HDAC3 (histone deacetylase 3) - Rat Genome Database

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Gene: HDAC3 (histone deacetylase 3) Pan paniscus
Analyze
Symbol: HDAC3
Name: histone deacetylase 3
RGD ID: 11945878
Description: ENCODES a protein that exhibits chromatin binding (ortholog); deacetylase activity (ortholog); GTPase binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); cellular response to parathyroid hormone stimulus (ortholog); circadian regulation of gene expression (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); Anaphylaxis (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24136,869,766 - 136,885,755 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15135,009,317 - 135,025,306 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05136,981,790 - 136,997,786 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15143,094,406 - 143,110,322 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5143,094,406 - 143,110,322 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to fluid shear stress  (IEA)
cellular response to mechanical stimulus  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
chromatin organization  (IEA)
chromatin remodeling  (IEA)
circadian regulation of gene expression  (IEA,ISO)
cornified envelope assembly  (IEA)
DNA repair-dependent chromatin remodeling  (IEA)
epidermis development  (IEA)
establishment of mitotic spindle orientation  (IEA)
establishment of skin barrier  (IEA)
gene expression  (IEA)
in utero embryonic development  (IEA)
negative regulation of cardiac muscle cell differentiation  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of interleukin-1 production  (ISO)
negative regulation of JNK cascade  (IEA)
negative regulation of myotube differentiation  (ISO)
negative regulation of protein export from nucleus  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of tumor necrosis factor production  (ISO)
neural precursor cell proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of protein import into nucleus  (IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of protein ubiquitination  (IEA)
positive regulation of TOR signaling  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of type B pancreatic cell apoptotic process  (ISO)
protein modification process  (ISO)
regulation of circadian rhythm  (IEA)
regulation of mitotic cell cycle  (IEA,ISO)
regulation of multicellular organism growth  (IEA,ISO)
regulation of protein stability  (IEA)
response to dexamethasone  (ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
spindle assembly  (IEA)
transcription by RNA polymerase II  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HDAC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24136,869,766 - 136,885,755 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15135,009,317 - 135,025,306 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05136,981,790 - 136,997,786 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15143,094,406 - 143,110,322 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5143,094,406 - 143,110,322 (-)Ensemblpanpan1.1panPan2
HDAC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385141,620,881 - 141,636,849 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5141,620,876 - 141,636,849 (-)EnsemblGRCh38hg38GRCh38
GRCh375141,000,448 - 141,016,416 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365140,980,627 - 140,996,607 (-)NCBINCBI36Build 36hg18NCBI36
Build 345140,980,626 - 140,996,596NCBI
Celera5137,077,171 - 137,093,151 (-)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5136,145,083 - 136,160,930 (-)NCBIHuRef
CHM1_15140,433,725 - 140,449,704 (-)NCBICHM1_1
T2T-CHM13v2.05142,146,886 - 142,162,855 (-)NCBIT2T-CHM13v2.0
Hdac3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391838,070,024 - 38,088,073 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1838,068,897 - 38,088,069 (-)EnsemblGRCm39 Ensembl
GRCm381837,936,971 - 37,955,015 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1837,935,844 - 37,955,016 (-)EnsemblGRCm38mm10GRCm38
MGSCv371838,096,625 - 38,114,642 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361838,062,953 - 38,080,909 (-)NCBIMGSCv36mm8
Celera1839,280,295 - 39,298,302 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1819.81NCBI
Hdac3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81830,021,847 - 30,041,061 (-)NCBIGRCr8
mRatBN7.21829,770,637 - 29,789,850 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1829,770,636 - 29,793,856 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1829,874,943 - 29,894,123 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01830,636,921 - 30,656,319 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01829,972,266 - 29,991,665 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01831,073,057 - 31,094,347 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1831,073,058 - 31,094,303 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01830,764,344 - 30,782,387 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41830,857,209 - 30,875,986 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11830,883,855 - 30,902,632 (-)NCBI
