LCAT (lecithin-cholesterol acyltransferase)

Gene: LCAT (lecithin-cholesterol acyltransferase) Pan paniscus

Analyze

Symbol:

LCAT

Name:

lecithin-cholesterol acyltransferase

RGD ID:

11956345

Description:

ENCODES a protein that exhibits phosphatidylcholine-sterol O-acyltransferase activity (ortholog); phospholipase A2 activity (ortholog); INVOLVED IN aflatoxin metabolic process (ortholog); cholesterol metabolic process (ortholog); cholesterol transport (ortholog); PARTICIPATES IN reverse cholesterol transport pathway; ASSOCIATED WITH arteriosclerosis (ortholog); autosomal dominant dyskeratosis congenita 6 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); high-density lipoprotein particle (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

phosphatidylcholine-sterol acyltransferase

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	77,466,086 - 77,470,404 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	83,374,671 - 83,381,831 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	48,278,137 - 48,285,305 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	67,668,646 - 67,673,127 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	67,668,646 - 67,673,127 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

arteriosclerosis (ISO)

autosomal dominant dyskeratosis congenita 6 (ISO)

Chemical and Drug Induced Liver Injury (ISO)

end stage renal disease (ISO)

familial hyperlipidemia (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

Hypertriglyceridemia (ISO)

myocardial infarction (ISO)

Norum disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aflatoxin metabolic process (ISO)

cholesterol homeostasis (IEA)

cholesterol metabolic process (IEA,ISO)

cholesterol transport (IEA,ISO)

high-density lipoprotein particle remodeling (IEA)

lipid metabolic process (IEA)

lipoprotein biosynthetic process (IEA,ISO)

lipoprotein metabolic process (ISO)

phosphatidylcholine biosynthetic process (IEA)

phosphatidylcholine metabolic process (IEA)

phospholipid metabolic process (IEA)

regulation of high-density lipoprotein particle assembly (IEA)

response to copper ion (ISO)

response to glucocorticoid (ISO)

reverse cholesterol transport (IEA)

very-low-density lipoprotein particle remodeling (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IEA)

high-density lipoprotein particle (IEA)

membrane (IEA)

Molecular Function

1-alkyl-2-acetylglycerophosphocholine esterase activity (IEA)

apolipoprotein A-I binding (IEA)

O-acyltransferase activity (IEA)

phosphatidylcholine-sterol O-acyltransferase activity (IEA,ISO)

phospholipase A2 activity (ISO)

platelet-activating factor acetyltransferase activity (IEA)

protein binding (ISO)

sterol esterase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

reverse cholesterol transport pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

LCAT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	77,466,086 - 77,470,404 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	83,374,671 - 83,381,831 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	48,278,137 - 48,285,305 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	67,668,646 - 67,673,127 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	67,668,646 - 67,673,127 (-)	Ensembl	panpan1.1		panPan2

LCAT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	67,939,750 - 67,944,120 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	67,939,750 - 67,944,131 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	67,973,653 - 67,978,023 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	66,531,288 - 66,535,516 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	66,531,287 - 66,535,516	NCBI
Celera	16	52,482,244 - 52,486,472 (-)	NCBI		Celera
Cytogenetic Map	16	q22.1	NCBI
HuRef	16	53,847,357 - 53,851,585 (-)	NCBI		HuRef
CHM1_1	16	69,381,858 - 69,386,086 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	73,735,523 - 73,739,893 (-)	NCBI		T2T-CHM13v2.0

Lcat
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	106,666,183 - 106,670,034 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	106,666,183 - 106,670,014 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	105,939,551 - 105,943,402 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	105,939,551 - 105,943,382 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	108,463,451 - 108,467,302 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	108,828,681 - 108,832,511 (-)	NCBI		MGSCv36	mm8
Celera	8	110,167,599 - 110,171,451 (-)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	53.06	NCBI

Lcat
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	50,744,598 - 50,748,064 (-)	NCBI		GRCr8
mRatBN7.2	19	33,834,748 - 33,838,214 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	33,834,403 - 33,838,231 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	40,650,291 - 40,653,750 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	41,303,606 - 41,307,065 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	43,602,142 - 43,605,607 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	37,913,333 - 37,916,799 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	37,913,336 - 37,916,813 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	48,780,364 - 48,783,830 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	35,781,507 - 35,784,966 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	35,786,383 - 35,789,855 (-)	NCBI
Celera	19	33,262,304 - 33,265,763 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

Lcat
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	8,772,692 - 8,776,122 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955484	8,772,692 - 8,776,122 (+)	NCBI	ChiLan1.0	ChiLan1.0

LCAT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	81,556,047 - 81,559,313 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	81,545,969 - 81,549,297 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	81,991,308 - 81,994,637 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	81,968,753 - 81,994,636 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	81,817,519 - 81,820,847 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	81,499,651 - 81,502,979 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	82,141,864 - 82,145,195 (+)	NCBI		UU_Cfam_GSD_1.0

Lcat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	41,291,681 - 41,295,101 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	18,293,716 - 18,298,248 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	18,294,013 - 18,297,433 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LCAT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	28,550,358 - 28,553,566 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	28,550,356 - 28,553,561 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LCAT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	59,495,936 - 59,500,530 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	59,497,115 - 59,500,448 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	22,222,310 - 22,225,874 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lcat
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	18,437,429 - 18,441,806 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	18,438,308 - 18,441,650 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008964568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034940481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000047800 ⟹ ENSPPAP00000024974

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	16	67,668,646 - 67,673,127 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000047805 ⟹ ENSPPAP00000024979

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	16	67,668,668 - 67,672,860 (-)	Ensembl

RefSeq Acc Id:

