GSTM4 (glutathione S-transferase mu 4)

Gene: GSTM4 (glutathione S-transferase mu 4) Pan paniscus

Analyze

Symbol:

GSTM4

Name:

glutathione S-transferase mu 4

RGD ID:

11916345

Description:

ENCODES a protein that exhibits enzyme binding (inferred); glutathione binding (inferred); glutathione transferase activity (inferred); INVOLVED IN nitrobenzene metabolic process (ortholog); xenobiotic catabolic process (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Chemical and Drug Induced Liver Injury (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); intercellular bridge (inferred)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

glutathione S-transferase Mu 2; LOC100987265; LOC117974950; uncharacterized LOC117974950

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	117,629,559 - 117,648,713 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	116,774,969 - 116,808,377 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	112,033,462 - 112,337,606 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	111,261,585 - 111,270,912 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	111,261,585 - 111,270,919 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Chemical and Drug Induced Liver Injury (ISO)

genetic disease (ISO)

hereditary spastic paraplegia 63 (ISO)

neurodegenerative disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glutathione metabolic process (IEA)

lipid metabolic process (IEA)

long-chain fatty acid biosynthetic process (IEA)

nitrobenzene metabolic process (ISO)

xenobiotic catabolic process (IEA,ISO)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

intercellular bridge (IEA)

Molecular Function

enzyme binding (IEA)

glutathione binding (IEA)

glutathione transferase activity (IEA)

identical protein binding (IEA)

leukotriene-C4 synthase activity (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

transferase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

GSTM4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	117,629,559 - 117,648,713 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	116,774,969 - 116,808,377 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	112,033,462 - 112,337,606 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	111,261,585 - 111,270,912 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	111,261,585 - 111,270,919 (+)	Ensembl	panpan1.1		panPan2

GSTM4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	109,656,099 - 109,667,727 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	109,656,099 - 109,665,496 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	110,198,721 - 110,208,119 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	110,000,226 - 110,009,648 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	108,463,772 - 108,473,180 (+)	NCBI		Celera
Cytogenetic Map	1	p13.3	NCBI
HuRef	1	108,086,984 - 108,096,416 (+)	NCBI		HuRef
CHM1_1	1	110,313,519 - 110,322,944 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	109,684,537 - 109,696,166 (+)	NCBI		T2T-CHM13v2.0

Gstm4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	107,937,887 - 107,952,495 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	107,947,724 - 107,952,210 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	108,030,571 - 108,045,179 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	108,040,408 - 108,044,894 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	107,843,326 - 107,847,777 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	108,168,464 - 108,172,845 (-)	NCBI		MGSCv36	mm8
Celera	3	110,373,991 - 110,378,442 (-)	NCBI		Celera
Cytogenetic Map	3	F2.3	NCBI
cM Map	3	46.83	NCBI

Gstm4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	198,356,114 - 198,373,487 (-)	NCBI		GRCr8
mRatBN7.2	2	195,667,940 - 195,685,315 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	195,680,004 - 195,685,323 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	203,322,478 - 203,327,732 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	201,204,594 - 201,209,850 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	196,021,555 - 196,026,811 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	210,834,013 - 210,839,242 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	210,833,884 - 210,839,295 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	230,302,889 - 230,308,113 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	203,605,593 - 203,610,817 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	188,325,385 - 188,330,613 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Gstm4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955435	13,063,966 - 13,210,264 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955435	13,064,691 - 13,069,734 (+)	NCBI	ChiLan1.0	ChiLan1.0

LOC479912
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	42,201,697 - 42,207,886 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	44,977,327 - 44,983,514 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	42,533,367 - 42,539,560 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	42,534,290 - 42,539,704 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	42,266,138 - 42,272,342 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	42,223,891 - 42,230,078 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	42,658,872 - 42,665,063 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101958900
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	18,963,655 - 18,971,183 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936704	1,143,010 - 1,148,567 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936704	1,142,990 - 1,150,491 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC106510200
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	4	110,378,016 - 110,413,483 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	120,750,531 - 120,784,580 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001367587	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008964685	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034960048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010112643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000049576 ⟹ ENSPPAP00000026740

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	111,261,585 - 111,270,919 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000049579 ⟹ ENSPPAP00000026743

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	111,261,585 - 111,266,848 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000049586 ⟹ ENSPPAP00000026750

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	111,261,899 - 111,269,281 (+)	Ensembl

RefSeq Acc Id:

NM_001367587 ⟹ NP_001354516

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	117,643,287 - 117,648,553 (-)	NCBI
NHGRI_mPanPan1	1	116,803,100 - 116,808,364 (-)	NCBI
Mhudiblu_PPA_v0	1	112,033,471 - 112,038,735 (+)	NCBI

RefSeq Acc Id:

XM_008964685 ⟹ XP_008962933

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	117,642,962 - 117,648,573 (-)	NCBI
NHGRI_mPanPan1	1	116,802,743 - 116,808,377 (-)	NCBI
Mhudiblu_PPA_v0	1	112,033,462 - 112,039,092 (+)	NCBI
PanPan1.1	1	111,261,585 - 111,266,848 (+)	NCBI

