
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl634,112,595 - 34,144,490 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000049552   ⟹   ENSPPAP00000026716
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl634,113,808 - 34,139,608 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000049553   ⟹   ENSPPAP00000026717
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl634,122,882 - 34,142,713 (+)Ensembl
RefSeq Acc Id: XM_034961848   ⟹   XP_034817739
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,905,069 - 47,938,759 (+)NCBI
NHGRI_mPanPan1643,772,255 - 43,805,902 (+)NCBI
Mhudiblu_PPA_v0632,999,408 - 33,033,067 (+)NCBI
RefSeq Acc Id: XM_055113472   ⟹   XP_054969447
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,905,073 - 47,938,759 (+)NCBI
NHGRI_mPanPan1643,772,262 - 43,805,902 (+)NCBI
RefSeq Acc Id: XM_055113473   ⟹   XP_054969448
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,915,470 - 47,938,759 (+)NCBI
NHGRI_mPanPan1643,782,627 - 43,805,902 (+)NCBI
RefSeq Acc Id: XM_055113474   ⟹   XP_054969449
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,910,581 - 47,938,759 (+)NCBI
NHGRI_mPanPan1643,777,750 - 43,805,902 (+)NCBI
RefSeq Acc Id: XM_055113475   ⟹   XP_054969450
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,913,042 - 47,938,759 (+)NCBI
NHGRI_mPanPan1643,780,214 - 43,805,902 (+)NCBI
RefSeq Acc Id: XM_057302483   ⟹   XP_057158466
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,905,074 - 47,936,968 (+)NCBI
NHGRI_mPanPan1643,772,264 - 43,804,110 (+)NCBI
RefSeq Acc Id: XM_063604821   ⟹   XP_063460891
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,905,075 - 47,938,759 (+)NCBI
RefSeq Acc Id: XM_063604822   ⟹   XP_063460892
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,905,076 - 47,938,759 (+)NCBI
RefSeq Acc Id: XM_063604823   ⟹   XP_063460893
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,905,074 - 47,938,759 (+)NCBI
RefSeq Acc Id: XM_063604824   ⟹   XP_063460894
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,905,073 - 47,938,759 (+)NCBI
RefSeq Acc Id: XM_063604825   ⟹   XP_063460895
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,905,074 - 47,933,942 (+)NCBI
RefSeq Acc Id: XM_063604826   ⟹   XP_063460896
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,905,073 - 47,936,968 (+)NCBI
RefSeq Acc Id: XR_004671946
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,905,075 - 47,936,966 (+)NCBI
NHGRI_mPanPan1643,772,265 - 43,804,108 (+)NCBI
Mhudiblu_PPA_v0632,999,457 - 33,031,270 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034817739   ⟸   XM_034961848
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BIN6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000026710   ⟸   ENSPPAT00000049545
RefSeq Acc Id: ENSPPAP00000026716   ⟸   ENSPPAT00000049552
RefSeq Acc Id: ENSPPAP00000026717   ⟸   ENSPPAT00000049553
RefSeq Acc Id: ENSPPAP00000026693   ⟸   ENSPPAT00000049528
RefSeq Acc Id: ENSPPAP00000026691   ⟸   ENSPPAT00000049526
RefSeq Acc Id: XP_054969447   ⟸   XM_055113472
- Peptide Label: isoform X4
- UniProtKB: A0A2R9BEG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054969449   ⟸   XM_055113474
- Peptide Label: isoform X10
- UniProtKB: A0A2R9BC69 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054969450   ⟸   XM_055113475
- Peptide Label: isoform X10
- UniProtKB: A0A2R9BC69 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054969448   ⟸   XM_055113473
- Peptide Label: isoform X7
- UniProtKB: A0A2R9BC69 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_057158466   ⟸   XM_057302483
- Peptide Label: isoform X8
- UniProtKB: A0A2R9BEI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063460894   ⟸   XM_063604824
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063460896   ⟸   XM_063604826
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063460893   ⟸   XM_063604823
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063460895   ⟸   XM_063604825
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063460891   ⟸   XM_063604821
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063460892   ⟸   XM_063604822
- Peptide Label: isoform X3
Protein Domains
C2   PH   Ras-GAP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036420 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000049526.1 UniProtKB/TrEMBL
  ENSPPAT00000049528.1 UniProtKB/TrEMBL
  ENSPPAT00000049545.1 UniProtKB/TrEMBL
  ENSPPAT00000049552.1 UniProtKB/TrEMBL
  ENSPPAT00000049553.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DUF3498 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Ras_GTPase UniProtKB/TrEMBL
  RasGAP_CS UniProtKB/TrEMBL
  RasGAP_dom UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  SynGAP_PH UniProtKB/TrEMBL
NCBI Gene SYNGAP1 ENTREZGENE
PANTHER PTHR10194 UniProtKB/TrEMBL
  RAS/RAP GTPASE-ACTIVATING PROTEIN SYNGAP UniProtKB/TrEMBL
Pfam DUF3498 UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  RasGAP UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_1 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_2 UniProtKB/TrEMBL
SMART RasGAP UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48350 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
UniProt A0A2R9BAR7_PANPA UniProtKB/TrEMBL
  A0A2R9BC69 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BEG5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BEI7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BIN6 ENTREZGENE, UniProtKB/TrEMBL