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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | affects phosphorylation | ISO | RGD:2290 | 6480464 | Catechin affects the phosphorylation of CCKBR protein | CTD | PMID:15134381 | 17beta-estradiol | multiple interactions | ISO | RGD:735565 | 6480464 | ESR1 protein affects the reaction [Estradiol results in increased expression of CCKBR mRNA] | CTD | PMID:15223131 | 17beta-estradiol | increases expression | ISO | RGD:735565 | 6480464 | Estradiol results in increased expression of CCKBR mRNA | CTD | PMID:15223131 | 3',5'-cyclic AMP | multiple interactions | EXP | | 6480464 | CCKBR protein affects the reaction [[quinelorane binds to and results in increased activity of DRD2 protein] which results in decreased abundance of Cyclic AMP] | CTD | PMID:11880531 | ammonium chloride | affects expression | ISO | RGD:2290 | 6480464 | Ammonium Chloride affects the expression of CCKBR mRNA | CTD | PMID:16483693 | amphetamine | affects response to substance | EXP | | 6480464 | CCKBR protein affects the susceptibility to Amphetamine | CTD | PMID:16916582 more ... | amphetamine | affects response to substance | EXP | | 6480464 | CCKBR protein affects the susceptibility to Amphetamine | CTD | PMID:11403953 more ... | amphetamine | affects response to substance | EXP | | 6480464 | CCKBR protein affects the susceptibility to Amphetamine | CTD | PMID:11702094 more ... | amphetamine | affects response to substance | EXP | | 6480464 | CCKBR protein affects the susceptibility to Amphetamine | CTD | PMID:16916582 more ... | amphetamine | affects response to substance | EXP | | 6480464 | CCKBR protein affects the susceptibility to Amphetamine | CTD | PMID:11403953 more ... | apomorphine | affects response to substance | EXP | | 6480464 | CCKBR protein affects the susceptibility to Apomorphine | CTD | PMID:11702094 | bisphenol A | increases expression | ISO | RGD:735565 | 6480464 | bisphenol A results in increased expression of CCKBR mRNA | CTD | PMID:15223131 | bisphenol A | multiple interactions | ISO | RGD:735565 | 6480464 | ESR1 protein affects the reaction [bisphenol A results in increased expression of CCKBR mRNA] | CTD | PMID:15223131 | clozapine | increases expression | EXP | | 6480464 | Clozapine results in increased expression of CCKBR mRNA | CTD | PMID:17266109 | cobalt dichloride | multiple interactions | ISO | RGD:735565 | 6480464 | CCKBR protein promotes the reaction [cobaltous chloride results in increased expression of GAST mRNA] | CTD | PMID:22593272 | cocaine | decreases expression | ISO | RGD:735565 | 6480464 | Cocaine results in decreased expression of CCKBR mRNA | CTD | PMID:18000554 | cocaine | increases response to substance | EXP | | 6480464 | CCKBR protein results in increased susceptibility to Cocaine | CTD | PMID:11403953 | cytarabine | decreases expression | ISO | RGD:735565 | 6480464 | Cytarabine results in decreased expression of CCKBR mRNA | CTD | PMID:21198554 | dexamethasone | decreases expression | ISO | RGD:2290 | 6480464 | Dexamethasone results in decreased expression of CCKBR mRNA | CTD | PMID:20032058 | dexamethasone | multiple interactions | ISO | RGD:2290 | 6480464 | Testosterone inhibits the reaction [Dexamethasone results in decreased expression of CCKBR mRNA] | CTD | PMID:20032058 | dibutyl phthalate | decreases expression | ISO | RGD:2290 | 6480464 | Dibutyl Phthalate results in decreased expression of CCKBR mRNA | CTD | PMID:15620428 | dichlorine | decreases expression | ISO | RGD:2290 | 6480464 | Chlorine results in decreased expression of CCKBR mRNA | CTD | PMID:18636392 | dichlorine | multiple interactions | ISO | RGD:2290 | 6480464 | [Ozone co-treated with Chlorine] results in increased expression of CCKBR mRNA | CTD | PMID:18636392 | dieldrin | increases expression | ISO | RGD:2290 | 6480464 | Dieldrin results in increased expression of CCKBR mRNA | CTD | PMID:20682304 | dioxygen | multiple interactions | ISO | RGD:735565 | 6480464 | CCKBR protein promotes the reaction [Oxygen deficiency results in increased expression of GAST mRNA] | CTD | PMID:22593272 | DPDPE | affects response to substance | EXP | | 6480464 | CCKBR protein affects the susceptibility to Enkephalin, D-Penicillamine (2,5)- | CTD | PMID:11880531 | genistein | increases expression | ISO | RGD:2290 | 6480464 | Genistein results in increased expression of CCKBR mRNA | CTD | PMID:21782745 | morphine | affects response to substance | EXP | | 6480464 | CCKBR protein affects the susceptibility to Morphine | CTD | PMID:11403953 PMID:11880531 | morphine | affects response to substance | EXP | | 6480464 | CCKBR protein affects the susceptibility to Morphine | CTD | PMID:11880531 PMID:11403953 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | RGD:2290 | 6480464 | Ethylnitrosourea results in increased mutagenesis of CCKBR gene | CTD | PMID:16495775 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:2290 | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCKBR mRNA | CTD | PMID:18164116 | omeprazole | multiple interactions | ISO | RGD:735565 | 6480464 | [Omeprazole co-treated with CCKBR protein] results in increased expression of IER3 | CTD | PMID:17704804 | ozone | multiple interactions | ISO | RGD:2290 | 6480464 | [Ozone co-treated with Chlorine] results in increased expression of CCKBR mRNA | CTD | PMID:18636392 | paraquat | decreases expression | ISO | RGD:2290 | 6480464 | Paraquat results in decreased expression of CCKBR mRNA | CTD | PMID:17077588 | perfluorooctane-1-sulfonic acid | increases expression | ISO | RGD:2290 | 6480464 | perfluorooctane sulfonic acid results in increased expression of CCKBR mRNA | CTD | PMID:20136073 | phencyclidine | increases expression | EXP | | 6480464 | Phencyclidine results in increased expression of CCKBR mRNA | CTD | PMID:17266109 