NOTCH4 (notch receptor 4) - Rat Genome Database

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Gene: NOTCH4 (notch receptor 4) Pan paniscus
Analyze
Symbol: NOTCH4
Name: notch receptor 4
RGD ID: 11681587
Description: ENCODES a protein that exhibits calcium ion binding (inferred); cis-regulatory region sequence-specific DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN branching involved in blood vessel morphogenesis (ortholog); endothelial cell differentiation (ortholog); endothelial cell morphogenesis (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH AIDS-Associated Nephropathy (ortholog); alopecia areata (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytoplasmic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neurogenic locus notch homolog protein 4; notch 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,657,915 - 46,687,084 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,619,989 - 42,648,574 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,842,233 - 31,871,412 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,722,112 - 32,750,978 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,722,112 - 32,750,978 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NOTCH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,657,915 - 46,687,084 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,619,989 - 42,648,574 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,842,233 - 31,871,412 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,722,112 - 32,750,978 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,722,112 - 32,750,978 (-)Ensemblpanpan1.1panPan2
NOTCH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,194,843 - 32,224,067 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,194,843 - 32,224,067 (-)EnsemblGRCh38hg38GRCh38
GRCh37632,162,620 - 32,191,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,270,598 - 32,299,822 (-)NCBINCBI36Build 36hg18NCBI36
Build 34632,270,598 - 32,299,822NCBI
Celera633,729,664 - 33,758,884 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef631,916,815 - 31,946,041 (-)NCBIHuRef
CHM1_1632,165,104 - 32,194,322 (-)NCBICHM1_1
T2T-CHM13v2.0632,048,032 - 32,077,265 (-)NCBIT2T-CHM13v2.0
Notch4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,783,257 - 34,807,517 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,783,242 - 34,807,477 (+)EnsemblGRCm39 Ensembl
GRCm381734,564,286 - 34,588,543 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,564,268 - 34,588,503 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,701,240 - 34,725,488 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,172,386 - 34,196,552 (+)NCBIMGSCv36mm8
Celera1737,659,444 - 37,683,703 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.15NCBI
Notch4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,164,969 - 4,189,072 (-)NCBIGRCr8
mRatBN7.2204,160,362 - 4,184,466 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,160,445 - 4,184,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,867,047 - 4,890,265 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,228,799 - 4,252,017 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,759,694 - 4,786,711 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,329,794 - 4,353,868 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,329,811 - 4,353,785 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,409,125 - 6,433,141 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,263,205 - 4,287,312 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,263,431 - 4,287,539 (-)NCBI
Celera203,846,498 - 3,869,836 (+)NCBICelera
Cytogenetic Map20p12NCBI
Notch4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955437658,076 - 679,338 (-)NCBIChiLan1.0ChiLan1.0
NOTCH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,585,249 - 1,608,721 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,587,918 - 1,607,760 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,720,443 - 1,742,455 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,724,977 - 1,746,984 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1121,587,999 - 1,609,976 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,653,597 - 1,675,505 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,719,919 - 1,741,905 (-)NCBIUU_Cfam_GSD_1.0
Notch4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494636,152,409 - 36,174,550 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367271,386,842 - 1,409,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTCH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,231,293 - 24,256,281 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,231,293 - 24,256,281 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2728,052,185 - 28,077,374 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOTCH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,806,864 - 39,837,101 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1739,808,035 - 39,837,365 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604432,094,646 - 32,124,232 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Notch4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,108,661 - 24,128,053 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000037157   ⟹   ENSPPAP00000014471
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl632,722,112 - 32,750,978 (-)Ensembl
RefSeq Acc Id: XM_003829762   ⟹   XP_003829810
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2546,657,915 - 46,687,084 (-)NCBI
NHGRI_mPanPan1642,619,989 - 42,648,574 (-)NCBI
Mhudiblu_PPA_v0631,842,233 - 31,871,412 (-)NCBI
PanPan1.1632,722,112 - 32,750,978 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008955130   ⟹   XP_008953378
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2546,657,915 - 46,687,074 (-)NCBI
NHGRI_mPanPan1642,619,989 - 42,648,564 (-)NCBI
Mhudiblu_PPA_v0631,842,233 - 31,871,412 (-)NCBI
PanPan1.1632,722,112 - 32,750,978 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003829810 (Get FASTA)   NCBI Sequence Viewer  
  XP_008953378 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000014471.1
Reference Protein Sequences
RefSeq Acc Id: XP_008953378   ⟸   XM_008955130
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003829810   ⟸   XM_003829762
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSPPAP00000014471   ⟸   ENSPPAT00000037157
Protein Domains
EGF-like   LNR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030396 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000037157.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  3.30.300.320 UniProtKB/TrEMBL
  3.30.70.3310 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
  Notch-like_dom_sf UniProtKB/TrEMBL
  Notch_4 UniProtKB/TrEMBL
  Notch_dom UniProtKB/TrEMBL
  Notch_NOD_dom UniProtKB/TrEMBL
  Notch_NODP_dom UniProtKB/TrEMBL
KEGG Report pps:100988436 UniProtKB/TrEMBL
NCBI Gene NOTCH4 ENTREZGENE
PANTHER NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4 UniProtKB/TrEMBL
  NOTCH LIGAND FAMILY MEMBER UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
PIRSF Notch UniProtKB/TrEMBL
PRINTS LNOTCHREPEAT UniProtKB/TrEMBL
  NOTCH UniProtKB/TrEMBL
  NOTCH4 UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LNR UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  SM00004 UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF48403 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  SSF90193 UniProtKB/TrEMBL
UniProt A0A2R9AC37_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-08 NOTCH4  notch receptor 4    notch 4  Symbol and/or name change 5135510 APPROVED