HTT (huntingtin) - Rat Genome Database

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Pathways
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Gene: HTT (huntingtin) Pan paniscus
Analyze
Symbol: HTT
Name: huntingtin
RGD ID: 11748327
Description: ENCODES a protein that exhibits diazepam binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN anatomical structure morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); associative learning (ortholog); PARTICIPATES IN Huntington's disease pathway; ASSOCIATED WITH Cadmium Poisoning (ortholog); cerebral palsy (ortholog); cherubism (ortholog); FOUND IN axon (ortholog); clathrin-coated vesicle (ortholog); cytoplasmic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v233,375,839 - 3,582,435 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan143,344,543 - 3,515,858 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v043,215,081 - 3,388,587 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.143,116,810 - 3,287,644 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl43,128,718 - 3,283,730 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure morphogenesis  (ISO)
anterior/posterior pattern specification  (ISO)
associative learning  (ISO)
axo-dendritic transport  (ISO)
brain development  (ISO)
cellular senescence  (ISO)
central nervous system development  (ISO)
citrulline metabolic process  (ISO)
determination of adult lifespan  (ISO)
dopamine receptor signaling pathway  (ISO)
endoplasmic reticulum organization  (ISO)
endoplasmic reticulum to Golgi vesicle-mediated transport  (ISO)
endosomal transport  (ISO)
establishment of mitotic spindle orientation  (IEA)
gastrulation  (ISO)
Golgi organization  (IEA)
grooming behavior  (ISO)
hormone metabolic process  (ISO)
insulin secretion  (ISO)
lactate biosynthetic process from pyruvate  (ISO)
learning  (ISO)
learning or memory  (ISO)
locomotory behavior  (ISO)
microtubule depolymerization  (ISO)
microtubule-based transport  (IEA)
mitochondrial transport  (ISO)
mitochondrion organization  (ISO)
mRNA transport  (ISO)
multicellular organismal-level iron ion homeostasis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cysteine-type endopeptidase activity  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA)
neural plate formation  (ISO)
neurogenesis  (ISO)
neuron development  (ISO)
olfactory lobe development  (ISO)
paraxial mesoderm formation  (ISO)
peptide hormone secretion  (ISO)
positive regulation of aggrephagy  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of cilium assembly  (IEA,ISO)
positive regulation of lipophagy  (IEA)
positive regulation of mitophagy  (IEA)
positive regulation of motile cilium assembly  (ISO)
positive regulation of non-motile cilium assembly  (ISO)
postsynapse to nucleus signaling pathway  (ISO)
protein destabilization  (IEA)
protein localization to centrosome  (ISO)
protein localization to nucleus  (ISO)
quinolinate biosynthetic process  (ISO)
regulation of CAMKK-AMPK signaling cascade  (IEA)
regulation of gene expression  (ISO)
regulation of intracellular mRNA localization  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of protein localization to nucleus  (ISO)
regulation of synaptic plasticity  (ISO)
response to calcium ion  (ISO)
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  (IEA)
social behavior  (ISO)
spermatogenesis  (ISO)
striatum development  (ISO)
urea cycle  (ISO)
vesicle transport along microtubule  (IEA,ISO)
visual learning  (ISO)
vocal learning  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HTT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v233,375,839 - 3,582,435 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan143,344,543 - 3,515,858 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v043,215,081 - 3,388,587 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.143,116,810 - 3,287,644 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl43,128,718 - 3,283,730 (+)Ensemblpanpan1.1panPan2
HTT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3843,074,681 - 3,243,960 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl43,041,363 - 3,243,957 (+)EnsemblGRCh38hg38GRCh38
GRCh3743,076,408 - 3,245,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3643,046,206 - 3,215,485 (+)NCBINCBI36Build 36hg18NCBI36
Build 3443,113,411 - 3,282,656NCBI
Celera42,987,658 - 3,157,211 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef43,014,819 - 3,184,168 (+)NCBIHuRef
CHM1_143,074,471 - 3,243,442 (+)NCBICHM1_1
T2T-CHM13v2.043,073,408 - 3,242,718 (+)NCBIT2T-CHM13v2.0
Htt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,919,084 - 35,069,878 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,919,084 - 35,069,878 (+)EnsemblGRCm39 Ensembl
