MAS1 (MAS1 proto-oncogene, G protein-coupled receptor)

Gene: MAS1 (MAS1 proto-oncogene, G protein-coupled receptor) Pan paniscus

Analyze

Symbol:

MAS1

Name:

MAS1 proto-oncogene, G protein-coupled receptor

RGD ID:

11744585

Description:

ENCODES a protein that exhibits angiotensin receptor activity (inferred); G protein-coupled receptor activity (inferred); peptide binding (inferred); INVOLVED IN cellular response to peptide hormone stimulus (ortholog); G protein-coupled receptor signaling pathway (ortholog); hippocampus development (ortholog); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; ASSOCIATED WITH 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ortholog); Alveolar Bone Loss (ortholog); chronic kidney disease (ortholog); FOUND IN cell surface (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

MAS1 oncogene; proto-oncogene Mas

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	179,989,640 - 180,015,684 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	177,894,549 - 177,920,364 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	157,774,098 - 157,799,983 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	162,785,263 - 162,802,530 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	162,801,416 - 162,802,393 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ISO)

Alveolar Bone Loss (ISO)

chronic kidney disease (ISO)

congestive heart failure (ISO)

dilated cardiomyopathy (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

glaucoma (ISO)

hypertension (ISO)

Prenatal Exposure Delayed Effects (ISO)

primary biliary cholangitis (ISO)

thrombosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiotensin-activated signaling pathway (IEA)

cellular response to peptide hormone stimulus (ISO)

G protein-coupled receptor signaling pathway (IEA,ISO)

hippocampus development (ISO)

male gonad development (ISO)

negative regulation of protein phosphorylation (ISO)

positive regulation of canonical NF-kappaB signal transduction (IEA,ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of DNA replication (ISO)

positive regulation of inositol phosphate biosynthetic process (ISO)

protein kinase C signaling (IEA)

regulation of inflammatory response (IEA,ISO)

response to activity (ISO)

response to gonadotropin (ISO)

response to peptide hormone (ISO)

response to xenobiotic stimulus (ISO)

signal transduction (IEA)

spermatogenesis (ISO)

Cellular Component

cell surface (ISO)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

angiotensin receptor activity (IEA)

G protein-coupled receptor activity (IEA)

peptide binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

angiotensin (1-7) signaling pathway (ISO)

renin-angiotensin cascade pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

MAS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	179,989,640 - 180,015,684 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	177,894,549 - 177,920,364 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	157,774,098 - 157,799,983 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	162,785,263 - 162,802,530 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	162,801,416 - 162,802,393 (+)	Ensembl	panpan1.1		panPan2

MAS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	159,888,787 - 159,917,447 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	159,890,988 - 159,917,447 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	160,312,020 - 160,338,479 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	160,247,964 - 160,249,098 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	160,298,384 - 160,299,519	NCBI
Celera	6	160,974,252 - 160,975,386 (+)	NCBI		Celera
Cytogenetic Map	6	q25.3	NCBI
HuRef	6	157,798,119 - 157,799,253 (+)	NCBI		HuRef
CHM1_1	6	160,590,238 - 160,591,372 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	161,134,461 - 161,165,992 (+)	NCBI		T2T-CHM13v2.0

Mas1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	13,056,981 - 13,087,037 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	13,059,966 - 13,087,030 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	12,838,841 - 12,868,150 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	12,841,079 - 12,868,143 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	13,033,871 - 13,061,009 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	12,684,009 - 12,711,075 (-)	NCBI		MGSCv36	mm8
Celera	17	12,872,985 - 12,900,041 (-)	NCBI		Celera
Cytogenetic Map	17	A1	NCBI
cM Map	17	8.69	NCBI

Mas1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	50,428,064 - 50,459,537 (+)	NCBI		GRCr8
mRatBN7.2	1	47,879,956 - 47,911,500 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	47,880,309 - 47,911,709 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	48,571,963 - 48,603,158 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	54,557,771 - 54,588,840 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	48,647,488 - 48,678,679 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	48,076,761 - 48,108,218 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	48,077,033 - 48,108,216 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	51,644,462 - 51,675,365 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	42,154,786 - 42,185,750 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	42,157,730 - 42,188,693 (+)	NCBI
Celera	1	43,680,754 - 43,711,122 (+)	NCBI		Celera
RH 3.4 Map	1	544.2	RGD
Cytogenetic Map	1	q11	NCBI

Mas1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	20,956,862 - 20,957,839 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955439	20,956,862 - 20,957,839 (-)	NCBI	ChiLan1.0	ChiLan1.0

MAS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	49,090,041 - 49,105,244 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	49,090,041 - 49,105,244 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	49,931,512 - 49,946,711 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	49,272,721 - 49,299,228 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	49,274,155 - 49,289,356 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	49,156,624 - 49,171,810 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	49,028,114 - 49,043,315 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	49,643,019 - 49,658,218 (+)	NCBI		UU_Cfam_GSD_1.0

MAS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	7,527,861 - 7,528,838 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	7,527,566 - 7,542,110 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	9,326,523 - 9,339,701 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	87,520,860 - 87,523,523 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	87,521,947 - 87,523,098 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	59,898,097 - 59,920,293 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mas1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624855	2,969,444 - 2,970,421 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624855	2,968,111 - 3,008,728 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003807398	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034963190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034963191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_004672243	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000003844 ⟹ ENSPPAP00000000822

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	6	162,801,416 - 162,802,393 (+)	Ensembl

RefSeq Acc Id:

