MAP2K6 (mitogen-activated protein kinase kinase 6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: MAP2K6 (mitogen-activated protein kinase kinase 6) Pan paniscus
Analyze
Symbol: MAP2K6
Name: mitogen-activated protein kinase kinase 6
RGD ID: 11759110
Description: ENCODES a protein that exhibits identical protein binding (ortholog); MAP kinase kinase activity (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); cellular response to sorbitol (ortholog); MAPK cascade (ortholog); PARTICIPATES IN adenosine signaling pathway; cardiomyopathy pathway; FasL mediated signaling pathway; ASSOCIATED WITH allergic disease (ortholog); Animal Mammary Neoplasms (ortholog); Brain Death (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity mitogen-activated protein kinase kinase 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21985,434,352 - 85,573,837 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11790,255,171 - 90,400,452 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01763,342,720 - 63,483,926 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11768,730,011 - 68,870,713 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1768,730,011 - 68,870,454 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
nucleoplasm  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MAP2K6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21985,434,352 - 85,573,837 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11790,255,171 - 90,400,452 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01763,342,720 - 63,483,926 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11768,730,011 - 68,870,713 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1768,730,011 - 68,870,454 (+)Ensemblpanpan1.1panPan2
MAP2K6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381769,414,697 - 69,553,865 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1769,414,697 - 69,553,865 (+)EnsemblGRCh38hg38GRCh38
GRCh371767,410,838 - 67,550,006 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361764,922,433 - 65,050,065 (+)NCBINCBI36Build 36hg18NCBI36
Build 341765,010,164 - 65,051,067NCBI
Celera1763,982,421 - 64,110,030 (+)NCBICelera
Cytogenetic Map17q24.3NCBI
HuRef1762,796,464 - 62,924,594 (+)NCBIHuRef
CHM1_11767,475,265 - 67,603,400 (+)NCBICHM1_1
T2T-CHM13v2.01770,291,653 - 70,430,810 (+)NCBIT2T-CHM13v2.0
Map2k6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911110,289,928 - 110,416,348 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11110,289,948 - 110,416,348 (+)EnsemblGRCm39 Ensembl
GRCm3811110,399,102 - 110,525,522 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11110,399,122 - 110,525,522 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711110,260,436 - 110,374,951 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611110,215,212 - 110,329,727 (+)NCBIMGSCv36mm8
Celera11122,139,172 - 122,253,133 (+)NCBICelera
Cytogenetic Map11E1- E2NCBI
cM Map1173.6NCBI
Map2k6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81095,872,747 - 95,987,747 (+)NCBIGRCr8
mRatBN7.21095,373,304 - 95,490,406 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1095,373,204 - 95,488,293 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10100,429,713 - 100,544,144 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01099,892,740 - 100,007,172 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01095,301,015 - 95,415,445 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01098,707,160 - 98,823,054 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1098,706,960 - 98,823,287 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01098,413,927 - 98,527,709 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41099,859,684 - 99,974,446 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11099,873,953 - 99,989,003 (+)NCBI
Celera1094,024,106 - 94,137,678 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Map2k6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554783,331,607 - 3,448,842 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554783,331,607 - 3,448,840 (-)NCBIChiLan1.0ChiLan1.0
MAP2K6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1915,840,714 - 15,962,400 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl915,840,983 - 15,952,026 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha916,731,937 - 16,853,765 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0917,501,891 - 17,623,440 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl917,501,897 - 17,614,738 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1916,445,924 - 16,567,352 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0910,966,413 - 11,088,091 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0910,965,262 - 11,086,973 (-)NCBIUU_Cfam_GSD_1.0
MAP2K6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1210,894,966 - 11,018,641 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11210,891,445 - 11,018,617 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21211,145,143 - 11,264,150 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11652,045,398 - 52,188,416 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1652,057,784 - 52,187,997 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607722,937,949 - 23,081,340 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248704,287,835 - 4,416,559 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248704,224,108 - 4,420,217 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000051567   ⟹   ENSPPAP00000028719
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1768,730,011 - 68,861,551 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000051601   ⟹   ENSPPAP00000028753
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1768,818,819 - 68,861,551 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000051611   ⟹   ENSPPAP00000028763
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1768,821,985 - 68,858,607 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000051624   ⟹   ENSPPAP00000028776
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1768,836,845 - 68,870,454 (+)Ensembl
RefSeq Acc Id: XM_003808944   ⟹   XP_003808992
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21985,434,352 - 85,573,837 (+)NCBI
NHGRI_mPanPan11790,255,171 - 90,400,452 (+)NCBI
Mhudiblu_PPA_v01763,342,720 - 63,483,926 (+)NCBI
PanPan1.11768,730,011 - 68,861,551 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008961092   ⟹   XP_008959340
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21985,472,041 - 85,573,837 (+)NCBI
NHGRI_mPanPan11790,292,881 - 90,400,452 (+)NCBI
Mhudiblu_PPA_v01763,380,155 - 63,472,386 (+)NCBI
PanPan1.11768,767,064 - 68,861,551 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008961093   ⟹   XP_008959341
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21985,523,022 - 85,573,837 (+)NCBI
NHGRI_mPanPan11790,343,941 - 90,400,452 (+)NCBI
Mhudiblu_PPA_v01763,431,256 - 63,472,386 (+)NCBI
PanPan1.11768,818,708 - 68,861,551 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008961094   ⟹   XP_008959342
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21985,524,161 - 85,573,837 (+)NCBI
NHGRI_mPanPan11790,344,914 - 90,400,452 (+)NCBI
Mhudiblu_PPA_v01763,431,256 - 63,483,926 (+)NCBI
PanPan1.11768,818,774 - 68,870,713 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003808992   ⟸   XM_003808944
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BGH1 (UniProtKB/TrEMBL),   A0A2R9BHH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008959340   ⟸   XM_008961092
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BHH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008959341   ⟸   XM_008961093
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BHG8 (UniProtKB/TrEMBL),   A0A2R9BHH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008959342   ⟸   XM_008961094
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BHG8 (UniProtKB/TrEMBL),   A0A2R9BHH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000028719   ⟸   ENSPPAT00000051567
RefSeq Acc Id: ENSPPAP00000028763   ⟸   ENSPPAT00000051611
RefSeq Acc Id: ENSPPAP00000028776   ⟸   ENSPPAT00000051624
RefSeq Acc Id: ENSPPAP00000028753   ⟸   ENSPPAT00000051601
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037391 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000051567.1 UniProtKB/TrEMBL
  ENSPPAT00000051601.1 UniProtKB/TrEMBL
  ENSPPAT00000051611.1 UniProtKB/TrEMBL
  ENSPPAT00000051624.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report pps:100972424 UniProtKB/TrEMBL
NCBI Gene MAP2K6 ENTREZGENE
PANTHER DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED UniProtKB/TrEMBL
  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PIRSF Integrin-linked_kinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9BGH1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BHG8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BHH8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BQ61_PANPA UniProtKB/TrEMBL