SCN5A (sodium voltage-gated channel alpha subunit 5) - Rat Genome Database

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Pathways
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Gene: SCN5A (sodium voltage-gated channel alpha subunit 5) Pan paniscus
Analyze
Symbol: SCN5A
Name: sodium voltage-gated channel alpha subunit 5
RGD ID: 11898467
Description: ENCODES a protein that exhibits ankyrin binding (ortholog); fibroblast growth factor binding (ortholog); INVOLVED IN brainstem development (ortholog); cardiac ventricle development (ortholog); cerebellum development (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); atrial fibrillation (ortholog); atrial standstill 1 (ortholog); FOUND IN intercalated disc (ortholog); lateral plasma membrane (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium channel protein type 5 subunit alpha; sodium channel, voltage-gated, type V, alpha subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,500,346 - 38,602,017 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,505,110 - 38,606,779 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,444,421 - 38,546,364 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,726,612 - 38,825,308 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,728,897 - 38,812,202 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
arrhythmogenic right ventricular cardiomyopathy  (ISO)
atrial fibrillation  (ISO)
atrial standstill 1  (ISO)
atrioventricular block  (ISO)
brain ischemia  (ISO)
Brugada syndrome  (ISO)
Brugada syndrome 1  (ISO)
cardiac arrest  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Conduction Defect  (ISO)
Cardiac Conduction Defect, Nonprogressive  (ISO)
Cardiac Conduction Defect, Nonspecific  (ISO)
cardiomyopathy  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO)
congestive heart failure  (ISO)
Death  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1E  (ISO)
dilated cardiomyopathy 1H  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
Familial Atrial Fibrillation 10  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
fetal akinesia deformation sequence syndrome 1  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
heart conduction disease  (ISO)
hemiplegia  (ISO)
hereditary sensory and autonomic neuropathy type 7  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
Immunodeficiency 68  (ISO)
Infant Death  (ISO)
Left Ventricular Noncompaction 1  (ISO)
long QT syndrome  (ISO)
long QT syndrome 1  (ISO)
long QT syndrome 2  (ISO)
Long QT Syndrome 2/3  (ISO)
long QT syndrome 3  (ISO)
Long QT Syndrome 3/6  (ISO)
migraine  (ISO)
Nonprogressive Heart Block  (ISO)
Paroxysmal Ventricular Fibrillation  (ISO)
progressive familial heart block  (ISO)
Progressive Familial Heart Block Type I  (ISO)
progressive familial heart block type IA  (ISO)
Romano-Ward Syndrome  (ISO)
sick sinus syndrome  (ISO)
Sick Sinus Syndrome 1, Autosomal Recessive  (ISO)
sinoatrial node disease  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
sudden infant death syndrome  (ISO)
Sudden Unexpected Nocturnal Death Syndrome  (ISO)
Syncope  (ISO)
Torsades de Pointes  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Fibrillation, Paroxysmal Familial, 1  (ISO)
Ventricular Tachycardia  (ISO)
Visceral Heterotaxy 4, Autosomal  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
atrial cardiac muscle cell action potential  (IEA)
AV node cell action potential  (IEA)
AV node cell to bundle of His cell communication  (IEA)
brainstem development  (ISO)
bundle of His cell action potential  (IEA)
cardiac muscle cell action potential involved in contraction  (IEA)
cardiac muscle contraction  (IEA)
cardiac ventricle development  (ISO)
cellular response to calcium ion  (IEA)
cerebellum development  (ISO)
membrane depolarization  (IEA)
membrane depolarization during action potential  (IEA)
membrane depolarization during atrial cardiac muscle cell action potential  (IEA)
membrane depolarization during AV node cell action potential  (IEA)
membrane depolarization during bundle of His cell action potential  (IEA)
membrane depolarization during cardiac muscle cell action potential  (IEA)
membrane depolarization during Purkinje myocyte cell action potential  (IEA)
membrane depolarization during SA node cell action potential  (IEA)
monoatomic cation transmembrane transport  (IEA)
monoatomic ion transmembrane transport  (IEA)
monoatomic ion transport  (IEA)
neuronal action potential  (IEA)
odontogenesis of dentin-containing tooth  (ISO)
positive regulation of action potential  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of sodium ion transport  (IEA)
regulation of atrial cardiac muscle cell membrane depolarization  (IEA)
regulation of atrial cardiac muscle cell membrane repolarization  (IEA)
regulation of cardiac muscle cell contraction  (IEA,ISO)
regulation of heart rate  (IEA)
regulation of heart rate by cardiac conduction  (IEA,ISO)
regulation of sodium ion transmembrane transport  (IEA)
regulation of ventricular cardiac muscle cell membrane depolarization  (IEA)
regulation of ventricular cardiac muscle cell membrane repolarization  (IEA)
response to denervation involved in regulation of muscle adaptation  (ISO)
response to organic cyclic compound  (ISO)
SA node cell action potential  (IEA)
sodium ion import across plasma membrane  (ISO)
sodium ion transmembrane transport  (IEA,ISO)
sodium ion transport  (IEA)
telencephalon development  (ISO)
transmembrane transport  (IEA)
ventricular cardiac muscle cell action potential  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
fosphenytoin pharmacokinetics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SCN5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,500,346 - 38,602,017 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,505,110 - 38,606,779 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,444,421 - 38,546,364 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,726,612 - 38,825,308 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,728,897 - 38,812,202 (-)Ensemblpanpan1.1panPan2
SCN5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,548,062 - 38,649,687 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,548,057 - 38,649,687 (-)EnsemblGRCh38hg38GRCh38
GRCh37338,589,553 - 38,691,178 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,564,557 - 38,666,167 (-)NCBINCBI36Build 36hg18NCBI36
Build 34338,564,557 - 38,666,167NCBI
Cytogenetic Map3p22.2NCBI
HuRef338,631,798 - 38,733,467 (-)NCBIHuRef
CHM1_1338,541,190 - 38,642,759 (-)NCBICHM1_1
T2T-CHM13v2.0338,554,106 - 38,661,891 (-)NCBIT2T-CHM13v2.0
