Gene: Nkx2-1 (NK2 homeobox 1)  Mus musculus
Symbol: Nkx2-1
Name: NK2 homeobox 1
Description: ENCODES a protein that exhibits RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; INVOLVED IN anatomical structure formation involved in morphogenesis; axon guidance; brain development; PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH abnormal adrenal cortex morphology; abnormal branching involved in lung morphogenesis; abnormal bronchus epithelium morphology; ASSOCIATED WITH Carcinoma, Endometrioid (ortholog); Chorea (ortholog); Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress (ortholog); FOUND IN nucleus; transcription factor complex; nucleoplasm (ortholog); INTERACTS WITH choline; folic acid; L-methionine
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AV026640; homeobox protein Nkx-2.1; Nkx2.1; T/EBP; thyroid nuclear factor 1; thyroid transcription factor 1; thyroid-specific enhancer-binding protein; tinman; Titf1; Ttf-1
Orthologs: Homo sapiens : NKX2-1 (NK2 homeobox 1)  HGNC
Rattus norvegicus : Nkx2-1 (NK2 homeobox 1)
Latest Assembly: Mouse Genome Assembly Build 37
NCBI Annotation Information: Note: Ttf1 (GeneID 22130) and Nkx2-1 (GeneID 21869) loci share the Ttf1 symbol/alias in common. Ttf1 is a widely used alternative name for thyroid transcription factor 1 (Nkx2-1) conflicting with the official symbol for transcription termination factor, RNA polymerase I (Ttf1). [04 Dec 2012]
Position:
MapChrPositionStrandSource
Mouse Genome Assembly GRCm381256,531,935 - 56,536,908-NCBI
Mouse cM Map1224.42 NCBI
Mouse Celera Assembly1257,681,286 - 57,686,296-NCBI
Mouse Genome Assembly Build 371257,632,922 - 57,637,895-NCBI
Mouse Genome Assembly Build 36.11257,632,945 - 57,637,895-NCBI
Mouse Cytogenetic Map12 C1-C3 NCBI
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QTLs in Region (Mouse Genome Assembly Build 37)

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RGD Object Information
RGD ID: 11420
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2013-04-16
Status: ACTIVE



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