Gene: Dlx5 (distal-less homeobox 5)
Mus musculus
Symbol:
Dlx5
Name:
distal-less homeobox 5
Description:
ENCODES a protein that exhibits DNA binding; HMG box domain binding; transcription regulatory region DNA binding; INVOLVED IN anatomical structure formation involved in morphogenesis; axon guidance; axonogenesis; ASSOCIATED WITH abnormal alisphenoid bone morphology; abnormal axial skeleton morphology; abnormal axon outgrowth; ASSOCIATED WITH SPLIT-HAND/FOOT MALFORMATION 1 WITH SENSORINEURAL HEARING LOSS (ortholog); FOUND IN cytoplasm; nucleus; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 5-azacytidine
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AI385752; homeobox protein DLX-5; OTTMUSP00000023382
Orthologs:
Homo sapiens : DLX5
(distal-less homeobox 5)
HGNC
Rattus norvegicus : Dlx5
(distal-less homeobox 5)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 6 6,877,805 - 6,882,068 - NCBI Mouse cM Map 6 2.83 NCBI Mouse Celera Assembly 6 7,023,868 - 7,028,132 - NCBI Mouse Genome Assembly Build 37 6 6,827,805 - 6,832,068 - NCBI Mouse Genome Assembly Build 36.1 6 6,827,805 - 6,832,068 - NCBI Mouse Cytogenetic Map 6 A1 NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
1,2,4-trimethylbenzene increases expression ISO RGD:2506 6480464 pseudocumene results in increased expression of DLX5 protein CTD PMID:17337753 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of DLX5 mRNA CTD PMID:17555576 17alpha-ethynylestradiol decreases expression ISO RGD:2506 6480464 Ethinyl Estradiol results in decreased expression of DLX5 mRNA CTD PMID:12075121 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DLX5 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of DLX5 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of DLX5 mRNA CTD PMID:16962184 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of DLX5 mRNA CTD PMID:15034205 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of DLX5 mRNA CTD PMID:17586704 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of DLX5 mRNA CTD PMID:17942748 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of DLX5 mRNA CTD PMID:17942748 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of DLX5 mRNA CTD PMID:17942748 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of DLX5 mRNA CTD PMID:20130022 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DLX5 mRNA CTD PMID:17942748 5-azacytidine increases expression EXP 6480464 Azacitidine results in increased expression of DLX5 mRNA CTD PMID:17085970 acetohydrazide decreases expression EXP 6480464 acetylhydrazine results in decreased expression of DLX5 mRNA CTD PMID:15282401 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of DLX5 protein CTD PMID:17551590 all-trans-retinoic acid increases expression ISO RGD:2506 6480464 Tretinoin results in increased expression of DLX5 mRNA CTD PMID:20488242 ammonium chloride affects expression ISO RGD:2506 6480464 Ammonium Chloride affects the expression of DLX5 mRNA CTD PMID:16483693 benzo[a]pyrene decreases expression ISO RGD:2506 6480464 Benzo(a)pyrene results in decreased expression of DLX5 mRNA CTD PMID:21839799 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of DLX5 mRNA CTD PMID:15034205 bisphenol A decreases expression ISO RGD:2506 6480464 bisphenol A results in decreased expression of DLX5 mRNA CTD PMID:12075121 C60 fullerene increases expression ISO RGD:2506 6480464 fullerene C60 results in increased expression of DLX5 mRNA CTD PMID:19167457 carbonyl sulfide increases expression ISO RGD:2506 6480464 carbonyl sulfide results in increased expression of DLX5 mRNA CTD PMID:19395590 