Scn5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,312,470 - 119,408,096 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,312,474 - 119,408,082 (-)EnsemblGRCm39 Ensembl
GRCm389119,483,404 - 119,579,030 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,483,408 - 119,579,016 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,392,529 - 119,488,134 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,332,109 - 119,427,714 (-)NCBIMGSCv36mm8
Celera9119,954,231 - 120,036,580 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
Scn5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,098,613 - 128,196,515 (-)NCBIGRCr8
mRatBN7.28119,220,905 - 119,318,816 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,220,905 - 119,318,769 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,802,735 - 124,900,397 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08123,001,756 - 123,099,420 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,835,478 - 120,933,167 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,169,191 - 128,266,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,169,191 - 128,266,639 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,375,781 - 127,471,879 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,446,479 - 124,545,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,467,115 - 124,565,038 (-)NCBI
Celera8118,371,960 - 118,468,948 (-)NCBICelera
RH 3.4 Map81282.5RGD
Cytogenetic Map8q32NCBI
Scn5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542725,295,514 - 25,371,552 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542725,295,517 - 25,371,419 (+)NCBIChiLan1.0ChiLan1.0
SCN5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,278,844 - 8,374,614 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,280,793 - 8,358,560 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha238,320,845 - 8,398,617 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0238,569,755 - 8,663,508 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,567,803 - 8,663,608 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,383,566 - 8,461,346 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,524,281 - 8,602,312 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0238,517,525 - 8,595,709 (-)NCBIUU_Cfam_GSD_1.0
Scn5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,744,951 - 194,825,418 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647327,883,526 - 27,963,994 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647327,883,526 - 27,963,994 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCN5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,336,153 - 23,424,755 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,336,143 - 23,424,755 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,515,907 - 25,618,584 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SCN5A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115767,854 - 869,787 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl15794,963 - 867,457 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660639,497,334 - 9,599,195 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scn5a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247312,401,380 - 2,498,211 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247312,401,358 - 2,498,212 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000050214   ⟹   ENSPPAP00000027374
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl338,728,897 - 38,812,202 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000050216   ⟹   ENSPPAP00000027376
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl338,728,897 - 38,812,202 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000050218   ⟹   ENSPPAP00000027378
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl338,728,897 - 38,812,202 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000050222   ⟹   ENSPPAP00000027382
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl338,728,897 - 38,812,202 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000050224   ⟹   ENSPPAP00000027384
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl338,728,897 - 38,812,202 (-)Ensembl
RefSeq Acc Id: XM_034956141   ⟹   XP_034812032
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2238,549,406 - 38,602,017 (-)NCBI
NHGRI_mPanPan1338,554,230 - 38,606,779 (-)NCBI
Mhudiblu_PPA_v0338,444,421 - 38,546,337 (-)NCBI
RefSeq Acc Id: XM_057301688   ⟹   XP_057157671
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2238,500,346 - 38,602,017 (-)NCBI
NHGRI_mPanPan1338,505,110 - 38,606,779 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034812032 (Get FASTA)   NCBI Sequence Viewer  
  XP_057157671 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000027374.1
  ENSPPAP00000027376.1
  ENSPPAP00000027378.1
  ENSPPAP00000027382.1
  ENSPPAP00000027384.1
Reference Protein Sequences
RefSeq Acc Id: XP_034812032   ⟸   XM_034956141
- Peptide Label: isoform X1
RefSeq Acc Id: ENSPPAP00000027376   ⟸   ENSPPAT00000050216
RefSeq Acc Id: ENSPPAP00000027374   ⟸   ENSPPAT00000050214
RefSeq Acc Id: ENSPPAP00000027384   ⟸   ENSPPAT00000050224
RefSeq Acc Id: ENSPPAP00000027382   ⟸   ENSPPAT00000050222
RefSeq Acc Id: ENSPPAP00000027378   ⟸   ENSPPAT00000050218
RefSeq Acc Id: XP_057157671   ⟸   XM_057301688
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BGH4 (UniProtKB/TrEMBL)
Protein Domains
Ion transport   Sodium ion transport-associated   Voltage-gated Na+ ion channel cytoplasmic


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036665 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000050214.1 UniProtKB/TrEMBL
  ENSPPAT00000050216.1 UniProtKB/TrEMBL
  ENSPPAT00000050218.1 UniProtKB/TrEMBL
  ENSPPAT00000050222.1 UniProtKB/TrEMBL
  ENSPPAT00000050224.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  iswi atpase UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  Na_channel_a5su UniProtKB/TrEMBL
  Na_channel_asu UniProtKB/TrEMBL
  Na_chnl_inactivation_gate UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
  Na_trans_cytopl UniProtKB/TrEMBL
  VGCC_Ca_Na UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene SCN5A ENTREZGENE
PANTHER PTHR10037 UniProtKB/TrEMBL
  SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
  Na_trans_cytopl UniProtKB/TrEMBL
PRINTS NACHANNEL UniProtKB/TrEMBL
  NACHANNEL5 UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A2R9BCK9_PANPA UniProtKB/TrEMBL
  A0A2R9BCP4_PANPA UniProtKB/TrEMBL
  A0A2R9BCQ4_PANPA UniProtKB/TrEMBL
  A0A2R9BDX6_PANPA UniProtKB/TrEMBL
  A0A2R9BGH4 ENTREZGENE, UniProtKB/TrEMBL