SOX10 (SRY-box transcription factor 10) - Rat Genome Database

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Gene: SOX10 (SRY-box transcription factor 10) Pan paniscus
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Symbol: SOX10
Name: SRY-box transcription factor 10
RGD ID: 11722784
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN cell differentiation (ortholog); cell maturation (ortholog); cellular response to progesterone stimulus (ortholog); ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); Anosmia (ortholog); Charcot-Marie-Tooth disease (ortholog); FOUND IN chromatin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SRY-box 10; transcription factor SOX-10
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22347,828,983 - 47,841,204 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12250,517,348 - 50,529,603 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02218,885,679 - 18,897,927 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12236,712,128 - 36,724,192 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2236,713,310 - 36,723,439 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IEA,ISO)
cell maturation  (IEA,ISO)
cellular response to progesterone stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
central nervous system myelination  (IEA)
developmental growth  (IEA,ISO)
developmental process  (IEA)
digestive tract morphogenesis  (IEA,ISO)
enteric nervous system development  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
lacrimal gland development  (IEA,ISO)
melanocyte differentiation  (IEA,ISO)
morphogenesis of a branching epithelium  (IEA,ISO)
morphogenesis of an epithelium  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of Schwann cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
neural crest cell migration  (IEA)
neuroblast proliferation  (IEA,ISO)
oligodendrocyte development  (IEA)
oligodendrocyte differentiation  (IEA,ISO)
peripheral nervous system development  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of gliogenesis  (IEA)
positive regulation of myelination  (ISO)
positive regulation of neuroblast proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of DNA-templated transcription  (ISO)
stem cell differentiation  (ISO)
transcription by RNA polymerase II  (IEA,ISO)
transcription elongation by RNA polymerase II  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SOX10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22347,828,983 - 47,841,204 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12250,517,348 - 50,529,603 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02218,885,679 - 18,897,927 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12236,712,128 - 36,724,192 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2236,713,310 - 36,723,439 (-)Ensemblpanpan1.1panPan2
SOX10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,972,312 - 37,984,555 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,970,686 - 37,987,422 (-)EnsemblGRCh38hg38GRCh38
GRCh372238,368,319 - 38,380,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,698,265 - 36,710,485 (-)NCBINCBI36Build 36hg18NCBI36
Build 342236,692,819 - 36,705,039NCBI
Celera2222,170,048 - 22,182,268 (-)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2221,334,376 - 21,346,534 (-)NCBIHuRef
CHM1_12238,327,060 - 38,339,280 (-)NCBICHM1_1
T2T-CHM13v2.02238,433,934 - 38,446,177 (-)NCBIT2T-CHM13v2.0
Sox10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,039,113 - 79,048,690 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,039,108 - 79,049,440 (-)EnsemblGRCm39 Ensembl
GRCm381579,154,913 - 79,164,490 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,154,908 - 79,165,240 (-)EnsemblGRCm38mm10GRCm38
MGSCv371578,985,343 - 78,994,920 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361578,982,168 - 78,992,495 (-)NCBIMGSCv36mm8
Celera1581,267,600 - 81,277,195 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.7NCBI
Sox10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87112,605,721 - 112,615,097 (-)NCBIGRCr8
mRatBN7.27110,725,274 - 110,734,651 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,725,274 - 110,735,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7112,473,920 - 112,483,178 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,697,448 - 114,706,706 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,666,769 - 114,676,030 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,393,238 - 120,403,523 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,393,254 - 120,403,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,387,071 - 120,397,340 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47117,138,694 - 117,149,939 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17117,172,923 - 117,184,169 (-)NCBI
Celera7107,059,767 - 107,070,023 (-)NCBICelera
RH 3.4 Map7839.3RGD
Cytogenetic Map7q34NCBI
Sox10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541324,311,783 - 24,323,315 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541324,313,311 - 24,323,112 (-)NCBIChiLan1.0ChiLan1.0
SOX10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11026,680,441 - 26,690,530 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1026,681,122 - 26,689,882 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1026,635,515 - 26,646,171 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01027,472,272 - 27,482,931 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1027,472,118 - 27,482,924 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,192,256 - 27,202,906 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01027,503,817 - 27,514,467 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01027,681,016 - 27,691,677 (+)NCBIUU_Cfam_GSD_1.0
Sox10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,163,344 - 10,174,369 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,173,741 - 3,185,024 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364923,173,770 - 3,183,423 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOX10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl59,891,525 - 9,901,743 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.159,890,439 - 9,901,746 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.257,289,992 - 7,299,054 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOX10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11920,673,053 - 20,685,506 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045105,090,681 - 105,103,173 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sox10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247529,965,756 - 9,973,777 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247529,965,015 - 9,976,244 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014343299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSPPAT00000032993   ⟹   ENSPPAP00000010343
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2236,713,310 - 36,723,439 (-)Ensembl
RefSeq Acc Id: XM_014343299   ⟹   XP_014198785
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22347,828,983 - 47,841,204 (-)NCBI
NHGRI_mPanPan12250,517,348 - 50,529,603 (-)NCBI
Mhudiblu_PPA_v02218,885,679 - 18,897,927 (-)NCBI
PanPan1.12236,712,128 - 36,724,192 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_014198785 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000010343.1
RefSeq Acc Id: XP_014198785   ⟸   XM_014343299
- Sequence:
RefSeq Acc Id: ENSPPAP00000010343   ⟸   ENSPPAT00000032993
Protein Domains
HMG box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028389 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032993.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
InterPro HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  Sox_N UniProtKB/TrEMBL
KEGG Report pps:100970122 UniProtKB/TrEMBL
NCBI Gene SOX10 ENTREZGENE
PANTHER SOX100B UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR SOX-10 UniProtKB/TrEMBL
Pfam HMG_box UniProtKB/TrEMBL
  Sox_N UniProtKB/TrEMBL
PROSITE HMG_BOX_2 UniProtKB/TrEMBL
SMART HMG UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/TrEMBL
UniProt A0A2R9A0H5_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-18 SOX10  SRY-box transcription factor 10  SOX10  SRY-box 10  Symbol and/or name change 5135510 APPROVED