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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:9986
Term: vinclozolin
Definition: A racemate comprising equimolar amounts of (R)- and (S)-vinclozolin. A fungicide used mainly on oilseed rape, vines, fruit and vegetables to control Botrytis, Sclerotinia and Monilia spp.
Chemical ID: MESH:C025643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgraffects expressionEXP 6480464CTDvinclozolin affects the expression of PGR mRNAPMID:23410115
Pgrdecreases expressionEXP 6480464CTDvinclozolin results in decreased expression of PGR mRNAPMID:23160963
Pgrincreases expressionEXP 6480464CTDvinclozolin results in increased expression of PGR mRNAPMID:29863768
Pgrmultiple interactionsEXP 6480464CTD[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PGR mRNA; [Genistein co-treated with vinclozolin] affects the expression of PGR mRNAPMID:23410115 PMID:25607892
Pgraffects bindingISOPGR (Homo sapiens)6480464CTDvinclozolin binds to PGR proteinPMID:14579009
Pgrincreases expressionISOPgr (Mus musculus)6480464CTDvinclozolin results in increased expression of PGR mRNAPMID:16504050
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTDvinclozolin binds to and results in decreased activity of PGR protein; vinclozolin inhibits the reaction [Progesterone binds to PGR protein]; vinclozolin inhibits the reaction [Progesterone results in increased expression of PGR protein]PMID:14579009 PMID:16750840 PMID:18262749
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