GRCm38534,761,721 - 34,912,534 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,761,740 - 34,912,534 (+)EnsemblGRCm38mm10GRCm38
MGSCv37535,104,389 - 35,252,045 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36535,078,597 - 35,226,253 (+)NCBIMGSCv36mm8
Celera532,235,862 - 32,383,257 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.92NCBI
Htt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81480,070,456 - 80,219,668 (-)NCBIGRCr8
mRatBN7.21475,845,836 - 75,996,094 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,845,836 - 75,995,070 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,298,810 - 80,447,778 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,539,465 - 81,688,433 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,984,701 - 78,133,668 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01481,105,139 - 81,254,637 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,105,139 - 81,254,637 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,793,632 - 81,942,093 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,490,322 - 81,636,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,492,926 - 81,639,072 (-)NCBI
Celera1474,771,910 - 74,919,669 (-)NCBICelera
Cytogenetic Map14q21NCBI
Htt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,906,502 - 2,038,889 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,906,189 - 2,042,357 (+)NCBIChiLan1.0ChiLan1.0
HTT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1361,076,934 - 61,221,462 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl361,079,904 - 61,330,290 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha363,660,661 - 63,805,148 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0361,552,532 - 61,697,091 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl361,555,965 - 61,697,087 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1361,044,140 - 61,188,581 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0361,248,468 - 61,393,186 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0361,608,204 - 61,752,888 (-)NCBIUU_Cfam_GSD_1.0
LOC101966195
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528566,741,409 - 66,966,567 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647720,599,635 - 20,668,265 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_00493647720,443,113 - 20,577,071 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647720,443,101 - 20,577,167 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,809,785 - 1,934,024 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,809,768 - 1,934,002 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,461,795 - 1,586,182 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8pNCBI
HTT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12745,493,467 - 45,657,690 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2745,497,352 - 45,657,621 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660511,852,227 - 1,977,171 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,603,490 - 24,729,333 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475524,602,955 - 24,729,584 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000034384   ⟹   ENSPPAP00000011723
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl43,128,718 - 3,283,730 (+)Ensembl
RefSeq Acc Id: XM_003812979   ⟹   XP_003813027
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v233,408,588 - 3,582,435 (+)NCBI
NHGRI_mPanPan143,344,543 - 3,515,858 (+)NCBI
Mhudiblu_PPA_v043,215,081 - 3,388,587 (+)NCBI
PanPan1.143,116,810 - 3,287,644 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063603488   ⟹   XP_063459558
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v233,375,839 - 3,582,435 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003813027 (Get FASTA)   NCBI Sequence Viewer  
  XP_063459558 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000011723.1
Reference Protein Sequences
RefSeq Acc Id: XP_003813027   ⟸   XM_003812979
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSPPAP00000011723   ⟸   ENSPPAT00000034384
RefSeq Acc Id: XP_063459558   ⟸   XM_063603488
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029038 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000034384.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Htt_bridge UniProtKB/TrEMBL
  Htt_C-HEAT_rpt UniProtKB/TrEMBL
  Htt_N_HEAT_rpt-1 UniProtKB/TrEMBL
  Huntingtin UniProtKB/TrEMBL
  Huntingtin_fam UniProtKB/TrEMBL
  Huntingtin_middle-repeat UniProtKB/TrEMBL
NCBI Gene HTT ENTREZGENE
PANTHER HUNTINGTIN UniProtKB/TrEMBL
  PTHR10170 UniProtKB/TrEMBL
Pfam DUF3652 UniProtKB/TrEMBL
  Htt_bridge UniProtKB/TrEMBL
  Htt_C-HEAT UniProtKB/TrEMBL
  Htt_N-HEAT_1 UniProtKB/TrEMBL
PRINTS HUNTINGTIN UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A2R9A365_PANPA UniProtKB/TrEMBL