ACSM4 (acyl-CoA synthetase medium chain family member 4)

Gene: ACSM4 (acyl-CoA synthetase medium chain family member 4) Pan paniscus

Analyze

Symbol:

ACSM4

Name:

acyl-CoA synthetase medium chain family member 4

RGD ID:

11699731

Description:

ENCODES a protein that exhibits decanoate-CoA ligase activity (ortholog); fatty-acyl-CoA synthase activity (ortholog); INVOLVED IN acyl-CoA metabolic process (ortholog); PARTICIPATES IN fatty acid beta degradation pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 21 (ortholog); genetic disease (ortholog); Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); FOUND IN mitochondrial matrix (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

acyl-CoA synthetase medium-chain family member 4; acyl-coenzyme A synthetase ACSM4, mitochondrial

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	12,883,063 - 12,909,325 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	12,879,822 - 12,906,084 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	7,448,372 - 7,474,634 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	7,613,474 - 7,637,536 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	7,613,474 - 7,637,536 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy 21 (ISO)

genetic disease (ISO)

Hyperphosphatemic Familial Tumoral Calcinosis 1 (ISO)

Klippel-Feil syndrome 3 (ISO)

lymphoproliferative syndrome 2 (ISO)

peroxisome biogenesis disorder 2B (ISO)

Temtamy syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acyl-CoA metabolic process (IEA,ISO)

fatty acid biosynthetic process (IEA)

lipid metabolic process (IEA)

Cellular Component

mitochondrial matrix (IEA)

Molecular Function

acid-thiol ligase activity (IEA)

CoA-ligase activity (IEA)

decanoate-CoA ligase activity (ISO)

fatty acid ligase activity (IEA)

fatty-acyl-CoA synthase activity (IEA,ISO)

ligase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

fatty acid beta degradation pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

ACSM4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	12,883,063 - 12,909,325 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	12,879,822 - 12,906,084 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	7,448,372 - 7,474,634 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	7,613,474 - 7,637,536 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	7,613,474 - 7,637,536 (+)	Ensembl	panpan1.1		panPan2

ACSM4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	7,304,072 - 7,328,719 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	7,304,072 - 7,328,719 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	7,456,668 - 7,481,315 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	7,348,195 - 7,372,236 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	9,032,423 - 9,056,412 (+)	NCBI		Celera
Cytogenetic Map	12	p13.31	NCBI
HuRef	12	7,269,572 - 7,293,615 (+)	NCBI		HuRef
CHM1_1	12	7,455,112 - 7,479,154 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	7,317,413 - 7,342,059 (+)	NCBI		T2T-CHM13v2.0

Acsm4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	119,289,249 - 119,313,789 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	119,289,249 - 119,313,788 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	119,690,026 - 119,714,566 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	119,690,026 - 119,714,565 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	126,833,540 - 126,858,080 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	119,481,239 - 119,505,714 (+)	NCBI		MGSCv36	mm8
Celera	7	119,610,226 - 119,634,756 (+)	NCBI		Celera
Cytogenetic Map	7	F2	NCBI
cM Map	7	64.1	NCBI

Acsm4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	183,485,259 - 183,509,712 (+)	NCBI		GRCr8
mRatBN7.2	1	174,053,931 - 174,078,345 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	174,053,931 - 174,078,341 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	182,369,435 - 182,393,842 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	189,555,471 - 189,579,882 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	182,292,971 - 182,317,825 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	189,432,604 - 189,458,799 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	189,432,604 - 189,457,048 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	196,367,995 - 196,392,443 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	177,972,234 - 177,996,687 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	178,111,479 - 178,135,933 (+)	NCBI
Celera	1	171,803,936 - 171,828,330 (+)	NCBI		Celera
Cytogenetic Map	1	q35	NCBI

Acsm4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955493	6,023 - 31,418 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955493	6,023 - 31,418 (+)	NCBI	ChiLan1.0	ChiLan1.0