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of DLX5 mRNA CTD PMID:17585979 fonofos increases methylation ISO RGD:733723 6480464 Fonofos results in increased methylation of DLX5 promoter CTD PMID:22847954 genistein decreases expression ISO RGD:2506 6480464 Genistein results in decreased expression of DLX5 mRNA CTD PMID:12075121 ketamine decreases expression ISO RGD:2506 6480464 Ketamine results in decreased expression of DLX5 mRNA CTD PMID:20080153 morphine increases expression EXP 6480464 Morphine results in increased expression of DLX5 mRNA CTD PMID:21178816 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of DLX5 mRNA CTD PMID:20036863 parathion increases methylation ISO RGD:733723 6480464 Parathion results in increased methylation of DLX5 promoter CTD PMID:22847954 rosiglitazone decreases expression EXP 6480464 rosiglitazone results in decreased expression of DLX5 mRNA CTD PMID:14500573 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of DLX5 mRNA CTD PMID:17555576 terbufos increases methylation ISO RGD:733723 6480464 terbufos results in increased methylation of DLX5 promoter CTD PMID:22847954 tetrachloromethane decreases expression ISO RGD:2506 6480464 Carbon Tetrachloride results in decreased expression of DLX5 mRNA CTD PMID:16239168 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of DLX5 mRNA CTD PMID:22045034 zinc atom decreases expression ISO RGD:2506 6480464 Zinc deficiency results in decreased expression of DLX5 mRNA CTD PMID:21893222 zinc(0) decreases expression ISO RGD:2506 6480464 Zinc deficiency results in decreased expression of DLX5 mRNA CTD PMID:21893222
Biological Process
anatomical structure formation involved in morphogenesis IGI MGI:MGI:101927 2290270 MGI:MGI:3765253|PMID:17878916 MGI MGI:MGI:3765253 PMID:17878916 axon guidance IMP MGI:MGI:2180475 2290270 MGI:MGI:3722740|PMID:17804636 MGI MGI:MGI:3722740 PMID:17804636 axonogenesis IMP MGI:MGI:1857789 2290270 MGI:MGI:2449888|PMID:12533617 MGI MGI:MGI:2449888 PMID:12533617 bone morphogenesis IMP MGI:MGI:2180474 2290270 MGI:MGI:3611627|PMID:16330189 MGI MGI:MGI:3611627 PMID:16330189 cell proliferation ISO UniProtKB:P56178 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 ear development IMP MGI:MGI:2180474 2290270 MGI:MGI:3611627|PMID:16330189 MGI MGI:MGI:3611627 PMID:16330189 embryonic limb morphogenesis IGI MGI:MGI:101927 2290270 MGI:MGI:2181241|PMID:12112878 MGI MGI:MGI:2181241 PMID:12112878 endochondral ossification IMP 2290270 MGI:MGI:4413604|PMID:19956613 UniProtKB MGI:MGI:4413604 PMID:19956613 epithelial cell differentiation IGI MGI:MGI:101927 2290270 MGI:MGI:3765253|PMID:17878916 MGI MGI:MGI:3765253 PMID:17878916 face morphogenesis IMP MGI:MGI:2180474 2290270 MGI:MGI:3611627|PMID:16330189 MGI MGI:MGI:3611627 PMID:16330189 head development IGI MGI:MGI:101927 2290270 MGI:MGI:3056210|PMID:15306564 MGI MGI:MGI:3056210 PMID:15306564 inner ear morphogenesis IMP MGI:MGI:2180474 2290270 MGI:MGI:2384365|PMID:12142028 MGI MGI:MGI:2384365 PMID:12142028 inner ear morphogenesis IGI MGI:MGI:101927 2290270 MGI:MGI:3689133|PMID:16900517 MGI MGI:MGI:3689133 PMID:16900517 multicellular organismal development IEA UniProtKB-KW:KW-0217 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 olfactory pit development IMP MGI:MGI:1857789 2290270 MGI:MGI:2449888|PMID:12533617 MGI MGI:MGI:2449888 PMID:12533617 ossification IEA UniProtKB-KW:KW-0892 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 osteoblast differentiation IDA 2290270 MGI:MGI:3522068|PMID:15383550 UniProtKB MGI:MGI:3522068 PMID:15383550 palate development IMP MGI:MGI:2180474 