XM_003807398 ⟹ XP_003807446

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	179,989,640 - 180,015,684 (+)	NCBI
NHGRI_mPanPan1	6	177,894,549 - 177,920,364 (+)	NCBI
Mhudiblu_PPA_v0	6	157,774,098 - 157,799,983 (+)	NCBI
PanPan1.1	6	162,785,263 - 162,802,530 (+)	NCBI

Sequence:

show sequence

GGGACCGGAGACCCTGCAGGCTGGCTGGGCATTGATGCCCCAGATGTGAAGGGGCAGCCAACCT
GTTGGCCACGTCTGACCCTTCCTGAGCAAATGACACCAACATCCCTTTTGTGAGAAGAAAGAGA
GGAGGGAAGATGCTCTGTGATGCTGCCAGTAATGCTGACCAGTCGTGGTGCTGTCACCTCCTTG
GCTGTCTTTGCAATCTGTTCCCAACTGAGGTTTCCGTTGCAGTGTAATTGACCACTCCAGAGGC
CACTGAGGGCTGTCAGGATGAGCTATCCTTCCACCCTAGGCTGTCACTGCCAGAAAATTACCTG
AAGAGTTCCAGCCTGAGGCCTCCTCATGGATGGGTCAAACGTGACATCATTTGTTGTTGAGGAA
CCCACGAACATCTCAACTGGCAGGAACGCCTCAGTCGGGAATGCACATCGGCAAATCCCCATCG
TGCACTGGGTCATTATGAGCATCTCCCCAGTGGGCTTTGTTGAGAATGGGATTCTCCTCTGGTT
CCTGTGCTTCCGGATGAGAAGAAATCCCTTCACTGTCTACATCACCCACCTATCTATCGCAGAC
ATCTCACTGCTCTTCTGTATTTTCATCTTGTCTATCGACTATGCTTTAGATTATGAGCTTTCTT
CTGGCCATTACTACACAATTGTCACATTATCAGTGACTTTTCTGTTTGGCTACAACACGGGCCT
CTATCTGCTGACGGCCATTAGTGTGGAGAGGTGCCTGTCAGTCCTTTACCCCATCTGGTACCGA
TGCCATCGCCCCAAGTACCAGTCGGCATTGGTCTGTGCCCTTCTGTGGGCTCTTTCTTGCTTGG
TGACCACCATGGAGTATGTCATGTGCATCGACAGAGAAGAAGAGAGTCACTCTCGGAGTGACTG
CCGGGCAGTCATCATCTTTATAGCCATCCTGAGCTTCCTGGTCTTCACACCCCTCATGCTGGTG
TCCAGCACCATCTTGGTCATGAAGATCCGGAAGAACACGTGGGCTTCCCATTCCTCCAAGCTTT
ACATAGTCATCATGGTCACCATCATTATATTCCTCATCTTCGCTATGCCCATGAGACTCCTTTA
CCTGCTGTACTATGAGTATTGGTCGACCTTTGGGAACCTACACCACATTTCCCTGCTCTTCTCC
ACAATCAACAGTAGCGCCAACCCTTTCATTTACTTCTTTGTGGGAAGCAGTAAGAAGAAGAGAT
TCAAGGAGTCCTTAAAAGTTGTTCTGACCAGGGCTTTCAAAGATGAAATGCAACCTCGGCGCCA
GGAAGACAATTGTAATACGGTCACAGTTGAGACTGTCGTCTAAGAACTGTGAGGGAAGTTGTGG
ATAAAAATGGTGGAGCACAGGTCATTTTTAGTTTGTGCTTGGAATATGACTTAAGTATCTCCTA
AATGTGATACAGAAGGACATCTCATCCCATATGCATGAGATACTAATTAATG

hide sequence

RefSeq Acc Id:

XM_034963190 ⟹ XP_034819081

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	179,989,640 - 180,015,684 (+)	NCBI
NHGRI_mPanPan1	6	177,894,549 - 177,920,364 (+)	NCBI
Mhudiblu_PPA_v0	6	157,774,098 - 157,796,635 (+)	NCBI

RefSeq Acc Id:

XR_004672243

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	179,989,640 - 180,001,734 (+)	NCBI
NHGRI_mPanPan1	6	177,894,549 - 177,906,957 (+)	NCBI
Mhudiblu_PPA_v0	6	157,774,098 - 157,786,016 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003807446	(Get FASTA)	NCBI Sequence Viewer
	XP_034819081	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000000822
	ENSPPAP00000000822.1

RefSeq Acc Id:

XP_003807446 ⟸ XM_003807398

- UniProtKB:

A0A2R8Z7J2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISPVGFVENGILLWFLCFRMRRN
PFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISV
ERCLSVLYPIWYRCHRPKYQSALVCALLWALSCLVTTMEYVMCIDREEESHSRSDCRAVIIFIA
ILSFLVFTPLMLVSSTILVMKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYYEYWS
TFGNLHHISLLFSTINSSANPFIYFFVGSSKKKRFKESLKVVLTRAFKDEMQPRRQEDNCNTVT
VETVV

hide sequence

RefSeq Acc Id:	XP_034819081 ⟸ XM_034963190
- UniProtKB:	A0A2R8Z7J2 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSPPAP00000000822 ⟸ ENSPPAT00000003844

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000003542	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000003844.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	MRGPCRFAMILY	UniProtKB/TrEMBL
	Proto-oncogene_Mas	UniProtKB/TrEMBL
KEGG Report	pps:100992694	UniProtKB/TrEMBL
NCBI Gene	MAS1	ENTREZGENE
PANTHER	MAS-RELATED G-PROTEIN COUPLED RECEPTOR MRG-RELATED	UniProtKB/TrEMBL
	PTHR11334	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	MASONCOGENE	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A2R8Z7J2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations