PDGFRA (platelet derived growth factor receptor alpha) - Rat Genome Database

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Gene: PDGFRA (platelet derived growth factor receptor alpha) Pan paniscus
Analyze
Symbol: PDGFRA
Name: platelet derived growth factor receptor alpha
RGD ID: 11838483
Description: ENCODES a protein that exhibits phosphatidylinositol 3-kinase binding (ortholog); platelet-derived growth factor alpha-receptor activity (ortholog); INVOLVED IN adrenal gland development (ortholog); anatomical structure morphogenesis (ortholog); animal organ morphogenesis (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); Brain Injuries (ortholog); brain stem glioma (ortholog); FOUND IN axon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: platelet-derived growth factor receptor alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2375,493,805 - 75,564,589 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1475,697,777 - 75,768,556 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0469,639,081 - 69,709,870 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1476,200,871 - 76,271,105 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl476,199,382 - 76,271,097 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
B-lymphoblastic leukemia/lymphoma  (ISO)
Brain Injuries  (ISO)
brain stem glioma  (ISO)
breast carcinoma  (ISO)
Chronic Allograft Nephropathy  (ISO)
chronic ulcer of skin  (ISO)
cleft palate  (ISO)
colon carcinoma  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation type IIk  (ISO)
congestive heart failure  (ISO)
Craniofacial Abnormalities  (ISO)
craniopharyngioma  (ISO)
Diabetic Nephropathies  (ISO)
Endometrioid Carcinomas  (ISO)
Eosinophilia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fetal Death  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypereosinophilic syndrome  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
in situ carcinoma  (ISO)
isolated cleft palate  (ISO)
Kidney Reperfusion Injury  (ISO)
leukemia  (ISO)
Leydig cell tumor  (ISO)
lung disease  (ISO)
lung sarcomatoid carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
mesenchymal chondrosarcoma  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Polyps and Recurrent Inflammatory Fibroid, Gastrointestinal  (ISO)
myeloid leukemia  (ISO)
myeloid sarcoma  (ISO)
myeloproliferative neoplasm  (ISO)
Neointima  (ISO)
oligohydramnios  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
Pdgfra-Associated Chronic Eosinophilic Leukemia  (ISO)
prostate adenocarcinoma  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
Respiratory System Abnormalities  (ISO)
sciatic neuropathy  (ISO)
scimitar syndrome  (ISO)
seminoma  (ISO)
spina bifida  (ISO)
Stroke  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
Uterine Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEA,ISO)
anatomical structure morphogenesis  (IEA,ISO)
animal organ morphogenesis  (IEA,ISO)
cardiac myofibril assembly  (IEA)
cell chemotaxis  (IEA)
cell migration  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to growth factor stimulus  (IEA)
cellular response to interleukin-1  (ISO)
cellular response to reactive oxygen species  (IEA,ISO)
chemotaxis  (IEA)
embryonic cranial skeleton morphogenesis  (IEA)
embryonic digestive tract morphogenesis  (IEA)
estrogen metabolic process  (IEA,ISO)
extracellular matrix organization  (IEA,ISO)
face morphogenesis  (IEA,ISO)
female gonad development  (IEA,ISO)
hematopoietic progenitor cell differentiation  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
inner ear development  (ISO)
Leydig cell differentiation  (IEA,ISO)
lung development  (IEA,ISO)
lung growth  (ISO)
luteinization  (IEA,ISO)
male genitalia development  (IEA,ISO)
male gonad development  (ISO)
metanephric glomerular capillary formation  (IEA)
negative regulation of platelet activation  (IEA)
odontogenesis of dentin-containing tooth  (IEA,ISO)
platelet aggregation  (IEA)
platelet-derived growth factor receptor signaling pathway  (IEA,ISO)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
positive regulation of branching involved in lung morphogenesis  (ISO)
positive regulation of calcium-mediated signaling  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway  (IEA)
positive regulation of chemotaxis  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
regulation of mesenchymal stem cell differentiation  (IEA)
response to cytokine  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to formaldehyde  (ISO)
response to hormone  (ISO)
response to hyperoxia  (ISO)
response to inorganic substance  (ISO)
response to organic substance  (ISO)
retina vasculature development in camera-type eye  (IEA)
roof of mouth development  (IEA,ISO)
signal transduction involved in regulation of gene expression  (IEA,ISO)
skeletal system morphogenesis  (IEA,ISO)
white fat cell differentiation  (IEA,ISO)
wound healing  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PDGFRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2375,493,805 - 75,564,589 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1475,697,777 - 75,768,556 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0469,639,081 - 69,709,870 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1476,200,871 - 76,271,105 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl476,199,382 - 76,271,097 (-)Ensemblpanpan1.1panPan2
PDGFRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38454,229,293 - 54,298,245 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl454,229,280 - 54,298,245 (+)EnsemblGRCh38hg38GRCh38
GRCh37455,095,460 - 55,164,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36454,790,204 - 54,859,169 (+)NCBINCBI36Build 36hg18NCBI36
Build 34454,936,129 - 55,005,339NCBI
Celera452,596,023 - 52,665,170 (+)NCBICelera
Cytogenetic Map4q12NCBI
HuRef451,043,324 - 51,112,555 (+)NCBIHuRef
CHM1_1455,130,846 - 55,199,987 (+)NCBICHM1_1
T2T-CHM13v2.0457,718,046 - 57,786,996 (+)NCBIT2T-CHM13v2.0
Pdgfra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39575,311,988 - 75,358,867 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl575,312,953 - 75,358,876 (+)EnsemblGRCm39 Ensembl