LOC479821
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	24,616,607 - 24,639,441 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	24,616,610 - 24,639,255 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	22,705,542 - 22,760,798 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	24,772,496 - 24,827,769 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	6	24,573,420 - 24,628,676 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	24,468,596 - 24,523,839 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	24,852,732 - 24,908,007 (-)	NCBI		UU_Cfam_GSD_1.0

ACSM4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	25,296,206 - 25,327,054 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	25,296,202 - 25,327,054 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	26,080,604 - 26,106,349 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACSM4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	7,319,468 - 7,345,076 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	7,320,091 - 7,344,563 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	864,781 - 890,438 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Acsm4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624782	6,862,648 - 6,885,450 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624782	6,862,210 - 6,885,556 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003811804	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000038844 ⟹ ENSPPAP00000016151

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	12	7,613,474 - 7,637,536 (+)	Ensembl

RefSeq Acc Id:

XM_003811804 ⟹ XP_003811852

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	10	12,883,063 - 12,909,325 (+)	NCBI
NHGRI_mPanPan1	12	12,879,822 - 12,906,084 (+)	NCBI
Mhudiblu_PPA_v0	12	7,448,372 - 7,474,634 (+)	NCBI
PanPan1.1	12	7,613,474 - 7,637,536 (+)	NCBI

Sequence:

show sequence

ATGAAGATTTTTTTCCACTACCAGACATTTAGATTCATCTGGCTCACCAAGCCACCTGGCTGGC
GCTTACACAAAGATCACCAGCTTTGGACGCCTCTGACTCTTGCTGACTTTGAAGCCATAAATCG
CTGTAACAGGCCATTGCCTAAAAACTTTAACTTTGCTGCAGATGTGCTGGACCAGTGGTCCCAA
AAGGAGAAGACAGGGGAGAGACCAGCTAACCCAGCCCTGTGGTGGGTGAATGGCAAAGGGGATG
AGGTAAAATGGAGCTTCAGAGAACTGGGCTCCTTGTCCCGAAAAGCTGCCAACATGCTCACCAA
GCCCTGTGGCCTGCAGAGAGGAGGCCGTGTGGCCGTGATTCTGCCCCGAATCCCTGAGTGGTGG
CTGGTCAACGTAGCTTGCATACGAACAGGGATCATCTTCATGCCGGGAACAATCCAGCTGACAG
CAAAAGACATCCTCTACCGGCTGCGAGCATCCAAGGCCAAGTGCATTGTGGCCAGTGAGGAGGT
GGCCCCAGCGGTGGAGTCCATTGTATTGGAGTGTCCTGACCTTAAGACAAAACTCCTGGTGTCT
CCACAAAGCCGGAATGGGTGGCTCAGCTTCCAGGAGTTATTTCAATTCGCCTCTGAAGAGCACA
GCTGTGTGGAAACAGGAAGTCAAGAACCAATGACCATTTATTTCACCAGCGGGACCACAGGCTT
TCCTAAAATGGCCCAGCACTCTCAGAGCAGCCTCGGCATTGGGTTCACCCTCTGCGGAAGGTAT
TGGCTGGACTTGAAGTCCTCAGATATCATATGGAATATGTCTGACACGGGCTGGGTCAAGGCCG
CCATTGGCAGTGTGTTTTCTTCCTGGCTGTGTGGAGCCTGTGTTTTTGTGCATCGAATGGCACA
GTTTGACACTGACACCTTCCTAGACACACTTACTACTTATCCCATCACGACCCTGTGCAGTCCT
CCCACCGTGTACCGGATGCTCGTGCAAAAAGACCTTAAGAGATATAAATTCAAGAGTCTGCGGC
ACTGCTTGACCGGAGGGGAGCCACTCAACCCAGAAGTGCTGGAGCAGTGGAGGGCGCAAACTGG
GCTGGACCTATATGAGGGCTATGGACAGACGGAAGTGGGAATGATTTGTGCCAATCAGAAAGGC
CAAGAAATTAAACCAGGTTCAATGGGGAAAGGAATGCTGCCCTATGATGTCCAGATTATAGATG
AAAATGGCAATGTTCTACCACCTGGCAAAGAAGGGGAAATTGCCCTCAGACTCAAACCTACACG
GCCCTTCTGTTTCTTCTCTAAATATGTGGACAATCCACAGAAAACTGCTGCCACGATAAGAGGA
GATTTTTATGTCACTGGAGACAGAGGAGTGATGGACAGTGATGGGTATTTCTGGTTTGTCGGCA
GAGCTGATGATGTCATTATATCCTCTGGGTACCGTATTGGGCCATTTGAAGTGGAGAGTGCACT
CATTGAGCATCCGGCAGTTGTTGAATCGGCTGTTGTCAGTAGTCCAGATCAAATCCGCGGAGAG
GTGGTGAAAGCTTTTGTTGTCTTAGCTGCACCCTTTAAGTCCTACAACCCAGAGAAATTAACTC
TTGAACTTCAGGATCATGTGAAAAAATCAACTGCACCTTACAAATATCCAAGAAAGGTGGAATT
TGTTCAAGAACTCCCAAAGACAATCACTGGGAAAATCAAACGCAACGTTTTAAGAGACCAAGAA
TGGAGAGGAAGACAGTTTGATAACAAAGCTGAAGGGTTAAGCAGTAATATGGTTGCTTTCTTTT
AG

