CLCN6 (chloride voltage-gated channel 6) - Rat Genome Database

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Gene: CLCN6 (chloride voltage-gated channel 6) Pan paniscus
Analyze
Symbol: CLCN6
Name: chloride voltage-gated channel 6
RGD ID: 11737930
Description: ENCODES a protein that exhibits ATP binding (inferred); chloride transmembrane transporter activity (inferred); voltage-gated chloride channel activity (inferred); INVOLVED IN response to mechanical stimulus (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); Childhood-onset Neurodegeneration with Hypotonia, Respiratory Insufficiency and Brain Imaging Abnormalities (ortholog); chromosome 1p36 deletion syndrome (ortholog); FOUND IN intracellular membrane-bounded organelle (inferred); lysosomal membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: chloride transport protein 6; H(+)/Cl(-) exchange transporter 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,380,834 - 216,418,073 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,026,384 - 215,063,498 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,568,222 - 10,605,459 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,785,643 - 11,822,505 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,785,643 - 11,822,505 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CLCN6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,380,834 - 216,418,073 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,026,384 - 215,063,498 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,568,222 - 10,605,459 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,785,643 - 11,822,505 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,785,643 - 11,822,505 (+)Ensemblpanpan1.1panPan2
CLCN6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,806,191 - 11,843,130 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,806,096 - 11,848,079 (+)EnsemblGRCh38hg38GRCh38
GRCh37111,866,248 - 11,903,187 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,788,794 - 11,825,788 (+)NCBINCBI36Build 36hg18NCBI36
Celera110,979,829 - 11,016,824 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,021,210 - 11,058,258 (+)NCBIHuRef
CHM1_1111,854,047 - 11,891,095 (+)NCBICHM1_1
T2T-CHM13v2.0111,350,275 - 11,387,211 (+)NCBIT2T-CHM13v2.0
Clcn6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,088,716 - 148,123,270 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,088,716 - 148,123,278 (-)EnsemblGRCm39 Ensembl
GRCm384148,004,259 - 148,038,813 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,004,259 - 148,038,821 (-)EnsemblGRCm38mm10GRCm38
MGSCv374147,380,593 - 147,412,876 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364146,850,284 - 146,882,567 (-)NCBIMGSCv36mm8
Celera4150,272,852 - 150,305,364 (-)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.67NCBI
Clcn6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,715,593 - 163,748,301 (-)NCBIGRCr8
mRatBN7.25158,434,299 - 158,465,174 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,434,299 - 158,465,059 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,151,048 - 161,181,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05162,978,934 - 163,010,217 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05162,935,283 - 162,966,566 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,811,815 - 164,844,554 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,811,816 - 164,844,586 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,469,718 - 168,502,323 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,079,773 - 165,110,594 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,090,327 - 165,120,752 (-)NCBI
Celera5156,716,141 - 156,746,803 (-)NCBICelera
Cytogenetic Map5q36NCBI
Clcn6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,064,916 - 2,096,317 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,066,317 - 2,096,317 (-)NCBIChiLan1.0ChiLan1.0
CLCN6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,410,740 - 84,443,874 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,413,612 - 84,445,033 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,943,970 - 80,978,766 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,075,630 - 85,110,501 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,075,631 - 85,108,811 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,824,232 - 81,859,027 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,824,152 - 82,858,937 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,886,934 - 83,921,795 (-)NCBIUU_Cfam_GSD_1.0
