PTGER4 (prostaglandin E receptor 4) - Rat Genome Database

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Gene: PTGER4 (prostaglandin E receptor 4) Pan paniscus
Analyze
Symbol: PTGER4
Name: prostaglandin E receptor 4
RGD ID: 11679912
Description: ENCODES a protein that exhibits prostaglandin E receptor activity (ortholog); INVOLVED IN bone development (ortholog); cellular response to glucose stimulus (ortholog); cellular response to interleukin-1 (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Alzheimer's disease (ortholog); ankylosing spondylitis (ortholog); FOUND IN neuron projection terminus (ortholog); neuronal cell body (ortholog); nuclear membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: prostaglandin E2 receptor EP4 subtype
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2469,643,990 - 69,657,266 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1567,797,598 - 67,810,852 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0569,686,906 - 69,700,739 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1574,731,470 - 74,745,121 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl574,731,470 - 74,745,148 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IEA)
bone development  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to mechanical stimulus  (IEA)
cellular response to prostaglandin E stimulus  (IEA,ISO)
chemokinesis  (ISO)
ductus arteriosus closure  (ISO)
ERK1 and ERK2 cascade  (ISO)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
immune response  (IEA)
inflammatory response  (IEA)
JNK cascade  (ISO)
maternal process involved in parturition  (ISO)
negative regulation of cytokine production  (IEA)
negative regulation of ductus arteriosus closure  (ISO)
negative regulation of endothelin production  (ISO)
negative regulation of eosinophil extravasation  (IEA)
negative regulation of hydrogen peroxide metabolic process  (ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of integrin activation  (IEA)
negative regulation of interleukin-1 alpha production  (ISO)
negative regulation of nitric-oxide synthase biosynthetic process  (ISO)
negative regulation of peptide secretion  (ISO)
negative regulation of small intestine smooth muscle contraction  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
positive regulation of antral ovarian follicle growth  (ISO)
positive regulation of bone resorption  (ISO)
positive regulation of calcitonin secretion  (ISO)
positive regulation of cAMP-mediated signaling  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokinesis  (ISO)
positive regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
positive regulation of cytokine production  (IEA)
positive regulation of cytosolic calcium ion concentration  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of hyaluronan biosynthetic process  (ISO)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of matrix metallopeptidase secretion  (ISO)
positive regulation of mucus secretion  (ISO)
positive regulation of neutrophil extravasation  (ISO)
positive regulation of ossification  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of ovarian follicle development  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of substance P secretion  (ISO)
positive regulation of substance P secretion, neurotransmission  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of urine volume  (ISO)
positive regulation of wound healing  (ISO)
regulation of circadian sleep/wake cycle, wakefulness  (ISO)
regulation of ossification  (IEA,ISO)
regulation of stress fiber assembly  (IEA)
response to amino acid  (ISO)
response to interleukin-1  (ISO)
response to lipopolysaccharide  (IEA,ISO)
response to mechanical stimulus  (IEA)
response to nematode  (IEA,ISO)
response to organic cyclic compound  (ISO)
response to progesterone  (ISO)
response to prostaglandin E  (ISO)
response to salt  (ISO)
response to water-immersion restraint stress  (ISO)
response to xenobiotic stimulus  (ISO)
T-helper cell differentiation  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTGER4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2469,643,990 - 69,657,266 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1567,797,598 - 67,810,852 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0569,686,906 - 69,700,739 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1574,731,470 - 74,745,121 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl574,731,470 - 74,745,148 (-)Ensemblpanpan1.1panPan2
PTGER4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38540,679,915 - 40,746,800 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl540,679,915 - 40,693,735 (+)EnsemblGRCh38hg38GRCh38
GRCh37540,680,017 - 40,693,837 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36540,715,789 - 40,729,594 (+)NCBINCBI36Build 36hg18NCBI36
Build 34540,715,788 - 40,729,592NCBI
Celera540,568,598 - 40,582,403 (+)NCBICelera
Cytogenetic Map5p13.1NCBI
HuRef540,632,020 - 40,645,825 (+)NCBIHuRef
CHM1_1540,681,992 - 40,695,797 (+)NCBICHM1_1
T2T-CHM13v2.0540,936,331 - 41,003,197 (+)NCBIT2T-CHM13v2.0
Ptger4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,262,880 - 5,273,668 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl155,236,142 - 5,273,668 (-)EnsemblGRCm39 Ensembl
