HNF4A (hepatocyte nuclear factor 4 alpha) - Rat Genome Database

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Pathways
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Gene: HNF4A (hepatocyte nuclear factor 4 alpha) Pan paniscus
Analyze
Symbol: HNF4A
Name: hepatocyte nuclear factor 4 alpha
RGD ID: 11712253
Description: ENCODES a protein that exhibits arachidonic acid binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); fatty acid binding (ortholog); INVOLVED IN acyl-CoA metabolic process (ortholog); cell differentiation (ortholog); cell-cell junction organization (ortholog); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; ASSOCIATED WITH Congenital Hyperinsulinism (ortholog); diabetes mellitus (ortholog); Diabetic Nephropathies (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hepatocyte nuclear factor 4-alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,086,788 - 50,166,233 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,079,892 - 50,159,336 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02040,684,450 - 40,763,824 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12041,823,939 - 41,856,536 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2041,779,034 - 41,856,536 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acyl-CoA metabolic process  (ISO)
blood coagulation  (IEA)
cell differentiation  (IEA,ISO)
cell-cell junction organization  (ISO)
cellular response to hypoxia  (ISO)
cholesterol homeostasis  (IEA)
establishment of tissue polarity  (ISO)
glucose homeostasis  (IEA)
hepatocyte differentiation  (ISO)
intracellular receptor signaling pathway  (IEA)
lipid homeostasis  (IEA)
lipid metabolic process  (IEA,ISO)
negative regulation of activation of Janus kinase activity  (ISO)
negative regulation of cell growth  (IEA)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of protein import into nucleus  (ISO)
negative regulation of tyrosine phosphorylation of STAT protein  (ISO)
ornithine metabolic process  (IEA)
phospholipid homeostasis  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of circadian rhythm  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of gastrulation  (IEA,ISO)
regulation of insulin secretion  (IEA)
regulation of lipid metabolic process  (IEA)
regulation of microvillus assembly  (ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to cAMP  (ISO)
response to dexamethasone  (ISO)
response to glucose  (IEA,ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to trichostatin A  (ISO)
response to xenobiotic stimulus  (ISO)
sex differentiation  (IEA,ISO)
signal transduction involved in regulation of gene expression  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
triglyceride homeostasis  (IEA)
xenobiotic metabolic process  (IEA)

Cellular Component
cytoplasm  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HNF4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,086,788 - 50,166,233 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,079,892 - 50,159,336 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02040,684,450 - 40,763,824 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12041,823,939 - 41,856,536 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2041,779,034 - 41,856,536 (+)Ensemblpanpan1.1panPan2
HNF4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382044,355,699 - 44,434,596 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2044,355,699 - 44,432,845 (+)EnsemblGRCh38hg38GRCh38
GRCh372042,984,339 - 43,063,236 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362042,417,855 - 42,493,444 (+)NCBINCBI36Build 36hg18NCBI36
Build 342042,463,337 - 42,486,690NCBI
Celera2039,693,092 - 39,768,681 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2039,720,990 - 39,802,805 (+)NCBIHuRef
CHM1_12042,886,684 - 42,964,390 (+)NCBICHM1_1
T2T-CHM13v2.02046,090,439 - 46,170,188 (+)NCBIT2T-CHM13v2.0
Hnf4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392163,348,731 - 163,414,827 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2163,348,728 - 163,414,830 (+)EnsemblGRCm39 Ensembl
GRCm382163,506,811 - 163,572,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2163,506,808 - 163,572,910 (+)EnsemblGRCm38mm10GRCm38
MGSCv372163,372,924 - 163,398,643 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362163,238,629 - 163,264,348 (+)NCBIMGSCv36mm8
Celera2169,490,574 - 169,516,277 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.32NCBI
Hnf4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83172,606,220 - 172,667,758 (+)NCBIGRCr8
mRatBN7.23152,186,787 - 152,248,320 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,186,787 - 152,248,320 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3155,994,276 - 156,055,801 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03164,493,207 - 164,554,741 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,237,152 - 162,298,687 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03159,902,441 - 159,965,003 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3159,902,441 - 159,965,003 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,093,091 - 166,155,667 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43154,459,863 - 154,482,825 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13154,365,898 - 154,388,861 (+)NCBI
Celera3150,839,856 - 150,901,426 (+)NCBICelera
RH 3.4 Map31376.5RGD
Cytogenetic Map3q42NCBI
Hnf4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544512,924,662 - 12,984,281 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544512,925,248 - 12,962,501 (-)NCBIChiLan1.0ChiLan1.0