Clcn6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,813,213 - 34,844,601 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474637,978 - 669,833 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474637,930 - 669,383 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCN6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,881,972 - 71,916,029 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,881,912 - 71,915,016 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,791,512 - 65,825,675 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLCN6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,948,442 - 119,987,553 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,948,448 - 119,987,419 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,816,466 - 23,855,604 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clcn6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,151,981 - 1,184,616 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,151,981 - 1,184,648 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000049185   ⟹   ENSPPAP00000026352
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,785,643 - 11,822,505 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000049207   ⟹   ENSPPAP00000026374
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,785,810 - 11,819,586 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000049212   ⟹   ENSPPAP00000026379
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,785,810 - 11,818,349 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000049215   ⟹   ENSPPAP00000026382
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,785,810 - 11,813,368 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000049219   ⟹   ENSPPAP00000026386
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,785,810 - 11,799,826 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000049223   ⟹   ENSPPAP00000026390
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,812,935 - 11,817,772 (+)Ensembl
RefSeq Acc Id: XM_003822067   ⟹   XP_003822115
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21216,380,834 - 216,418,073 (-)NCBI
NHGRI_mPanPan11215,026,384 - 215,063,498 (-)NCBI
Mhudiblu_PPA_v0110,568,222 - 10,605,459 (+)NCBI
PanPan1.1111,785,643 - 11,822,505 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004670405
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21216,385,525 - 216,418,073 (-)NCBI
NHGRI_mPanPan11215,031,076 - 215,063,498 (-)NCBI
Mhudiblu_PPA_v0110,568,222 - 10,601,360 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003822115 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000026352.1
  ENSPPAP00000026374.1
  ENSPPAP00000026379.1
  ENSPPAP00000026382.1
  ENSPPAP00000026386.1
  ENSPPAP00000026390.1
Reference Protein Sequences
RefSeq Acc Id: XP_003822115   ⟸   XM_003822067
- Sequence:
RefSeq Acc Id: ENSPPAP00000026352   ⟸   ENSPPAT00000049185
RefSeq Acc Id: ENSPPAP00000026374   ⟸   ENSPPAT00000049207
RefSeq Acc Id: ENSPPAP00000026386   ⟸   ENSPPAT00000049219
RefSeq Acc Id: ENSPPAP00000026382   ⟸   ENSPPAT00000049215
RefSeq Acc Id: ENSPPAP00000026379   ⟸   ENSPPAT00000049212
RefSeq Acc Id: ENSPPAP00000026390   ⟸   ENSPPAT00000049223
Protein Domains
CBS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036215 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000049185.1 UniProtKB/TrEMBL
  ENSPPAT00000049207.1 UniProtKB/TrEMBL
  ENSPPAT00000049212.1 UniProtKB/TrEMBL
  ENSPPAT00000049215.1 UniProtKB/TrEMBL
  ENSPPAT00000049219.1 UniProtKB/TrEMBL
  ENSPPAT00000049223.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.580.10 UniProtKB/TrEMBL
  Clc chloride channel UniProtKB/TrEMBL
InterPro CBS_dom UniProtKB/TrEMBL
  CBS_dom_sf UniProtKB/TrEMBL
  Cl-channel_core UniProtKB/TrEMBL
  Cl-channel_volt-gated UniProtKB/TrEMBL
  Cl_channel-6 UniProtKB/TrEMBL
KEGG Report pps:100975125 UniProtKB/TrEMBL
NCBI Gene CLCN6 ENTREZGENE
PANTHER CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER UniProtKB/TrEMBL
  H(+)_CL(-) EXCHANGE TRANSPORTER 6 UniProtKB/TrEMBL
Pfam CBS UniProtKB/TrEMBL
  Voltage_CLC UniProtKB/TrEMBL
PRINTS CLCHANNEL UniProtKB/TrEMBL
  CLCHANNEL6 UniProtKB/TrEMBL
PROSITE CBS UniProtKB/TrEMBL
SMART CBS UniProtKB/TrEMBL
Superfamily-SCOP SSF54631 UniProtKB/TrEMBL
  SSF81340 UniProtKB/TrEMBL
UniProt A0A2R9B9V4_PANPA UniProtKB/TrEMBL
  A0A2R9B9V8_PANPA UniProtKB/TrEMBL
  A0A2R9BB90_PANPA UniProtKB/TrEMBL
  A0A2R9BBA9_PANPA UniProtKB/TrEMBL
  A0A2R9BDL5_PANPA UniProtKB/TrEMBL
  A0A2R9BHM3_PANPA UniProtKB/TrEMBL