Thpol1 (thrombopoietin like 1) - Rat Genome Database

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Pathways
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Gene: Thpol1 (thrombopoietin like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Thpol1
Name: thrombopoietin like 1
RGD ID: 11455920
Description: Predicted to enable cytokine activity and hormone activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; megakaryocyte development; and positive regulation of intracellular signal transduction. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in aplastic anemia; essential thrombocythemia; thrombocytopenia; and thrombocytosis. Orthologous to human THPO (thrombopoietin).
Type: protein-coding
Previously known as: LOC108348162; NEWGENE_621438; Thpo; thrombopoietin
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
UTH_Rnor_SHR_Utx1188,905,624 - 88,910,879 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,559,040 - 81,564,295 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,620,102 - 80,625,357 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01183,867,549 - 83,874,670 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1182,848,853 - 82,852,425 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,868,655 - 83,873,910 (+)EnsemblRnor6.0rn6Rnor6.0
Cytogenetic Map11q23NCBI


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.

Genomics


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 41 41 41 2 5 29 23 8 2
Below cutoff 13 3 3 5 5 45 12 22 7 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000072402   ⟹   ENSRNOP00000067269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,182,820 - 80,188,167 (+)Ensembl
Rnor_6.0 Ensembl1183,868,655 - 83,873,910 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000073743   ⟹   ENSRNOP00000065517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1182,848,853 - 82,852,425 (+)Ensembl
RefSeq Acc Id: XM_008768827   ⟹   XP_008767049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01183,868,608 - 83,874,670 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768828   ⟹   XP_008767050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01183,868,600 - 83,874,670 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768829   ⟹   XP_008767051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01183,867,549 - 83,874,670 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598180   ⟹   XP_017453669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01183,867,549 - 83,874,670 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598181   ⟹   XP_017453670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01183,868,600 - 83,874,670 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008767049 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767050 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767051 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453669 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453670 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067269.2
Reference Protein Sequences
RefSeq Acc Id: XP_017453669   ⟸   XM_017598180
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008767051   ⟸   XM_008768829
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017453670   ⟸   XM_017598181
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008767050   ⟸   XM_008768828
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008767049   ⟸   XM_008768827
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000067269   ⟸   ENSRNOT00000072402
RefSeq Acc Id: ENSRNOP00000065517   ⟸   ENSRNOT00000073743

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698275
Promoter ID:EPDNEW_R8793
Type:initiation region
Name:Thpol1_1
Description:thrombopoietin like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01183,868,614 - 83,868,674EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:11455920 AgrOrtholog
Ensembl Genes ENSRNOG00000046850 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000050172 Ensembl
Ensembl Transcript ENSRNOT00000072402.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  EPO/TPO_CS UniProtKB/TrEMBL
  EPO_TPO UniProtKB/TrEMBL
  Thrombopoietin UniProtKB/TrEMBL
NCBI Gene Thpo ENTREZGENE
PANTHER PTHR10560 UniProtKB/TrEMBL
  THROMBOPOIETIN UniProtKB/TrEMBL
Pfam EPO_TPO UniProtKB/TrEMBL
PhenoGen Thpol1 PhenoGen
PRINTS THROMBOPTN UniProtKB/TrEMBL
PROSITE EPO_TPO UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046850 RatGTEx
  ENSRNOG00000050172 RatGTEx
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt A0A8L2QZ16_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-24 Thpol1  thrombopoietin like 1  NEWGENE_621438  thrombopoietin  Name and Symbol changed 629549 APPROVED