WDR5 (WD repeat domain 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: WDR5 (WD repeat domain 5) Pan paniscus
Analyze
Symbol: WDR5
Name: WD repeat domain 5
RGD ID: 11878797
Description: ENCODES a protein that exhibits histone H3K4 methyltransferase activity (ortholog); INVOLVED IN gluconeogenesis (ortholog); neuron projection development (ortholog); positive regulation of gluconeogenesis (ortholog); PARTICIPATES IN histone modification pathway; RNA polymerase II transcription initiation pathway; ASSOCIATED WITH congenital heart disease (ortholog); developmental and epileptic encephalopathy 14 (ortholog); Ehlers-Danlos syndrome classic type 1 (ortholog); FOUND IN ATAC complex (ortholog); MLL1 complex (ortholog); MLL1/2 complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: WD repeat-containing protein 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,211,185 - 5,235,964 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan195,213,518 - 5,238,324 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09105,241,415 - 105,265,925 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19133,848,185 - 133,872,889 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,848,185 - 133,872,889 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
WDR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,211,185 - 5,235,964 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan195,213,518 - 5,238,324 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09105,241,415 - 105,265,925 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19133,848,185 - 133,872,889 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,848,185 - 133,872,889 (+)Ensemblpanpan1.1panPan2
WDR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389134,135,199 - 134,159,968 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9134,135,365 - 134,159,968 (+)EnsemblGRCh38hg38GRCh38
GRCh379137,000,321 - 137,025,090 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,991,031 - 136,014,915 (+)NCBINCBI36Build 36hg18NCBI36
Build 349134,034,467 - 134,053,330NCBI
Celera9107,546,368 - 107,570,384 (+)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9106,494,213 - 106,518,092 (+)NCBIHuRef
CHM1_19137,147,954 - 137,171,840 (+)NCBICHM1_1
T2T-CHM13v2.09146,348,934 - 146,373,713 (+)NCBIT2T-CHM13v2.0
Wdr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39227,405,159 - 27,426,547 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl227,405,169 - 27,426,547 (+)EnsemblGRCm39 Ensembl
GRCm38227,515,147 - 27,536,535 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl227,515,157 - 27,536,535 (+)EnsemblGRCm38mm10GRCm38
MGSCv37227,370,667 - 27,392,055 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36227,337,223 - 27,358,544 (+)NCBIMGSCv36mm8
Celera227,217,888 - 27,239,293 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.38NCBI
Wdr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8331,233,048 - 31,254,730 (+)NCBIGRCr8
mRatBN7.2310,836,964 - 10,856,682 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,837,025 - 10,856,671 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,905,180 - 13,924,115 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0322,490,606 - 22,509,541 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,745,229 - 20,764,191 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.036,061,892 - 6,080,724 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl36,061,940 - 6,080,680 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0311,422,748 - 11,441,574 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,432,879 - 6,451,846 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.136,432,099 - 6,450,947 (+)NCBI
Celera35,632,259 - 5,651,225 (+)NCBICelera
Cytogenetic Map3p12NCBI
Wdr5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555133,198,980 - 3,216,468 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555133,198,655 - 3,213,754 (+)NCBIChiLan1.0ChiLan1.0
WDR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1950,352,600 - 50,371,224 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl950,352,472 - 50,371,236 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,631,684 - 49,651,782 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0951,225,059 - 51,245,284 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl951,225,396 - 51,245,435 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,985,941 - 50,006,039 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0950,328,703 - 50,348,976 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0950,406,626 - 50,426,733 (+)NCBIUU_Cfam_GSD_1.0
Wdr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947200,415,266 - 200,430,169 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366692,943,656 - 2,958,409 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366692,943,759 - 2,959,788 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,560,283 - 273,578,063 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11273,560,274 - 273,577,827 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21307,533,235 - 307,550,804 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WDR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1123,982,998 - 4,007,605 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl123,983,013 - 4,007,119 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660581,089,087 - 1,113,046 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wdr5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247602,274,813 - 2,292,379 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247602,275,660 - 2,291,796 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000037616   ⟹   ENSPPAP00000014928
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl9133,848,185 - 133,872,889 (+)Ensembl
RefSeq Acc Id: XM_008976039   ⟹   XP_008974287
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2115,211,185 - 5,235,702 (-)NCBI
NHGRI_mPanPan195,213,518 - 5,238,036 (-)NCBI
Mhudiblu_PPA_v09105,241,415 - 105,265,925 (+)NCBI
PanPan1.19133,848,185 - 133,872,889 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034929438   ⟹   XP_034785329
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2115,211,185 - 5,235,128 (-)NCBI
NHGRI_mPanPan195,213,518 - 5,237,461 (-)NCBI
Mhudiblu_PPA_v09105,242,014 - 105,265,925 (+)NCBI
RefSeq Acc Id: XM_055117493   ⟹   XP_054973468
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2115,211,185 - 5,234,804 (-)NCBI
NHGRI_mPanPan195,213,518 - 5,237,137 (-)NCBI
RefSeq Acc Id: XM_055117494   ⟹   XP_054973469
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2115,211,185 - 5,234,775 (-)NCBI
NHGRI_mPanPan195,213,518 - 5,237,108 (-)NCBI
RefSeq Acc Id: XM_057298610   ⟹   XP_057154593
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2115,211,185 - 5,235,964 (-)NCBI
NHGRI_mPanPan195,213,518 - 5,238,324 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008974287   ⟸   XM_008976039
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AH98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034785329   ⟸   XM_034929438
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AH98 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000014928   ⟸   ENSPPAT00000037616
RefSeq Acc Id: XP_054973468   ⟸   XM_055117493
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054973469   ⟸   XM_055117494
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AH98 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_057154593   ⟸   XM_057298610
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030638 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000037616.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100988935 UniProtKB/TrEMBL
NCBI Gene WDR5 ENTREZGENE
PANTHER CANNONBALL-RELATED UniProtKB/TrEMBL
  TRANSCRIPTION INITIATION FACTOR TFIID UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PIRSF GN-bd_beta UniProtKB/TrEMBL
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt A0A2R9AH98 ENTREZGENE, UniProtKB/TrEMBL