LOC100972994 (HLA class II histocompatibility antigen, DQ beta 1 chain) - Rat Genome Database

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Gene: LOC100972994 (HLA class II histocompatibility antigen, DQ beta 1 chain) Pan paniscus
Analyze
Symbol: LOC100972994 (Ensembl: HLA-DQB1)
Name: HLA class II histocompatibility antigen, DQ beta 1 chain (Ensembl:major histocompatibility complex, class II, DQ beta 1)
RGD ID: 11958717
Description: ENCODES a protein that exhibits peptide antigen binding (ortholog); protein antigen binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN antigen processing and presentation (ortholog); antigen processing and presentation of exogenous peptide antigen via MHC class II (ortholog); antigen processing and presentation of peptide antigen (ortholog); ASSOCIATED WITH achalasia (ortholog); acute disseminated encephalomyelitis (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); external side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: HLA class II histocompatibility antigen, DQ beta 1 chain-like; LOC100993847
RGD Orthologs
Human
Mouse
Dog
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,142,796 - 47,149,644 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,014,552 - 43,021,397 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,237,395 - 32,244,201 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1633,353,599 - 33,360,284 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,353,599 - 33,360,272 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
achalasia  (ISO)
acute disseminated encephalomyelitis  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
Addison's disease  (ISO)
agranulocytosis  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic disease  (ISO)
alopecia areata  (ISO)
alveolar echinococcosis  (ISO)
Amebic Liver Abscess  (ISO)
angioedema  (ISO)
ankylosing spondylitis  (ISO)
antiphospholipid syndrome  (ISO)
aplastic anemia  (ISO)
arthritis  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (ISO)
atrophic gastritis  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune pancreatitis  (ISO)
autoimmune polyendocrine syndrome  (ISO)
autoimmune polyendocrine syndrome type 2  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
autoimmune thyroiditis  (ISO)
bacterial infectious disease  (ISO)
Behcet's disease  (ISO)
beta thalassemia  (ISO)
Cataplexy  (ISO)
celiac disease  (ISO)
cervical cancer  (ISO)
cervical dystonia  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chikungunya  (ISO)
choreatic disease  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
cicatricial pemphigoid  (ISO)
colorectal cancer  (ISO)
common variable immunodeficiency  (ISO)
common wart  (ISO)
COVID-19  (ISO)
Creutzfeldt-Jakob disease  (ISO)
Crohn's disease  (ISO)
cystic echinococcosis  (ISO)
degenerative myopia  (ISO)
Delayed Hypersensitivity  (ISO)
dental caries  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1H  (ISO)
Drug Eruptions  (ISO)
Drug-induced Neutropenia  (ISO)
End Stage Liver Disease  (ISO)
erythema multiforme  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
glaucoma  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
Helicobacter Infections  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
hyperthyroidism  (ISO)
hypothyroidism  (ISO)
Idiopathic Hypersomnolence  (ISO)
IgA glomerulonephritis  (ISO)
immunoglobulin alpha deficiency  (ISO)
iridocyclitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
latex allergy  (ISO)
liver cirrhosis  (ISO)
marginal zone lymphoma  (ISO)
multidrug-resistant tuberculosis  (ISO)
multiple sclerosis  (ISO)
myasthenia gravis  (ISO)
mycosis fungoides  (ISO)
myocarditis  (ISO)
myositis  (ISO)
narcolepsy  (ISO)
Nasal Polyps  (ISO)
neuromyelitis optica  (ISO)
optic neuritis  (ISO)
Oropharyngeal Neoplasms  (ISO)
osteomyelitis  (ISO)
paroxysmal nocturnal hemoglobinuria  (ISO)
pemphigus  (ISO)
pemphigus vulgaris  (ISO)
Plasmodium falciparum malaria  (ISO)
pneumoconiosis  (ISO)
pneumocystosis  (ISO)
pre-eclampsia  (ISO)
primary progressive multiple sclerosis  (ISO)
primary sclerosing cholangitis  (ISO)
proteasome-associated autoinflammatory syndrome 1  (ISO)
psoriasis  (ISO)
pulmonary tuberculosis  (ISO)
pure red-cell aplasia  (ISO)
Recurrent Respiratory Papillomatosis  (ISO)
rheumatic fever  (ISO)
rheumatic heart disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
rhinoscleroma  (ISO)
Rhinosinusitis, Allergic Fungal  (ISO)
sarcoidosis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Sleep Initiation and Maintenance Disorders  (ISO)
Small Fiber Neuropathy  (ISO)
Stevens-Johnson syndrome  (ISO)
stomach disease  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombotic thrombocytopenic purpura  (ISO)
Transplant Rejection  (ISO)
tropical spastic paraparesis  (ISO)
tuberculosis  (ISO)
Tubulointerstitial Nephritis and Uveitis  (ISO)
type 1 diabetes mellitus  (ISO)
typhoid fever  (ISO)
ulcerative colitis  (ISO)
urticaria  (ISO)
Uterine Cervical Dysplasia  (ISO)
uveitis  (ISO)
Veno-Occlusive Disease  (ISO)
vitiligo  (ISO)
Vogt-Koyanagi-Harada disease  (ISO)
vulva cancer  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
LOC100972994