GRCm38575,151,322 - 75,198,206 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl575,152,292 - 75,198,215 (+)EnsemblGRCm38mm10GRCm38
MGSCv37575,548,316 - 75,594,229 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36575,434,045 - 75,479,893 (+)NCBIMGSCv36mm8
Celera572,441,591 - 72,487,596 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map539.55NCBI
Pdgfra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81433,360,027 - 33,408,604 (-)NCBIGRCr8
mRatBN7.21433,005,838 - 33,054,347 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1433,005,839 - 33,054,335 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1433,356,581 - 33,405,000 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01434,664,393 - 34,712,811 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01433,149,650 - 33,198,062 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01435,527,926 - 35,581,130 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1435,527,927 - 35,581,031 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01435,356,434 - 35,409,311 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41435,369,422 - 35,418,126 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11435,369,672 - 35,418,126 (-)NCBI
Celera1432,273,077 - 32,324,887 (-)NCBICelera
RH 3.4 Map14432.47RGD
Cytogenetic Map14p11NCBI
Pdgfra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544716,569,909 - 16,612,373 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544716,570,652 - 16,613,410 (-)NCBIChiLan1.0ChiLan1.0
PDGFRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11346,729,722 - 46,775,828 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1346,730,703 - 46,773,278 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1346,687,151 - 46,733,378 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01347,339,954 - 47,386,179 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1347,340,084 - 47,386,176 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11347,012,519 - 47,058,684 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01346,544,815 - 46,590,877 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01347,418,193 - 47,464,247 (+)NCBIUU_Cfam_GSD_1.0
Pdgfra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528529,444,794 - 29,494,171 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648216,807,569 - 16,853,587 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648216,804,129 - 16,853,539 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDGFRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl840,967,493 - 41,021,441 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1840,966,568 - 41,021,440 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2843,067,784 - 43,081,654 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDGFRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1714,243,291 - 14,307,373 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl714,241,070 - 14,307,422 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606615,086,695 - 15,149,115 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdgfra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476115,225,356 - 15,269,810 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476115,223,789 - 15,269,685 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000040423   ⟹   ENSPPAP00000017712
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl476,199,382 - 76,241,545 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000040427   ⟹   ENSPPAP00000017716
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl476,200,871 - 76,271,097 (-)Ensembl
RefSeq Acc Id: XM_003806461   ⟹   XP_003806509
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2375,493,805 - 75,564,589 (-)NCBI
NHGRI_mPanPan1475,697,777 - 75,768,556 (-)NCBI
Mhudiblu_PPA_v0469,639,081 - 69,709,870 (-)NCBI
PanPan1.1476,200,871 - 76,271,105 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008954166   ⟹   XP_008952414
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2375,493,805 - 75,560,094 (-)NCBI
NHGRI_mPanPan1475,697,777 - 75,764,271 (-)NCBI
Mhudiblu_PPA_v0469,639,081 - 69,705,326 (-)NCBI
PanPan1.1476,200,871 - 76,266,242 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008954172   ⟹   XP_008952420
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2375,493,805 - 75,561,532 (-)NCBI
NHGRI_mPanPan1475,697,777 - 75,764,620 (-)NCBI
Mhudiblu_PPA_v0469,639,081 - 69,705,944 (-)NCBI
PanPan1.1476,200,871 - 76,267,116 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034958806   ⟹   XP_034814697
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2375,493,805 - 75,561,716 (-)NCBI
NHGRI_mPanPan1475,697,777 - 75,765,689 (-)NCBI
Mhudiblu_PPA_v0469,639,081 - 69,706,997 (-)NCBI
RefSeq Acc Id: XM_063603819   ⟹   XP_063459889
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2375,493,805 - 75,563,807 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003806509   ⟸   XM_003806461
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008952420   ⟸   XM_008954172
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008952414   ⟸   XM_008954166
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034814697   ⟸   XM_034958806
- Peptide Label: isoform X1
RefSeq Acc Id: ENSPPAP00000017712   ⟸   ENSPPAT00000040423
RefSeq Acc Id: ENSPPAP00000017716   ⟸   ENSPPAT00000040427
RefSeq Acc Id: XP_063459889   ⟸   XM_063603819
- Peptide Label: isoform X1
Protein Domains
Ig-like   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031952 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000040423.1 UniProtKB/TrEMBL
  ENSPPAT00000040427.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PDGFRA UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_rcpt_3_CS UniProtKB/TrEMBL
KEGG Report pps:100982337 UniProtKB/TrEMBL
NCBI Gene PDGFRA ENTREZGENE
PANTHER PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PIRSF Alpha-PDGF_receptor UniProtKB/TrEMBL
  TyrPK_CSF1-R UniProtKB/TrEMBL
PRINTS VEGFRECEPTOR UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_III UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9AK21_PANPA UniProtKB/TrEMBL