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of CCKBR mRNA | CTD | PMID:20813756 | resveratrol | affects phosphorylation | ISO | RGD:2290 | 6480464 | resveratrol affects the phosphorylation of CCKBR protein | CTD | PMID:15134381 | sevoflurane | affects expression | ISO | RGD:2290 | 6480464 | sevoflurane affects the expression of CCKBR mRNA | CTD | PMID:15967596 | sulpiride | affects response to substance | EXP | | 6480464 | CCKBR protein affects the susceptibility to Sulpiride | CTD | PMID:11403953 | testosterone | multiple interactions | ISO | RGD:2290 | 6480464 | Testosterone inhibits the reaction [Dexamethasone results in decreased expression of CCKBR mRNA] | CTD | PMID:20032058 | trans-resveratrol | affects phosphorylation | ISO | RGD:2290 | 6480464 | resveratrol affects the phosphorylation of CCKBR protein | CTD | PMID:15134381 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Calcium signaling pathway |
| Gastric acid secretion | |
| Neuroactive ligand-receptor interaction | |
Phenotype AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Calcium signaling pathway |
| Gastric acid secretion | |
| Neuroactive ligand-receptor interaction | |
Phenotype Annotations
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References - curated| 1. |
Glowacki G, etal., Gene 2001 Sep 19;275(2):267-77. |
| 2. |
Gulpinar MA, etal., Life Sci. 2004 May 21;75(1):77-91. |
| 3. |
Hosing VG, etal., J Neural Transm Suppl 2004;(68):147-56. |
| 4. |
Juarez-Rojop IE, etal., Pain. 2006 May;122(1-2):118-25. Epub 2006 Mar 9. |
| 5. |
Julien S, etal., Diabetes 2004 Jun;53(6):1526-34. |
| 6. |
Mathieu A, etal., Int J Cancer. 2005 May 20;115(1):46-54. |
| 7. |
MGD and Homologene mouse data transfer |
| 8. |
MGD data from the GO Consortium |
| 9. |
MGD IEA |
| 10. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 11. |
Povoski SP, etal., Pancreas. 1993 Sep;8(5):615-21. |
| 12. |
Reubi JC, etal., Gastroenterology. 2003 Jul;125(1):98-106. |
| 13. |
RGD automated import pipeline |
| 14. |
RGD automated import pipeline for gene-chemical interactions |
| 15. |
Xie JY, etal., J Neurosci. 2005 Jan 12;25(2):409-16. |
| 16. |
Zhao XY, etal., World J Gastroenterol. 2005 Jun 14;11(22):3405-10. |
| 17. |
Zhou W, etal., Cancer Res. 1992 Dec 15;52(24):6905-11. |
| 18. |
Zhou W, etal., Carcinogenesis. 1993 Oct;14(10):2189-92. |
References - uncurated| PubMed | 10349636 |
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| 11880531 | |
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| 12946603 | |
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RGD Disease Portals| Cckbr has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Cckbr (Mus musculus) |
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| CCKBR (Homo sapiens) |
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| Cckbr (Rattus norvegicus) |
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Position Markers| Cckbr |
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| Cckbr |
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| Cckbr |
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| Cckbr |
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| Cckbr |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_007627 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01065124 | (Get FASTA) | Search GEO for Microarray Profiles |
| AC125055 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF019371 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF264177 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF264178 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK028325 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK039721 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK053307 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC103530 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC103531 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC103537 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC103538 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466531 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_007627 | |||||||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_031653 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_031653 | (Get FASTA) |
| GenBank Protein | AAB71863 | (Get FASTA) |
| AAG09801 | (Get FASTA) | |
| AAI03531 | (Get FASTA) | |
| AAI03532 | (Get FASTA) | |
| AAI03539 | (Get FASTA) | |
| BAC25881 | (Get FASTA) | |
| BAC30428 | (Get FASTA) | |
| BAC35337 | (Get FASTA) | |
| EDL16771 | (Get FASTA) | |
| P56481 | (Get FASTA) |
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000030898 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000033189 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000033189 | ENTREZGENE |
| Entrez Gene | 12426 | ENTREZGENE |
| Germonline | ENSMUSG00000030898 | |
| HomoloGene Group ID | 7258 | ENTREZGENE |
| InterPro | 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot |
| Cholcskin_rcpt | UniProtKB/Swiss-Prot | |
| Gastrin_rcpt | UniProtKB/Swiss-Prot | |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| KEGG Report | mmu:12426 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:99479 | ENTREZGENE |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| PRINTS | CCYSTOKININR | UniProtKB/Swiss-Prot |
| GASTRINR | UniProtKB/Swiss-Prot | |
| GPCRRHODOPSN | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| UniGene | Mm.44513 | ENTREZGENE |
| UniProt | GASR_MOUSE | UniProtKB/Swiss-Prot |
| Q3ZB46_MOUSE | UniProtKB/TrEMBL | |
| Q3ZB53_MOUSE | UniProtKB/TrEMBL | |
| Q8BKF6_MOUSE | UniProtKB/TrEMBL | |
| Q8BYG7_MOUSE | UniProtKB/TrEMBL |
| More on Cckbr | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 10300 |
| Created: | 2000-05-25 |
| Species: | Mus musculus |
| Last Modified: | 2013-02-27 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.