SLC6A12 (solute carrier family 6 member 12) - Rat Genome Database

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Gene: SLC6A12 (solute carrier family 6 member 12) Pan paniscus
Analyze
Symbol: SLC6A12
Name: solute carrier family 6 member 12
RGD ID: 11873272
Description: ENCODES a protein that exhibits gamma-aminobutyric acid:sodium:chloride symporter activity (inferred); monocarboxylic acid transmembrane transporter activity (inferred); symporter activity (inferred); INVOLVED IN cellular hyperosmotic response (ortholog); glycine betaine transport (ortholog); intracellular water homeostasis (ortholog); ASSOCIATED WITH genetic disease (ortholog); Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); Neoplasm Invasiveness (ortholog); FOUND IN basolateral plasma membrane (inferred); lateral plasma membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium- and chloride-dependent betaine transporter; solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2105,672,278 - 5,698,978 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1125,669,013 - 5,695,736 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012247,905 - 274,518 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112224,566 - 249,340 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12224,566 - 249,202 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC6A12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2105,672,278 - 5,698,978 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1125,669,013 - 5,695,736 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012247,905 - 274,518 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112224,566 - 249,340 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12224,566 - 249,202 (-)Ensemblpanpan1.1panPan2
SLC6A12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812183,848 - 214,157 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12190,077 - 214,570 (-)EnsemblGRCh38hg38GRCh38
GRCh3712299,247 - 323,323 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612169,513 - 192,753 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412169,512 - 192,759NCBI
Celera121,907,867 - 1,932,231 (-)NCBICelera
Cytogenetic Map12p13.33NCBI
HuRef12151,965 - 176,483 (-)NCBIHuRef
CHM1_112298,191 - 322,361 (-)NCBICHM1_1
T2T-CHM13v2.012179,876 - 211,078 (-)NCBIT2T-CHM13v2.0
Slc6a12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396121,319,533 - 121,342,732 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6121,320,035 - 121,342,734 (+)EnsemblGRCm39 Ensembl
GRCm386121,342,574 - 121,365,773 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6121,343,076 - 121,365,775 (+)EnsemblGRCm38mm10GRCm38
MGSCv376121,296,715 - 121,315,791 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366121,312,316 - 121,331,392 (+)NCBIMGSCv36mm8
Celera6123,182,872 - 123,201,958 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.25NCBI
Slc6a12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84156,257,518 - 156,275,870 (+)NCBIGRCr8
mRatBN7.24154,585,386 - 154,603,750 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4154,585,500 - 154,603,750 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4160,851,569 - 160,869,938 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04156,635,049 - 156,653,409 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04155,258,488 - 155,276,847 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04153,921,199 - 153,941,333 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4153,921,115 - 153,941,391 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04221,009,224 - 221,029,242 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44157,781,178 - 157,800,038 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14158,026,113 - 158,044,974 (+)NCBI
Celera4143,424,065 - 143,442,410 (+)NCBICelera
Cytogenetic Map4q42NCBI
Slc6a12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554546,948,664 - 6,974,425 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554546,946,486 - 6,970,247 (+)NCBIChiLan1.0ChiLan1.0
SLC6A12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12742,270,427 - 42,301,874 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2742,270,448 - 42,336,464 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,389,231 - 4,413,912 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02742,628,605 - 42,656,421 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2742,628,606 - 42,655,432 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12742,569,709 - 42,594,385 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02742,541,235 - 42,565,923 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0273,749,203 - 3,773,888 (+)NCBIUU_Cfam_GSD_1.0
