NEU4 (neuraminidase 4) - Rat Genome Database

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Gene: NEU4 (neuraminidase 4) Pan paniscus
Analyze
Symbol: NEU4
Name: neuraminidase 4
RGD ID: 11725225
Description: ENCODES a protein that exhibits exo-alpha-(2->3)-sialidase activity (inferred); exo-alpha-(2->6)-sialidase activity (inferred); exo-alpha-(2->8)-sialidase activity (inferred); INVOLVED IN negative regulation of neuron projection development (ortholog); ASSOCIATED WITH Bethlem Myopathy 1A (ortholog); chromosome 2q37 deletion syndrome (ortholog); D-2-hydroxyglutaric aciduria 1 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); lysosome (ortholog); mitochondrial inner membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100968718; sialidase-4
RGD Orthologs
Human
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213144,517,325 - 144,526,774 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B144,532,652 - 144,541,671 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012130,824,179 - 130,833,287 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NEU4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213144,517,325 - 144,526,774 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B144,532,652 - 144,541,671 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012130,824,179 - 130,833,287 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NEU4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,809,193 - 241,817,413 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,809,065 - 241,817,413 (+)EnsemblGRCh38hg38GRCh38
GRCh372242,750,288 - 242,758,739 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362242,400,746 - 242,407,407 (+)NCBINCBI36Build 36hg18NCBI36
Build 342242,472,062 - 242,478,724NCBI
Celera2236,415,462 - 236,423,972 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2234,501,226 - 234,509,785 (+)NCBIHuRef
CHM1_12242,756,215 - 242,764,748 (+)NCBICHM1_1
T2T-CHM13v2.02242,310,986 - 242,319,206 (+)NCBIT2T-CHM13v2.0


Expression


Sequence


RefSeq Acc Id: XM_003804455   ⟹   XP_003804503
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213144,519,588 - 144,526,774 (+)NCBI
NHGRI_mPanPan12B144,534,487 - 144,541,671 (+)NCBI
Mhudiblu_PPA_v012130,826,073 - 130,833,287 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008960072   ⟹   XP_008958320
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213144,519,589 - 144,526,774 (+)NCBI
NHGRI_mPanPan12B144,534,488 - 144,541,671 (+)NCBI
Mhudiblu_PPA_v012130,826,073 - 130,833,287 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008960076   ⟹   XP_008958324
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213144,517,325 - 144,526,774 (+)NCBI
NHGRI_mPanPan12B144,532,657 - 144,541,671 (+)NCBI
Mhudiblu_PPA_v012130,824,179 - 130,833,287 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034934966   ⟹   XP_034790857
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213144,519,588 - 144,526,774 (+)NCBI
NHGRI_mPanPan12B144,534,488 - 144,541,671 (+)NCBI
Mhudiblu_PPA_v012130,826,073 - 130,833,287 (+)NCBI
RefSeq Acc Id: XM_034934967   ⟹   XP_034790858
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213144,519,588 - 144,526,774 (+)NCBI
NHGRI_mPanPan12B144,534,488 - 144,541,671 (+)NCBI
Mhudiblu_PPA_v012130,826,073 - 130,833,287 (+)NCBI
RefSeq Acc Id: XM_034934969   ⟹   XP_034790860
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213144,519,588 - 144,526,774 (+)NCBI
NHGRI_mPanPan12B144,534,488 - 144,541,671 (+)NCBI
Mhudiblu_PPA_v012130,826,073 - 130,833,287 (+)NCBI
RefSeq Acc Id: XM_034934971   ⟹   XP_034790862
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213144,517,325 - 144,526,774 (+)NCBI
NHGRI_mPanPan12B144,532,652 - 144,541,671 (+)NCBI
Mhudiblu_PPA_v012130,824,179 - 130,833,287 (+)NCBI
RefSeq Acc Id: XM_034934972   ⟹   XP_034790863
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213144,523,664 - 144,526,774 (+)NCBI
NHGRI_mPanPan12B144,538,575 - 144,541,671 (+)NCBI
Mhudiblu_PPA_v012130,830,133 - 130,833,287 (+)NCBI
RefSeq Acc Id: XP_008958324   ⟸   XM_008960076
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_034790862   ⟸   XM_034934971
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034790857   ⟸   XM_034934966
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034790860   ⟸   XM_034934969
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034790858   ⟸   XM_034934967
- Peptide Label: isoform X3
RefSeq Acc Id: XP_003804503   ⟸   XM_003804455
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008958320   ⟸   XM_008960072
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034790863   ⟸   XM_034934972
- Peptide Label: isoform X4
Protein Domains
Sialidase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000000043 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000000043.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.10 UniProtKB/TrEMBL
InterPro Sialidase UniProtKB/TrEMBL
  Sialidase_fam UniProtKB/TrEMBL
  Sialidase_sf UniProtKB/TrEMBL
KEGG Report pps:100968718 UniProtKB/TrEMBL
NCBI Gene NEU4 ENTREZGENE
PANTHER PTHR10628 UniProtKB/TrEMBL
  PTHR10628:SF22 UniProtKB/TrEMBL
Pfam BNR_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF50939 UniProtKB/TrEMBL
UniProt A0A2R8Z5M6_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-25 NEU4  neuraminidase 4  LOC100968718  sialidase-4  Symbol and/or name change 5135510 APPROVED
2020-07-01 LOC100968718  sialidase-4  NEU4  neuraminidase 4  Symbol and/or name change 5135510 APPROVED