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,142,796 - 47,149,644 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,014,552 - 43,021,397 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,237,395 - 32,244,201 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1633,353,599 - 33,360,284 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,353,599 - 33,360,272 (-)Ensemblpanpan1.1panPan2
HLA-DQB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,659,467 - 32,666,657 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,659,467 - 32,668,383 (-)EnsemblGRCh38hg38GRCh38
GRCh37632,627,244 - 32,634,434 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,735,635 - 32,742,444 (-)NCBINCBI36Build 36hg18NCBI36
Celera634,177,338 - 34,182,264 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,368,943 - 32,376,157 (-)NCBIHuRef
CHM1_1632,629,719 - 32,636,944 (-)NCBICHM1_1
T2T-CHM13v2.0632,482,491 - 32,489,842 (-)NCBIT2T-CHM13v2.0
H2-Ab1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,482,201 - 34,488,392 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,476,663 - 34,488,393 (+)EnsemblGRCm39 Ensembl
GRCm381734,263,227 - 34,269,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,257,689 - 34,269,419 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,400,172 - 34,406,363 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,871,432 - 33,877,605 (+)NCBIMGSCv36mm8
Celera1737,017,337 - 37,030,239 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
DLA-DQB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,305,307 - 2,307,711 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0122,520,814 - 2,526,447 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1122,243,878 - 2,249,524 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,325,185 - 2,330,844 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,399,342 - 2,404,990 (-)NCBIUU_Cfam_GSD_1.0
LOC101703821
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,895,607 - 23,906,713 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,895,509 - 23,902,487 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000059963   ⟹   ENSPPAP00000037067
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl633,353,599 - 33,360,272 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000059971   ⟹   ENSPPAP00000037075
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl633,354,369 - 33,360,202 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000059975   ⟹   ENSPPAP00000037079
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl633,356,014 - 33,360,202 (-)Ensembl
RefSeq Acc Id: XM_003808611   ⟹   XP_003808659
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,142,796 - 47,149,644 (-)NCBI
NHGRI_mPanPan1643,014,552 - 43,021,397 (-)NCBI
Mhudiblu_PPA_v0632,237,395 - 32,244,192 (-)NCBI
PanPan1.1633,353,599 - 33,360,284 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063605266   ⟹   XP_063461336
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,142,796 - 47,149,615 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003808659   ⟸   XM_003808611
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSPPAP00000037075   ⟸   ENSPPAT00000059971
RefSeq Acc Id: ENSPPAP00000037079   ⟸   ENSPPAT00000059975
RefSeq Acc Id: ENSPPAP00000037067   ⟸   ENSPPAT00000059963
RefSeq Acc Id: XP_063461336   ⟸   XM_063605266
- Peptide Label: isoform X1
Protein Domains
Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038080 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAG00000041275 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000053548.1 UniProtKB/TrEMBL
  ENSPPAT00000054151.1 UniProtKB/TrEMBL
  ENSPPAT00000054212.1 UniProtKB/TrEMBL
  ENSPPAT00000054215.1 UniProtKB/TrEMBL
  ENSPPAT00000054275.1 UniProtKB/TrEMBL
  ENSPPAT00000054318.1 UniProtKB/TrEMBL
  ENSPPAT00000054347.1 UniProtKB/TrEMBL
  ENSPPAT00000059963.1 UniProtKB/TrEMBL
  ENSPPAT00000059971.1 UniProtKB/TrEMBL
  ENSPPAT00000059975.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/TrEMBL
  MHC_II_a/b_N UniProtKB/TrEMBL
  MHC_II_b_N UniProtKB/TrEMBL
KEGG Report pps:100972994 UniProtKB/TrEMBL
NCBI Gene LOC100972994 ENTREZGENE
PANTHER HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ BETA 1 CHAIN UniProtKB/TrEMBL
  MHC CLASS II-RELATED UniProtKB/TrEMBL
Pfam C1-set UniProtKB/TrEMBL
  MHC_II_beta UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
SMART IGc1 UniProtKB/TrEMBL
  MHC_II_beta UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF54452 UniProtKB/TrEMBL
UniProt A0A2R9BM12_PANPA UniProtKB/TrEMBL
  A0A2R9BNV8_PANPA UniProtKB/TrEMBL
  A0A2R9BP03_PANPA UniProtKB/TrEMBL
  A0A2R9BPW1_PANPA UniProtKB/TrEMBL
  A0A2R9BSD8_PANPA UniProtKB/TrEMBL
  A0A2R9BSR7_PANPA UniProtKB/TrEMBL
  A0A2R9BXP9_PANPA UniProtKB/TrEMBL
  A0A2R9C577_PANPA UniProtKB/TrEMBL
  A0A2R9C5H7_PANPA UniProtKB/TrEMBL
  A0A2R9CFN7_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-11 LOC100972994  HLA class II histocompatibility antigen, DQ beta 1 chain  LOC100993847  HLA class II histocompatibility antigen, DQ beta 1 chain  Data merged from RGD:11825615 737654 PROVISIONAL
2018-05-08 LOC100993847  HLA class II histocompatibility antigen, DQ beta 1 chain    HLA class II histocompatibility antigen, DQ beta 1 chain-like  Symbol and/or name change 5135510 APPROVED