Slc6a12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945108,768,079 - 108,796,759 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936606384,124 - 411,698 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936606387,342 - 412,684 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC6A12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl567,550,289 - 67,572,588 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1567,550,285 - 67,573,858 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2569,838,027 - 69,861,857 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC6A12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111192,590 - 223,809 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11192,398 - 215,991 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660638,120,189 - 8,148,179 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc6a12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247358,445,405 - 8,468,083 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247358,441,046 - 8,469,611 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000005361   ⟹   ENSPPAP00000001144
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl12224,566 - 249,202 (-)Ensembl
RefSeq Acc Id: XM_003820382   ⟹   XP_003820430
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2105,672,279 - 5,698,249 (-)NCBI
NHGRI_mPanPan1125,669,040 - 5,695,011 (-)NCBI
Mhudiblu_PPA_v012247,905 - 273,783 (-)NCBI
PanPan1.112224,566 - 248,609 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008973826   ⟹   XP_008972074
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2105,672,279 - 5,698,978 (-)NCBI
NHGRI_mPanPan1125,669,040 - 5,695,736 (-)NCBI
Mhudiblu_PPA_v012247,905 - 274,518 (-)NCBI
PanPan1.112224,566 - 249,340 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008973827   ⟹   XP_008972075
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2105,672,279 - 5,698,814 (-)NCBI
NHGRI_mPanPan1125,669,040 - 5,695,566 (-)NCBI
Mhudiblu_PPA_v012247,905 - 274,347 (-)NCBI
PanPan1.112224,566 - 249,202 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008973829   ⟹   XP_008972077
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2105,672,278 - 5,698,820 (-)NCBI
NHGRI_mPanPan1125,669,013 - 5,695,574 (-)NCBI
Mhudiblu_PPA_v012247,905 - 274,354 (-)NCBI
PanPan1.112224,566 - 249,202 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034935070   ⟹   XP_034790961
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2105,673,908 - 5,698,819 (-)NCBI
NHGRI_mPanPan1125,670,693 - 5,695,572 (-)NCBI
Mhudiblu_PPA_v012249,522 - 274,352 (-)NCBI
RefSeq Acc Id: XM_034935071   ⟹   XP_034790962
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2105,672,279 - 5,698,818 (-)NCBI
NHGRI_mPanPan1125,669,040 - 5,695,571 (-)NCBI
Mhudiblu_PPA_v012247,905 - 274,352 (-)NCBI
RefSeq Acc Id: XM_055095210   ⟹   XP_054951185
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2105,672,279 - 5,698,813 (-)NCBI
NHGRI_mPanPan1125,669,040 - 5,695,566 (-)NCBI
RefSeq Acc Id: XP_008972074   ⟸   XM_008973826
- Peptide Label: isoform X1
- UniProtKB: A0A2R8Z8I0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008972077   ⟸   XM_008973829
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008972075   ⟸   XM_008973827
- Peptide Label: isoform X1
- UniProtKB: A0A2R8Z8I0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003820430   ⟸   XM_003820382
- Peptide Label: isoform X1
- UniProtKB: A0A2R8Z8I0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034790962   ⟸   XM_034935071
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034790961   ⟸   XM_034935070
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000001144   ⟸   ENSPPAT00000005361
RefSeq Acc Id: XP_054951185   ⟸   XM_055095210
- Peptide Label: isoform X1
- UniProtKB: A0A2R8Z8I0 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000004813 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000005361.1 UniProtKB/TrEMBL
InterPro Na/ntran_symport UniProtKB/TrEMBL
  Na/ntran_symport_betaine UniProtKB/TrEMBL
  SNS_sf UniProtKB/TrEMBL
KEGG Report pps:100980438 UniProtKB/TrEMBL
NCBI Gene SLC6A12 ENTREZGENE
PANTHER PTHR11616 UniProtKB/TrEMBL
  SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER UniProtKB/TrEMBL
Pfam SNF UniProtKB/TrEMBL
PRINTS BETTRANSPORT UniProtKB/TrEMBL
  NANEUSMPORT UniProtKB/TrEMBL
PROSITE NA_NEUROTRAN_SYMP_1 UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_2 UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF161070 UniProtKB/TrEMBL
UniProt A0A2R8Z8I0 ENTREZGENE, UniProtKB/TrEMBL