XM_008964568 ⟹ XP_008962816

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	77,466,086 - 77,470,404 (-)	NCBI
NHGRI_mPanPan1	16	83,374,671 - 83,381,831 (-)	NCBI
Mhudiblu_PPA_v0	16	48,280,798 - 48,285,305 (-)	NCBI
PanPan1.1	16	67,668,646 - 67,673,127 (-)	NCBI

Sequence:

show sequence

TGAGGCCTGACTTTTTCAATAAAACATTGTGTACTTCTGGACCTCCTGCTGCCCCGGCTCTGTT
TCCCCTGGCGCCAAGAGAAGAAGGCGGAACTGAACCCAGGCCCAGAGCCGGCTCCCTGAGGCTG
TGCCCCTTTCCGGCAATCTCTGGCCACAACCCCCACTGGCCAGGCCGTCCCTCCCACTGGCCCT
AGGGCCCCTCCCACTCCCACACCAGATAAGGACAGCCCAGTGCCGCTTTCTCTGGCAGTAGGCA
CCAGGGCTGGAATGGGGCCGCCCGGCTCCCCATGGCAGTGGGTAACGCTGCTGCTGGGGCTGCT
GCTCCCTCCTGCCGCCCCCTTCTGGCTCCTCAATGTGCTCTTCCCCCCGCACACCACGCCCAAG
GCTGAACTCAGTAACCACACACGGCCCGTCATCCTCGTGCCCGGCTGCCTGGGGAATCAGCTAG
AAGCCAAGCTGGACAAACCAGATGTGGTGAACTGGATGTGCTACCGCAAGACAGAGGACTTCTT
CACCATCTGGCTGGATCTCAACATGTTCCTACCCCTTGGGGTAGACTGCTGGATCGATAACACC
AGGGTTGTCTACAACCGGAGCTCTGGGCTCGTGTCCAACGCCCCTGGTGTCCAGATCCGCGTCC
CTGGCTTTGGCAAGACCTACTCTGTGGAGTACCTGGACAGCAGCAAGCTGGCAGGGTACCTGCA
CACACTGGTGCAGAACCTGGTCAACAACGGCTACGTGCGGGACGAGACTGTGCGCGCCGCCCCC
TATGACTGGCGGCTGGAGCCCGGCCAGCAGGAGGAGTACTACCGCAAGCTCGCAGGGCTGGTGG
AGGAGATGCACGCTGCCTATGGGAAGCCTGTCTTCCTCATTGGCCACAGCCTCGGCTGTCTACA
CTTGCTCTATTTCCTGCTGCGCCAGCCCCAGGCCTGGAAGGACCGCTTTATTGATGGCTTCATC
TCTCTTGGGGCTCCCTGGGGTGGCTCCATCAAGCCCATGCTGGTCTTGGCCTCAGGTGACAACC
AGGGCATCCCCATCATGTCCAGCATCAAGCTGAAAGAGGAGCAGCGCATAACCACCACCTCCCC
CTGGATGTTTCCCTCTCGCATGGCGTGGCCTGAGGACCACGTGTTCATTTCCACACCCAGCTTC
AACTACACAGGCCGTGACTTCCAACGCTTCTTTGCAGACCTGCACTTTGAGGAAGGCTGGTACA
TGTGGCTGCAGTCACGTGACCTCCTGGCAGGACTCCCAGCACCTGGTGTGGAAGTATACTGTCT
TTACGGCGTGGGCCTGCCCACGCCCCGCACCTACATCTACGACCACGGCTTCCCCTACACGGAC
CCTGTGGGTGTGCTCTATGAGGATGGTGATGACACGGTGGCGACCCGCAGCACCGAGCTCTGTG
GCCTGTGGCAGGGCCGCCAGCCACAGCCTGTGCACCTGCTGCCCCTGCACGGGATACAGCATCT
CAACATGGTCTTCAGCAACCTGACCCTGGAGCACATCAATGCCATCCTGCTGGGTGCCTACCGC
CAGGGTCCCCCTGCATCCCCGACTGCCAGCCCAGAGCCCCCGCCTCCTGAATAAAGACCTTCCT
TTGCTACCGTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008962816	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000024974
	ENSPPAP00000024974.1
	ENSPPAP00000024979.1

RefSeq Acc Id:

XP_008962816 ⟸ XM_008964568

- UniProtKB:

A0A2R9BD07 (UniProtKB/TrEMBL), A0A2R9BD11 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGPPGSPWQWVTLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKL
DKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGVQIRVPGFG
KTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMH
AAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGIP
IMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGRDFQRFFADLHFEEGWYMWLQ
SRDLLAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQ
GRQPQPVHLLPLHGIQHLNMVFSNLTLEHINAILLGAYRQGPPASPTASPEPPPPE

hide sequence

RefSeq Acc Id:

ENSPPAP00000024974 ⟸ ENSPPAT00000047800

RefSeq Acc Id:

ENSPPAP00000024979 ⟸ ENSPPAT00000047805

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000035631	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000047800.1	UniProtKB/TrEMBL
	ENSPPAT00000047805.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1820	UniProtKB/TrEMBL
InterPro	AB_hydrolase	UniProtKB/TrEMBL
	LACT/PDAT_acylTrfase	UniProtKB/TrEMBL
KEGG Report	pps:100976085	UniProtKB/TrEMBL
NCBI Gene	LCAT	ENTREZGENE
PANTHER	LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED	UniProtKB/TrEMBL
	PHOSPHATIDYLCHOLINE-STEROL ACYLTRANSFERASE	UniProtKB/TrEMBL
Pfam	LCAT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53474	UniProtKB/TrEMBL
UniProt	A0A2R9BD07	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9BD11	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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