Sequence:

show sequence

AAGCTGGCGAGGCCGAGCCCCACCTAGTGCTTCCGGACCTTGCTCCCTGAACACTCGGAGGTGG
CGGTGGATCTTACTCCTTTCAGCCAGTGAGGATCCAGCGAGCTGCTCCGTGCCTCCCGCGCCTG
TTGGTTGGAAGTGACGACCTTGAAGATCGGCCGGTTGGAAGTGACGACCTTGAAGATCGGCGGG
CGCAGCGGGGCCGAGGGGGCGGGTCTGGCGCTAGGTCCAGCCCCTGCGTGCCGGGAACCCCAGA
GGAGGTCGCAGTTCAGCCCAGCTGAGGCCTGTCTGCAGAATCGACACCAACCAGCATCATGTCC
ATGACACTGGGGTACTGGGACATCCGCGGGCTGGCCCACGCCATCCGCCTGCTCCTGGAATACA
CAGACTCAAGCTACGAGGAAAAGAAGTACACGATGGGGGACGCTCCTGACTATGACAGAAGCCA
GTGGCTGAATGAAAAATTCAAGCTGGGCCTGGACTTTCCCAATCTGCCCTACTTGATTGATGGG
GCTCACAAGATCACCCAGAGCAACGCCATCCTGCGCTACATTGCCCGCAAGCACAACCTGTGTG
GGGAGACAGAAGAGGAGAAGATTCGTGTGGACATTTTGGAGAATCAGGCTATGGACGTCTCCAA
TCAGCTGGCCAGAGTCTGCTACAGCCCTGACTTTGAGAAACTGAAGCCAGAATACTTGGAGGAA
CTTCCTACAATGATGCAGCACTTCTCACAGTTCCTGGGGAAGAGGCCATGGTTTGTTGGAGACA
AGATCACCTTTGTAGATTTCCTCGCCTATGATGTCCTTGACCTCCACCGTATATTTGAGCCCAA
GTGCTTGGACGCCTTTCCAAATCTGAAGGACTTCATCTCCCGCTTTGAGTGTTCCAGGTGTTCC
CCCTGTGAGATGAGTAGCACACTGATTTTACTCCTATTCACCGACCTTCTCCTCTGCATGAGGC
AGGGTGTGAGGCACAGTGGGAGATGCATAGATGACTGCCCCCTCCTGGAAATGAGTGCAGTGAG
AGGCCTGCAGGCAGAGCAGCCTGTGAGGGCTTGGAGAAGATCTCTGCCTACATGAAGTCCAGCC
GCTTCCTCCCAAAACCTCTGTACACAAGGGTGGCTGTCTGGGGCAACAAGTAATGCCTTGAAGG
CCAGGAGGTGGGAGTGAGGAGCCCATACTCAGCCTGCTGCCCAGACTGTGCAGCGCAGCTGGAC
TCTGCATCCCAGCACCTGCCTCCTCGTTCCTTTCTCCTGTTTATT

hide sequence

RefSeq Acc Id:

XR_010112643

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	117,629,559 - 117,648,713 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001354516	(Get FASTA)	NCBI Sequence Viewer
	XP_008962933	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000026740.1
	ENSPPAP00000026743.1
	ENSPPAP00000026750.1

RefSeq Acc Id:

XP_008962933 ⟸ XM_008964685

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSMTLGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLI
DGAHKITQSNAILRYIARKHNLCGETEEEKIRVDILENQAMDVSNQLARVCYSPDFEKLKPEYL
EELPTMMQHFSQFLGKRPWFVGDKITFVDFLAYDVLDLHRIFEPKCLDAFPNLKDFISRFECSR
CSPCEMSSTLILLLFTDLLLCMRQGVRHSGRCIDDCPLLEMSAVRGLQAEQPVRAWRRSLPT

hide sequence

RefSeq Acc Id:	NP_001354516 ⟸ NM_001367587
- UniProtKB:	A0A2R9BAV5 (UniProtKB/TrEMBL), A0A2R9BIZ3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSPPAP00000026743 ⟸ ENSPPAT00000049579

RefSeq Acc Id:

ENSPPAP00000026740 ⟸ ENSPPAT00000049576

RefSeq Acc Id:

ENSPPAP00000026750 ⟸ ENSPPAT00000049586

Protein Domains

GST C-terminal GST N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000036450	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000049576.1	UniProtKB/TrEMBL
	ENSPPAT00000049579.1	UniProtKB/TrEMBL
	ENSPPAT00000049586.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1050.10	UniProtKB/TrEMBL
	Glutaredoxin	UniProtKB/TrEMBL
InterPro	Glutathione-S-Trfase_C-like	UniProtKB/TrEMBL
	Glutathione-S-Trfase_C_sf	UniProtKB/TrEMBL
	Glutathione_S-Trfase	UniProtKB/TrEMBL
	Glutathione_S-Trfase_N	UniProtKB/TrEMBL
	GST_C	UniProtKB/TrEMBL
	GST_mu	UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/TrEMBL
NCBI Gene	GSTM4	ENTREZGENE
PANTHER	GLUTATHIONE S-TRANSFERASE	UniProtKB/TrEMBL
	GLUTATHIONE S-TRANSFERASE MU 4	UniProtKB/TrEMBL
Pfam	GST_C	UniProtKB/TrEMBL
	GST_N	UniProtKB/TrEMBL
PRINTS	GSTRNSFRASEM	UniProtKB/TrEMBL
PROSITE	GST_CTER	UniProtKB/TrEMBL
	GST_NTER	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47616	UniProtKB/TrEMBL
	SSF52833	UniProtKB/TrEMBL
UniProt	A0A2R9BAV5	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9BIV1_PANPA	UniProtKB/TrEMBL
	A0A2R9BIZ3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-04-20	GSTM4	glutathione S-transferase mu 4	LOC117974950	uncharacterized LOC117974950	Data merged from RGD:32732091	737654	PROVISIONAL
2020-06-11	GSTM4	glutathione S-transferase mu 4	LOC100987265	glutathione S-transferase Mu 2	Data merged from RGD:11977486	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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