HNF4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12431,847,864 - 31,908,337 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2431,847,961 - 31,905,916 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2431,489,547 - 31,550,077 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02432,554,576 - 32,615,122 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2432,536,281 - 32,612,159 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12431,817,381 - 31,877,879 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02431,930,338 - 31,991,205 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02432,472,512 - 32,533,044 (+)NCBIUU_Cfam_GSD_1.0
Hnf4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640180,851,597 - 180,905,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365302,401,043 - 2,454,466 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365302,401,053 - 2,425,989 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNF4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1746,783,777 - 46,847,500 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11746,783,772 - 46,847,505 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21752,232,425 - 52,296,703 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HNF4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1219,390,870 - 19,466,300 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl219,388,891 - 19,421,664 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605068,060,334 - 68,135,869 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnf4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479010,038,999 - 10,100,649 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479010,039,344 - 10,065,167 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000052740   ⟹   ENSPPAP00000029887
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2041,779,034 - 41,856,536 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052757   ⟹   ENSPPAP00000029903
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2041,813,319 - 41,853,351 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052766   ⟹   ENSPPAP00000029913
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2041,823,939 - 41,856,536 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052770   ⟹   ENSPPAP00000029916
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2041,826,033 - 41,853,351 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052774   ⟹   ENSPPAP00000029920
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2041,826,597 - 41,853,351 (+)Ensembl
RefSeq Acc Id: XM_034947041   ⟹   XP_034802932
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,086,811 - 50,166,233 (+)NCBI
NHGRI_mPanPan12050,079,915 - 50,159,336 (+)NCBI
Mhudiblu_PPA_v02040,684,450 - 40,762,081 (+)NCBI
RefSeq Acc Id: XM_034947042   ⟹   XP_034802933
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,086,811 - 50,166,233 (+)NCBI
NHGRI_mPanPan12050,079,915 - 50,159,336 (+)NCBI
Mhudiblu_PPA_v02040,684,450 - 40,763,824 (+)NCBI
RefSeq Acc Id: XM_057300799   ⟹   XP_057156782
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,132,435 - 50,166,233 (+)NCBI
NHGRI_mPanPan12050,125,404 - 50,159,336 (+)NCBI
RefSeq Acc Id: XM_057300800   ⟹   XP_057156783
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,121,521 - 50,166,233 (+)NCBI
NHGRI_mPanPan12050,114,624 - 50,159,336 (+)NCBI
RefSeq Acc Id: XM_057300801   ⟹   XP_057156784
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,121,521 - 50,166,233 (+)NCBI
NHGRI_mPanPan12050,114,624 - 50,159,336 (+)NCBI
RefSeq Acc Id: XM_057300802   ⟹   XP_057156785
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,132,435 - 50,166,233 (+)NCBI
NHGRI_mPanPan12050,125,538 - 50,159,336 (+)NCBI
RefSeq Acc Id: XR_008622246
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,121,618 - 50,163,043 (+)NCBI
NHGRI_mPanPan12050,114,624 - 50,156,146 (+)NCBI
RefSeq Acc Id: XR_008622247
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,121,618 - 50,163,043 (+)NCBI
NHGRI_mPanPan12050,114,624 - 50,156,146 (+)NCBI
RefSeq Acc Id: XR_008622248
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,086,788 - 50,163,043 (+)NCBI
NHGRI_mPanPan12050,079,892 - 50,156,146 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034802933   ⟸   XM_034947042
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BJS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034802932   ⟸   XM_034947041
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BN80 (UniProtKB/TrEMBL),   A0A2R9BJS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000029887   ⟸   ENSPPAT00000052740
RefSeq Acc Id: ENSPPAP00000029903   ⟸   ENSPPAT00000052757
RefSeq Acc Id: ENSPPAP00000029913   ⟸   ENSPPAT00000052766
RefSeq Acc Id: ENSPPAP00000029916   ⟸   ENSPPAT00000052770
RefSeq Acc Id: ENSPPAP00000029920   ⟸   ENSPPAT00000052774
RefSeq Acc Id: XP_057156783   ⟸   XM_057300800
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BKI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_057156784   ⟸   XM_057300801
- Peptide Label: isoform X4
RefSeq Acc Id: XP_057156782   ⟸   XM_057300799
- Peptide Label: isoform X6
RefSeq Acc Id: XP_057156785   ⟸   XM_057300802
- Peptide Label: isoform X5
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037962 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000052740.1 UniProtKB/TrEMBL
  ENSPPAT00000052757.1 UniProtKB/TrEMBL
  ENSPPAT00000052766.1 UniProtKB/TrEMBL
  ENSPPAT00000052770.1 UniProtKB/TrEMBL
  ENSPPAT00000052774.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro HNF4-like_DBD UniProtKB/TrEMBL
  HNF4_LBD UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
KEGG Report pps:100977071 UniProtKB/TrEMBL
NCBI Gene HNF4A ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/TrEMBL
  PTHR24083:SF41 UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS COUPTNFACTOR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF48508 UniProtKB/TrEMBL
UniProt A0A2R9BJS2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BKI5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BKJ5_PANPA UniProtKB/TrEMBL
  A0A2R9BN80 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BTL0_PANPA UniProtKB/TrEMBL