Celera1829,414,681 - 29,434,382 (-)NCBICelera
Cytogenetic Map18p11NCBI
Hdac3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541512,138,870 - 12,154,234 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541512,138,520 - 12,154,234 (+)NCBIChiLan1.0ChiLan1.0
HDAC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1236,583,283 - 36,598,121 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl236,583,283 - 36,597,682 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha233,635,234 - 33,650,086 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0237,037,462 - 37,052,393 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl237,037,381 - 37,052,025 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1234,112,034 - 34,126,890 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0234,923,559 - 34,938,422 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0235,730,823 - 35,745,706 (-)NCBIUU_Cfam_GSD_1.0
Hdac3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213150,956,557 - 150,972,579 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650412,530,528 - 12,546,556 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650412,530,546 - 12,546,556 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDAC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2143,273,192 - 143,287,399 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12143,273,188 - 143,287,421 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22149,475,764 - 149,490,030 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HDAC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12344,246,296 - 44,263,127 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603433,589,487 - 33,606,357 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hdac3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624774845,358 - 863,809 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624774845,970 - 864,080 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000051618   ⟹   ENSPPAP00000028770
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5143,094,406 - 143,110,322 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000051634   ⟹   ENSPPAP00000028786
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5143,094,998 - 143,110,260 (-)Ensembl
RefSeq Acc Id: XM_003829117   ⟹   XP_003829165
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24136,869,766 - 136,885,699 (-)NCBI
NHGRI_mPanPan15135,009,317 - 135,025,306 (-)NCBI
Mhudiblu_PPA_v05136,981,790 - 136,997,758 (-)NCBI
PanPan1.15143,094,406 - 143,110,322 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024928734   ⟹   XP_024784502
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24136,873,714 - 136,885,755 (-)NCBI
NHGRI_mPanPan15135,013,265 - 135,025,306 (-)NCBI
Mhudiblu_PPA_v05136,985,743 - 136,997,786 (-)NCBI
PanPan1.15143,098,444 - 143,110,322 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034960668   ⟹   XP_034816559
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24136,869,766 - 136,885,755 (-)NCBI
NHGRI_mPanPan15135,009,317 - 135,025,306 (-)NCBI
Mhudiblu_PPA_v05136,981,790 - 136,997,758 (-)NCBI
RefSeq Acc Id: XM_055112730   ⟹   XP_054968705
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24136,869,766 - 136,885,468 (-)NCBI
NHGRI_mPanPan15135,009,317 - 135,025,019 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003829165 (Get FASTA)   NCBI Sequence Viewer  
  XP_024784502 (Get FASTA)   NCBI Sequence Viewer  
  XP_034816559 (Get FASTA)   NCBI Sequence Viewer  
  XP_054968705 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000028770
  ENSPPAP00000028770.1
  ENSPPAP00000028786.1
RefSeq Acc Id: XP_003829165   ⟸   XM_003829117
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BGK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024784502   ⟸   XM_024928734
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034816559   ⟸   XM_034960668
- Peptide Label: isoform X3
RefSeq Acc Id: ENSPPAP00000028770   ⟸   ENSPPAT00000051618
RefSeq Acc Id: ENSPPAP00000028786   ⟸   ENSPPAT00000051634
RefSeq Acc Id: XP_054968705   ⟸   XM_055112730
- Peptide Label: isoform X4
Protein Domains
Histone deacetylase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037408 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000051618.1 UniProtKB/TrEMBL
  ENSPPAT00000051634.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.800.20 UniProtKB/TrEMBL
InterPro His_deacetylse UniProtKB/TrEMBL
  His_deacetylse_1 UniProtKB/TrEMBL
  His_deacetylse_dom UniProtKB/TrEMBL
  His_deacetylse_dom_sf UniProtKB/TrEMBL
  Ureohydrolase_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100978769 UniProtKB/TrEMBL
NCBI Gene HDAC3 ENTREZGENE
PANTHER HISTONE DEACETYLASE 2-RELATED UniProtKB/TrEMBL
  HISTONE DEACETYLASE 3 UniProtKB/TrEMBL
Pfam Hist_deacetyl UniProtKB/TrEMBL
PIRSF His_deacetylse_1 UniProtKB/TrEMBL
PRINTS HDASUPER UniProtKB/TrEMBL
  HISDACETLASE UniProtKB/TrEMBL
Superfamily-SCOP SSF52768 UniProtKB/TrEMBL
UniProt A0A2R9BGK3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BQ70_PANPA UniProtKB/TrEMBL