2290270 MGI:MGI:3611627|PMID:16330189 MGI MGI:MGI:3611627 PMID:16330189 palate development IGI MGI:MGI:101927|MGI:MGI:99458 2290270 MGI:MGI:3714538|PMID:17420000 MGI MGI:MGI:3714538 PMID:17420000 positive regulation of canonical Wnt receptor signaling pathway IMP MGI:MGI:2180475 2290270 MGI:MGI:3722740|PMID:17804636 MGI MGI:MGI:3722740 PMID:17804636 positive regulation of epithelial cell proliferation IGI MGI:MGI:101927 2290270 MGI:MGI:3689133|PMID:16900517 MGI MGI:MGI:3689133 PMID:16900517 positive regulation of osteoblast differentiation ISO UniProtKB:P50575 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of transcription from RNA polymerase II promoter IGI MGI:MGI:99458 2290270 MGI:MGI:3714538|PMID:17420000 MGI MGI:MGI:3714538 PMID:17420000 positive regulation of transcription, DNA-dependent IDA 2290270 MGI:MGI:3522068|PMID:15383550 UniProtKB MGI:MGI:3522068 PMID:15383550 positive regulation of transcription, DNA-dependent ISO UniProtKB:P56178 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of transcription, DNA-dependent IMP MGI:MGI:2180474 2290270 MGI:MGI:2384365|PMID:12142028 MGI MGI:MGI:2384365 PMID:12142028 regulation of transcription, DNA-dependent IEA InterPro:IPR001356 2290270 MGI:MGI:2152098 GOC MGI:MGI:2152098 transcription, DNA-dependent IEA UniProtKB-KW:KW-0804 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
Cellular Component
cytoplasm IDA 2290270 MGI:MGI:1346965|PMID:10516593 MGI MGI:MGI:1346965 PMID:10516593 nucleus IDA 2290270 MGI:MGI:1346965|PMID:10516593 MGI MGI:MGI:1346965 PMID:10516593 nucleus ISO UniProtKB:P56178 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177
Molecular Function
DNA binding IDA 2290270 MGI:MGI:1100181|PMID:9415433 MGI MGI:MGI:1100181 PMID:9415433 HMG box domain binding IPI UniProtKB:O55170|UniProtKB:Q05066 2290270 MGI:MGI:5284787|PMID:16582099 UniProtKB MGI:MGI:5284787 PMID:16582099 protein binding IPI UniProtKB:Q9QYH6 2290270 MGI:MGI:1930091|PMID:11084035 MGI MGI:MGI:1930091 PMID:11084035 sequence-specific DNA binding IEA InterPro:IPR017970|InterPro:IPR001356 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 sequence-specific DNA binding transcription factor activity IEA InterPro:IPR001356 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 transcription regulatory region DNA binding IDA 2290270 MGI:MGI:3522068|PMID:15383550 UniProtKB MGI:MGI:3522068 PMID:15383550 transcription regulatory region DNA binding ISO UniProtKB:P56178 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 transcription regulatory region sequence-specific DNA binding IEA InterPro:IPR000047 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098
1300731 Smdq3_m segregation of mitochondrial DNA QTL 3 (mouse) Not determined 6 4199207 38199326 Mouse 1357848 Brmth5_m behavioral response to methamphetamines 5 (mouse) Not determined 6 503004 34503097 Mouse 1558761 Nsila5_m novelty/stress induced locomotor activation 5 (mouse) Not determined 6 1 33619037 Mouse 5491191 Mobq2_m multigenic obesity QTL 2 (mouse) Not determined 6 1 32094496 Mouse 1302168 Imgt1_m impaired glucose tolerance 1 (mouse) Not determined 6 1 32094496 Mouse 1301145 Mob2_m multigenic obesity 2 (mouse) Not determined 6 1 32094496 Mouse 1301131 Chol2_m cholesterol 2 (mouse) Not determined 6 1 32094496 Mouse 1302024 Skull7_m skull morphology 7 (mouse) Not determined 6 1 32094496 Mouse 1301178 Lith10_m lithogenic gene 10 (mouse) Not determined 6 1 21415015 Mouse 1357503 Nhdlq5_m non-HDL QTL 5 (mouse) Not determined 6 1 21415015 Mouse 1301326 Trbv4c2_m T cell receptor beta variable 4 (mouse) Not determined 6 1 21415015 Mouse