hide sequence

Protein Sequences


Protein RefSeqs	XP_003811852	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000016151.1

RefSeq Acc Id:

XP_003811852 ⟸ XM_003811804

- UniProtKB:

A0A2R9AFR0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKIFFHYQTFRFIWLTKPPGWRLHKDHQLWTPLTLADFEAINRCNRPLPKNFNFAADVLDQWSQ
KEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANMLTKPCGLQRGGRVAVILPRIPEWW
LVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASEEVAPAVESIVLECPDLKTKLLVS
PQSRNGWLSFQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRY
WLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQFDTDTFLDTLTTYPITTLCSP
PTVYRMLVQKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRAQTGLDLYEGYGQTEVGMICANQKG
QEIKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRG
DFYVTGDRGVMDSDGYFWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGE
VVKAFVVLAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQE
WRGRQFDNKAEGLSSNMVAFF

hide sequence

RefSeq Acc Id:

ENSPPAP00000016151 ⟸ ENSPPAT00000038844

Protein Domains

AMP-binding enzyme C-terminal AMP-dependent synthetase/ligase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000031185	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000038844.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.300.30	UniProtKB/TrEMBL
	3.40.50.12780	UniProtKB/TrEMBL
InterPro	AMP-bd_C	UniProtKB/TrEMBL
	AMP-bd_C_sf	UniProtKB/TrEMBL
	AMP-binding_CS	UniProtKB/TrEMBL
	AMP-dep_Synth/Lig	UniProtKB/TrEMBL
	ANL_N_sf	UniProtKB/TrEMBL
KEGG Report	pps:100992481	UniProtKB/TrEMBL
NCBI Gene	ACSM4	ENTREZGENE
PANTHER	ACYL-COENZYME A SYNTHETASE	UniProtKB/TrEMBL
	ACYL-COENZYME A SYNTHETASE ACSM4, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	AMP-binding	UniProtKB/TrEMBL
	AMP-binding_C	UniProtKB/TrEMBL
PROSITE	AMP_BINDING	UniProtKB/TrEMBL
Superfamily-SCOP	Acetyl-CoA synthetase-like	UniProtKB/TrEMBL
UniProt	A0A2R9AFR0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-06-20	ACSM4	acyl-CoA synthetase medium chain family member 4		acyl-CoA synthetase medium-chain family member 4	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

RGD Manual Annotations