GRCm38155,233,399 - 5,244,187 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,206,661 - 5,244,187 (-)EnsemblGRCm38mm10GRCm38
MGSCv37155,183,404 - 5,193,831 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36155,181,080 - 5,191,046 (-)NCBIMGSCv36mm8
Celera155,082,719 - 5,093,146 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map151.99NCBI
Ptger4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8256,061,699 - 56,074,594 (-)NCBIGRCr8
mRatBN7.2254,330,563 - 54,347,451 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl254,335,424 - 54,346,670 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx261,442,386 - 61,453,021 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0259,501,061 - 59,511,697 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0254,511,378 - 54,522,007 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0254,951,625 - 54,966,470 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl254,952,821 - 54,963,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0273,974,390 - 73,987,294 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4254,423,280 - 54,433,907 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1254,351,507 - 54,362,753 (-)NCBI
Celera249,982,896 - 49,993,523 (-)NCBICelera
Cytogenetic Map2q16NCBI
Ptger4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542624,997,811 - 25,010,822 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542624,997,811 - 25,010,822 (+)NCBIChiLan1.0ChiLan1.0
PTGER4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1468,663,362 - 68,676,241 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl468,663,364 - 68,676,358 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha468,339,460 - 68,352,693 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0469,169,559 - 69,182,795 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl469,169,566 - 69,182,795 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1468,929,030 - 68,942,269 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0469,042,114 - 69,055,368 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0469,581,192 - 69,594,491 (-)NCBIUU_Cfam_GSD_1.0
Ptger4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213229,454,672 - 229,468,133 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365181,903,725 - 1,916,746 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365181,903,636 - 1,916,746 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGER4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1625,670,862 - 25,686,552 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11625,670,832 - 25,686,556 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PTGER4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1439,440,697 - 39,453,983 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl439,440,276 - 39,454,004 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607129,862,058 - 29,876,121 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptger4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475914,244,899 - 14,258,445 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475914,243,887 - 14,259,090 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000035527   ⟹   ENSPPAP00000012860
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl574,731,470 - 74,745,148 (-)Ensembl
RefSeq Acc Id: XM_055112421   ⟹   XP_054968396
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2469,643,990 - 69,657,266 (-)NCBI
NHGRI_mPanPan1567,797,619 - 67,810,852 (-)NCBI
RefSeq Acc Id: XM_055112422   ⟹   XP_054968397
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2469,643,990 - 69,657,221 (-)NCBI
NHGRI_mPanPan1567,797,619 - 67,810,852 (-)NCBI
RefSeq Acc Id: XM_055112423   ⟹   XP_054968398
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2469,643,990 - 69,657,262 (-)NCBI
NHGRI_mPanPan1567,797,619 - 67,810,852 (-)NCBI
RefSeq Acc Id: XM_055112424   ⟹   XP_054968399
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2469,643,990 - 69,657,221 (-)NCBI
NHGRI_mPanPan1567,797,598 - 67,810,852 (-)NCBI
Protein Sequences
Protein RefSeqs XP_054968396 (Get FASTA)   NCBI Sequence Viewer  
  XP_054968397 (Get FASTA)   NCBI Sequence Viewer  
  XP_054968398 (Get FASTA)   NCBI Sequence Viewer  
  XP_054968399 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000012860.1
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000012860   ⟸   ENSPPAT00000035527
RefSeq Acc Id: XP_054968399   ⟸   XM_055112424
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054968397   ⟸   XM_055112422
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A7J0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054968396   ⟸   XM_055112421
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054968398   ⟸   XM_055112423
- Peptide Label: isoform X3
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029600 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000035527.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Prost_EP4_rcpt UniProtKB/TrEMBL
  Prostanoid_rcpt UniProtKB/TrEMBL
  Prostglndn_DP_rcpt UniProtKB/TrEMBL
KEGG Report pps:100975287 UniProtKB/TrEMBL
NCBI Gene PTGER4 ENTREZGENE
PANTHER PTHR11866 UniProtKB/TrEMBL
  PTHR11866:SF6 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  PROSTAGLNDNR UniProtKB/TrEMBL
  PROSTANOIDR UniProtKB/TrEMBL
  PRSTNOIDEP4R UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A2R9A7J0 ENTREZGENE, UniProtKB/TrEMBL